Active ingredient depot

Dr. Hanna Hartmann
Head of Biomedicine & Material Sciences
Dr. Xin Xiong
Group Leader Biofunctionalized Surfaces

Local application of e.g. anti-inflammatory and immunomodulatory drugs may be superior to systemic administration in terms of efficacy and side effects.

A depot formulation with modulated release kinetics may allow a reduction of the systemic injection frequency of subcutaneous formulations and thus help to increase patient compliance.

At the NMI, active ingredients are incorporated into coatings, capsules, foams, or hydrogels, for example, to intelligently achieve controlled and on-demand release.

A few of our focus areas:

  • Active ingredient immobilization (coatings, micro- & nano-capsules, nanoplexes, liposomes)
  • Drug release under simulated physiological conditions and characterization according to applicable standards such as DIN EN ISO 10993, USP
  • Drug uptake in cells and evaluation of cell- / immunobiological reactions


  • InGel-NxG- Next generation injectable adaptive hydrogels
  • OtoPep- Peptide nanomatrix as a carrier for siRNA for the treatment of diseases of the central and sensory nervous system
  • Nano4Neuro- Nano-Functionalised Implants for the Regenerative Treatment of Spinal Cord and Nerve Lesions
  • RNA-Stent- RNA stent coated coronary stents to prevent restenosis
  • Enzcaps
  • 6D-BioBone- Multidimensional biomimetic scaffold for dental bone regeneration
  • OKEM - Patient-specific on-site functionalization of bone graft substitutes with long-term antibiotic activity