Sequence Variant Analysis

Dr. Anne Zeck
Group Leader Bioanalytics

+49 7121 51530-811

E-Mail

anzeigen

Identifying and quantifying errors in protein biosynthesis

The presence of sequence variants (SV) contribute to the heterogeneity of recombinant biotherapeutics. Determining the SV profile is essential to demonstrate the correct primary structure, consistent quality of biotechnological manufacturing process, and the stability of the production cell line. We offer to support your biotherapeutic development by the determination, localization and relative quantification of sequence variants.

Our services

• Identification, localization and relative quantification of sequence variants

Methods

• Peptide Mapping
• LC
• MS
• HCD-MS/MS

Publications

• Zeck A. et al. Low level sequence variant analysis of recombinant proteins: an optimized approach. PLoS One. 2012;7(7):e40328. doi: 10.1371/journal.pone.0040328. Epub 2012 Jul 6. PMID: 22792284; PMCID: PMC3391300.