Dr. Peter D. Jones
Group Leader Biomedical Micro and Nano Engineering

+49 7121 51530-800

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Advanced solutions for organoid, spheroid and tissue models

Our mesh microelectrode arrays (mesh MEAs) are optimal tools for researchers studying electrophysiology of 3D neural and cardiac tissue models. Designed for non-invasive, long-term electrophysiology, our mesh MEAs integrate within spheroids and organoids, for straightforward recording and stimulation inside the tissue.

Benefits of mesh MEAs

• 3D Compatibility: The mesh structure gently suspends organoids away from any rigid surfaces. The hammock-like mesh initially supports the organoid, and over time the cells grow through and around the mesh, resulting in electrodes embedded within the tissue. In contrast, traditional planar MEAs contact only superficial cells, restrict nutrient and gas exchange, and disturb the 3D organoid shape.
• Long-Term Viability: Designed for months-long culture, our devices enable longitudinal studies of electrical activity or chronic exposure or disease models. Organoids can be transferred to the mesh MEA at any stage of development.
• Scalable & Easy to Use: We produce mesh MEAs using state-of-the-art microfabrication methods designed for efficient production with high yield. Our MEAs are designed for use with commercial amplifiers and fluidic handling systems.
• High-Resolution Data Acquisition: Our low-impedance microelectrodes are optimized for low-noise recordings, capturing spontaneous and evoked activity with precision.

Applications

• Functional characterization of brain organoids and neural spheroids
• Electrophysiological studies in cardiac spheroids and engineered heart tissues
• Pharmacological screening and toxicology testing in 3D cellular models
• Development of personalized medicine and disease modeling platforms

Custom devices, electrophysiology services & collaborations

We provide tailored solutions to match your research needs. Whether you need modifications in electrode density, device architecture, or integration with your experimental setup, we can deliver customized MEAs that meet your requirements.

Or do you want to investigate electrical activity in your model, and don’t know where to start? We can advise you on the best methods for your question, and support you with MEA recordings, calcium imaging and patch clamp electrophysiology.

Get in Touch

Ready to enhance your 3D electrophysiology research? Contact us to learn more about our services or discuss collaboration opportunities.