MEA (microelectrode array) offers extracellular recording with optional optical or electrical stimulation. It is performed on electrogenic tissue on the top of substrate integrated electrodes.
MEA shows certain benefits over other methods in electrophysiology:
MEA recordings can be performed using different models such as neurons, cardiomyocytes, brain/cardiac slices, iPSC-derived neurons/cardiomyocytes etc.
Different MEA systems are available depending on the application (high number of electrodes e.g. for neuronal applications, high-throughput systems (96-well format), 96-channel pipettor for parallelized substance application).