HTS Calcium Imaging

Dr. Udo Kraushaar
Group Leader Electrophysiology

+49 7121 51530-851

E-Mail

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Live-cell Ca²⁺  imaging with high spatio-temporal resolution or in HTS format (96/384-well)

Unlock unparalleled insights into the intricate cellular dynamics of neurons and cardiomyocytes with our cutting-edge calcium imaging services!

We are thrilled to offer a comprehensive suite of advanced tools and techniques to investigate neuro- and cardiotoxicity, as well as in vitro safety pharmacology.

Our services

• Safety profiling (effects of seizures on neurons, arrhythmia on cardiac cells)
• Compound MoA
• Intracellular Ca²⁺ handling
• Subcellular Ca²⁺ handling

We use different models for studies that require live cell imaging approaches. Rat/mouse cortex, chicken cardiomyocytes, hiPSC-derived neurons with or without astrocytes, hiPSC-derived cardiomyocytes are a few we have to mention. In case such studies might help you with your scientific project, let us know.

Methods

• High spatial resolution (Zeiss)
• Confocal (Zeiss)
• Low cell numbers (Hamamatsu)
• High throughput (Hamamatsu; 96/384 well)
• Recording at physiological temperature 37°C
• High-speed parallelized recording (Hamamatsu; up to 120 Hz)

Instruments

• Hamamatsu FDSS/μCell (HTS)
• Zeis Cell Explorer (kilobeam confocal system)