Deciphering disease mechanisms and drug development for the central nervous system
Diseases of the nervous system are often very complex and cannot be clearly traced to a single cause. To understand the pathomechanisms behind these diseases, we aim to identify individual molecular mechanisms that interact with others in the development of brain diseases. Our focus is on mechanisms involved in the organization of synapses and the function of neuronal networks, as several CNS diseases are related to synaptic dysfunction, such as age-related, neurodegenerative diseases as well as anxiety disorders. Influences on synaptic organization at intact neuronal networks are studied in vivo and correlated in behavioral experiments in cooperation with external partners. Molecular pathomechanisms are investigated using primary neuronal cultures available for drug testing in vitro.