Cardiac Ion Channel Testing Service

Dr. Timm Danker
Group Leader Electrophysiology

+49 7121 51530-896

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Detect safety issues at the early stages of drug development

In line with the currently discussed expansion of cardiac safety assessment from hERG screening to a comprehensive assessment of ion channel effects, we offer a premium panel of CiPA-compliant cardiac ion channel assays. Our safety panel includes the key cardiac channels, providing a robust, cost-effective approach to cardiac safety testing.

Our services

Our Cardiac Ion Channel Panel services as well as our “Multiwell Cardiac Screen” Assay use human cardiomyocytes to allow a greater insight into potential cardiac risks, and allow for more effective decision making in early preclinical development.

• hERG                delayed rectifier potassium current (IKr)
• Cav1.2               L-type calcium current (ICa)
• Nav1.5               sodium current (INa)
• Kir2.1                 inward rectifier potassium current (IK1)
• KvLQT1/minK    delayed rectifier potassium current (IKs)
• Kv4.3                 transient outward potassium current (Ito)
• Kv1.5                 delayed rectifier potassium current (IKur)

Methods

• Manual Patch Clamp
• Automated Patch Clamp (Qpatch)

Instruments

• Sophion Qpatch 16X