Precision oncology presents practitioners with the challenge of adapting and interpreting clinical and imaging data, histological and molecular pathology results and genetic analyses to the individual

The search for neuroactive substances that can be used therapeutically is accompanied by a high rate of exclusion of drug candidates. The new test platform is intended to help reduce this exclusion ra

Identification of new target proteins for pancreatic carcinoma Early stages of pancreatic tumors often cause no symptoms, while later-stage symptoms are often nonspecific. Pancreatic cancer is therefo

ERA-Net Eurotransbio: Models for Alzheimer's and similar diseases, drug development based on the mitochondrial cascade hypothesis Mitochondria are the powerhouses of cells. Recent investigations sugge

Identifizierung von Biomarkern zur Vorhersage des Ansprechens und der Resistenz gegenüber VEGFR/mTOR-Inhibitoren beim Nierenkarzinom

Agents are tested using neurons derived from induced pluripotent stem cells in comparison to animal models. Neurons derived from induced pluripotent stem cells (iPSCs) can be used as a relevant, near-

In a new approach, genetic tools are used to introduce additional mitochondrial dysfunction into transgenic mice with pathogenic Alzheimer's disease proteins to model age-related metabolic deficits. I

Traumatic experiences and stress are major contributors to anxiety disorders. In this context, a specific brain region, the amygdala, plays an important role by modulating other brain regions, such as

Psychoses describe an extremely heterogeneous group of diseases. As a result, diagnoses, prognoses and treatment decisions for individual patients are challenging. Within the project, biomarker signat

High-throughput sequencing of all mRNA molecules from patient tissues is used for personalized, predictive diagnostics as well as drug testing in vitro. Since the brain is not readily accessible for t