Degradation and Remodeling of Implant Materials

Dr. Julia Marzi
Group Leader Biophotonics & Spectroscopy
Dr. Dagmar Martin
Group Leader Interface Analysis in the Production Process
Dr. Hanna Hartmann
Head of Biomedicine & Material Sciences
Group Leader Regenerative Biomaterials

Interaction between (tissue-engineered) implants and the recipient

Non-destructive imaging modalities can by employed for the in vitro and ex vivo characterization of the build-up and degradation processes at biological interfaces such as vital implants, as well as the:

  • Investigation of degradation mechanisms of biodegradable implant materials
  • Visualization and quantification of processes of tissue formation
  • Identification of foreign body reactions and fibrotic changes
  • Prediction of potential immune response by in situ phenotyping of immune cells (e.g. macrophages)

 

Evaluation

  • Optical documentation
  • Mass, molecular weight
  • Mechanical properties (based on ISO 25539), rheology
  • Release kinetics of active ingredients
  • Detection of degradation products (based on DIN EN ISO 10993-13 and -15)

Further services

  • Development of product-specific test plans according to relevant standards