Dr. Anne Zeck
Dr. Anne Zeck
Group Leader Bioanalytics
Dr. Anne Zeck
- 2011 - today
- Group Leader Bioanalytics at the NMI
- 2007 - 2011
- Group Head, Roche Diagnostics GmbH, Penzberg
- 2006 - 2007
- Postdoc at Roche Diagnostics GmbH, Penzberg
- 2002 - 2004
- Postdoc am Barnett-Institut für chemische und biologische Analyse
Northeastern-Universität, Boston, USA - 1998 - 2001
- Dr. rer. nat. in Analytical Chemistry, Technical University of Munich (TUM)
- 1992 - 1998
- Study of chemistry and Dipl. Chem. at TU Karlsruhe and TUM
After completing her doctorate at the Technical University in Munich in 2001, she worked as a postdoc in Boston from 2002 to 2004. From 2007 to 2011 she worked as a group leader at Roche Diagnostics GmbH in Penzberg. Since 2011 Anne Zeck is group leader of the Bioanalytics group at the NMI. Her research interests include mass spectrometry, biopharmaceutical products and bioanalytics.
Selected publications
- Lambert T, Gramlich M, Stutzke L, Smith L, Deng D, Kaiser P, Rothbauer U, Benesch J, Wagner C, Koenig M, Pompach P, Novak P, Zeck A, and Rand K*. Development of a PNGase Rc Column for Online Deglycosylation of Complex Glycoproteins during HDX-MS. Mass spectrometry 2023; 34 (11): 2556-2566. https://doi.org/10.1021/jasms.3c00268
- Gramlich M, Maier S. Kaiser P.D., Traenkle B., Wagner T.R., Voglmeir J., Stoll D., Rothbauer U. Zeck A. A Novel PNGase Rc for Improved Protein N-Deglycosylation in Bioanalytics and Hydrogen–Deuterium Exchange Coupled With Mass Spectrometry Epitope Mapping under Challenging Conditions. Anal. Chem. 2022, 94, 27, 9863–9871 https://doi.org/10.1021/acs.analchem.2c01748
- Kratzer U, Sommersdorf C, Maier S, Wagner TR, Templin M, Joos TO, Rothbauer U, Zeck A, Poetz O. Tris(hydroxymethyl)aminomethane Compatibility with N-Hydroxysuccinimide Ester Chemistry: Biotinylation of Peptides and Proteins in TRIS Buffer Bioconjug Chem. 2021 Sep 15;32(9):1960-1965. doi: http://dx.doi.org/10.1021/acs.bioconjchem.1c00283
- Prade E, Zeck A, Stiefel F, Unsoeld A, Mentrup D, Arango Gutierrez E, Gorr IH. Cysteine in cell culture media induces acidic IgG1 species by disrupting the disulfide bond network. Biotechnol Bioeng. 2021 Mar;118(3):1091-1104. doi: http://dx.doi.org/10.1002/bit.27628
- Gramlich M, Hays HCW, Crichton S, Kaiser PD, Heine A, Schneiderhan-Marra N, Rothbauer U, Stoll D, Maier S, Zeck A. HDX-MS for Epitope Characterization of a Therapeutic ANTIBODY Candidate on the Calcium-Binding Protein Annexin-A1. Antibodies. 2021 10(1) 6. DOI: 10.3390/antib10010011
- De Leoz MLA, Zeck A. et al. NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods. Mol Cell Proteomics. 2020 Jan;19(1):11-30. doi: 10.1074/mcp.RA119.001677
ORCID: 0000-0001-7330-1654
Selected Projects
NMI Natural and Medical Sciences Institute
at the University of Tübingen
Markwiesenstraße 55, 72770 Reutlingen
Tel.: +49 7121 51530-0
Mail: info@nmi.de
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