The manual patch clamp technique is the gold standard of electrophysiology and provides a powerful and versatile set of tools for stimulation, modulation, and recording of ion channel activity of membrane fragments and whole cells.
Automated patch clamp solutions are designed to meet the higher throughput requirements of patch clamp technology.
The patch-clamp technique is mostly used for studies on the effect of compounds on a single ion channel type. The manual patch-clamp technique is also used for biophysical characterization of ion channels. We refer to compound effect studies as: