March 2024

Authors: Sophia-Marie Hartmann, Johanna Heider, Richard Wüst2, Andreas J. Fallgatter, Hansjürgen Volkmer

Microglia-neuron interactions in schizophrenia


Multiple lines of evidence implicate increased neuroinflammation mediated by glial cells to play a key role in neurodevelopmental disorders such as schizophrenia. Microglia, which are the primary innate immune cells of the brain, are crucial for the refinement of the synaptic circuitry during early brain development by synaptic pruning and the regulation of synaptic plasticity during adulthood. Schizophrenia risk factors as genetics or environmental influences may further be linked to increased activat