November 2023

Authors: Andrea Villoria-González , Bettina Zierfuss , Patricia Parzer , Elisabeth Heuböck , Violetta Zujovic , Petra Waidhofer-Söllner , Markus Ponleitner , Paulus Rommer , Jens Göpfert , Sonja Forss-Petter , Johannes Berger and Isabelle Weinhofer

Efficacy of HDAC Inhibitors in Driving Peroxisomal β-Oxidation and Immune Responses in Human Macrophages: Implications for Neuroinflammatory Disorders

Elevated levels of saturated very long-chain fatty acids (VLCFAs) in cell membranes and secreted lipoparticles have been associated with neurotoxicity and, therefore, require tight regulation. Excessive VLCFAs are imported into peroxisomes for degradation by β-oxidation. Impaired VLCFA catabolism due to primary or secondary peroxisomal alterations is featured in neurodegenerative and neuroinflammatory disorders such as X-linked adrenoleukodystrophy and multiple sclerosis (MS).