March 2023

Authors: Matthew McDonald; David Sebinger; Lisa Brauns; Laura Gonzalez-Cano; Yotam Menuchin-Lasowski; Michael Mierzejewski; Olympia-Ekaterini Psathaki; Angelika Stumpf; Jenny Wickham; Thomas Rauen; Hans Schöler; Peter D. Jones

A mesh microelectrode array for non-invasive electrophysiology within neural organoids


Organoids are emerging in vitro models of human physiology. Neural models require the evaluation of functional activity of single cells and networks, which is commonly measured by microelectrode arrays. The characteristics of organoids clash with existing in vitro or in vivo microelectrode arrays. With inspiration from implantable mesh electronics and growth of organoids on polymer scaffolds, we fabricated suspended hammock-like mesh microelectrode arrays for neural organoids