Publications

June 2024

Authors: Jonas Haas; Nils Rieger; Michael Schlegel; Kevin Strobel; Jannik C. Meyer

Nanometer-scale electron beam shaping with thickness controlled and stacked nanostructured graphite

The generation of small electron probes is the basis for various techniques in which such a probe is scanned across a sample, and special probe shapes like vortices can be desirable, e.g., to gain insight into magnetic properties. 

DOI

June 2024

Authors: Kevin R. Strobel, Michael Schlegel, Mitisha Jain, Silvan Kretschmer, Arkady V. Krasheninnikov, Jannik C. Meyer

Temperature-dependence of beam-driven dynamics in graphene-fullerene sandwiches

 

C60 fullerenes encapsulated between graphene sheets were investigated by aberration-corrected high-resolution transmission electron microscopy at different temperatures, namely about 93 K, 293 K and 733 K, and by molecular dynamics simulations. We studied beam-induced dynamics of the C60 fullerenes and the encapsulating graphene, measured the critical doses for the initial damage to the fullerenes and followed the beam-induced polymerization. We find that, while the dose

DOI

May 2024

Authors: Umair Nisar, Joachim Bansmann, Marco Hebel, Benedikt Reichel, Marilena Mancini, Margret Wohlfahrt-Mehrens, Markus Hölzle, Peter Axmann

Borate modified Co-free LiNi0.5Mn1.5O4 cathode material: A pathway to superior interface and cycling stability in LNMO/graphite full-cells

Spherical high quality, industrial-relevant LNMO materials developed. LNMO/electrolyte interface stabilized with borate-based interphase layer. Borate-modified LNMO exhibits superior electrochemical performance. The primary aging mechanism stems from LNMO/electrolyte interface instability.

DOI

May 2024

Authors: Tengku Ibrahim Maulana, Claudia Teufel, Madalena Cipriano, Julia Roosz, Lisa Lazarevski, Francinja E. van den Hil, Lukas Scheller, Valeria Orlova, André Koch, Michael Hudecek, Miriam Alb, Peter Loskill

Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells

Physiologically relevant human models that recapitulate the challenges of solid tumors and the tumor microenvironment are highly desired in the chimeric antigen receptor (CAR)-T cell field. We developed a breast cancer-on-chip model with an integrated endothelial barrier that enables the transmigration of perfused immune cells, their infiltration into the tumor, and concomitant monitoring of cytokine release during perfused culture.

DOI

March 2024

Authors: Lu Fan, Ole Jung, Markus Herrmann, Marina Shirokikh, Sanja Stojanovic, Stevo Najman, Fabian Körte, Xin Xiong, Katja Schenke-Layland, Mike Barbeck

Deciphering UVA/Riboflavin Collagen Crosslinking: A Pathway to Improve Biomedical Materials

Collagen crosslinking employing ultraviolet A rays and riboflavin has emerged as a pivotal technique in clinical therapies, especially in ophthalmology since the 1990s. Despite its clinical adoption, the lack of clarity of the detailed mechanism and the imperative for a refined manufacturing process necessitates further investigation.

DOI

March 2024

Authors: Sophia-Marie Hartmann, Johanna Heider, Richard Wüst2, Andreas J. Fallgatter, Hansjürgen Volkmer

Microglia-neuron interactions in schizophrenia

 

Multiple lines of evidence implicate increased neuroinflammation mediated by glial cells to play a key role in neurodevelopmental disorders such as schizophrenia. Microglia, which are the primary innate immune cells of the brain, are crucial for the refinement of the synaptic circuitry during early brain development by synaptic pruning and the regulation of synaptic plasticity during adulthood. Schizophrenia risk factors as genetics or environmental influences may further be linked to increased activat

DOI

March 2024

Authors: Johanna Heider, Aaron Stahl, Denise Sperlich, Sophia-Marie Hartmann, Sabrina Vogel, Ricarda Breitmeyer, Markus Templin & Hansjürgen Volkmer

Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons

 

 

Mutations in the gene DISC1 are associated with increased risk for schizophrenia, bipolar disorder and major depression. The study of mutated DISC1 represents a well-known and comprehensively characterized approach to understand neuropsychiatric disease mechanisms. However, previous studies have mainly used animal models or rather heterogeneous populations of iPSC-derived neurons, generated by undirected differentiation, to study the effects of DISC1 disruption. Since major hypothe

DOI

February 2024

Authors: Peter Jones, Beatriz Molina-Martinez, Anita Niedworok, Paolo Cesare

A microphysiological system for parallelized morphological and electrophysiological read-out of 3D neuronal cell culture

Three-dimensional in vitro models in microfluidic systems are promising tools for studying cell biology, with complex models using multiple cell types combined with high resolution imaging. Neuronal models demand electrical readout of the activity of networks of single neurons, yet classical planar microelectrode arrays struggle to capture extracellular action potentials when neural soma are suspended distant from the microelectrodes.

DOI

November 2023

Authors: Andrea Villoria-González , Bettina Zierfuss , Patricia Parzer , Elisabeth Heuböck , Violetta Zujovic , Petra Waidhofer-Söllner , Markus Ponleitner , Paulus Rommer , Jens Göpfert , Sonja Forss-Petter , Johannes Berger and Isabelle Weinhofer

Efficacy of HDAC Inhibitors in Driving Peroxisomal β-Oxidation and Immune Responses in Human Macrophages: Implications for Neuroinflammatory Disorders

Elevated levels of saturated very long-chain fatty acids (VLCFAs) in cell membranes and secreted lipoparticles have been associated with neurotoxicity and, therefore, require tight regulation. Excessive VLCFAs are imported into peroxisomes for degradation by β-oxidation. Impaired VLCFA catabolism due to primary or secondary peroxisomal alterations is featured in neurodegenerative and neuroinflammatory disorders such as X-linked adrenoleukodystrophy and multiple sclerosis (MS).

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