Publications

January 2025

Authors: Blum, J., Brüll, M., Hengstler, J. G., Dietrich, D. R., Gruber, A. J., Dipalo, M., Leist, M. Kraushaar, U.

The long way from raw data to NAM-based information: Overview on data layers and processing steps

Toxicological test methods generate raw data and provide instructions on how to use these to determine a final outcome such as a classification of test compounds as hits or non-hits.

DOI

December 2024

Authors: Nicole Vasilenko, Maria P. Tieck, Tanja Michel, Sonja Schembecker, Patricia Schwarz, Anna Guenther, Christoph Ruschil, Sven Poli, Ulf Ziemann, Antje Giede-Jeppe, Gisela Gabernet, Alex Dulovic, Markus C. Kowarik

In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis

The MS-specific, differential antibody response to EBV antigens confirms an altered immunological response to EBV in MS patients.

DOI

December 2024

Authors: Annabelle Neuhäusler, Katharina Rogg, Sebastian Schröder, Dieter Spiehl, Haris Zora, Elsa Arefaine, Julia Schettler, Hanna Hartmann, Andreas Blaeser

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel.

DOI

December 2024

Authors: Laubach, M., Hartmann, H., Holzapfel, B. M., Mayer-Wagner, S., Schenke-Layland, K., & Hutmacher, D. W.

3-D-Druck in der Chirurgie: Relevanz der Bewertung der Technologiereife in Forschungsstudien zum Bioprinting

Biological 3D printing (bioprinting) is an extension of what is defined as additive manufacturing in the American Society for Testing and Materials (ASTM) and International Organization for Standardization (ISO) standards and is based on the automated printing of living cells and biomaterials.

DOI

November 2024

Authors: Manuela Harries, Carolina J. Klett-Tammen, Isti Rodiah, Alex Dulovic, Veronika K Jaeger, Jessica Krepel, Sebastian Contreras, Katrin Maak, Patrick Marsall, Annette Möller, Jana-Kristin Heise, Stefanie Castell, Nicole Schneiderhan-Marra, André Karch, Berit Lange

Novel multiplex tools in an epidemic panel improve prediction of RSV infection dynamics and disease burden – a RESPINOW analysis

Respiratory Syncytial Virus (RSV) is one of the leading causes of morbidity and mortality among infants and adult risk groups worldwide. Substantial case-underdetection and gaps in the understanding of reinfection dynamics of RSV limit reliable projection estimates.

DOI

October 2024

Authors: Aaron Stahl, Johanna Heider, Richard Wüst, Andreas J. Fallgatter, Katja Schenke-Layland, Hansjürgen Volkmer, Markus Templin

Patient iPSC-derived neural progenitor cells display aberrant cell cycle control, p53, and DNA damage response protein expression in schizophrenia

SCZ neural progenitors displayed altered expression and phosphorylation patterns related to Wnt and MAPK signaling, protein synthesis, cell cycle regulation and DNA damage response.

DOI

October 2024

Authors: Simon Woelfel, Joel Dütschler, Daniel Junker, Marius König, Nicole Graf, Claudia Krieger, Samuel Truniger, Vasileios Oikonomou, Georg Leinenkugel, Seraina Koller, Katline Metzger-Peter, Jacqueline Wyss, Niklas Krupka, Nicola Frei, STAR SIGN Study Investigators, Werner C. Albrich, Matthias Friedrich, Jan Hendrik Niess, Nicole Schneiderhan-Marra, Alex Dulovic, Benjamin Misselwitz, Wolfgang Korte, Justus J. Bürgi, Stephan Brand

XBB.1.5-Adapted COVID-19 mRNA Vaccines but Not Infections With Previous Omicron Variants Boost Neutralisation Against the SARS-CoV-2 JN.1 Variant in Patients With Inflammatory Bowel Disease

Variant-adapted COVID-19 vaccines are recommended for patients with inflammatory bowel disease (IBD). However, many patients rely on pre-existing immunity by original vaccines or prior infections.

DOI

October 2024

Authors: Max Urbanczyk, Athar Abuhelou, Marie Köninger, Abiramy Jeyagaran, Daniel Carvajal-Berrio, Ellie Kim, Julia Marzi, Peter Loskill, Shannon L. Layland, and Katja Schenke-Layland

Heterogeneity of Endothelial Cells Impacts the Functionality of Human Pancreatic In Vitro Models

Endothelial cells form the inner lining of our vascular system facilitating the supply of oxygen and nutrients to and removal of waste from surrounding tissues. In this work, we investigate the differences between ECs from various tissues regarding their biochemical composition, angiogenic potential, adaptation to flow, and coculture properties in vitro in the context of diabetes research.

DOI

October 2024

Authors: Rinki Saha, Lisa-Sophie Wüstner, Darpan Chakraborty, Rachel Anunu, Silvia Mandel, Joyeeta Dutta Hazra, Martin Kriebel, Hansjuergen Volkmer, Hanoch Kaphzan, Gal Richter-Levin

Intra-BLA alteration of interneurons’ modulation of activity in rats, reveals a dissociation between effects on anxiety symptoms and extinction learning

The researchers have succeeded in demonstrating the influence of a brain region responsible for emotions, the amygdala, on the manifestation of anxiety symptoms by specifically altering the communication between nerve cells.

DOI