Prädiktive Diagnostik

Numerous diseases of great economic and social importance are based on a malfunction of the immune system. The diversity of diseases and individual immune responses require innovative diagnostic methods for improved individual health care. The project involves patient samples from different indications. Microsystem technology, highly sensitive protein diagnostics, molecular imaging and cellular model systems are integrated for the development of innovative, diagnostic tools for personalized medicine.

The NMI contributes to this project with highly sensitive protein analytics (Luminex, Simoa) to detect inflammatory factors in serum and cerebrospinal fluid (CSF). Patient-derived brain organoids will be used to compare inflammatory processes with serological/CSF data and build a new drug testing platform. Finally, nanobodies will be developed to image inflammatory processes in patients using imaging techniques.