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Publikationen

Oktober 2025

Autoren: Alex Siebner, Johanna Griesbaum et al.

Class switch toward IgG2 and IgG4 is more pronounced in BNT162b2 compared to mRNA-1273 COVID-19 vaccinees

Vaccination against SARS-CoV-2 induces antibodies that reduce the risk of severe disease.

DOI

Juli 2025

Autoren: Guilin Wang, Martin Weiss et al.

Non-invasive physical plasma activates stimulator of interferon genes pathway in triple negative breast cancer and is associated with increased host immune response

Triple-negative breast cancer (TNBC), characterized by the absence of ER, PR, and HER2 receptors, remains one of the most aggressive breast cancer subtypes, with limited therapeutic options and a high relapse rate. While immune checkpoint inhibitors (ICIs) have shown promise by leveraging TNBC’s immunogenic profile, their use is often accompanied by significant toxicity, necessitating the development of safer immunomodulatory strategies. 

DOI

Juli 2025

Autoren: Alex Dulovic et al.

Longitudinal analysis of humoral and cellular immunity in SARS-CoV-2 exposed families

Identification of previous SARS-CoV-2 infection typically relies on serology, yet T-cells play a key role in the adaptive immune response against SARS-CoV-2. 

DOI

Juli 2025

Autoren: Markus Laubach, Hanna Hartmann et al.

Clinical translation of 3D-printed patient-specific bone implants: a consensus statement

Extensive defects in long bones, resulting from trauma, disease, or other etiologies, impose significant morbidity on patients and may necessitate amputation, long-term disability, or premature mortality. 

DOI

Juli 2025

Autoren: Simon Woelfel, Nicole Schneiderhan-Marra, Alex Dulovic et al.

XBB.1.5 COVID-19 mRNA Vaccines Induce Inadequate Mucosal Immunity in Patients with Inflammatory Bowel Disease

Mucosal immunity plays a pivotal role in preventing infections with SARS-CoV-2. While COVID-19 mRNA vaccines induce robust systemic immune responses in patients with inflammatory bowel disease (IBD), little is known about their efficacy in the mucosal immune compartment.

DOI

Juni 2025

Autoren: Stefania Pezzana, Simone Blaess, Bjoern Traenkle et al.

PET-based immunomapping of intratumoral CD4+ cells to monitor acquired resistance to checkpoint inhibitors

CD4+ T cells are crucial in shaping response and resistance to immunotherapy. To enhance our understanding of their multifaceted functions, we developed copper-64–radiolabeled nanobodies targeting the human CD4 receptor (64Cu-CD4-Nb1) for positron emission tomography (PET). In human CD4-receptor knock-in mice, 64Cu-CD4-Nb1 specifically accumulated in different orthotopic tumors, correlating with histological CD4+ cell densities. 

DOI