Publikationen

Animal studies and clinical trials suggest that maintenance of gammaaminobutyric acid (GABA)-ergic activity may be crucial in coping with stressful conditions, anxiety and mood disorders. Drugs highly efficient in promoting anxiolysis were shown to activate this system, particularly via the α2-subunit of type A receptors (GABAA α2).

Recently updated COVID-19 mRNA vaccines encode the spike protein of the omicron subvariant XBB.1.5 and are recommended for patients with inflammatory bowel disease (IBD) on immunosuppressive treatment. Nonetheless, their immunogenicity in patients with IBD against rapidly expanding virus variants remains unknown.

The generation of small electron probes is the basis for various techniques in which such a probe is scanned across a sample, and special probe shapes like vortices can be desirable, e.g., to gain insight into magnetic properties. 

C₆₀ fullerenes encapsulated between graphene sheets were investigated by aberration-corrected high-resolution transmission electron microscopy at different temperatures, namely about 93 K, 293 K and 733 K, and by molecular dynamics simulations. We studied beam-induced dynamics of the C₆₀ fullerenes and the encapsulating graphene, measured the critical doses for the initial damage to the fullerenes and followed the beam-induced polymerization. We find that, while the dose<!

Spherical high quality, industrial-relevant LNMO materials developed. LNMO/electrolyte interface stabilized with borate-based interphase layer. Borate-modified LNMO exhibits superior electrochemical performance. The primary aging mechanism stems from LNMO/electrolyte interface instability.

Physiologically relevant human models that recapitulate the challenges of solid tumors and the tumor microenvironment are highly desired in the chimeric antigen receptor (CAR)-T cell field. We developed a breast cancer-on-chip model with an integrated endothelial barrier that enables the transmigration of perfused immune cells, their infiltration into the tumor, and concomitant monitoring of cytokine release during perfused culture.

Die Kollagenvernetzung mit ultravioletten A-Strahlen und Riboflavin hat sich seit den 1990er Jahren zu einem zentralen Verfahren in der klinischen Therapie, insbesondere in der Augenheilkunde, entwickelt. Trotz der klinischen Anwendung sind weitere Untersuchungen erforderlich, da der genaue Mechanismus nicht klar ist und ein verfeinertes Herstellungsverfahren erforderlich ist.

Multiple lines of evidence implicate increased neuroinflammation mediated by glial cells to play a key role in neurodevelopmental disorders such as schizophrenia. Microglia, which are the primary innate immune cells of the brain, are crucial for the refinement of the synaptic circuitry during early brain development by synaptic pruning and the regulation of synaptic plasticity during adulthood. Schizophrenia risk factors as genetics or environmental influences may further be linked to increased activatio