Publikationen

Toxicological test methods generate raw data and provide instructions on how to use these to determine a final outcome such as a classification of test compounds as hits or non-hits.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel.

Biologische 3‑D-Druckverfahren (sog. Bioprinting) sind eine Erweiterung dessen, was in den American Society for Testing and Materials(ASTM)- und International Organization for Standardization(ISO)-Normen als additive Fertigung definiert ist, und basieren auf dem automatisierten Druck von lebenden Zellen und Biomaterialien.

SCZ neural progenitors displayed altered expression and phosphorylation patterns related to Wnt and MAPK signaling, protein synthesis, cell cycle regulation and DNA damage response.

Endothelial cells form the inner lining of our vascular system facilitating the supply of oxygen and nutrients to and removal of waste from surrounding tissues. In this work, we investigate the differences between ECs from various tissues regarding their biochemical composition, angiogenic potential, adaptation to flow, and coculture properties in vitro in the context of diabetes research.

Den Forschenden ist es gelungen, durch gezielte Veränderung der Kommunikation zwischen Nervenzellen den Einfluss einer für Emotionen verantwortlichen Hirnregion, des Mandelkerns (Amygdala), auf die Manifestation von Angstsymptomen nachzuweisen.

Traditional genomic profiling and mutation analysis of single cells like Circulating Tumor Cells (CTCs) fails to capture post-translational and functional alterations of proteins, often leading to limited treatment efficacy.

Animal studies and clinical trials suggest that maintenance of gammaaminobutyric acid (GABA)-ergic activity may be crucial in coping with stressful conditions, anxiety and mood disorders. Drugs highly efficient in promoting anxiolysis were shown to activate this system, particularly via the α2-subunit of type A receptors (GABAA α2).

Cardiac hypertrophy is characterized by remodeling of the myocardium, which involves alterations in the ECM (extracellular matrix) and cardiomyocyte structure. These alterations critically contribute to impaired contractility and relaxation, ultimately leading to heart failure.