Publikationen

Intra-amygdala metaplasticity modulation of fear extinction learning

Saha R., Kriebel M., Anunu R., Volkmer H., Richter-Levin G.

DOI: 10.1111/ejn.15080

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A Molecularly Characterized Preclinical Platform of Subcutaneous Renal Cell Carcinoma (RCC) Patient-Derived Xenograft Models to Evaluate Novel Treatment Strategies

Gürgen, D., Becker, M., Dahlmann, M., Flechsig, S., Schäffeler, E., Büttner, F., Schmees, C., Bohnert, R., Bedke, J., Schwab, M., Wendler, J., Schostak, M., Jandrig, B., Walther, W., Hoffmann, J.

https://doi.org/10.3389/fonc.2022.889789

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A Platform of Patient-Derived Microtumors Identifies Individual Treatment Responses and Therapeutic Vulnerabilities in Ovarian Cancer

Anderle, N., Koch, A., Gierke, B., Keller, A. L., Staebler, A., Hartkopf, A., Brucker, S. Y., Pawlak, M., Schenke-Layland, K., & Schmees, C.

Cancers, 14(12), 2895. https://doi.org/10.3390/cancers14122895

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The interaction between anti-PF4 antibodies and anticoagulants in vaccine-induced thrombotic thrombocytopenia

Singh, A., Toma, F., Uzun, G., Wagner, T., Pelzl, L., Zlamal, J., Freytag, V., Weich, K., Nowak-Hamau, S., Rothbauer, U., Althaus, K., Bakchoul, T.

https://doi.org/10.1182/blood.2021013839

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Cell Type-Specific Anti-Adhesion Properties of Peritoneal Cell Treatment with Plasma-Activated Media (PAM)

Holl, M., Rasch, M., Becker, L., Keller, A., Schultze-Rhonhof, L., Ruoff, F., Templin, M., Keller, S., Neis, F., Keßler, F., Andress, J., Bachmann, C., Krämer, B., Schenke-Layland, K., Brucker, S., Marzi, J., Weiss, M.

10.3390/biomedicines10040927

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Noninvasive Physical Plasma as Innovative and Tissue-Preserving Therapy for Women Positive for Cervical Intraepithelial Neoplasia

Marzi, J., Stope, M., Henes, M., Koch, A., Wenzel, T., Holl, M., Layland, S., Neis, F., Bösmüller, H., Ruoff, F., Templin, M., Krämer, B., Stäbler, A., Barz, J., Berrio, D., Enderle, M., Loskill, P., Brucker, S., Schenke-Layland, K., Weiss, M.

10.3390/cancers14081933

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Neurofilament proteins as a potential biomarker in chemotherapy-induced polyneuropathy

Huehnchen, P., Schinke, C., Bangemann, N., Dordevic, A., Kern, J., Maierhof, S., Hew, L., Nolte, L., Körtvelyessy, P., Göpfert, J., Ruprecht, K., Somps, C., Blohmer, J., Sehouli, J., Endres, M., Boehmerle, W.

https://doi.org/10.1172/jci.insight.154395.

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Disruption of Amygdala Tsc2 in Adolescence Leads to Changed Prelimbic Cellular Activity and Generalized Fear Responses at Adulthood in Rats

Joly F, Jeckel P, Kriebel M, Raut S, El Massioui N, Vaillend C, Johnson LR, Volkmer H, Doyère V.

Cereb Cortex. 2022 Feb 12:bhab506. doi: 10.1093/cercor/bhab506. Epub ahead of print. PMID: 35149865.

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Single-Domain Antibodies for Targeting, Detection, and In Vivo Imaging of Human CD4+ Cells

Traenkle B, Kaiser PD, Pezzana S, Richardson J, Gramlich M, Wagner TR, Seyfried D, Weldle M, Holz S, Parfyonova Y, Nueske S, Scholz AM, Zeck A, Jakobi M, Schneiderhan-Marra N, Schaller M, Maurer A, Gouttefangeas C, Kneilling M, Pichler BJ, Sonanini D, Rothbauer U

Front Immunol. 2021 Dec 9;12:799910. doi: 10.3389/fimmu.2021.799910. PMID: 34956237; PMCID: PMC8696186.

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Targeted Protein Profiling of In Vivo NIPP-Treated Tissues Using DigiWest Technology

Ruoff, F.; Henes, M.; Templin, M.; Enderle, M.; Bösmüller, H.; Wallwiener, D.; Brucker, S.Y.; Schenke-Layland, K.; Weiss, M.

Appl. Sci. 2021, 11, 11238. https://doi.org/10.3390/app112311238

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Comparative transcriptional analysis of the satellite glial cell injury response

Elgaard Jager S, Pallesen L T, Lin L, Izzi F, Pinheiro A, Villa-Hernandez S, Cesare P, Bjerggaard Vaegter C, Denk F

doi: https://doi.org/10.1101/2021.11.22.469443

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Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems

Schneider S, Bubeck M, Rogal J, Weener HJ, Rojas C, Weiss M, Heymann M, van der Meer AD, Loskill P

Lab Chip. 2021 Oct 12;21(20):3963-3978. doi: 10.1039/d1lc00494h. PMID: 34636813.

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Serum IFNα2 measured by single-molecule array associates with systemic disease manifestations in Sjögren's syndrome

Huijser E, Göpfert J, Brkic Z, van Helden-Meeuwsen CG, Jansen S, Mandl T, Olsson P, Schrijver B, Schreurs MWJ, van Daele PLA, Dik WA, Versnel MA

Rheumatology (Oxford). 2021 Sep 10:keab688. doi: 10.1093/rheumatology/keab688. Epub ahead of print. PMID: 34505866.

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Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M.

Arch Toxicol. 2021 Oct 10. doi: 10.1007/s00204-021-03168-z. Epub ahead of print. PMID: 34628512.

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Characterization of hepatic zonation in mice by mass-spectrometric and antibody-based proteomics approaches

Kling S, Lang B, Hammer HS, Naboulsi W, Sprenger H, Frenzel F, Pötz O, Schwarz M, Braeuning A, Templin MF

Biol Chem. 2021 Oct 4. doi: 10.1515/hsz-2021-0314. Epub ahead of print. PMID: 34599868.

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Human iPSC-Derived Glia as a Tool for Neuropsychiatric Research and Drug Development

Heider J, Vogel S, Volkmer H and Breitmeyer R

Int. J. Mol. Sci. 2021

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Nanobodies - Little helpers unravelling intracellular signaling

Wagner TR, Rothbauer U

Free Radic Biol Med. 2021 Nov 20;176:46-61. doi: 10.1016/j.freeradbiomed.2021.09.005. Epub 2021 Sep 15. PMID: 34536541.

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Challenging the pipeline

Loskill P, Hardwick R N, Roth A

Stem Cell Reports Volume 16, Issue 9, 14 September 2021, Pages 2033-2037

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Staphylococcus aureus Depends on Eap Proteins for Preventing Degradation of Its Phenol-Soluble Modulin Toxins by Neutrophil Serine Proteases

Kretschmer D, Breitmeyer R, Gekeler C, Lebtig M, Schlatterer K, Nega M, Stahl M, Stapels D, Rooijakkers S, Peschel A

Front Immunol. 2021 Sep 6;12:701093. doi: 10.3389/fimmu.2021.701093. PMID: 34552584; PMCID: PMC8451722.

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Reduced serum neutralization capacity against SARS-CoV-2 variants in a multiplex ACE2 RBD competition assay

Junker D, Dulovic A, Becker M, Wagner T R, Kaiser P D, Traenkle B, Rothbauer U, Kienzle K, Bunk S, Strümper C, Häberle H, Schmauder K, Malek N, Althaus K, Koeppen M, Bitzer M, Göpel S, Schneiderhan-Marra N

medRxiv, https://doi.org/10.1101/2021.08.20.21262328

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Diminishing immune responses against variants of concern in dialysis patients four months after SARS-CoV-2 mRNA vaccination

Dulovic A, Strengert M, Morillas Ramos G, Becker M, Griesbaum J, Junker D, Lürken K, Beigel A, Wrenger E, Lonnemann G, Cossmann A, Stankov M, Dopfer-Jablonka A, Kaiser P, Traenkle B, Rothbauer U, Krause G, Schneiderhan-Marra N, Behrens G M.N.

medRxiv, https://doi.org/10.1101/2021.08.16.21262115

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A broadly neutralizing biparatopic Nanobody protects mice from lethal challenge with SARS-CoV-2 variants of concern

Wagner T, Schnepf D, Beer J, Klingel K, Ruetalo N, Kaiser P, Junker D, Sauter M, raenkle B, Frecot D, Becker M, Schneiderhan-Marra N, Ohnemus A, Schwemmle M, Schindler M, Rothbauer U

bioRxiv, doi: https://doi.org/10.1101/2021.08.08.455562

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Advancement of precision oncology by integration of highly sensitive protein profiling technologies and patient-derived cell models for functional efficacy testing

Pawlak, M., Templin, M., & Schmees, C.

Immuno-Oncology Insights, 2(4), 171–185. https://doi.org/10.18609/ioi.2021.013

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Cellular and humoral immunogenicity of a SARS-CoV-2 mRNA vaccine in patients on haemodialysis

Strengert M, Becker M, Morillas Ramos G, Dulovic A, Gruber J, Juengling J, Lürken K, Beigel A, Wrenger E, Lonnemann G, Cossmann A, Stankov M, Dopfer-Jablonka A, Kaiser P, Traenkle B, Rothbauer U, Krause G, Schneiderhan-Marra N, Behrens G M.N.

Lancet EBioMedicine, Published: August 11, 2021DOI:https://doi.org/10.1016/j.ebiom.2021.103524

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Collagen and Endothelial Cell Coculture Improves β-Cell Functionality and Rescues Pancreatic Extracellular Matrix

Zbinden A, Urbanczyk M, Layland SL, Becker L, Marzi J, Bosch M, Loskill P, Duffy GP, Schenke-Layland K

Tissue Eng Part A. 2021 Jul;27(13-14):977-991. doi: 10.1089/ten.TEA.2020.0250. Epub 2020 Nov 6. PMID: 33023407.

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Typically asymptomatic but with robust antibody formation: Children’s unique humoral immune response to SARS-CoV-2.

Renk H, Dulovic A, Becker M, Fabricius D, Zernickel M, Junker D, Seidel A, Groß R, Hilger A, Bode S, Fritsch L, Frieh P, Haddad A, Görne T, Remppis J, Ganzemueller T, Dietz A, Huzly D, Hengel H, Kaier K, Weber S, Jacobsen EM, Kaise P, Traenkle B, Rothbauer U, Stich M, Tönshoff B, Hoffmann H, Müller B, Ludwig C, Jahrsdörfer B, Schrezenmeier H, Peter A, Hörber S, Iftner T, Münch J, Stamminger T, Groß HJ, Wolkewitz M, Engel C, Rizzi M, Henneke P, Franz AR, Debatin KM, Schneiderhan-Marra N, Janda A, Elling R

medRxiv, doi: https://doi.org/10.1101/2021.07.20.21260863

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Beyond PDMS and Membranes: New Materials for Organ-on-a-Chip Devices

Radisic M and Loskill P

Publication Date: July 12, 2021 https://doi.org/10.1021/acsbiomaterials.1c00831

Zur Publikation

Generation and characterization of the human induced pluripotent stem cell line NMIi010-A from peripheral blood mononuclear cells of a healthy 49–year old male individual

Keller AK, Binner A, Breitmeyer R, Vogel S, Anderle N, Rothbauer U, Schenke-Layland K, Schmees C

Stem Cell Research Volume 54, July 2021, 102427, https://doi.org/10.1016/j.scr.2021.102427

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A purification platform for antibodies and derived fragments using a de novo designed affinity adsorbent

M.J.B. Matos, F. Trovão, J. Gonçalves, U. Rothbauer, M.G. Freire, A.M.J.B. Barbosa, A.S. Pina, A.C.A. Roque

https://doi.org/10.1016/j.seppur.2021.118476

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Generation and characterization of the human induced pluripotent stem cell line NMIi010-A from peripheral blood mononuclear cells of a healthy 49–year old male individual

Keller AL, Binner A, Breitmeyer R, Vogel S, Anderle N, Rothbauer U, Schenke-Layland K, Schmees C

tem Cell Res. 2021 Jul;54:102427. doi: 10.1016/j.scr.2021.102427. Epub 2021 Jun 11. PMID: 34139596.

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Immune response to SARS-CoV-2 variants of concern in vaccinated individuals

Becker M, Dulovic A, Junker D, Ruetalo N, PKaiser PD, Pinilla YT, Heinzel C, Haering J, Traenkle B, Wagner TR, Layer M, Mehrlaender M, Mirakaj V, Held J, Planatscher H, Schenke-Layland K, Krause G, Strengert M, Bakchoul T, Althaus K, Fendel R, Kreidenweiss A, Koeppen M, Rothbauer U, Schindler M & Schneiderhan-Marra N

NATURE COMMUNICATIONS| (2021) 12:3109 | https://doi.org/10.1038/s41467-021-23473-6 | www.nature.com/naturecommunications11234567890():,;

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Autism Spectrum Disorder Risk Factor Met Regulates the Organization of Inhibitory Synapses

Jeckel P, Kriebel M, Volkmer H

Front. Mol. Neurosci., 13 May 2021 | https://doi.org/10.3389/fnmol.2021.659856

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Targeting CSF1R Alone or in Combination with PD1 in Experimental Glioma

Przystal JM, Becker H, Canjuga C, Tsiami F, Anderle N, Keller A, Pohl A, Ries CH, Schmittnaegel M, Korinetska N, Koch M, Schittenhelm J, Tatagiba M, Schmees C, Beck SC, Tabatabai G

Cancers 2021, 13(10), 2400; https://doi.org/10.3390/cancers13102400

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NeutrobodyPlex - monitoring SARS-CoV-2 neutralizing immune responses using nanobodies

Wagner TR, Ostertag E, Kaiser PD, Gramlich M, Ruetalo N, Junker D, Haering J, Traenkle B, Becker M, Dulovic A, Schweizer H, Nueske S, Scholz A, Zeck A, Schenke-Layland K, Nelde A, Strengert M, Walz JS, Zocher G, Stehle T, Schindler M, Schneiderhan-Marra N, Rothbauer U

EMBO Rep. 2021 May 5;22(5):e52325. doi: 10.15252/embr.202052325. Epub 2021 Apr 27. PMID: 33904225; PMCID: PMC8097376.

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A multimodal 3D neuro-microphysiological system with neurite-trapping microelectrodes

Molina-Martínez B, Jentsch LV, Ersoy F, van der Moolen M, Donato S, V. Ness T, Heutink P, Jones P, Cesare P

published in Biofabrication doi: 10.1088/1758-5090/ac463b

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Immunocompetent cancer-on-chip models to assess immuno-oncology therapy

Maulana TI, Kromidas E, Wallstabe L, Cipriano M, Alb M, Zaupa C, Hudecek M, Fogal B, Loskill P

Adv Drug Deliv Rev. 2021 Jun;173:281-305. doi: 10.1016/j.addr.2021.03.015. Epub 2021 Mar 30. PMID: 33798643.

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Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons

Loser D, Hinojosa MG, Blum J, Schaefer J, Brüll M, Johansson Y, Suciu I, Grillberger K, Danker T, Möller C, Gardner I, Ecker GF, Bennekou SH, Forsby A, Kraushaar U, Leist M

Arch Toxicol (2021). https://doi.org/10.1007/s00204-021-03031-1

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HDX-MS for Epitope Characterization of a Therapeutic ANTIBODY Candidate on the Calcium-Binding Protein Annexin-A1

Gramlich M, Hays HCW, Crichton S, Kaiser PD, Heine A, Schneiderhan-Marra N, Rothbauer U, Stoll D, Maier S, Zeck A

Antibodies (Basel). 2021 Mar 19;10(1):11. doi: 10.3390/antib10010011. PMID: 33808657; PMCID: PMC8006148. Copy Downloa

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Multiplexed Serum Antibody Screening Platform Using Virus Extracts from Endemic Coronaviridae and SARS-CoV-2

Fink S., Ruoff F., Stahl A., Becker M., Kaiser P., Traenkle B., Junker D., Weise F., Ruetalo N., Hörber S., Peter A., Nelde A., Walz j., Krause G., Baillot A., Schenke-Layland K., Joos TO., Rothbauer U., Schneiderhan-Marra N., Schindler M., Templin MF

ACS Infectious Diseases 2021; https://doi.org/10.1021/acsinfecdis.0c00725.

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Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity

Becker M, Strengert M, Junker D, Kaiser P, Kerrinnes T, Traenkle B, Dinter H, Häring J, Ghozzi S, Zeck A, Weise F, Peter A, Hörber S, Fink S, Ruoff F, Dulovic A, Bakchoul T, Baillot A, Lohse S, Cornberg M, Illig T, Gottlieb J, Smola S, Karch A, Berger K, Rammensee HG, Schenke-Layland K, Nelde A, Märklin M, Heitmann JS, Walz JS, Templin M, Joos TO, Rothbauer U, Krause K & Schneiderhan-Marra N

NATURE COMMUNICATIONS | (2021) 12:1152 | https://doi.org/10.1038/s41467-021-20973-3 | www.nature.com/naturecommunications

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Functional brain defects in a mouse model of a chromosomal t(1;11) translocation that disrupts DISC1 and confers increased risk of psychiatric illness

Bonneau M, O' Sullivan ST, Gonzalez-Lozano MA, Baxter P, Gautier P, Marchisella E, Hardingham NR, Chesters RA, Torrance H, Howard DM, Jansen MA, McMillan M, Singh Y, Didier M, Koopmans F, Semple CA, McIntosh AM, Volkmer H, Loos M, Fox K, Hardingham GE, Vernon AC, Porteous DJ, Smit AB, Price DJ, Millar JK

Transl Psychiatry . 2021 Feb 19;11(1):135. doi: 10.1038/s41398-021-01256-3.

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The Inflammatory Profile of Obesity and the Role on Pulmonary Bacterial and Viral Infections

Hornung F, Rogal J, Loskill P, Löffler B and Deinhardt-Emmer S

Int. J. Mol. Sci. 2021, 22(7), 3456; https://doi.org/10.3390/ijms22073456

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Integration of Electrospun Membranes into Low-Absorption Thermoplastic Organ-on-Chip

Chuchuy J, Rogal J, Ngo T, Stadelmann K, Antkowiak L, Achberger K, Liebau S, Schenke-Layland K, Loskill P

ACS Biomater Sci Eng. 2021 Jul 12;7(7):3006-3017. doi: 10.1021/acsbiomaterials.0c01062. Epub 2021 Feb 16. PMID: 33591723.

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Laparoscopic Peritoneal Wash Cytology-Derived Primary Human Mesothelial Cells for In Vitro Cell Culture and Simulation of Human Peritoneum

Holl M, Becker L, Keller AL, Feuerer N, Marzi J, Carvajal Berrio DA, Jakubowski P, Neis F, Pauluschke-Fröhlich J, Brucker SY, Schenke-Layland K, Krämer B, Weiss M

Biomedicines. 2021 Feb 10;9(2):176. doi: 10.3390/biomedicines9020176. PMID: 33578986; PMCID: PMC7916778.

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Magnetic Bead-Based Immunoassay Allows Rapid, Inexpensive, and Quantitative Detection of Human SARS-CoV-2 Antibodies

Huergo LF, Selim KA, Conzentino MS, Gerhardt ECM, Santos ARS, Wagner B, Alford JT, Deobald N, Pedrosa FO, de Souza EM, Nogueira MB, Raboni SM, Souto D, Rego FGM, Zanette DL, Aoki MN, Nardin JM, Fornazari B, Morales HMP, Borges VA, Nelde A, Walz JS, Becker M, Schneiderhan-Marra N, Rothbauer U, Reis RA, Forchhammer K

ACS Sensors 2021, 6(3):703-708, https://doi.org/10.1021/acssensors.0c02544

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The potential of induced pluripotent stem cells for discriminating neurodevelopmental disorders

Stock R, Jeckel P, Kraushaar U, Wüst R, Fallgatter A, Volkmer H

STEM CELLS Transl Med. 2021;10:50-56. https://doi.org/10.1002/sctm.20-0206

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Cysteine in cell culture media induces acidic IgG1 species by disrupting the disulfide bond network

Prade E, Zeck A, Stiefel F, Unsoeld A, Mentrup D, Arango Gutierrez E, Gorr IH

Biotechnol Bioeng. 2021 Mar;118(3):1091-1104. doi: 10.1002/bit.27628. Epub 2020 Dec 16. PMID: 33200817; PMCID: PMC7986432.

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The Impact of Biomaterial Cell Contact on the Immunopeptidome

Ghosh M, Hartmann H, Jakobi M, März L, Bichmann L, Freudenmann L K, Mühlenbruch L, Segan S, Rammensee H-G, Schneiderhan-Marra N, Shipp C, Stevanovic S, Joos T O

Front. Bioeng. Biotechnol., 2020, Vol. 8 https://doi.org/10.3389/fbioe.2020.571294

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NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response

Wagner T., Ostertag E., Kaiser P., Gramlich M., Ruetalo N., Junker D., Haering J., Traenkle B., Becker M., Dulovic A., Schweizer H., Nueske S., Scholz A., Zeck A., Schenke-Layland K., Nelde A., Strengert M., Walz J., Zocher G., Stehle T., Schindler M., Schneiderhan-Marra N., Rothbauer U

In EMBO Reports 2021; 22(5):e52325. https://doi.org/10.15252/embr.202052325

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Human neuronal signaling and communication assays to assess functional neurotoxicity

Loser D, Schaefer J, Danker T, Möller C, Brüll M, Suciu I, Ückert AK, Klima S, Leist M, Kraushaar U.

Arch Toxicol. 2021 Jan;95(1):229-252. doi: 10.1007/s00204-020-02956-3. Epub 2020 Dec 2. PMID: 33269408; PMCID: PMC7811517.

Zur Publikation

SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

Nelde A., Bilich T., Heitmann JS., Maringer Y., Salih HR., Roerden R., Luebke M., Bauer J., Rieth J., Wacker M., Peter A., Hörber S., Traenkle B., Kaiser PD., Rothbauer U., Becker M., Junker D., Krause G., Strengert M., Schneiderhan-Marra N., Joos TO., Kowalewski D.J., Stos-Zweifel V., Fehr M., Graf M., Gruber L., Rachfalski D., Preuß B., Hagelstein I., Märklin M., Bakchoul T., Gouttefangeas C., Kohlbacher O., Klein R., Stevanović S., Rammensee H.-G., Walz J.S.

Nature Immunology 2021; 22:74–85, DOI: https://doi.org/10.1038/s41590-020-00808-x

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Generation and characterization of human induced pluripotent stem cells lines from four patients diagnosed with schizophrenia and one healthy control

Stock R, Vogel S, Mau-Holzmann U, Kriebel M, Wüst R, Fallgatter A, Volkmer H

Stem Cell Research, 48 (2020) 101961, https://doi.org/10.1016/j.scr.2020.101961

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A novel epitope tagging system to visualize and monitor antigens in live cells with chromobodies

Traenkle B, Segan S, Funmilayo F , Kaiser P, Rothbauer U

Scientific Reports, 10, (2020) 10:14267, https://doi.org/10.1038/s41598-020-71091-x

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HepaChip-MP – a twenty-four chamber microplate for a continuously perfused liver coculture model

Busche M, Tomilova O, Schütte J, Werner S, Beer M, Groll N, Hagmeyer B, Pawlak M, Jones P D, Schmees C, Becker H, Schnabel J, Gall K, Hemmler R, Matz-Soja M, Damm G, Beuck S, Klaassen T, Moer J, Ullrich A, Runge D, Schenke-Layland K, Gebhardt R und Stelzle M

Lab on a Chip, DOI: 10.1039/d0lc00357c

Zur Publikation

Systematic Investigation of Polyurethane Biomaterial Surface Roughness on Human Immune Responses in vitro

Segan S, Jakobi M, Khokhani P, Klimosch S, Billing F, Schneider M, Martin D, Metzger U, Biesemeier A, Xiong X, Mukherjee A, Steuer H, Keller B-M, Joos T, Schmolz M, Rothbauer U, Hartmann H, Burkhardt C, Lorenz G ,Schneiderhan-Marra N, and Shipp C

BioMed Research International, 2020, https://doi.org/10.1155/2020/3481549

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PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and disease

Thejer, B. M., Adhikary, P. P., Teakel, S. L., Fang, J., Weston, P. A., Gurusinghe, S., Anwer, A. G., Gosnell, M., Jazayeri, J. A., Ludescher, M., Gray, L. A., Pawlak, M., Wallace, R. H., Pant, S. D., Wong, M., Fischer, T., New, E. J., Fehm, T. N., Neubauer, H., Goldys, E. M., … Cahill, M. A.

BMC molecular and cell biology, 21(1), 26. https://doi.org/10.1186/s12860-020-00268-z

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PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth

Thejer, B. M., Adhikary, P. P., Kaur, A., Teakel, S. L., Van Oosterum, A., Seth, I., Pajic, M., Hannan, K. M., Pavy, M., Poh, P., Jazayeri, J. A., Zaw, T., Pascovici, D., Ludescher, M., Pawlak, M., Cassano, J. C., Turnbull, L., Jazayeri, M., James, A. C., Coorey, C. P., … Cahill, M. A.

BMC molecular and cell biology, 21(1), 24. https://doi.org/10.1186/s12860-020-00256-3

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Interference With Complex IV as a Model of Age-Related Decline in Synaptic Connectivity

Kriebel M, Ebel J, Battke F, Griesbach S, Volkmer H

Front. Mol. Neurosci., 2020 (13), https://doi.org/10.3389/fnmol.2020.00043

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Incorporation of Stem Cell-Derived Astrocytes into Neuronal Organoids to Allow Neuro-Glial Interactions in Toxicological Studies

Markus Brüll, Anna-Sophie Spreng, Simon Gutbier, Dominik Loser, Alice Krebs, Marvin Reich, Udo Kraushaar, Markus Britschgi, Marcel Leist

ALTEX. 2020 Mar 7 doi:10.14573/altex.1911111

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A mass spectrometry guided approach for the identification of novel vaccine candidates in gramnegative pathogens

Hornburg D, Kruse T, Anderl F, Daschkin C, Semper R P, Klar K, Guenther A, Mejías-Luque R, Schneiderhan-Marra N, Mann M, Meissner F & Gerhard M

Sci Rep 9, 17401 (2019) https://doi.org/10.1038/s41598-019-53493-8

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A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer

Rammensee H-G, Wiesmüller K-H, Chandran P A, Zelab H, Rusch E, Gouttefangea C, Kowalewski D J, Di Marco M, Hean S P, Walz J S, Gloria Y C, Bödder J, Schertel J-M, Tunger A, Müller L, Kießler M, Wehner R, Schmitz M, Jakobi M, Schneiderhan-Marra N, Klein R, Laske K, Artzner K, Backert L, Schuster H, Schwenck J, Weber A N R, Pichler B J, Kneilling M, la Fougère C, Forchhammer S, Metzler G, Bauer J, Weide B, Schippert W, Stevanovic S u. Löffler M W

Journal for ImmunoTherapy of Cancer (2019) 7:307 https://doi.org/10.1186/s40425-019-0796-5

Zur Publikation

High Precision RPPA: Concept, Features, and Application Performance of the Integrated Zeptosens Platform

Kresbach, G. M., & Pawlak, M.

Advances in experimental medicine and biology, 1188, 31–59. https://doi.org/10.1007/978-981-32-9755-5_3

Zur Publikation

A mass spectrometry guided approach for the identification of novel vaccine candidates in gramnegative pathogens

Hornburg D, Kruse T, Anderl F, Daschkin C, Semper R. P., Klar K, Guenther A, Mejías-Luque R, Schneiderhan-Marra N, Mann M, Meissner F & Gerhard M

Sci Rep 9, 17401 (2019). https://doi.org/10.1038/s41598-019-53493-8

Zur Publikation

The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience

Ardi Z, Richter-Levin A, Xu L, Cao X, Volkmer H, Stork O, Richter-Levin G

Sci Rep. 2019 Sep 18;9(1):13513. doi: 10.1038/s41598-019-49824-4.

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Assay Procedures for Compound Testing of hiPSC-Derived Cardiomyocytes Using Multiwell Microelectrode Arrays

Udo Kraushaar and Elke Guenther

Cell-Based Assays Using iPSCs for Drug Development and Testing (Mandenius C-F, Ross JA, eds), pp 197–208. New York, NY: Springer New York.

Zur Publikation

Comparative characterization of humaninduced pluripotent stem cells (hiPSC) derived from patients with schizophreniaand autism

Grunwald L-M, Stock R, Haag K, Buckenmaier S, Eberle M-C, Wildgruber D, Storchak H, Kriebel M, Weißgraeber S, Mathew L, Loos M, Li kw, Kraushaar U, Fallgatter AJ, Volkmer H

Translational Psychiatry (2019) 9:179

Zur Publikation

Regenerative potential of adipocytes in hypertrophic scars is mediated by myofibroblast reprogramming

Hoerst K, van den Broek L, Sachse C, Klein O, von Fritschen U, Gibbs S, Hedtrich S

Journal of Molecular Medicine, June 2019, Volume 97, Issue 6, pp 761–775

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MEK inhibitors activate Wnt signalling and inducestem cell plasticity in colorectal cancer

Zhan T, Ambrosi G, Wandmacher AM, Rauscher B, Betge J, Rindtorff N, Häussler R, Hinsenkamp I, Bamberg L, Hessling B, Müller-Decker K, Erdmann G, Burgermeister E, Ebert MP, Boutros M

Nature Communications, 2019, 10:2197, https://doi.org/10.1038/s41467-019-09898-0

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Heparin Differentially Impacts Gene Expression of Stromal Cells from Various Tissues

Laner-Plamberger S, Oeller M, Poupardin R, Krisch L, Hochmann S, Kalathur R, Pachler K, Kreutzer C, Erdmann G, Rohde E, Strunk D, Schallmoser K

Scientific Reports (2019) 9:7258

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Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures

Schumacher D, Andrieux G, Boehnke K, Keil M, Silvestri A, Silvestrov M, Keilholz U, Haybaeck J, Erdmann G, Sachse C, Templin M, Hoffmann J, Boerries M, Schafer R, Regenbrecht CRA

PLoS Genet 15(3): e1008076. https://doi.org/10.1371/journal.pgen.1008076

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Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures

Schumacher D, Andrieux G, Boehnke K, Keil M, Silvestri A, Silvestrov M, Keilholz U, Haybaeck J, Erdmann G, Sachse C, Templin M, Hoffmann J, Boerries M, Schäfer R, Regenbrecht C

PLoS Genet 15(3): e1008076.

Zur Publikation

A Strategy to Optimize the Generation of Stable Chromobody Cell Lines for Visualization and Quantification of Endogenous Proteins in Living Cells

Keller B, Maier J, Weldle M, Segan S, Traenkle B, Rothbauer U

Antibodies 2019, 8, 10; doi:10.3390/antib8010010

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Application of Mass Spectrometry-Based Immunoassays for the Species- and Tissue-Specific Quantification of Banned Processed Animal Proteins in Feeds

Steinhilber A, Schmidt F, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos T, Poetz O

Analytical Chemistry. 2019 Feb 27. doi: 10.1021/acs.analchem.8b04652 Epub ahead of print

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Serum inflammatory profile for the discrimination of clinical subtypes in Parkinson’s disease

Yilmaz R, Strafella A, Bernard A, Schulte C, van den Huevel L, Schneiderhan-Marra N, Knorpp T, Joos T, Leypoldt F, Geritz J, Hansen C, Apel A, Gasser T, Lang A, Berg D, Maetzler W, Marras C

Front Neurol., 2018 Dec 21 DOI:/10.3389/fneur.2018.01123

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Imaging fibrosis in inflammatory diseases: Targeting exposed extracellular matrix

Beziere N, Fuchs K, Maurer A, Reischl B, Brück J, Ghoreschi K, Carvajal Berrio D, Schenke-Layland K, Kohlhofer U, Quintanilla-Martinez L, Gawaz M, Kneilling M, Pichler B

Theranostics in press

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Chromobodies to quantify changes of endogenous protein concentration in living cells

Keller BM, Maier J, Secker KA, Egetemaier SM, Parfyonova Y, Rothbauer U, Traenkle B

Mol Cell Proteomics. 2018 Dec;17(12):2517-2533. doi: 10.1074/mcp.TIR118.000914. Epub 2018 Sep 18.

Zur Publikation

Comparative study of MSCA-1 and CD146 isolated periosteal cell subpopulations

Umrath F, Thomalla C, Pöschel S, Schenke-Layland K, Reinert S, Alexander D

Cell Physiol Biochem. 2018;51(3):1193-1206. doi: 10.1159/000495497. Epub 2018 Dec 12.

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Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation

Braeuning A, Kollotzek F, Zeller E, Knorpp T, Templin MF, Schwarz M

Drug Metab Dispos. 2018 Nov;46(11):1462-1465. doi: 10.1124/dmd.118.083014. Epub 2018 Aug 16.

Zur Publikation

A high-throughput pipeline for validation of antibodies

Sikorski K, Mehta A, Inngjerdingen M, Thakor F, Kling S, Kalina T, Nyman TA, Stensland ME, Zhou W, de Souza GA, Holden L, Stuchly J, Templin M, Lund-Johansen F

Nat Methods. 2018 Nov;15(11):909-912. doi: 10.1038/s41592-018-0179-8. Epub 2018 Oct 30.

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Stem cell-based organ-on-a-chip models for diabetes research

Rogal J, Zbinden A, Schenke-Layland K, Loskill P

Adv Drug Deliv Rev 2018 in press (Review)

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International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

Blinova K, Dang Q, Millard D, Smith G, Pierson J, Guo L, Brock M, Lu HR, Kraushaar U, Zeng H, Shi H, Zhang X, Sawada K, Osada T, Kanda Y, Sekino Y, Pang L, Feaster TK, Kettenhofen R, Stockbridge N, Strauss DG, Gintant G

Cell Rep. 2018 Sep 25;24(13):3582-3592. doi: 10.1016/j.celrep.2018.08.079.

Zur Publikation

Species Differentiation and Quantification of Processed Animal Proteins and Blood Products in Fish Feed Using an 8-Plex Mass Spectrometry-Based Immunoassay

Steinhilber AE, Schmidt FF, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos TO, Poetz O

J Agric Food Chem. 2018 Oct 3;66(39):10327-10335. doi: 10.1021/acs.jafc.8b03934. Epub 2018 Sep 24.

Zur Publikation

Improved long-term durability of allogeneic heart valves in the orthotopic sheep model

Biermann AC, Marzi J, Brauchle E, Wichmann JL, Arendt CT, Puntmann V, Nagel E, Abdelaziz S, Winter AG, Brockbank KGM, Layland S, Schenke-Layland K, Stock UA

Eur J Cardiothorac Surg. 2018 Aug 24. doi: 10.1093/ejcts/ezy292. [Epub ahead of print]

Zur Publikation

Electrode-size dependent thresholds in subretinal neuroprosthetic stimulation

Corna A, Herrmann T, Zeck G.

J Neural Eng. 2018 Aug;15(4):045003. doi: 10.1088/1741-2552/aac1c8. Epub 2018 May 2.

Zur Publikation

Biomechanical and biomolecular characterization of ECM in human colon carcinomas

Brauchle E, Kasper J, Daum R, Schierbaum N, Falch C, Kirschniak A, Schäffer T, Schenke-Layland K

Matrix Biol. 2018 Aug;68-69:180-193. doi: 10.1016/j.matbio.2018.03.016. Epub 2018 Mar 29.

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Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study

Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G.

Toxicol Sci. 2018 Aug 1;164(2):550-562. doi: 10.1093/toxsci/kfy110.

Zur Publikation

Increased Energy Expenditure, Lipolysis and Hyperinsulinemia Confer Resistance to Central Obesity and Type 2 Diabetes in Mice Lacking Alpha2α-Adrenoceptors

Ruohonen ST, Valve L, Tuomainen K, Ailanen L, Röyttä M, Manz G, Baur N, Joos TO, Savontaus E, Scheinin M

Neuroendocrinology. 2018 Jul 24. doi: 10.1159/000492387. [Epub ahead of print]

Zur Publikation

Influence of aflibercept on platelet activation profile

Sobolewska B, Golenko J, Poeschel S, Grimmel C, Gatsiou A, Sopova K, Biedermann T, Schenke-Layland K, Stellos K, Ziemssen F

Exp Eye Res. 2018 Oct; 175:166-172. doi: 10.1016/j.exer.2018.06.009. Epub 2018 Jun 15. PMID: 29908884.

Zur Publikation

Combining two photon microscopy and CMOS MEA to uncover the mechanism of aberrant activity in blind retina

Lee M-J, Srivastava P, Rogerson L, Berens P, Euler T, Schubert T, Zeck G

MEA Meeting 2018, 10.3389/conf.fncel.2018.38.00022, 2018

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Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report

Mulder P, de Korte T, Dragicevic E, Kraushaar U, Printemps R, Vlaming MLH, Braam SR, Valentin JP.

J Pharmacol Toxicol Methods. 2018 May-Jun;91:36-42. doi: 10.1016/j.vascn.2018.01.003. Epub 2018 Feb 4.

Zur Publikation

Low-picomolar, label-free procalcitonin analytical detection with an electrolyte-gated organic field-effect transistor based electronic immunosensor. Biosens Bioelectron

Seshadri P, Manoli K, Schneiderhan-Marra N, Anthes U, Wierzchowiec P, Bonrad K, Di Franco C, Torsi L.

Biosens Bioelectron. 2018 May 1;104:113-119. doi: 10.1016/j.bios.2017.12.041. Epub 2017 Dec 26.

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PGRMC1 Predicts Poor Prognosis and Promotes Tumour Progression of Breast Cancer through Upregulation of ERα Expression

Willibald M, Stahlhut V, Stamm N, Gierke B, Pawlak M, Fehm T, Neubauer H

Senologie. 2018; 15(02):e52. DOI: 10.1055/s-0038-1651821

Zur Publikation

Peptide-Based Sandwich Immunoassay for the Quantification of the Membrane Transporter Multidrug Resistance Protein

Poetz O, Dieze T, Hammer H, Weiß F, Sommersdorf C, Templin MF, Esdar C, Zimmermann A, Stevanovic S, Bedke J, Stenzl A, Joos TO.

Anal Chem. 2018 May 1;90(9):5788-5794. doi: 10.1021/acs.analchem.8b00152. Epub 2018 Apr 12.

Zur Publikation

Speed up to find the right ones: rapid discovery of functional nanobodies

Nat Struct Mol Biol. 2018 Mar;25(3):199-201.

Zur Publikation

Mass Spectrometry-Based Immunoassay for the Quantification of Banned Ruminant Processed Animal Proteins in Vegetal Feeds

Steinhilber AE, Schmidt FF, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos T, Poetz O

Anal Chem. 2018 Mar 20;90(6):4135-4143. doi: 10.1021/acs.analchem.8b00120. Epub 2018 Mar 7.

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A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo

Yger P, Spampinato GLB, Esposito E, Lefebvre B, Deny S, Gardella C, Zeck G, Picaud S, Duebel J, Marre O

Elife. 2018 Mar 20;7. pii: e34518. doi: 10.7554/eLife.34518.

Zur Publikation

A peptide tag-specific nanobody enables high-quality labeling for dSTORM imaging

Virant D, Traenkle B, Maier J, Kaiser PD, Bodenhöfer M, Schmees C, Vojnovic I, Pisak-Lukáts B, Endesfelder U, Rothbauer U

Nature Communications. 2018 Mar;9:930. DOI:10.1038/s41467-018-03191-2

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Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor.

de Boussac H, Gondeau C, Briolotti P, Duret C, Treindl F, Römer M, Fabre JM, Herrero A, Ramos J, Maurel P, Templin M, Gerbal-Chaloin S, Daujat-Chavanieu M

Drug Metab Dispos. 2018 Mar;46(3):223-236. doi: 10.1124/dmd.117.078683. Epub 2017 Dec 21.

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Structure-dependent induction of apoptosis by hepatotoxic pyrrolizidine alkaloids in the human hepatoma cell line HepaRG: Single versus repeated exposure

Waizenegger J, Braeuning A, Templin M, Lampen A, Hessel-Pras S

Food Chem Toxicol. 2018 Apr;114:215-226. doi: 10.1016/j.fct.2018.02.036. Epub 2018 Feb 16.

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Neurofascin Knock Down in the Basolateral Amygdala Mediates Resilience of Memory and Plasticity in the Dorsal Dentate Gyrus Under Stress

Saha R, Kriebel M, Volkmer H, Richter-Levin G, Albrecht A

Molecular Neurobiology. 2018 Sept; 55(9): 7317-7326. DOI: 10.1007/s12035-018-0930-2

Zur Publikation

Nanofluidic technology for chemical neurostimulation

Tübingen: Dissertation, Mathematisch-Naturwissenschaftliche Fakultät, Eberhard Karls Universität Tübingen, 2018. 129 Seiten.

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Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

Weiß F, Hammer HS, Klein K, Planatscher H, Zanger UM, Norén A, Wegler C, Artursson P, Joos TO, Poetz O

Drug Metab Dispos. 2018 Apr;46(4):387-396. doi: 10.1124/dmd.117.078626. Epub 2018 Jan 17.

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Platelet protein biomarker panel for ovarian cancer diagnosis

Lomnytska M, Pinto R, Becker S, Engström U, Gustafsson S, Björklund C, Templin M, Bergstrand J, Xu L, Widengren J, Epstein E, Franzén B, Auer G.

Biomark Res. 2018 Jan 12;6:2. doi: 10.1186/s40364-018-0118-y.

Zur Publikation

Functional protein and pathway profiling of patient-derived tumor models for drug testing and precision medicine applications using Reverse Phase Protein Arrays (RPPA)

Gierke B, Bodenhofer M, Schmees C, Pawlak M

European Journal of Cancer. 2018 November 13-16; 103S1 (e21–e1489):e109

Zur Publikation

Investigation of the functional retinal output using Microelectrode arrays

Methods Mol Biol. 2018;1695:81-88. doi: 10.1007/978-1-4939-7407-8_8.

Zur Publikation

Electrophysiological Characterization of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for the Development of new in vitro Assays in Preclinical Cardiac Risk Assessment of Drugs

Masterthesis, 2017; Brandenburgische Technische Universität Cottbus-Senftenberg.

Zur Publikation

The influence of mechanical stress during the differentiation on the electrophysiological properties of human embryonic stem cell – derived cardiomyocytes

Masterthesis, 2017; Brandenburgische Technische Universität Cottbus-Senftenberg.

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Perturbation of GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Induces Trans-regional Metaplasticity at the Medial Prefrontal Cortex

Saha R, Shrivastava K, Jing L, Schayek R, Maroun M, Kriebel M, Volkmer H, Richter-Levin G

Cereb Cortex. 2017 Nov; 9:1-16. doi: 10.1093/cercor/bhx300.

Zur Publikation

Development and Validation of an Ultrasensitive Procalcitonin Sandwich Immunoassay

Carcamo Yañez V, Göpfert J, Otto M, Tumani H, Peter A, Joos T

High-Throughput. 2017; 6(4): 18. https://doi.org/10.3390/ht6040018

Zur Publikation

Validation of HAV biomarker 2A for differential diagnostic of hepatitis A infected and vaccinated individuals using multiplex serology

Bohm K, Filomena A, Schneiderhan-Marra N, Krause G, Sievers C

Vaccine. 2017 Oct 13;35(43):5883-5889. doi: 10.1016/j.vaccine.2017.08.089. Epub 2017 Sep 14.

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Performance of a Multiplex Serological Helicobacter pylori Assay on a Novel Microfluidic Assay Platform

Filomena A, Guenther A, Planatscher H, Topin F, She J, Formichella L, Terradot L, Gerhard M, Joos TO, Meyer H, Schneiderhan-Marra N

Proteomes. 2017 Oct 3;5(4). pii: E24. doi: 10.3390/proteomes5040024.

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Study of the Humoral Immune Response towards HCV Genotype 4 Using a Bead-Based Multiplex Serological Assay

Filomena A, Göpfert JC, Duffy D, Pol S, Abdel-Hamid M, Esmat G, Fontanet A, Albert M, Joos T, Schneiderhan-Marra N

High-Throughput. 2017; 6(4): 15.

Zur Publikation

Development of a Bead-Based Multiplex Assay for the Analysis of the Serological Response against the Six Pathogens HAV, HBV, HCV, CMV, T. gondii, and H. pylori

Filomena A, Pessler F, Akmatov M, Krause G, Duffy D, Gärtner B, Gerhard M, Albert M, Joos T, Schneiderhan-Marra N,

High-Throughput. 2017; 6(4): 14.

Zur Publikation

Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells

Toulany M, Maier J, Iida M, Rebholz S, Holler M, Grottke A, Jüker M, Wheeler DL, Rothbauer U, Rodemann HP

Cell Death Discovery. 2017; 3:17072

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Tau plasma levels in subjective cognitive decline: Results from the DELCODE study

Muller S, Preische O, Gopfert JC, Yanez VAC, Joos TO, Boecker H, Duzel E, Falkai P, Priller J, Buerger K, Catak C, Janowitz D, Heneka MT, Brosseron F, Nestor P, Peters O, Menne F, Schipke CG, Schneider A, Spottke A, Fliessbach K, Kilimann I, Teipel S, Wagner M, Wiltfang J, Jessen F, Laske C

Sci Rep. 2017 Aug 25;7(1):9529. doi: 10.1038/s41598-017-08779-0.

Zur Publikation

Development and clinical testing of individual immunoassays for the quantification of serum glycoproteins to diagnose prostate cancer

Endt K, Goepfert J, Omlin A, Athanasiou A, Tennstedt P, Guenther A, Rainisio M, Engeler DS, Steuber T, Gillessen S, Joos T, Schiess R

PLoS One. 2017 Aug 2;12(8):e0181557. doi: 10.1371/journal.pone.0181557. eCollection 2017.

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Correlative Microscopy Combining Secondary Ion Mass Spectrometry and Electron Microscopy: Comparison of Intensity–Hue–Saturation and Laplacian Pyramid Methods for Image Fusion

Vollnhals F, Audinot J-N, Wirtz, T, Mercier-Bonin M, Fourquaux I, Schroeppel B, Kraushaar U, Lev-Ram V, Ellisman MH, Eswara S

Anal. Chem. (2017), Bd. 89, H. 20, S. 10702-10710, https://doi.org/10.1021/acs.analchem.7b01256

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Under the Microscope: Single-Domain Antibodies for Live-Cell Imaging and Super-Resolution Microscopy

Traenkle B, Rothbauer U

Front Immunol. 2017 Aug 24;8:1030. doi: 10.3389/fimmu.2017.01030. eCollection 2017.

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Impact of S-sulfocysteine on fragments and trisulfide bond linkages in monoclonal antibodies

Seibel R, Maier S, Schnellbaecher A, Bohl S, Wehsling M, Zeck A, Zimmer A

MAbs. 2017 Aug/Sep;9(6):889-897. doi: 10.1080/19420862.2017.1333212. Epub 2017 Jun 5.

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Impact of serum and dialysates obtained from chronic hemodialysis patients maintained on high cut-off membranes on inflammation profile in human THP-1 monocytes

Trojanowicz B, Ulrich C, Fiedler R, Storr M, Boehler T, Martus P, Pawlak M, Glomb MA, Henning C, Templin M, Werner K, Zickler D, Willy K, Schindler R, Girndt M

Hemodial Int. 2017 Jul;21(3):348-358. doi: 10.1111/hdi.12494. Epub 2016 Sep 26.

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Reverse Phase Protein Arrays elucidate mechanisms-of-action and phenotypic response in 2D and 3D models

Pawlak M, Carragher NO (2017)

Drug Discov Today Technol. 2017 Mar;23:7-16. doi: 10.1016/j.ddtec.2017.05.002. Epub 2017 May 30.

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Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

Schelle J, Hasler LM, Gopfert JC, Joos TO, Vanderstichele H, Stoops E, Mandelkow EM, Neumann U, Shimshek DR, Staufenbiel M, Jucker M, Kaeser SA

Alzheimers Dement. 2017 Jun;13(6):701-709. doi: 10.1016/j.jalz.2016.09.005. Epub 2016 Oct 14.

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GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Projection Neurons Modulate Fear Extinction

Saha R, Knapp S, Chakraborty D, Horovitz O, Albrecht A, Kriebel M, Kaphzan H, Ehrlich I, Volkmer H, Richter-Levin G

Neuropsychopharmacology. 2017 Jan;42(2):473-484. doi: 10.1038/npp.2016.205. Epub 2016 Sep 16.

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Steps toward Maturation of Embryonic Stem Cell-Derived Cardiomyocytes by Defined Physical Signals

Shen N, Knopf A, Westendorf C, Kraushaar U, Riedl J, Bauer H, Poschel S, Layland SL, Holeiter M, Knolle S, Brauchle E, Nsair A, Hinderer S, Schenke-Layland K

Stem Cell Reports. 2017 Jul 11;9(1):122-135. doi: 10.1016/j.stemcr.2017.04.021. Epub 2017 May 18.

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Pharmacodynamics of Oxaliplatin-Derived Platinum Compounds During Hyperthermic Intraperitoneal Chemotherapy (HIPEC): An Emerging Aspect Supporting the Rational Design of Treatment Protocols

Loffler MW, Schuster H, Zeck A, Quilitz N, Weinreich J, Tolios A, Haen SP, Horvath P, Lob S, Rammensee HG, Konigsrainer I, Konigsrainer A, Beckert S

Ann Surg Oncol. 2017 Jun;24(6):1650-1657. doi: 10.1245/s10434-017-5790-x. Epub 2017 Feb 3.

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Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease

Brockmann K, Schulte C, Schneiderhan-Marra N, Apel A, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Bernard A, Gasser T, Marras C, Schule B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Berg D, Maetzler W

Eur J Neurol. 2017 Feb;24(2):427-e6. doi: 10.1111/ene.13223.

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Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice

Marx-Stoelting P, Ganzenberg K, Knebel C, Schmidt F, Rieke S, Hammer H, Schmidt F, Potz O, Schwarz M, Braeuning A

Arch Toxicol. 2017 Aug;91(8):2895-2907. doi: 10.1007/s00204-016-1925-2. Epub 2017 Jan 6.

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Innate immune system favors emergency monopoiesis at the expense of DC-differentiation to control systemic bacterial infection in mice

Pasquevich KA, Bieber K, Gunter M, Grauer M, Potz O, Schleicher U, Biedermann T, Beer-Hammer S, Buhring HJ, Rammensee HG, Zender L, Autenrieth IB, Lengerke C, Autenrieth SE

Eur J Immunol. 2015 Oct;45(10):2821-33. doi: 10.1002/eji.201545530. Epub 2015 Jul 24.

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Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

Beck F, Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ, Mindukshev I, Potz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U, Zahedi RP, Sickmann A

Blood. 2017 Jan 12;129(2):e1-e12. doi: 10.1182/blood-2016-05-714048. Epub 2016 Nov 9.

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Miniaturized Multiplexed Protein Binding Assays

Templin MF, Poetz O, Schwenk JM, Stoll D, Joos TO

W.-L. Xing and J. Cheng. Frontiers in Biochip Technology. Boston, MA: Springer US; 2006. 61-87.

Zur Publikation

Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA)

Kraushaar U, Guenther E, Hess D

Stem Cell-Derived Models in Toxicology. M. Clements and L. Roquemore. New York, NY: Springer New York; 2017. 293-309.

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Medium Cut-Off (MCO) Membranes Reduce Inflammation in Chronic Dialysis Patients-A Randomized Controlled Clinical Trial

Zickler D, Schindler R, Willy K, Martus P, Pawlak M, Storr M, Hulko M, Boehler T, Glomb MA, Liehr K, Henning C, Templin M, Trojanowicz B, Ulrich C, Werner K, Fiedler R, Girndt M

PLoS One. 2017 Jan 13;12(1):e0169024. doi: 10.1371/journal.pone.0169024. eCollection 2017.

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A Nexus Consisting of Beta-Catenin and Stat3 Attenuates BRAF Inhibitor Efficacy and Mediates Acquired Resistance to Vemurafenib

Sinnberg T, Makino E, Krueger MA, Velic A, Macek B, Rothbauer U, Groll N, Potz O, Czemmel S, Niessner H, Meier F, Ikenberg K, Garbe C, Schittek B

EBioMedicine. 2016 Jun;8:132-49. doi: 10.1016/j.ebiom.2016.04.037. Epub 2016 May 1.

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Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells

Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Gohring G, Drager G, Potz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R

Nat Commun. 2016 Dec 9;7:13602. doi: 10.1038/ncomms13602.

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Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

Schelle J, Hasler L, Gopfert JC, Joos TO, Vanderstichele H, Stoops E, Mandelkow EM, Neumann U, Shimshek DR, Staufenbiel M, Jucker M, Kaeser SA

Alzheimers Dement. 2017 Jun;13(6):701-709. doi: 10.1016/j.jalz.2016.09.005. Epub 2016 Oct 14.

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Plasma matrix metalloproteinase 2 levels and breast cancer risk

Aroner SA, Rosner BA, Tamimi RM, Tworoger SS, Baur N, Joos TO, Hankinson SE

Cancer Epidemiol. 2015 Jun;39(3):321-7. doi: 10.1016/j.canep.2015.02.010. Epub 2015 Mar 19.

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Selective p38alpha MAP kinase/MAPK14 inhibition in enzymatically-modified LDL-stimulated human monocytes: implications for atherosclerosis

Cheng F, Twardowski L, Fehr S, Aner C, Schaeffeler E, Joos T, Knorpp T, Dorweiler B, Laufer S, Schwab M, Torzewski M

FASEB J. 2017 Feb;31(2):674-686. doi: 10.1096/fj.201600669R. Epub 2016 Nov 8.

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Coordinate regulation of Cyp2e1 by beta-catenin- and hepatocyte nuclear factor 1alpha-dependent signaling

Groll N, Petrikat T, Vetter S, Colnot S, Weiss F, Poetz O, Joos TO, Rothbauer U, Schwarz M, Braeuning A

Toxicology. 2016 Mar 28;350-352:40-8. doi: 10.1016/j.tox.2016.05.004. Epub 2016 May 3.

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Coordinating Role of RXRalpha in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling

Keller R, Klein M, Thomas M, Drager A, Metzger U, Templin MF, Joos TO, Thasler WE, Zell A, Zanger UM

PLoS Comput Biol. 2016 Jan 4;12(1):e1004431. doi: 10.1371/journal.pcbi.1004431. eCollection 2016 Jan.

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Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors

Kropp C, Kempf H, Halloin C, Robles-Diaz D, Franke A, Scheper T, Kinast K, Knorpp T, Joos TO, Haverich A, Martin U, Zweigerdt R, Olmer R

Stem Cells Transl Med. 2016 Oct;5(10):1289-1301. Epub 2016 Jul 1.

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Evaluation of novel biomarkers of nephrotoxicity in Cynomolgus monkeys treated with gentamicin

Gautier JC, Zhou X, Yang Y, Gury T, Qu Z, Palazzi X, Leonard JF, Slaoui M, Veeranagouda Y, Guizon I, Boitier E, Filali-Ansary A, van den Berg BH, Poetz O, Joos T, Zhang T, Wang J, Detilleux P, Li B

Toxicol Appl Pharmacol. 2016 Jul 15;303:1-10. doi: 10.1016/j.taap.2016.04.012. Epub 2016 Apr 19.

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Inhibition of beta-catenin signaling by phenobarbital in hepatoma cells in vitro

Groll N, Petrikat T, Vetter S, Wenz C, Dengjel J, Gretzmeier C, Weiss F, Poetz O, Joos TO, Schwarz M, Braeuning A

Toxicology. 2016 Aug 31;370:94-105. doi: 10.1016/j.tox.2016.09.018. Epub 2016 Sep 30.

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Role of BCL9L in transforming growth factor-beta (TGF-beta)-induced epithelial-to-mesenchymal-transition (EMT) and metastasis of pancreatic cancer

Sannino G, Armbruster N, Bodenhofer M, Haerle U, Behrens D, Buchholz M, Rothbauer U, Sipos B, Schmees C

Oncotarget. 2016 Oct 4; 7:73725-73738. doi: 10.18632/oncotarget.12455.

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GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Projection Neurons Modulate Fear Extinction

Saha R, Knapp S, Chakraborty D, Horovitz O, Albrecht A, Kriebel M, Kaphzan H, Ehrlich I, Volkmer H, Richter-Levin G

Neuropsychopharmacology. 2017 Jan;42(2):473-484. doi: 10.1038/npp.2016.205. Epub 2016 Sep 16.

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Generierung und Analyse von Zielgen-Knockouts in Pankreastumorzelllinien unter Einsatz der CRISPR-Cas Methode

Bachelor-Thesis 2016, Studiengang Pharmazeutische Biotechnologie, Fakultät für pharmazeutische Biotechnologie, Hochschule Biberach. 83 Seiten.

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Veredeln statt verbrennen

Xiong X, Schmid R

Nachrichten aus der Chemie. 2016; 64(7-8): 758-760.

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China: mehr pflanzliche Arzneien

Xiong X, Schmid R

Nachrichten aus der Chemie: 2016 May; 64(5): 524-526.

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Electrical Imaging of Aberrant Activity in Neural Tissues Using High Density Microelectrode Arrays

Doktorarbeit, Medizinische Fakultät, Eberhard Karls Universität Tübingen. 2016. 118 Seiten.

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In vitro Differenzierung humaner iPS-Zellen und Generierung einer DISC1-Knockout-Zelllinie mithilfe des CRISPR-Cas9-Systems

Master-Thesis, Studiengang Biomedical Sciences, Fakultät Life Sciences, Hochschule Albstadt-Sigmaringen. 2016. 70 Seiten.

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Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection

Rast G, Kraushaar U, Buckenmaier S, Ittrich C, Guth BD

J Pharmacol Toxicol Methods. 2016 Nov - Dec;82:74-82. doi: 10.1016/j.vascn.2016.08.002. Epub 2016 Aug 9.

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Development of MS-based immunoassays and quantification of cytochrome P450 enzymes in mice

Master-Thesis, Department of Natural Sciences , University of Applied Sciences Bonn-Rhein-Sieg. 2016. 60 Seiten.

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Design of intelligent chitosan/heparin hollow microcapsules for drug delivery

Sun L, Xiong X, Zou Q, Ouyang P, Burkhardt C, Krastev R

Journal of Applied Polymer Science. 2017 Feb 5;134(5), 44425.

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Introduction to polymer-based solid-contact ion-selective electrodes-basic concepts, practical considerations, and current research topics

Bieg C, Fuchsberger K, Stelzle M

Anal Bioanal Chem. 2017 Jan;409(1):45-61. doi: 10.1007/s00216-016-9945-6. Epub 2016 Oct 1.

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Subretinal electrical stimulation reveals intact network activity in the blind mouse retina

Stutzki H, Helmhold F, Eickenscheidt M, Zeck G

J Neurophysiol. 2016 Oct 1;116(4):1684-1693. doi: 10.1152/jn.01095.2015. Epub 2016 Jul 13.

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Unsupervised neural spike sorting for high-density microelectrode arrays with convolutive independent component analysis

Leibig C, Wachtler T, Zeck G

J Neurosci Methods. 2016 Sep 15;271:1-13. doi: 10.1016/j.jneumeth.2016.06.006. Epub 2016 Jun 15.

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Electrochemical noise and impedance of Au electrode/electrolyte interfaces enabling extracellular detection of glioma cell populations

Rocha PR, Schlett P, Kintzel U, Mailander V, Vandamme LK, Zeck G, Gomes HL, Biscarini F, de Leeuw DM

Sci Rep. 2016 Oct 6;6:34843. doi: 10.1038/srep34843.

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Nanobody Platform for Determination of Protein Structure, Application of Peptides and Proteins

Traenkle B, Kaiser PD, Rothbauer U

2016. in: Encyclopedia of Analytical Chemistry, John Wiley & Sons, Ltd, 2006.

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Visualizing Epithelial-Mesenchymal Transition Using the Chromobody Technology

Maier J, Traenkle B, Rothbauer U

Cancer Res. 2016 Oct 1;76(19):5592-5596. Epub 2016 Sep 15.

Zur Publikation

Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection.

Rast G, Kraushaar U, Buckenmaier S, Ittrich C, Guth BD

J Pharmacol Toxicol Methods. 2016 Aug 9;82:74-82. doi: 10.1016/j.vascn.2016.08.002. [Epub ahead of print]

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A standardized production pipeline for high profile targets from Mycobacterium tuberculosis

Milewski MC, Broger T, Kirkpatrick J, Filomena A, Komadina D, Schneiderhan-Marra N, Wilmanns M, Parret AH

Proteomics Clin Appl. 2016 Oct;10(9-10):1049-1057. doi: 10.1002/prca.201600033. Epub 2016 Aug 3.

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Personalized peptide vaccine induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient

Loffler MW, Anoop Chandran P, Laske K, Schroeder C, Bonzheimm I, Walzer M, Hilke FJ, Trautwein N, Kowalewski DJ, Schuster H, Gunder M, Carcamo Yanez VA, Mohr C, Sturm M, Nguyen HP, Riess O, Bauer P, Nahnsen S, Nadalin S, Zieker D, Glatzle J, Thiel K, Schneiderhan-Marra N, Clasen S, Bosmuller H, Fend F, Kohlbacher O, Gouttefangeas C, Stevanovic S, Konigsrainer A, Rammensee HG

J Hepatol. 2016 Oct;65(4):849-855. doi: 10.1016/j.jhep.2016.06.027. Epub 2016 Jul 7.

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Entwicklung eines multiplexen HBV Assays zur Unterscheidung von geimpften und natürlich infizierten Personen

Bachelor-Thesis, Studiengang Lebensmittel, Ernährung und Hygiene, Fakultät Life Science, Hochschule Albstadt-Sigmaringen. 2016. 49 Seiten.

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Receptor tyrosine kinase EphA7 is required for interneuron connectivity at specific subcellular compartments of granule cells

Beuter S, Ardi Z, Horovitz O, Wuchter J, Keller S, Saha R, Tripathi K, Anunu R, Kehat O, Kriebel M, Richter-Levin G, Volkmer H

Scientific Reports. 2016 July 13;6:29710

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Inflammatory profile in LRRK2-associated prodromal and clinical PD

Brockmann K, Apel A, Schulte C, Schneiderhan-Marra N, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Gasser T, Schule B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Marras C, Berg D, Maetzler W

J Neuroinflammation. 2016 May 24;13(1):122. doi: 10.1186/s12974-016-0588-5.

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Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury

Mikus M, Drobin K, Gry M, Bachmann J, Lindberg J, Yimer G, Aklillu E, Makonnen E, Aderaye G, Roach J, Fier I, Kampf C, Gopfert J, Perazzo H, Poynard T, Stephens C, Andrade RJ, Lucena MI, Arber N, Uhlen M, Watkins PB, Schwenk JM, Nilsson P, Schuppe-Koistinen I

Liver Int. 2017 Jan;37(1):132-140. doi: 10.1111/liv.13174. Epub 2016 Jun 22.

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Fine-tuned PEGylation of chitosan to maintain optimal siRNA-nanoplex bioactivity

Gutoaia A, Schuster L, Margutti S, Laufer S, Schlosshauer B, Krastev R, Stoll D, Hartmann H

Carbohydr Polym. 2016 Jun 5;143:25-34. doi: 10.1016/j.carbpol.2016.01.010. Epub 2016 Jan 8.

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Expanding an efficient, electrically driven and CNT-tagged P450 system into the third dimension: a nanowired CNT containing and enzyme stabilising 3D sol-gel electrode

Llaudet E, Darimont D, Samba R, Matiychyn I, Stelzle M, Weissenborn MJ, Hauer B (2016).

Chembiochem. 2016 Jul 15;17(14):1367-73. doi: 10.1002/cbic.201600173. Epub 2016 Jun 17.

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High cut-off dialysis in chronic haemodialysis patients

Girndt M, Fiedler R, Martus P, Pawlak M, Storr M, Bohler T, Glomb MA, Liehr K, Henning C, Templin M, Trojanowicz B, Ulrich C, Werner K, Zickler D, Schindler R

Eur J Clin Invest. 2015 Dec;45(12):1333-40. doi: 10.1111/eci.12559.

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Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [(18)F] FDG-PET imaging combined with proteomic approaches

Tegnebratt T, Ruge E, Bader S, Ishii N, Aida S, Yoshimura Y, Ooi CH, Lu L, Mitsios N, Meresse V, Mulder J, Pawlak M, Venturi, M, Tessier J, Stone-Elander S

EJNMMI Res. 2014 Dec;4(1):34. doi: 10.1186/s13550-014-0034-6. Epub 2014 Sep 9.

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PEDOT-CNT coated electrodes stimulate retinal neurons at low voltage amplitudes and low charge densities

Samba R, Herrmann T, Zeck G

J Neural Eng. 2015 Feb;12(1):016014. doi: 10.1088/1741-2560/12/1/016014. Epub 2015 Jan 14.

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From Enzyme to Whole Blood: Sequential Screening Procedure for Identification and Evaluation of p38 MAPK Inhibitors

Bauer SM, Kubiak JM, Rothbauer U, Laufer S

Methods Mol Biol. 2016;1360:123-48. doi: 10.1007/978-1-4939-3073-9_10.

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RPPApipe: a pipeline for the analysis of reverse-phase protein array data

Eichner J, Heubach Y, Ruff M, Kohlhof H, Strobl S, Mayer B, Pawlak M, Templin MF

Biosystems. 2014 Aug;122:19-24. doi: 10.1016/j.biosystems.2014.06.009. Epub 2014 Jun 18.

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Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society

Akbani R, Becker KF, Carragher N, Goldstein T, de Koning L, Korf U, Liotta L, Mills GB, Nishizuka SS, Pawlak M, Petricoin EF 3rd, Pollard HB, Serrels B, Zhu J

Mol Cell Proteomics. 2014 Jul;13(7):1625-43. doi: 10.1074/mcp.O113.034918. Epub 2014 Apr 28.

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Evaluation of Protein Profiles From Treated Xenograft Tumor Models Identifies an Antibody Panel for Formalin-fixed and Paraffin-embedded (FFPE) Tissue Analysis by Reverse Phase Protein Arrays (RPPA)

Bader S, Zajac M, Friess T, Ruge E, Rieder N, Gierke B, Heubach Y, Thomas M, Pawlak M

Mol Cell Proteomics. 2015 Oct;14(10):2775-85. doi: 10.1074/mcp.O114.045542. Epub 2015 Jun 23.

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A Multiplexed High-Content Screening Approach Using the Chromobody Technology to Identify Cell Cycle Modulators in Living Cells

Schorpp K, Rothenaigner I, Maier J, Traenkle B, Rothbauer U, Hadian K

J Biomol Screen. 2016 Oct;21(9):965-77. doi: 10.1177/1087057116641935. Epub 2016 Apr 4.

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A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human Cells

Buchfellner A, Yurlova L, Nuske S, Scholz AM, Bogner J, Ruf B, Zolghadr K, Drexler SE, Drexler GA., Girst S, Greubel C, Reindl J, Siebenwirth C, Romer T, Friedl AA, Rothbauer U

PLoS One. 2016 Mar 7;11(3):e0151041. doi: 10.1371/journal.pone.0151041. eCollection 2016.

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Catch and Patch: A Pipette-Based Approach for Automating Patch Clamp That Enables Cell Selection and Fast Compound Application

Danker T, Braun F, Silbernagl N, Guenther E

Assay Drug Dev Technol. 2016 Mar;14(2):144-55. doi: 10.1089/adt.2015.696.

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PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways

Kaistha BP, Lorenz H, Schmidt H, Sipos B, Pawlak M, Gierke B, Kreider R, Lankat-Buttgereit B, Sauer M, Fiedler L, Krattenmacher A, Geisel B, Kraus JM, Frese KK, Kelkenberg S, Giese NA, Kestler HA, Gress TM, Buchholz M

Cancer Res. 2016 Jan 1;76(1):96-107. doi: 10.1158/0008-5472.CAN-15-0216. Epub 2015 Dec 15.

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EpCAM-Independent Enrichment of Circulating Tumor Cells in Metastatic Breast Cancer

Schneck, H., Gierke, B., Uppenkamp, F., Behrens, B., Niederacher, D., Stoecklein, N. H., Templin, M. F., Pawlak, M., Fehm, T., Neubauer, H.

Proteomics, 9(13), 3535–3548. https://doi.org/10.1002/pmic.200800159

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Aberrant activity in degenerated retinas revealed by electrical imaging

Frontiers in Cellular Neuroscience. 2016; 10 :15. doi: 10.3389/fncel.2016.00025

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Hypothermia Protects and Prolongs the Tolerance Time of Retinal Ganglion Cells against Ischemia

Schultheiss M, Schnichels S, Hermann T, Hurst J, Feldkaemper M, Arango-Gonzalez B, Ueffing M, Bartz-Schmidt KU, Zeck G, Spitzer MS

PLoS One. 2016 Feb 5;11(2):e0148616. doi: 10.1371/journal.pone.0148616. eCollection 2016.

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MASP-1 and MASP-2 Do Not Activate Pro-Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors

Oroszlan G, Kortvely E, Szakacs D, Kocsis A, Dammeier S, Zeck A, Ueffing M, Zavodszky P, Pal G, Gal P, Dobo J

J Immunol. 2016 Jan 15;196(2):857-65. doi: 10.4049/jimmunol.1501717. Epub 2015 Dec 16.

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Pre-Analytical Parameters Affecting Vascular Endothelial Growth Factor Measurement in Plasma: Identifying Confounders

Walz JM, Boehringer D, Deissler HL, Faerber L, Goepfert JC, Heiduschka P, Kleeberger SM, Klettner A, Krohne TU, Schneiderhan-Marra N, Ziemssen F, Stahl A

PLoS One. 2016 Jan 5;11(1):e0145375. doi: 10.1371/journal.pone.0145375. eCollection 2016.

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A bead-based western for high-throughput cellular signal transduction analyses

Treindl F, Ruprecht B, Beiter Y, Schultz S, Dottinger A, Staebler A, Joos TO, Kling S, Poetz O, Fehm T, Neubauer H, Kuster B, Templin MF

Nat Commun. 2016 Sep 23;7:12852. doi: 10.1038/ncomms12852.

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Peptides in headlock - a novel high-affinity and versatile peptide-binding nanobody for proteomics and microscopy

Braun MB, Traenkle B, Koch PA, Emele F, Weiss F, Poetz O, Stehle T, Rothbauer U

Sci Rep. 2016 Jan 21;6:19211. doi: 10.1038/srep19211.

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Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells

Groll N, Kollotzek F, Goepfert J, Joos TO, Schwarz M, Braeuning A

Biol Chem. 2016 Jan 1;397(1):91-6. doi: 10.1515/hsz-2015-0223.

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Selective, efficient modulation of activated CD4+ alphabetaT cells by the novel humanized antibody GZ-alphabetaTCR targeting human alphabetaTCR

Blank G, Welker C, Haarer J, Sterk M, Nadalin S, Yanez VA, Joos TO, Menrad A, Snell D, LaCorcia G, Konigsrainer A, Handgretinger R, Schilbach K

Bone Marrow Transplant. 2015 Mar;50(3):390-401. doi: 10.1038/bmt.2014.263. Epub 2014 Nov 17.

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Smooth Muscle-Like Cells Generated from Human Mesenchymal Stromal Cells Display Marker Gene Expression and Electrophysiological Competence Comparable to Bladder Smooth Muscle Cells

Brun J, Lutz KA, Neumayer KM, Klein G, Seeger T, Uynuk-Ool T, Worgotter K, Schmid S, Kraushaar U, Guenther E, Rolauffs B, Aicher WK, Hart ML

PLoS One. 2015 Dec 16;10(12):e0145153. doi: 10.1371/journal.pone.0145153. eCollection 2015.

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EpCAM-Independent Enrichment of Circulating Tumor Cells in Metastatic Breast Cancer

Schneck H, Gierke B, Uppenkamp F, Behrens B, Niederacher D, Stoecklein NH, Templin MF, Pawlak M, Fehm T, Neubauer H

PLoS One. 2015 Dec 22;10(12):e0144535. doi: 10.1371/journal.pone.0144535. eCollection 2015.

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miR-124 disinhibits neurite outgrowth in an inflammatory environment

Hartmann H, Hoehne K, Rist E, Louw AM, Schlosshauer B

Cell Tissue Res. 2015 Oct;362(1):9-20. doi: 10.1007/s00441-015-2183-y. Epub 2015 Apr 29.

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Immunoliposomes for Targeted Delivery of an Antifibrotic Drug

Schuster L, Seifert O, Vollmer S, Kontermann RE, Schlosshauer B, Hartmann H

Mol Pharm. 2015 Sep 8;12(9):3146-57. doi: 10.1021/acs.molpharmaceut.5b00012. Epub 2015 Jul 28.

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Real-time analysis of epithelial-mesenchymal transition using fluorescent single-domain antibodies

Maier J, Traenkle B, Rothbauer U

Sci Rep. 2015 Aug 21;5:13402. doi: 10.1038/srep13402.

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Evaluation of protein profiles from treated xenograft tumor models identifies an antibody panel for FFPE tissue analysis by reverse phase protein arrays

Bader S, Zajac M, Friess T, Ruge E, Rieder N, Gierke B, Heubach Y, Thomas M, Pawlak M

Mol Cell Proteomics. 2015 Oct;14(10):2775-85. doi: 10.1074/mcp.O114.045542. Epub 2015 Jun 23.

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Live imaging of endogenous protein dynamics in zebrafish using chromobodies.

Panza P, Maier J, Schmees C, Rothbauer U, Söllner C.

Development. 2015 May 15;142(10):1879-84. doi: 10.1242/dev.118943.

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Monitoring interactions and dynamics of endogenous beta-catenin with intracellular nanobodies in living cells

Traenkle B, Emele F, Anton R, Poetz O, Haeussler RS, Maier J, Kaiser PD, Scholz AM, Nueske S, Buchfellner A, Romer T, Rothbauer U

Mol Cell Proteomics. 2015 Mar;14(3):707-23. doi: 10.1074/mcp.M114.044016. Epub 2015 Jan 16.

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Generation of an alpaca-derived nanobody recognizing gamma-H2AX

Rajan M, Mortusewicz O, Rothbauer U, Hastert FD, Schmidthals K, Rapp A, Leonhardt H, Cardoso MC

FEBS Open Bio. 2015 Sep 21;5:779-88. doi: 10.1016/j.fob.2015.09.005. eCollection 2015.

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A Bead-Based Multiplex Sandwich Immunoassay to Assess the Abundance and Posttranslational Modification State of beta-Catenin

Groll N, Sommersdorf C, Joos TO, Poetz O

Methods Mol Biol. 2015;1295:441-53. doi: 10.1007/978-1-4939-2550-6_31.

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Human placenta-derived CD146-positive mesenchymal stromal cells display a distinct osteogenic differentiation potential

Ulrich C, Abruzzese T, Maerz JK, Ruh M, Amend B, Benz K, Rolauffs B, Abele H, Hart ML, Aicher WK

Stem Cells Dev. 2015 Jul 1;24(13):1558-69. doi: 10.1089/scd.2014.0465. Epub 2015 Apr 13.

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Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry

Weiß F, Schnabel A, Planatscher H, van den Berg BHJ, Serschnitzki B, Nuessler AK, Thasler WE, Weiss TS, Reuss M, Stoll D, Templin MF, Joos TO, Marcus K, Poetz O

Sci Rep. 2015 Mar 4;5:8759. doi: 10.1038/srep08759.

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Towards multiplexed protein-protein interaction analysis using protein tag-specific nanobodies

Groll N, Emele F, Poetz O, Rothbauer U

J Proteomics. 2015 Sep 8;127(Pt B):289-99. doi: 10.1016/j.jprot.2015.04.017. Epub 2015 May 1.

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Bead-Based Peptide Arrays for Profiling the Specificity of Modification State-Specific Antibodies

Filomena A, Beiter Y, Templin MF, Joos TO, Schneiderhan-Marra N, Poetz O

Methods Mol Biol. 2015;1348:251-65. doi: 10.1007/978-1-4939-2999-3_22.

Zur Publikation

PEDOT-CNT coated electrodes stimulate retinal neurons at low voltage amplitudes and low charge densities

Samba R, Herrmann T, Zeck G

J Neural Eng. 2015 Feb;12(1):016014. doi: 10.1088/1741-2560/12/1/016014. Epub 2015 Jan 14.

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Daylight vision repair by cell transplantation

Santos-Ferreira T, Postel K, Stutzki H, Kurth T, Zeck G, Ader M

Stem Cells. 2015 Jan; 33(1):79-90. doi: 10.1002/stem.1824.

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Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [18F] FDG-PET imaging combined with proteomic approaches

Tegnebratt T, Ruge E, Bader S, Ishii N, Aida S, Yoshimura Y, Ooi C-H, Lu L, Mitsios N, Meresse V, Mulder J, Pawlak M, Venturi M, Tessier J, Stone-Elander S

EJNMMI Res. 2014 Dec;4(1):34. doi: 10.1186/s13550-014-0034-6. Epub 2014 Sep 9.

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Plasma matrix metalloproteinase 1, 3, and 7 levels and breast cancer risk in the Nurses' Health study

Aroner SA, Rosner BA, Tamimi RM, Tworoger SS, Baur N, Joos TO, Hankinson SE

Cancer Causes Control. 2014 Dec;25(12):1717-23. doi: 10.1007/s10552-014-0462-7. Epub 2014 Sep 16.

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Dentate Gyrus Local Circuit is Implicated in Learning Under Stress-a Role for Neurofascin

Zitman FM, Lucas M, Trinks S, Grosse-Ophoff L, Kriebel M, Volkmer H, Richter-Levin G

Mol Neurobiol (2016) 53:842–850 DOI 10.1007/s12035-014-9044-7

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Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells

Kaistha BP, Honstein T, Muller V, Bielak S, Sauer M, Kreider R, Fassan M, Scarpa A, Schmees C, Volkmer H, Gress TM, Buchholz, M

Br J Cancer. 2014 Oct 28;111(9):1780-7. doi: 10.1038/bjc.2014.460. Epub 2014 Aug 19.

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Towards plug and play filling of microfluidic devices by utilizing networks of capillary stop valves

Hagmeyer B, Zechnall F, Stelzle M

Biomicrofluidics. 2014 Sep 19;8(5):056501. doi: 10.1063/1.4896063. eCollection 2014 Sep.

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Rhythmic Ganglion Cell Activity in Bleached and Blind Adult Mouse Retinas

Menzler J, Channappa L, Zeck G

PLoS One. 2014 Aug 25;9(8):e106047. doi: 10.1371/journal.pone.0106047. eCollection 2014.

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Realizing the Promise of Reverse Phase Protein Arrays for Clinical, Translational, and Basic Research: A Workshop Report: The RPPA (Reverse Phase Protein Array) Society

Akbani R, Becker KF, Carragher N, Goldstein T, de Koning L, Korf U, Liotta L, Mills GB, Nishizuka SS, Pawlak M, Petricoin EF, Pollard HB, Serrels B, Zhu J

Mol Cell Proteomics. 2014 Jul;13(7):1625-43. doi: 10.1074/mcp.O113.034918. Epub 2014 Apr 28.

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Polyelectrolyte multilayers as functional coatings for controlled biomolecular interactions

Hartmann H, Schlosshauer B

In: Biofunctional Surface Engineering. M. Scholz (Ed), Pan Stanford Publishing 2014: 27-46.

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Stress modulation of hippocampal activity - Spotlight on the dentate gyrus

Fa M, Xia L, Anunu R, Kehat O, Kriebel M, Volkmer H, Richter-Levin G

Neurobiol Learn Mem. 2014 Jul;112C:53-60. doi: 10.1016/j.nlm.2014.04.008. Epub 2014 Apr 18.

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Isolation, expansion and transplantation of postnatal murine progenitor cells of the enteric nervous system

Dettmann HM, Zhang Y, Wronna N, Kraushaar U, Guenther E, Mohr R, Neckel PH, Mack A, Fuchs J, Just L, Obermayr F

PLoS One. 2014 May 28;9(5):e97792. doi: 10.1371/journal.pone.0097792. eCollection 2014.

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A p38 substrate-specific MK2-EGFP translocation assay for identification and validation of new p38 inhibitors in living cells: a comprising alternative for acquisition of cellular p38 inhibition data

Anton R, Bauer SM, Keck PR, Laufer S, Rothbauer U

PLoS One. 2014 Apr 17;9(4):e95641. doi: 10.1371/journal.pone.0095641. eCollection 2014.

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Cross-platform toxicogenomics for the prediction of non-genotoxic hepatocarcinogenesis in rat

Romer M, Eichner J, Metzger U, Templin MF, Plummer S, Ellinger-Ziegelbauer H, Zell A

PLoS One. 2014 May 15;9(5):e97640. doi: 10.1371/journal.pone.0097640. eCollection 2014.

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Recent progress in generating intracellular functional antibody fragments to target and trace cellular components in living cells

Kaiser PD, Maier J, Traenkle B, Emele F, Rothbauer U

Biochim Biophys Acta. 2014 Nov;1844(11):1933-1942. doi: 10.1016/j.bbapap.2014.04.019. Epub 2014 May 2.

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Organ-Like Cell Cultures in Microfluidic Systems

Li D, Schütte J, Stelzle M

2015 in: Li D. (eds) Encyclopedia of Microfluidics and Nanofluidics. Springer, New York, NY.

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Action potentials in retinal ganglion cells are initiated at the site of maximal curvature of the extracellular potential

Eickenscheidt M, Zeck G

J Neural Eng. 2014 Jun;11(3):036006. doi: 10.1088/1741-2560/11/3/036006. Epub 2014 Apr 24.

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c-Jun/c-Fos heterodimers regulate cellular genes via a newly identified class of methylated DNA sequence motifs

Gustems M, Woellmer A, Rothbauer U, Eck SH, Wieland T, Lutter D, Hammerschmidt W

Nucleic Acids Res. 2014 Mar;42(5):3059-72. doi: 10.1093/nar/gkt1323. Epub 2013 Dec 25.

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The Fluorescent Two-Hybrid Assay to Screen for Protein-Protein Interaction Inhibitors in Live Cells: Targeting the Interaction of p53 with Mdm2 and Mdm4

Yurlova L, Derks M, Buchfellner A, Hickson I, Janssen M, Morrison D, Stansfield I, Brown CJ, Ghadessy FJ, Lane DP, Rothbauer U, Zolghadr K, Krausz E

J Biomol Screen. 2014 Apr;19(4):516-25. doi: 10.1177/1087057113518067. Epub 2014 Jan 29.

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A versatile assay for RNA-binding proteins in living cells

Strein C, Alleaume AM, Rothbauer U, Hentze MW, Castello A

RNA. 2014 May;20(5):721-31. doi: 10.1261/rna.043562.113. Epub 2014 Mar 24.

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Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays

Schonecker S, Kraushaar U, Dufer M, Sahr A, Hardtner C, Guenther E, Walther R, Lendeckel U, Barthlen W, Krippeit-Drews P, Drews G

Integr Biol (Camb). 2014 Mar 24; 2014(4):540-544

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Application of PEDOT-CNT Microelectrodes for Neurotransmitter Sensing

Samba R, Fuchsberger K, Matiychyn I, Epple S, Kiesel L, Stett A, Schuhmann W, Stelzle M

Electroanalysis. 2014 March; 26(3): 548-555. https://doi.org/10.1002/elan.201300547

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Ha-ras and β-Catenin oncoproteins orchestrate metabolic programs in mouse liver tumors

Unterberger EB, Eichner J, Wrzodek C, Lempiäinen H, Luisier R, Terranova R, Metzger U, Plummer S, Knorpp T, Braeuning A, Moggs J, Templin MF, Honndorf V, Piotto M, Zell A, Schwarz M

International Journal of Cancer. 2014 Oct 1; 135(7): 1574-1585. https://doi.org/10.1002/ijc.28798

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Inflammatory stimulation preserves physiological properties of retinal ganglion cells after optic nerve injury

Stutzki H, Leibig C, Andreadaki A, Fischer D, Zeck G

Front Cell Neurosci. 2014; 8: 38. doi: 10.3389/fncel.2014.00038

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Cell-type specific four-component hydrogel

Aberle T, Franke K, Rist E, Benz K, Schlosshauer B

PLoS One. 2014 Jan 27;9(1):e86740. doi: 10.1371/journal.pone.0086740. eCollection 2014.

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A touch of glue to complete bacteriophage assembly: the Tail-to-Head Joining Protein (THJP) family

Auzat I, Petitpas I, Lurz R, Weise F, Tavares P

Mol Microbiol. 2014 Jan 21;91(6): 1164-1178. doi: 10.1111/mmi.12526.

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Identification of short terminal motifs enriched by antibodies using peptide mass fingerprinting

Planatscher H, Weiss F, Eisen D, Zell A, Joos T, Poetz O

Bioinformatics. 2014 May 1;30(9):1205-13. doi: 10.1093/bioinformatics/btu009. Epub 2014 Jan 9.

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Organisation and Control of Neuronal Connectivity and Myelination by Cell Adhesion Molecule Neurofascin

Ebel J, Beuter S, Wuchter J, Kriebel M, Volkmer H

2014. in: Berezin V, Walmod P (eds). Cell Adhesion Molecules. Advances in Neurobiology, Springer New York. 8: 231-247

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A New In Vitro Model to Study Cellular Responses after Thermomechanical Damage in Monolayer Cultures

Hettler A, Werner S, Eick S, Laufer S, Weise F

PLoS One. 2013; 8(12): e82635. doi: 10.1371/journal.pone.0082635

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Development of a novel assay for proprotein converting enzyme activity on a multiplex bead-based array system

Albrecht A, Rahmoune H, Leedjarv K, Knorpp T, Joos T, Stocki P, Guest PC, Bahn S

Proteomics. 2013 Oct;13(20):2976-9. doi: 10.1002/pmic.201300060.

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Catch and measure-mass spectrometry-based immunoassays in biomarker research

Weiss F, van den Berg BH, Planatscher H, Pynn CJ, Joos TO, Poetz O

Biochim Biophys Acta. 2014 May; 1844(5);927-932. doi: 10.1016/j.bbapap.2013.09.010.

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Multiple Protein Analysis of Formalin-fixed and Paraffin-embedded Tissue Samples with Reverse phase Protein Arrays

Assadi M, Lamerz J, Jarutat T, Farfsing A, Paul H, Gierke B, Breitinger E, Templin MF, Essioux L, Arbogast S, Venturi M, Pawlak M, Langen H, Schindler T

Mol Cell Proteomics. 2013 Sep;12(9):2615-22. doi: 10.1074/mcp.M112.023051. Epub 2013 May 7.

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Label-free detection of tumor markers in a colon carcinoma tumor progression model by confocal Raman microspectroscopy

Scalfi-Happ C, Rück A, Udart M, Hauser C, Dürr C, Kriebel M

Proc. SPIE. Clinical and Biomedical Spectroscopy and Imaging III. 2013 June 18; 87980B. doi:10.1117/12.2032459;

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Adhesion to Extracellular Matrix Proteins can Differentiate Between Human Bone Marrow Derived Mesenchymal Stem Cells and Fibroblasts

Roncoroni LP, Maerz JK, Angres B, Steuer H, Benz K, Abruzzese T, Hart ML, Rolauffs B, Klein G, Stoll D, Aicher WK

J Tissue Sci Eng. 2012;3:3. doi: 10.4172/2157-7552.S1.003

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In vivo single branch axotomy induces GAP-43–dependent sprouting and synaptic remodeling in cerebellar cortex

Allegra Mascaroa AL, Cesare P, Sacconia L, Grasselli G, Mandolesi G, Maco BL, Knott GW, Huang L, De Paola V, Strata P, Pavone FS

PNAroc Natl Acad Sci U S A. 2013 Jun 25; 110(26): 10824–10829. doi: 10.1073/pnas.1219256110

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Cell-Based Therapy for the Deficient Urinary Sphincter

Hart ML, Neumayer KMH, Vaegler M, Daum L, Amend B, Sievert KD, Di Giovanni S, Kraushaar U, Guenther E, Stenzl A, Aicher WK

Curr Urol Rep. 2013 Oct;14(5):476-87. doi: 10.1007/s11934-013-0352-7.

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Maintenance of "stem cell" features of cartilage cell sub-populations during in vitro propagation

Benz K, Stippich C, Freudigmann C, Mollenhauer JA, Aicher WK

J Transl Med. 2013 Jan 30;11:27. doi: 10.1186/1479-5876-11-27.

Zur Publikation

Multiple protein analysis of FFPE tissue samples with reverse-phase protein arrays

Assadi M, Lamerz J, Jarutat T, Farfsing A, Paul H, Gierke B, Breitinger E, Templin MF, Essioux L, Arbogast S, Venturi M, Pawlak M, Langen H, Schindler T

Mol Cell Proteomics. 2013 Sep;12(9):2615-22. doi: 10.1074/mcp.M112.023051. Epub 2013 May 7.

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Regulation of Adhesion by Flexible Ectodomains of IgCAMs

Volkmer H, Schreiber J, Rathjen FG

Neurochem Res. 2013 Jun;38(6):1092-9. doi: 10.1007/s11064-012-0888-9. Epub 2012 Oct 9.

Zur Publikation

Hyaluronic acid / chitosan multilayer coatings on neuronal implants for localized delivery of siRNA nanoplexes

Hartmann H, Hossfeld S, Schlosshauer B, Mittnacht U, Pego AP, Dauner M, Doser M, Stoll D, Krastev R

J Control Release. 2013 Apr 4;168(3):289-297. doi: 10.1016/j.jconrel.2013.03.026.

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Prostate carcinoma cell growth-inhibiting hydrogel supports axonal regeneration in vitro

Franke K, Baur M, Daum L, Vaegler M, Sievert KD, Schlosshauer B

Neurosci Lett. 2013 Apr 29;541:248-52. doi: 10.1016/j.neulet.2013.01.057. Epub 2013 Feb 15.

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Axonale Leitungsgeschwindigkeiten in der Kaninchenretina gemessen mit Multitransistorarray

Diplomarbeit. Physik-Department, Technische Universität München. 2012. 61 Seiten.

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From spots to beads-PTM-peptide bead arrays for the characterization of anti-histone antibodies

Heubach Y, Planatscher H, Sommersdorf C, Maisch D, Maier J, Joos TO, Templin MF, Poetz O

Proteomics. 2013 Mar;13(6):1010-5. doi: 10.1002/pmic.201200383.

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Molecularly imprinted conductive polymers for controlled trafficking of neurotransmitters at solid-liquid interfaces

Paul N, Muller M, Paul A, Guenther E, Lauermann I, Muller-Buschbaum P, Lux-Steiner Muh

Soft Matter. 2013; 9(4): 1364-1371. DOI 10.1039/C2SM26896E

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Future strategies include pluripotent stem cell-derived cardiomyocytes

Notocord Newsletter 2013, March

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Is the Enhanced Adhesion of PEDOT Thin Films on Electrodes Due to Sulfur - Gold Interaction? - An XPS Study

Samba R, Chassé T, Stelzle M

The Open Surface Science Journal. 2013; 5: 17-20.

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Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion

Lempiainen H, Couttet P, Bolognani F, Muller A, Dubost V, Luisier R, Del Rio Espinola A, Vitry V, Unterberger EB, Thomson JP, Treindl F, Metzger U, Wrzodek C, Hahne F, Zollinger T, Brasa S, Kalteis M, Marcellin M, Giudicelli F, Braeuning A, Morawiec L, Zamurovic N, Langle U, Scheer N, Schubeler D, Goodman J, Chibout SD, Marlowe J, Theil D, Heard DJ, Grenet O, Zell A, Templin MF, Meehan RR, Wolf RC, Elcombe CR, Schwarz M, Moulin P, Terranova R, Moggs JG

Toxicol Sci. 2013 Feb;131(2):375-86. doi: 10.1093/toxsci/kfs303. Epub 2012 Oct 22.

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Determination of antibody glycosylation by mass spectrometry

Jager C, Ferrara C, Umana P, Zeck A, Regula JT, Koll H

Methods Mol Biol. 2012;901:195-208. doi: 10.1007/978-1-61779-931-0_13.

Zur Publikation

Plasma levels of soluble glycoprotein VI (sGPVI) are associated with ischemic stroke

Wurster T, Poetz O, Stellos K, Kremmer E, Melms A, Schuster A, Nagel E, Joos T, Gawaz M, Bigalke B

Platelets. 2013;24(7):560-5. doi: 10.3109/09537104.2012.746455. Epub 2012 Dec 5.

Zur Publikation

Concurrent epigenetic silencing of wnt/beta-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia

Moskalev EA, Luckert K, Vorobjev IA, Mastitsky SE, Gladkikh AA, Stephan A, Schrenk M, Kaplanov KD, Kalashnikova OB, Poets O, Joos TO, Hoheisel JD

BMC Cancer. 2012 Jun 6;12:213. doi: 10.1186/1471-2407-12-213.

Zur Publikation

The recombinant bifunctional protein alphaCD133-GPVI promotes repair of the infarcted myocardium in mice

Baumer Y, Leder C, Ziegler M, Schonberger T, Ochmann C, Perk A, Degen H, Schmid-Horch B, Elvers M, Munch G, Ungerer M, Schlosshauer B, Gawaz M

J Thromb Haemost. 2012 Jun;10(6):1152-64. doi: 10.1111/j.1538-7836.2012.04710.x.

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CVD-Synthese von Kohlenstoff-Nanoröhren zur Nutzung als Mikroelektroden für neuronale Anwendungen

Stamm B, Schneider K, Herrmann T, Burkhardt C, Nisch W, Fleischer M, Kern DP, Stett A

WOMag, 2012 Nov: 14-17.

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Low level sequence variant analysis of recombinant proteins: an optimized approach

Zeck A, Regula JT, Larraillet V, Mautz B, Popp O, Gopfert U, Wiegeshoff F, Vollertsen UE, Gorr IH, Koll H, Papadimitriou A

PLoS One. 2012;7(7):e40328. Epub 2012 Jul 6.

Zur Publikation

Characterization of immunologically active drugs in a novel organotypic co-culture model of the human gut and whole blood

Schmohl M, Schneiderhan-Marra N, Baur N, Hefner K, Blum M, Stein GM, Joos TO, Schmolz M

Int Immunopharmacol. 2012 Oct 24;14(4):722-728. doi: 10.1016/j.intimp.2012.10.010.

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Rezeptortyrosinkinasen regulieren die Oberflächenaggregation des neuronalen Gerüstproteins Gephyrin

Doktorarbeit, Mathematisch-Naturwissenschaftliche Fakultät, Eberhard Karls Universität Tübingen. 2012. 133 Seiten.

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Combining ultracentrifugation and peptide termini group-specific immunoprecipitation for multiplex plasma protein analysis

Volk S, Schreiber TD, Eisen D, Wiese C, Planatscher H, Pynn CJ, Stoll D, Templin MF, Joos TO, Poetz O

Mol Cell Proteomics. 2012 Jul;11(7):O111.015438. Epub 2012 Apr 23.

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A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins

Luckert K, Gujral TS, Chan M, Sevecka M, Joos TO, Sorger PK, Macbeat G, Poetz O

Sci Signal. 2012 Jan 10;5(206):pl1. doi: 10.1126/scisignal.2002372.

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A Comprehensive Small Interfering RNA Screen Identifies Signaling Pathways Required for Gephyrin Clustering

Wuchter J, Beuter S, Treindl F, Herrmann T, Zeck G, Templin MF, Volkmer H

The Journal of Neuroscience. 2012 Oct 17; 32(42):14821–14834

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Electrical stimulation of retinal neurons in epiretinal and subretinal configuration using a multicapacitor array

Eickenscheidt M, Jenkner M, Thewes R, Fromherz P, Zeck G

J Neurophysiol. 2012 May;107(10):2742-55. Epub 2012 Feb 22.

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Conditional Disruption of Axin1 Leads to Development of Liver Tumors in Mice

Feng GJ, Cotta W, Wei XQ, Poetz O, Evans R, Jarde T, Reed K, Meniel V, Williams GT, Clarke AR, Dale TC

Gastroenterologie. 2012;143:1650–1659. http://dx.doi.org/10.1053/j.gastro.2012.08.047

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Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors

Bauer M, Chicca A, Tamborrini M, Eisen D, Lerner R, Lutz B, Poetz O, Pluschke G, Gertsch J

J Biol Chem. 2012 Oct 26; 287(44): 36944–36967. doi: 10.1074/jbc.M112.382481

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Mycobacterium tuberculosis Antigen Arrays for the in-depth Characterization of the Serological Response of TB Infected Patient Cohorts

Doktorarbeit, Mathematisch-Naturwissenschaftliche Fakultät, Universität Tübingen. 2012. 134 Seiten.

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Receptor tyrosine kinase inhibitor profiling using bead-based multiplex sandwich immunoassays

Poetz O, Schneiderhan-Marra N, Henzler T, Herget T, Joos TO

Methods Mol Biol. 2012;795:191-202. doi: 10.1007/978-1-61779-337-0_13.

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The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice

Ziegler M, Elvers M, Baumer Y, Leder C, Ochmann C, Schonberger T, Jurgens T, Geisler T, Schlosshauer B, Lunov O, Engelhardt S, Simmet T, Gawaz M

Circulation. 2012 Feb 7;125(5):685-96. Epub 2012 Jan 5

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Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V.

Schmees C, Villaseñor R, Zheng W, Ma H, Zerial M, Heldin CH, Hellberg C

Mol Biol Cell. 2012 Jul 1; 23(13): 2571–2582. doi: 10.1091/mbc.E11-04-0317

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A Miniaturized Ligand Binding Assay for EGFR

Schwenk JM, Poetz O, Zeillinger R, Joos T

Int J Proteomics. 2012; 2012: 247059. doi: 10.1155/2012/247059

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Neurofascin: A switch between neuronal plasticity and stability

Kriebel M, Wuchter J, Trinks S, Volkmer H

Int J Biochem Cell Biol. 2012 May; 44(5): 694-697. doi: 10.1016/j.biocel.2012.01.012

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Entwicklung eines Immunoassays zur Quantifizierung von ALT 1 und ALT 2 in humanen Proben

Diplomarbeit, Interfakultäres Institut für Biochemie, Eberhard Karls Universität Tübingen. 2012. 133 Seiten.

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Analyse der Bindungseigenschaften von beta-Catenin nach Phosphorylierung von Ser552 und Ser675

Diplomarbeit, Interfaktultäres Institut für Biochemie, Eberhard Karls Universität Tübingen. 2012. 80 Seiten.

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Treatment with Actovegin(R) Improves Sensory Nerve Function and Pathology in Streptozotocin-Diabetic Rats via Mechanisms Involving Inhibition of PARP Activation

Dieckmann A, Kriebel M, Andriambeloson E, Ziegler D, Elmlinger M

Exp Clin Endocrinol Diabetes. 2012 Mar 120(3):132-8.

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A biomarker panel to discriminate between systemic inflammatory response syndrome and sepsis and sepsis severity

Punyadeera C, Schneider EM, Schaffer D, Hsu HY, Joos TO, Kriebel F, Weiss M, Verhaegh WF

J Emerg Trauma Shock. 2010 Jan;3(1):26-35. doi: 10.4103/0974-2700.58666

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Developmental dynamics of gap junction based neuronal coupling in the rat inferior olive

Mueller JR, Kriebel M, Volkmer H, Thier P

Neuroscience Meeting Planer. Washington DC: Society for Neuroscience, 2011.

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Enhanced predictive drug development: Functional screening of the GABAAR alpha1 subunit using receptor-specific RNA inference, MEA recordings and substance classification

Bader BM, Kniest S, Jügelt K, Kriebel M, Volkmer H, Schroeder OH-U, Gramowski-Voss A

euroscience Meeting Planer. Program No. 41.13/E24. 2011. Washington, DC: Society for Neuroscience, 2011.

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Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays

Pfeiffer T, Kraushaar U, Düfer M, Schönecker S, Haspel D, Günther E, Drews G, Krippeit-Drews P

Europ. J. Physiol. 2011, 462 (6): 835-840. DOI 10.1007/s00424-011-1029-z

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Bioartificial reconstruction of peripheral nerves using the rat median nerve model

Sinis N, Kraus A, Drakotos D, Doser M, Schlosshauer B, Muller HW, Skouras E, Bruck JC, Werdin F

Ann Anat. 2011 Jul;193(4):341-6. Epub 2011 Mar 22. DOI 10.1016/j.aanat.2011.02.018

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The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.

Min TH, Kriebel M, Hou S, Pera EM

Dev Biol. 2011 Oct 1;358(1):262-76. DOI 10.1016/j.ydbio.2011.07.035

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Numerical modelling and measurement of cell trajectories in 3-D under the influence of dielectrophoretic and hydrodynamic forces

Holzner F, Hagmeyer B, Schütte J, Kubon M, Angres B, Stelzle M

Electrophoresis. 2011 August; 32(17): 2366-2376. DOI 10.1002/elps.201100026

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Extracellular voltage noise probes the interfaces between retina and silicon chip

Zeitler R, Fromherz P, Zeck G

Applied Physics Letters. 2011 Dec; 99: 263702. DOI 10.1063/1.3672224

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Medicinal Chemistry Approaches for the Inhibition of the p38 MAPK Pathway

Laufer L, Margutti S, Hauser D

2011 in Protein Kinases as Drug Targets. G. M. B. Klebl, M. Hamacher. Weinheim, Wiley-VCH Verlag GmbH & Co. KGaA.

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Increased palmitoyl-myristoyl-phosphatidylcholine in neonatal rat surfactant is lung specific and correlates with oral myristic acid supply

Bernhard W, Raith M, Pynn CJ, Gille C, Stichtenoth G, Stoll D, Schleicher E, Poets CF

J Appl Physiol. 2011 Aug;111(2):449-57. Epub 2011 Jun 2. doi:10.1152/japplphysiol.00766.2010.

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Neuroprotective and anti-oxidative effects of the hemodialysate actovegin on primary rat neurons in vitro

Elmlinger MW, Kriebel M, Ziegler D

Neuromolecular Med. 2011 Dec;13(4):266-74. Epub 2011 Oct 9. doi: 10.1007/s12017-011-8157-7

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Neuronal and glial responses to siRNA-coated nerve guide implants in vitro

Hoffmann N, Mittnacht U, Hartmann H, Baumer Y, Kjems J, Oberhoffner S, Schlosshauer B

Neurosci Lett. 2011 Apr 20;494(1):14-8. Epub 2011 Feb 23. DOI 10.1016/j.neulet.2011.02.043

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Axonal transmission in the retina introduces a small dispersion of relative timing in the ganglion cell population response

Zeck G, Lambacher A, Fromherz P

PLoS One. 2011;6(6):e20810. Epub 2011 Jun 2.

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A generic operational strategy to qualify translational safety biomarkers

Matheis K, Laurie D, Andriamandroso C, Arber N, Badimon L, Benain X, Bendjama K, Clavier I, Colman P, Firat H, Goepfert J, Hall S, Joos T, Kraus S, Kretschmer A, Merz M, Planatscher H, Schneiderhan-Marra N

Drug Discov Today. 2011 July; 16(13-14): 600-608. DOI 10.1016/j.drudis.2011.04.011

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The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment

Kriebel M, Metzger J, Trinks S, Chugh D, Harvey RJ, Harvey K, Volkmer H

J Biol Chem. 2011 Jul 8; 286(27): 24385–24393. doi: 10.1074/jbc.M110.212191

Zur Publikation

Sandwich Immunoassay for Soluble Glycoprotein VI in Patients with Symptomatic Coronary Artery Disease

Bigalke B, Poetz O, Kremmer E, Geisler T, Seizer P, Puntmann VO, Phinikaridou A, Chiribiri A, Nagel E, Botnar RM, Joos T, Gawaz M

Clin Chem. 2011 Jun;57(6):898-904. Epub 2011 Apr 7. DOI: 10.1373/clinchem.2010.158527

Zur Publikation

Telomerase-based immortalization modifies the angiogenic/inflammatory responses of human coronary artery endothelial cells

Baumer Y, Scholz B, Ivanov S, Schlosshauer B

Exp Biol Med (Maywood). 2011 Jun 1;236(6):692-700. DOI: 10.1258/ebm.2011.010300

Zur Publikation

Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review

Mandenius CF, Steel D, Noor F, Meyer T, Heinzle E, Asp J, Arain S, Kraushaar U, Bremer S, Class R, Sartipy P

J Appl Toxicol. April 2011; 31(3): 191-205. https://doi.org/10.1002/jat.1663

Zur Publikation

The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment

Kriebel M, Metzger J, Trinks S, Chugh D, Harvey RJ, Harvey K, Volkmer H

J Biol Chem. 2011 Jul 8; 286(27): 24385–24393. doi: 10.1074/jbc.M110.212191

Zur Publikation

TRPV Channel Expression in Human Skin and Possible Role in Thermally Induced Cell Death

Radtke C, Sinis N, Sauter M, Jahn S, Kraushaar U, Guenther E, Rodemann HP, Rennekampff HO

J Burn Care Res. 2011 Jan-Feb;32(1):150-9. DOI 10.1097/BCR.0b013e318203350c

Zur Publikation

Molecular indicators of non-sentinel node status in breast cancer determined in preoperative biopsies by multiplexed sandwich immunoassays

Sauer G, Schneiderhan-Marra N, Muche R, Koretz K, Kazmaier C, Kreienberg R, Joos T, Deissler H

J Cancer Res Clin Oncol. 2011 Aug;137(8):1175-84. Epub 2011 Apr 24.

Zur Publikation

Network oscillations in rod-degenerated mouse retinas

Menzler J, Zeck G

J Neurosci. 2011 Feb 9;31(6):2280-91. DOI: 10.1523/JNEUROSCI.4238-10.2011

Zur Publikation

Cell Type-Specific and Site Directed N-Glycosylation Pattern of FcgammaRIIIa

Zeck A, Pohlentz G, Schlothauer T, Peter-Katalinic J, Regula JT

J. Proteome Res. 2011;10(7):3031–3039. DOI: 10.1021/pr1012653

Zur Publikation

Cell-based microarrays of infectious adenovirus encoding short hairpin RNA (shRNA)

Volkmer H, Weise F

Methods Mol Biol. 2011;706:97-106.

Zur Publikation

Snapshots of protein dynamics and posttranslational modifications in one experiment - [beta]-catenin and its functions

Luckert K, Goetschel F, Sorger PK, Hecht A, Joos TO, Poetz O

Mol Cell Proteomics. 2011 May;10(5):M110.007377. Epub 2011 Mar 4. doi: 10.1074/mcp.M110.007377

Zur Publikation

Structure and mechanism of the magnesium-independent aromatic prenyltransferase CloQ from the clorobiocin biosynthetic pathway

Metzger U, Keller S, Stevenson CE, Heide L, Lawson DM

J Mol Biol. 2010 Dec 10;404(4):611-26. doi: 10.1016/j.jmb.2010.09.067. Epub 2010 Oct 12.

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Wnt/beta-catenin signaling activates and determines hepatic zonal expression of glutathione S-transferases in mouse liver

Giera S, Braeuning A, Kohle C, Bursch W, Metzger U, Buchmann A, Schwarz M

Toxicol Sci. 2010 May;115(1):22-33. Epub 2010 Jan 30. doi: 10.1093/toxsci/kfq033.

Zur Publikation

Minimum information about a protein affinity reagent (MIAPAR)

Bourbeillon J, Orchard S, Benhar I, Borrebaeck C, Templin M, de Daruvar A, Dubel S, Frank R, Gibson F, Gloriam D, Haslam N, Hiltker T, Humphrey-Smith I, Hust M, Juncker D, Koegl M, Konthur Z, Korn B, et al.

NatBiotechnol. 2010 Jul;28(7):650-3. doi: 10.1038/nbt0710-650.

Zur Publikation

Triple-negative breast cancer: present challenges and new perspectives

Podo F, Buydens LM, Degani H, Hilhorst R, Klipp E, Gribbestad IS, Van Huffel S, van Laarhoven HW, Luts J, Monleon D, Postma GJ, Schneiderhan-Marra N, Santoro F, Wouters H, Russnes HG, Sorlie T et al.

Mol Oncol. 2010 Jun;4(3):209-29. Epub 2010 Apr 24. doi: 10.1016/j.molonc.2010.04.006

Zur Publikation

Targeting peptide termini - a novel immunoaffinity approach to reduce complexity in mass spectrometric protein identification

Hoeppe S, Schreiber TD, Planatscher H, Zell A, Templin MF, Stoll D, Joos TO, Poetz O

Mol Cell Proteomics. 2011 Feb;10(2):M110.002857. doi: 10.1074/mcp.M110.002857. Epub 2010 Oct 20.

Zur Publikation

Optimal selection of epitopes for TXP-immunoaffinity mass spectrometry

Planatscher H, Supper J, Poetz O, Stoll D, Joos T, Templin MF, Zell A

Algorithms Mol Biol. 2010 Jun 25;5:28. doi: 10.1186/1748-7188-5-28

Zur Publikation

Multiplexed immunoassays for the analysis of breast cancer biopsies

Schneiderhan-Marra N, Sauer G, Kazmaier C, Hsu HY, Koretz K, Deissler H, Joos TO

Anal Bioanal Chem. 2010 Aug;397(8):3329-38. doi: 10.1007/s00216-010-3873-7. Epub 2010 Jul 18.

Zur Publikation

Biocompatible molecularly imprinted polymers for the voltage regulated uptake and release of l-glutamate in neutral pH solutions

von Hauff E, Fuchs K, Hellmann D Ch, Parisi J, Weiler R, Burkhardt C, Kraushaar U, Guenther E

Biosens Bioelectron. 2010 Oct 15;26(2):596-601. Epub 2010 Jul 16. doi: 10.1016/j.bios.2010.07.022

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Does telomerase reverse transcriptase induce functional de-differentiation of human endothelial cells?

Baumer Y, Funk D, Schlosshauer B

Cell Mol Life Sci. 2010 Jul;67(14):2451-65. doi: 10.1007/s00018-010-0349-z. Epub 2010 Mar 30.

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Protein microarrays for personalized medicine

Yu X, Schneiderhan-Marra N, Joos TO

Clin Chem. 2010 Mar;56(3):376-87. Epub 2010 Jan 14. doi: 10.1373/clinchem.2009.137158

Zur Publikation

Suppression of adverse angiogenesis in an albumin-based hydrogel for articular cartilage and intervertebral disc regeneration

Scholz B, Kinzelmann C, Benz K, Mollenhauer J, Wurst H, Schlosshauer B

Eur Cell Mater. 2010 Jul 13;20:24-36; discussion 36-7.

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Cardiac slices as a predictive tool for arrhythmogenic potential of drugs and chemicals

Meyer T, Stuerz K, Guenther E, Edamura M, Kraushaar U

Expert Opin Drug Metab Toxicol. 2010 Dec;6(12):1461-75. Epub 2010 Nov 11. doi: 10.1517/17425255.2010.526601.

Zur Publikation

Chemical stimulation of adherent cells by localized application of acetylcholine from a microfluidic system

Zibek S, Hagmeyer B, Stett A, Stelzle M

Front Neuroeng. 2010 Nov 26;3:113. doi: 10.3389/fneng.2010.00113. eCollection 2010.

Zur Publikation

Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets

Swanton C, Larkin JM, Gerlinger M, Eklund AC, Boehme KA, Volkmer H, Howell M, Stamp G, Downward J, Gore M, Futreal PA, Escudier B, Andre F, Albiges L, Beuselinck B, Oudard S, Hoffmann J, Gyorffy B et al.

Genome Med. 2010 Aug 11;2(8):53. doi: 10.1186/gm174.

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In vivo and in vitro development of S- and M-cones in rat retina

Arango-Gonzalez B, Szabo A, Pinzon-Duarte G, Lukats A, Guenther E, Kohler K

Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5320-7. Epub 2010 May 12. doi: 10.1167/iovs.09-4741.

Zur Publikation

Protein-protein-interactions in a multiplexed, miniaturized format a functional analysis of Rho GTPase activation and inhibition

Schmohl M, Rimmele S, Potz O, Kloog Y, Gierschik P, Joos TO, Schneiderhan-Marra N

Proteomics. 2010 Apr;10(8):1716-20. doi: 10.1002/pmic.200900597.

Zur Publikation

Subretinal electronic chips allow blind patients to read letters and combine them to words

Zrenner E, Bartz-Schmidt KU, Benav H, Besch D, Bruckmann A, Gabel VP, Gekeler F, Greppmaier U, Harscher A, Kibbel S, Koch J, Kusnyerik A, Peters T, Stingl K, Sachs H, Stett A, Szurman P, Wilhelm B, Wilke R

Proc. R. Soc. B. 2010 Nov; 278(1711). DOI 10.1098/rspb.2010.1747

Zur Publikation

Tetrahydrochromenoimidazoles as Potassium-Competitive Acid Blockers (P-CABs): Structure-Activity Relationship of Their Antisecretory Properties and Their Affinity toward the hERG Channel (dagger)

Palmer AM, Chiesa V, Schmid A, Munch G, Grobbel B, Zimmermann PJ, Brehm C, Buhr W, Simon WA, Kromer W, Postius S, Volz J, Hess D

J Med Chem. 2010 May 13;53(9):3645-74. doi: 10.1021/jm100040c.

Zur Publikation

Bead-based protein-protein interaction assays for the analysis of Rho GTPase signaling

Rimmele S, Gierschik P, Joos TO, Schneiderhan-Marra N

J Mol Recognit. 2010 Nov-Dec;23(6):543-50. doi: 10.1002/jmr.1051.

Zur Publikation

Sequential multiplex analyte capturing for phosphor-protein profiling

Poetz O, Henzler T, Hartmann M, Kazmaier C, Templin MF, Herget T, Joos TO

Mol Cell Proteomics. 2010 Nov; 9(11): 2474–2481. Published online 2010 Aug 3. doi: 10.1074/mcp.M110.002709

Zur Publikation

The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria

Metzger U, Schall C, Zocher G, Unsold I, Stec E, Li SM, Heide L, Stehle T

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14309-14. doi: 10.1073/pnas.0904897106. Epub 2009 Aug 12.

Zur Publikation

Protein microarrays for diagnostic assays.

Hartmann M, Roeraade J, Stoll D, Templin MF, Joos TO

Anal Bioanal Chem. 2009 Mar;393(5):1407-16. Epub 2008 Sep 20. doi: 10.1007/s00216-008-2379-z.

Zur Publikation

Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS)

Bigalke B, Stellos K, Weig HJ, Geisler T, Seizer P, Kremmer E, Potz O, Joos T, May AE, Lindemann S, Gawaz M

Basic Res Cardiol. 2009 May;104(3):352-7. Epub 2009 Feb 3. doi: 10.1007/s00395-009-0779-7.

Zur Publikation

Neuroprotective effect of transretinal electrical stimulation on neurons in the inner nuclear layer of the degenerated retina

Schmid H, Herrmann T, Kohler K, Stett A

Brain Res Bull. 2009 Apr 6;79(1):15-25. Epub 2009 Jan 15. doi: 10.1016/j.brainresbull.2008.12.013.

Zur Publikation

Multiplex microsphere-based flow cytometric platforms for protein analysis and their application in clinical proteomics - from assays to results

Hsu HY, Joos TO, Koga H

Electrophoresis. 2009 Dec;30(23):4008-19. doi: 10.1002/elps.200900211.

Zur Publikation

Protein microarrays: potentials and limitations

Joos T, Bachmann J

Front Biosci. 2009 Jan 1;14:4376-85.

Zur Publikation

Expansion and Differentiation of Neural Progenitors Derived From the Human Adult Enteric Nervous System

Metzger M, Bareiss PM, Danker T, Wagner S, Hennenlotter J, Guenther E, Obermayr F, Stenzl A, Koenigsrainer A, Skutella T, Just L

Gastroenterology. 2009 Dec;137(6):2063-2073.e4. doi: 10.1053/j.gastro.2009.06.038. Epub 2009 Jun 21.

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Analysis of Non-canonical Fibroblast Growth Factor Receptor 1 (FGFR1) Interaction Reveals Regulatory and Activating Domains of Neurofascin

Kirschbaum K, Kriebel M, Kranz EU, Poetz O, Volkmer H

J Biol Chem. 2009 Oct 16;284(42):28533-42. doi: 10.1074/jbc.M109.004440. Epub 2009 Aug 7.

Zur Publikation

Forster resonance energy transfer-based total internal reflection fluorescence reader for apoptosis

Bruns T, Angres B, Steuer H, Weber P, Wagner M, Schneckenburger H

J Biomed Opt. 2009 Mar-Apr;14(2):021003. doi: 10.1117/1.3055622.

Zur Publikation

An improved electrophysiological method to study peripheral nerve regeneration in rats

Werdin F, Grussinger H, Jaminet P, Kraus A, Manoli T, Danker T, Guenther E, Haerlec M, Schaller HE, Sinis N

J Neurosci Methods. 2009 Aug 30;182(1):71-7. Epub 2009 Jun 6. doi: 10.1016/j.jneumeth.2009.05.017

Zur Publikation

On display on a bug: a systematic approach to characterize antibodies

Knorpp T, Templin MF

Nat Methods. 2008 Dec;5(12):1003-4. DOI: 10.1038/nmeth1208-1003

Zur Publikation

Novel functional profiling approach combining reverse phase protein microarrays and human 3-D ex vivo tissue cultures: expression of apoptosis-related proteins in human colon cancer.

Pirnia F, Pawlak M, Thallinger GG, Gierke B, Templin MF, Kappeler A, Betticher DC, Gloor B, Borner MM

Proteomics. 2009 Jul;9(13):3535-48. doi: 10.1002/pmic.200800159.

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Lokale Applikation von Deferroaxmin zur Verbesserung der Regeneration peripherer Nerven im Tierversuch

Werdin F, Scipio FD, Schonle P, Kraus A, Jaminet P, Koopmanns G, Danker T, Guenther E, Haerle M, Schaller HE, Geuna S, Mueller HW (2009)

Obere Extremitäten. 2009; 4(4): 217-223.

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Array-Technologien für die Multiparameteranalytik von Proteomen

Herget T, Henzler T, Hayes S, Joos T

2008. in: Schierack, Schröder. Mulitplex-DNA Mikropartikelpartien und deren Anwendung. Pabst Science Publishers. 3 - 15.

Zur Publikation

Proteome wide screening using peptide affinity capture

Poetz O, Hoeppe S, Templin MF, Stoll D, Joos TO

Proteomics. 2009 Mar;9(6):1518-23. doi: 10.1002/pmic.200800842.

Zur Publikation

Local administration of DFO-loaded lipid particles improves recovery after end-to-end reconstruction of rat median nerve

Sinis N, Di Scipio F, Schonle P, Werdin F, Kraus A, Koopmanns G, Masanneck C, Hermanns S, Danker T, Guenther E, Haerle M, Schaller HE, Geuna S, Mueller HW

Restor Neurol Neurosci. 2009;27(6):651-62. doi: 10.3233/RNN-2009-0517.

Zur Publikation

Influence of platelet count on the expression of platelet collagen receptor glycoprotein VI (GPVI) in patients with acute coronary syndrome

Bigalke B, Stellos K, Stakos D, Joos T, Potz O, Geisler T, Bischofs C, Kremmer E, Kramer BF, Seizer P, May AE, Lindemann S, Gawaz M

Thromb Haemost. 2009 May;101(5):911-5.

Zur Publikation

Regulation of p53--insights into a complex process

Boehme KA, Blattner C

Crit Rev Biochem Mol Biol. 2009 Nov-Dec;44(6):367-92.

Zur Publikation

Tumor promotion in liver of mice with a conditional Cx26 knockout.

Marx-Stoelting P, Mahr J, Knorpp T, Schreiber S, Templin MF, Ott T, Buchmann A, Schwarz M

Toxicol Sci. 2008 Jun;103(2):260-7. Epub 2008 Feb 27. doi: 10.1093/toxsci/kfn043

Zur Publikation

LED-based illumination system for the MEA60 system for full field stimulation of explanted retinas

Herrmann T, Krause T, Gerhardt M, Hesse M, Boven K-H, Stett A

Proceedings MEA Meeting 2008, Reutlingen, BioPro edition, Vol.5, p.199-200, ISBN 3-938345-05-5

Zur Publikation

Inhomogeneity of Cell Properties In The Cardiomyocyte Derived HL-1 Cell Line

Kraushaar U, Nagel J, Meyer T, Guenther E

Proceedings MEA Meeting 2008, Reutlingen, BioPro edition; 5:186-187, ISBN 3-938345-05-5

Zur Publikation

Vitreous Levels of Bevacizumab and Vascular Endothelial Growth Factor-A in Patients with Choroidal Neovascularization.

Zhu Q, Ziemssen F, Henke-Fahle S, Tatar O, Szurman P, Aisenbrey S, Schneiderhan-Marra N, Xu X, Bevacizumab T, Grisanti S

Ophthalmology. 2008 Oct;115(10):1750-5, 1755.e1. doi: 10.1016/j.ophtha.2008.04.023. Epub 2008 Aug 16.

Zur Publikation

Miniaturized parallelized sandwich immunoassays

Hsu HY, Wittemann S, Joos TO

Methods Mol Biol. 2007;428:247-62.

Zur Publikation

Suspension microarrays for the identification of the response patterns in hyperinflammatory diseases

Hsu HY, Wittemann S, Schneider EM, Weiss M, Joos TO

Med Eng Phys. 2008 Oct;30(8):976-83. Epub 2008 Mar 3. doi: 10.1016/j.medengphy.2008.01.003

Zur Publikation

A membrane-bound FRET-based caspase sensor for detection of apoptosis using fluorescence lifetime and total internal reflection microscopy.

Angres B, Steuer H, Weber P, Wagner M, Schneckenburger H

Cytometry A. 2009 May;75(5):420-7. doi: 10.1002/cyto.a.20698

Zur Publikation

Pathogen specific cytokine release reveals an effect of TLR2 Arg753Gln during Candida sepsis in humans

Woehrle T, Du W, Goetz A, Hsu HY, Joos TO, Weiss M, Bauer U, Brueckner UB, Marion Schneider E

Cytokine. 2008 Mar;41(3):322-9. Epub 2008 Jan 30. doi: 10.1016/j.cyto.2007.12.006

Zur Publikation

New frontiers in microarray technology development

Joos T, Kroeger P

Curr Opin Biotechnol. 2008 Feb;19(1):1-3. doi: 10.1016/j.copbio.2007.12.001. Epub 2008 Jan 18.

Zur Publikation

Expanding assay dynamics: a combined competitive and direct assay system for the quantification of proteins in multiplexed immunoassays

Hartmann M, Schrenk M, Dottinger A, Nagel S, Roeraade J, Joos TO, Templin MF

Clin Chem. 2008 Jun;54(6):956-63. Epub 2008 Apr 24. doi: 10.1373/clinchem.2007.099812

Zur Publikation

Prediction of Nodal Involvement in Breast Cancer Based on Multiparametric Protein Analyses from Preoperative Core Needle Biopsies of the Primary Lesion.

Sauer G, Schneiderhan-Marra N, Kazmaier C, Hutzel K, Koretz K, Muche R, Kreienberg R, Joos T, Deissler H

Clin Cancer Res. 2008 Jun 1;14(11):3345-3353. doi: 10.1158/1078-0432.CCR-07-4802.

Zur Publikation

A Cryptic Vascular Endothelial Growth Factor T-Cell Epitope: Identification and Characterization by Mass Spectrometry and T-Cell Assays

Weinzierl AO, Maurer D, Altenberend F, Schneiderhan-Marra N, Klingel K, Schoor O, Wernet D, Joos T, Rammensee HG, Stevanovic S (2008)

Cancer Res. 2008 Apr 1;68(7):2447-54. doi: 10.1158/0008-5472.CAN-07-2540

Zur Publikation

A novel reverse transduction adenoviral array for the functional analysis of shRNA libraries

Oehmig A, Klotzbucher A, Thomas M, Weise F, Hagner U, Brundiers R, Waldherr D, Lingnau A, Knappik A, Kubbutat, MH, Joos TO, Volkmer H

BMC Genomics. 2008 Sep 24;9:441. doi: 10.1186/1471-2164-9-441.

Zur Publikation

p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK

Boehme KA, Kulikov R, Blattner C

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7785-90. Epub 2008 May 27. doi: 10.1073/pnas.0703423105. Epub 2008 May 27.

Zur Publikation

Xeya3 regulates survival and proliferation of neural progenitor cells within the anterior neural plate of Xenopus embryos

Kriebel M, Müller F, Hollemann T

Dev Dyn. 2007 Jun;236(6):1526-34. DOI: 10.1002/dvdy.21170

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Retinal charge sensitivity and spatial discrimination obtainable by subretinal implants: key lessons learned from isolated chicken retina.

Stett A, Mai A, Herrmann T

J Neural Eng. 2007 Mar;4(1):S7-16. Epub 2007 Feb 20. DOI: 10.1088/1741-2560/4/1/S02

Zur Publikation

Identification of NCAM-binding peptides promoting neurite outgrowth via a heterotrimeric G-protein-coupled pathway

Hansen RK, Christensen C, Korshunova I, Kriebel M, Burkarth N, Kiselyov VV, Olsen M, Ostergaard S, Holm A, Volkmer H, Walmod PS, Berezin V, Bock E

J Neurochem. 2007 Nov;103(4):1396-407. Epub 2007 Sep 13. DOI: 10.1111/j.1471-4159.2007.04894.x

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Neurofascin regulates the formation of gephyrin clusters and their subsequent translocation to the axon hillock of hippocampal neurons

Burkarth N, Kriebel M, Kranz EU, Volkmer H

Mol Cell Neurosci. 2007 Sep;36(1):59-70. Epub 2007 Jun 27. DOI: 10.1016/j.mcn.2007.06.001

Zur Publikation

Long nerve gaps limit the regenerative potential of bioartificial nerve conduits filled with Schwann cells

Sinis N, Schaller H-E, Schulte-Eversum C, Becker ST, Schlosshauer B, Doser M, Rösner H, Dietz K, Müller H-W, Haerle M

Restor Neurol Neurosci. 2007;25(2):131-41.

Zur Publikation

Expression of serine/threonine protein-kinases and related factors in normal monkey and human retinas: the mechanistic understanding of a CDK2 inhibitor induced retinal toxicity

Saturno G, Pesenti M, Cavazzoli C, Rossi A, Giusti A, Gierke B, Pawlak M, Venturi M

Toxicol Pathol. 2007 Dec;35(7):972-83. DOI: 10.1080/01926230701748271

Zur Publikation

Aging Schwann cells in vitro

Funk D, Fricke C, Schlosshauer B

Eur J Cell Biol. 2007 Apr;86(4):207-19. Epub 2007 Feb 20. DOI: 10.1016/j.ejcb.2006.12.006

Zur Publikation

New cell models and assays in cardiac safety profiling

Meyer T, Sartipy P, Blind F, Leisgen C, Guenther E

Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):507-17. DOI: 10.1517/17425225.3.4.507

Zur Publikation

Blood-retina barriers

Handbook of Neurochemistry and Molecular Neurobiology 3rd Edition, Vol. 11 Neural Membranes and Transport (Ed. A. Lajtha and M.E.A Reith), Springer Publishers, New York, Springer Publishers N.Y., pages 486-506.

Zur Publikation

Protein chip based miniaturized assay for the simultaneous quantitative monitoring of cancer biomarkers in tissue extracts

Weissenstein U, Schneider MJ, Pawlak M, Cicenas J, Eppenberger-Castori S, Oroszlan P, Ehret S, Geurts-Moespot A, Sweep FC, Eppenberger U

Proteomics. 2006; 6 (5): 1427-1436. DOI: 10.1002/pmic.200500078

Zur Publikation

The Retinasensor: An In vitro Tool to Study Drug Effects on Retinal Signaling.

Guenther E, Herrmann T, Stett A

Advances in Network Electrophysiology Using Multi Electrode Arrays. 2006. Springer, Berlin: 321-331.

Zur Publikation

Increasing robustness and sensitivity of protein microarrays through microagitation and automation.

Hartmann M, Toegl A, Kirchner R, Templin MF, Joos TO

Anal Chim Acta. 2006 Mar 30;564(1):66-73. Epub 2006 Feb 21. DOI: 10.1016/j.aca.2006.01.041

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Current perspectives in protein array technology

Kricka LJ, Master SR, Joos TO, Fortina P

Ann Clin Biochem. 2006 Nov ; 43 (PT 6): 457-67.

Zur Publikation

Caspase-3 activation, Bcl-2 contents, and soluble FAS-ligand are not related to the inflammatory marker profile in patients with sepsis and septic shock

Kriebel F, Wittemann S, Hsu HY, Joos T, Weiss M, Schneider EM

Ann N Y Acad Sci. 2006 Dec ; 1090: 168-76. DOI: 10.1196/annals.1378.018

Zur Publikation

Combination of engineered neural cell adhesion molecules and GDF-5 for improved neurite extension in nerve guide concepts

Niere M, Braun B, Gass R, Sturany S, Volkmer H

Biomaterials. 2006 Jun;27(18):3432-40. Epub 2006 Feb 23. DOI: 10.1016/j.biomaterials.2006.01.037

Zur Publikation

Physical and biological performance of a novel block copolymer nerve guide.

Lietz M, Ullrich A, Schulte-Eversum C, Oberhoffner S, Fricke C, Muller HW, Schlosshauer B

Biotechnol Bioeng. 2006 Jan 5;93(1):99-109. DOI: 10.1002/bit.20688

Zur Publikation

The long and difficult road to the diagnostic market: protein microarrays.

Joos TO, Berger H

Drug Discov Today. 2006 Nov;11(21-22):959-61. Epub 2006 Oct 2. DOI: 10.1016/j.drudis.2006.09.014

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Protein Microarrays - Neue Systeme für die Proteomforschung

Joos TO, Pawlak M, Templin M, Stoll D

GIT Labor-Fachzeitschrift. 2006; 10, page 890-892.

Zur Publikation

A regulated switch of chick neurofascin isoforms modulates ligand recognition and neurite extension.

Pruss T, Kranz E U, Niere M, Volkmer H

Mol Cell Neurosci. 2006 Feb;31(2):354-65. Epub 2005 Nov 28. DOI: 10.1016/j.mcn.2005.10.009

Zur Publikation

Assessent of drug effects on myocyte function in vitro

Guenther E, Henes K, Pankow S, Boven KH, Meyer T

International Meeting on Substrate-Integrated Micro Electrode Arrays. BioPro. Reutlingen. 2006; 3: 136-139.

Zur Publikation

Guidelines for terminology for microtechnology in clinical laboratories.

Wilding P, Joos T, Kricka LJ, Shi L

Pure Appl. Chem. 2006; 78(3): 677-684. doi:10.1351/pac200678030677

Zur Publikation

Protein microarrays: applications and future challenges

Stoll D, Templin MF, Bachmann J, Joos TO

Curr Opin Drug Discov Devel. 2005 Mar;8(2):239-52.

Zur Publikation

Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance

Kulikov R, Boehme KA, Blattner C

Mol Cell Biol. 2005 Aug;25(16):7170-80. DOI: 10.1128/MCB.25.16.7170-7180.2005

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Protein Microarrays - A Promising Tool for Cancer Diagnosis

Schneiderhan-Marra N, Kirn A, Döttinger A, Templin M, Sauer G, Deissler H, Joos TO

Cancer Genomics & Proteomics. 2005 Jan; 2(1): 37-42.

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Protein biochips: the calm before the storm.

Bodovitz S, Joos T, Bachmann J

Drug Discov Today. 2005 Feb 15; 10(4): 283-287. DOI: 10.1016/S1359-6446(05)03373-8

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Age-dependent changes in the regulation mechanisms for intracellular calcium ions in ganglion cells of the mouse retina.

Mann M, Haq W, Zabel T, Guenther E, Zrenner E, Ladewig T

Eur J Neurosci. 2005 Dec;22(11):2735-43. DOI: 10.1111/j.1460-9568.2005.04475.x

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Identification of P2Y receptor subtypes in human Müller glial cells by physiology, single cell RT-PCR, and immunohistochemistry.

Fries JE, Goczalik IM, Wheeler-Schilling TH, Kohler K, Guenther E, Wolf S, Wiedemann P, Bringmann A, Reichenbach A, Francke M, Pannicke T

Invest Ophthalmol Vis Sci. 2005 Aug;46(8):3000-7. DOI: 10.1167/iovs.05-0043

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Protein microarrays: catching the proteome.

Poetz O, Schwenk JM, Kramer S, Stoll D, Templin MF, Joos TO

Mech Ageing Dev. 2005 Jan;126(1):161-70. DOI: 10.1016/j.mad.2004.09.030

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Retinoblastoma susceptibility gene product pRB activates hypoxia-inducible factor-1 (HIF-1)

Budde A, Schneiderhan-Marra N, Petersen G, Brune B

Oncogene. 2005; 24(10): 1802-8. DOI: 10.1038/sj.onc.1208369

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Differences in herbal and dietary supplement use in the Hispanic and non-Hispanic pediatric populations.

Guenther E, Mendoza J, Crouch BI, Moyer-Mileur LJ, Junkins EP Jr.

Pediatr Emerg Care. 2005 Aug;21(8):507-14.

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Protein microarrays for antibody profiling: Specificity and affinity determination on a chip.

Poetz O, Ostendorp R, Brocks B, Schwenk JM, Stoll D, Joos TO, Templin MF

Proteomics. 2005 Jun;5(9):2402-11. DOI: 10.1002/pmic.200401299

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Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein in Trypanosoma brucei.

Engstler M, Thilo L, Weise F, Grunfelder CG, Schwarz H, Boshart M, Overath P

J Cell Sci. 2004 Mar 1;117(Pt 7):1105-15. DOI: 10.1242/jcs.00938

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Functional re-establishment of the perforant pathway in organotypic co-cultures on microelectrode arrays

Hofmann F, Guenther E, Hammerle H, Leibrock C, Berezin V, Bock E, Volkmer H

Brain Res. 2004 Aug 13;1017(1-2):184-96. DOI: 10.1016/j.brainres.2004.05.044

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Expression of P2Y1, P2Y2, P2Y4, and P2Y6 receptor subtypes in the rat retina.

Fries JE, Wheeler-Schilling TH, Guenther E, Kohler K

Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3410-7. DOI: 10.1167/iovs.04-0141

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ATP-induced non-neuronal cell permeabilization in the rat inner retina

Innocenti B, Pfeiffer S, Zrenner E, Kohler K, Guenther E

J Neurosci. 2004 Sep 29;24(39):8577-83. DOI: 10.1523/JNEUROSCI.2812-04.2004

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The proteomics bottleneck: strategies for preliminary validation of potential biomarkers and drug targets

Bodovitz S, Joos T

Trends Biotechnol. 2004 Jan;22(1):4-7. DOI: 10.1016/j.tibtech.2003.10.013

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Mass spectrometric analysis of surfactant metabolism in human volunteers using deuteriated choline

Bernhard W, Pynn CJ, Jaworski A, Rau GA, Hohlfeld JM, Freihorst J, Poets CF, Stoll D, Postle AD

Am J Respir Crit Care Med. 2004 Jul 1;170(1):54-8. Epub 2004 Mar 24. DOI:10.1164/rccm.200401-089OC

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Automated higher-throughput compound screening on ion channel targets based on the Xenopus laevis oocyte expression system

Pehl U, Leisgen C, Gampe K, Guenther E

Assay Drug Dev Technol. 2004; 2(5): 515-24. DOI: 10.1089/adt.2004.2.515

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QT-screen: high-throughput cardiac safety pharmacology by extracellular electrophysiology on primary cardiac myocytes

Meyer T, Leisgen C, Gonser B, Günther E

Assay Drug Dev Technol. 2004 Oct;2(5):507-14. DOI: 10.1089/adt.2004.2.507

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Distribution of metabotropic P2Y receptors in the rat retina: a single-cell RT-PCR study.

Fries JE, Wheeler-Schilling TH, Kohler K, Guenther E

Brain Res Mol Brain Res. 2004 Nov 4;130(1-2):1-6. DOI: 10.1016/j.molbrainres.2004.06.041

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Protein microarrays and multiplexed sandwich immunoassays: what beats the beads?

Templin MF, Stoll D, Bachmann J, Joos TO

Comb Chem High Throughput Screen. 2004 May;7(3):223-9.

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Microarray technology: an increasing variety of screening tools for proteomic research.

Stoll D, Bachmann J, Templin MF, Joos TO

DDT:Targets. 2004 Dec 15; 9(24): 10-7

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Micro-electrode arrays in cardiac safety pharmacology: a novel tool to study QT interval prolongation

Meyer T, Guenther E, Boven KH

Drug Safety.2004 27(11):763-772. DOI: 10.2165/00002018-200427110-00002

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Homophilic interactions of chick neurofascin in trans are important for neurite induction

Pruss T, Niere M, Kranz EU, Volkmer H

Eur J Neurosci. 2004 Dec;20(11):3184-8. DOI: 10.1111/j.1460-9568.2004.03773.x

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Effects of brain-derived neurotrophic factor on cell survival, differentiation and patterning of neuronal connections and Muller glia cells in the developing retina

Pinzon-Duarte G, Arango-Gonzalez B, Guenther E, Kohler K

Eur J Neurosci. 2004 Mar;19(6):1475-84. DOI: 10.1111/j.1460-9568.2004.03252.x

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Developmental plasticity of NMDA receptor function in the retina and the influence of light.

Guenther E, Schmid S, Wheeler-Schilling T, Albach G, Grunder T, Fauser S, Kohler K

FASEB J. 2004 Sep;18(12):1433-5. Epub 2004 Jul 9. DOI: 10.1096/fj.03-0618fje

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Retinal colocalization and in vitro interaction of the glutamate transporter EAAT3 and the serum- and glucocorticoid-inducible kinase SGK1

Schniepp R, Kohler K, Ladewig T, Guenther E, Henke G, Palmada M, Boehmer C, Rothstein JD, Broer S, Lang F

Invest Ophthalmol Vis Sci. 2004 May;45(5):1442-9.

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BDNF regulates NMDA receptor activity in developing retinal ganglion cells

Ladewig T, Fellner S, Zrenner E, Kohler K, Guenther E

Neuroreport. 2004 Nov 15;15(16):2495-9.

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Propofol for procedural sedation in children in the emergency department

Bassett KE, Anderson JL, Pribble CG, Guenther E

Ann Emerg Med. 2003 Dec;42(6):773-82. DOI: 10.1016/S019606440300619X

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Propofol sedation by emergency physicians for elective pediatric outpatient procedures

Guenther E, Pribble CG, Junkins ER Jr, Kadish HA, Bassett KE, Nelson DS

Ann Emerg Med. 2003 Dec;42(6):783-91. DOI: 10.1016/S0196064403006346

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Endocytosis of a glycosylphosphatidylinositol-anchored protein via clathrin-coated vesicles, sorting by default in endosomes, and exocytosis via RAB11-positive carriers.

Grunfelder CG, Engstler M, Weise F, Schwarz H, Stierhof YD, Morgan GW, Field MC, Overath P

Mol Biol Cell. 2003 May;14(5):2029-40. Epub 2003 Feb 6. doi: 10.1091/mbc.E02-10-0640

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Protein microarrays: promising tools for proteomic research

Templin MF, Stoll D, Schwenk JM, Pötz O, Kramer S, Joos TO

Proteomics. 2003 Nov;3(11):2155-66.

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Enhanced antigenicity of a four-contact-residue epitope of the measles virus hemagglutinin protein by phage display libraries: evidence of a helical structure in the putative active site

Deroo S, El Kasmi K, Fournier P, Theisen D, Brons N, Herrmann M, Desmet J, Muller C

Molecular Immunology. 1998 June; 35(8):435-443. doi: 10.1016/S0161-5890(98)00057-1

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Combinatorial Peptide and Nonpeptide Libraries

Wiesmüller KH, Feiertag S, Fleckenstein B, Kienle S, Stoll D, Herrmann M, Jung G

VCH Publishers, Weinheim, Germany 1996

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