Publikationen

September 2024

Autoren: Mahdi Rivandi, André Franken, Liwen Yang, Anna Abramova, Nadia Stamm, Jens Eberhardt, Berthold Gierke, Meike Beer, Tanja Fehm, Dieter Niederacher, Michael Pawlak, Hans Neubauer

Miniaturized protein profiling permits targeted signaling pathway analysis in individual circulating tumor cells to improve personalized treatment

Traditional genomic profiling and mutation analysis of single cells like Circulating Tumor Cells (CTCs) fails to capture post-translational and functional alterations of proteins, often leading to limited treatment efficacy.

DOI

August 2024

Autoren: Kuldeep Tripathi, Somoday Hazra, Joyeeta Dutta Hazra, Silvia Mandel, Ruchi Anunu, Martin Kriebel, Hansjurgen Volkmer, Gal Richter-Levin

Selective knockdown of GABAA-α2 subunit in the dorsal dentate gyrus in adulthood induces anxiety, learning and memory deficits and impairs synaptic plasticity

Animal studies and clinical trials suggest that maintenance of gammaaminobutyric acid (GABA)-ergic activity may be crucial in coping with stressful conditions, anxiety and mood disorders. Drugs highly efficient in promoting anxiolysis were shown to activate this system, particularly via the α2-subunit of type A receptors (GABAA α2).

DOI

August 2024

Autoren: Manuel Sigle, Anne-Katrin Rohlfing, Melanie Cruz Santos, Timo Kopp, Konstantin Krutzke, Vincent Gidlund, Ferdinand Kollotzek, Julia Marzi, Saskia von Ungern-Sternberg, Antti Poso, Mathias Heikenwälder, Katja Schenke-Layland, Peter Seizer, Julia Möllmann, Nikolaus Marx, Robert Feil, Susanne Feil, Robert Lukowski, Oliver Borst, Tilman E. Schäffer, Karin Anne Lydia Müller, Meinrad P. Gawaz, and David Heinzmann

Targeting Cyclophilin A in the Cardiac Microenvironment Preserves Heart Function and Structure in Failing Hearts

Cardiac hypertrophy is characterized by remodeling of the myocardium, which involves alterations in the ECM (extracellular matrix) and cardiomyocyte structure. These alterations critically contribute to impaired contractility and relaxation, ultimately leading to heart failure.

DOI

Juli 2024

Autoren: Lana Kortenbrede, Johanna Heider, Heike Heckroth, Marc Leimenstoll, Heiko Steuer, Jan Sütterlin, Frank Weise, Tobias Hokamp

Development and Characterization of Biodegradable Polyurethane-Urea-Based Hydrogels for the Prevention of Postoperative Peritoneal Adhesions

DOI

Juli 2024

Autoren: Simon Woelfel, Joel Dütschler, Daniel Junker, Marius König, Georg Leinenkugel, Nicole Graf, Claudia Krieger, Samuel Truniger, Annett Franke, Seraina Koller, Katline Metzger-Peter, Melanie Oberholzer, Nicola Frei, Nora Geissler, Peter Schaub, Star Sign Investigators, Werner C. Albrich, Matthias Friedrich, Jan Hendrik Niess, Nicole Schneiderhan-Marra, Alex Dulovic, Wolfgang Korte, Justus J. Bürgi, Stephan Brand

Systemic and Mucosal Immunogenicity of Monovalent XBB.1.5-Adapted COVID-19 mRNA Vaccines in Patients with Inflammatory Bowel Disease

Recently updated COVID-19 mRNA vaccines encode the spike protein of the omicron subvariant XBB.1.5 and are recommended for patients with inflammatory bowel disease (IBD) on immunosuppressive treatment. Nonetheless, their immunogenicity in patients with IBD against rapidly expanding virus variants remains unknown.

DOI

Juni 2024

Autoren: Jonas Haas; Nils Rieger; Michael Schlegel; Kevin Strobel; Jannik C. Meyer

Nanometer-scale electron beam shaping with thickness controlled and stacked nanostructured graphite

The generation of small electron probes is the basis for various techniques in which such a probe is scanned across a sample, and special probe shapes like vortices can be desirable, e.g., to gain insight into magnetic properties. 

DOI

Juni 2024

Autoren: Kevin R. Strobel, Michael Schlegel, Mitisha Jain, Silvan Kretschmer, Arkady V. Krasheninnikov, Jannik C. Meyer

Temperature-dependence of beam-driven dynamics in graphene-fullerene sandwiches

C60 fullerenes encapsulated between graphene sheets were investigated by aberration-corrected high-resolution transmission electron microscopy at different temperatures, namely about 93 K, 293 K and 733 K, and by molecular dynamics simulations. We studied beam-induced dynamics of the C60 fullerenes and the encapsulating graphene, measured the critical doses for the initial damage to the fullerenes and followed the beam-induced polymerization. We find that, while the dose<!

DOI

Mai 2024

Autoren: Umair Nisar, Joachim Bansmann, Marco Hebel, Benedikt Reichel, Marilena Mancini, Margret Wohlfahrt-Mehrens, Markus Hölzle, Peter Axmann

Borate modified Co-free LiNi0.5Mn1.5O4 cathode material: A pathway to superior interface and cycling stability in LNMO/graphite full-cells

Spherical high quality, industrial-relevant LNMO materials developed. LNMO/electrolyte interface stabilized with borate-based interphase layer. Borate-modified LNMO exhibits superior electrochemical performance. The primary aging mechanism stems from LNMO/electrolyte interface instability.

DOI

Mai 2024

Autoren: Tengku Ibrahim Maulana, Claudia Teufel, Madalena Cipriano, Julia Roosz, Lisa Lazarevski, Francinja E. van den Hil, Lukas Scheller, Valeria Orlova, André Koch, Michael Hudecek, Miriam Alb, Peter Loskill

Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells

Physiologically relevant human models that recapitulate the challenges of solid tumors and the tumor microenvironment are highly desired in the chimeric antigen receptor (CAR)-T cell field. We developed a breast cancer-on-chip model with an integrated endothelial barrier that enables the transmigration of perfused immune cells, their infiltration into the tumor, and concomitant monitoring of cytokine release during perfused culture.

DOI