Dr. Simon Straß

Dr. Simon Straß studied Applied Chemistry at Reutlingen University from 2009 to 2014. From 2014 to 2016, he completed his Master's degree in Chemistry at the University of Marburg. He then worked as a medicinal chemist at Synovo GmbH, Tübingen, until 2023. After completing his PhD in Pharmaceutical Chemistry in 2023, Dr. Simon Straß works as a scientist in the Bioanalytics group at the NMI. His research interests include mass spectrometry, HDX MS and bioanalytical chemistry.

Selected publications

• Imidazoquinolines with Improved Pharmacokinetic Properties Induce a High IFNα to TNFα Ratio in Vitro and in Vivo. Keppler, M.; Straß, S.; Geiger, S.; Fischer, T.; Späth, N.; Weinstein, T.; Schwamborn, A.; Guezguez, J.; Guse, J.-H.; Laufer, S.; Burnet, M. Front. Immunol. 2023, 14, 1168252. https://doi.org/10.3389/fimmu.2023.1168252

• Immune Cell Targeted Fumaric Esters Support a Role of GPR109A as a Primary Target of Monomethyl Fumarate in Vivo. Straß, S.; Geiger, J.; Cloos, N.; Späth, N.; Geiger, S.; Schwamborn, A.; De Oliveira da Cunha, L.; Martorelli, M.; Guse, J.-H.; Sandri, T. L.; Burnet, M.; Laufer, S. Inflammopharmacol 2023, 31 (3), 1223–1239. https://doi.org/10.1007/s10787-023-01186-0.

• Synthesis, Characterization, and in Vivo Distribution of Intracellular Delivered Macrolide Short‐Chain Fatty Acid Derivatives. Straß, S.; Schwamborn, A.; Keppler, M.; Cloos, N.; Guezguez, J.; Guse, J.; Burnet, M.; Laufer, S. ChemMedChem 2021, 16 (14), 2254–2269. https://doi.org/10.1002/cmdc.202100139.

• Structural Changes within the Bifunctional Cryptochrome/Photolyase CraCRY upon Blue Light Excitation. Franz-Badur, S.; Penner, A.; Straß, S.; von Horsten, S.; Linne, U.; Essen, L.-O. Sci Rep 2019, 9 (1), 9896. https://doi.org/10.1038/s41598-019-45885-7.