Mediathek

NfL and GFAP in blood are emerging as important biomarkers in MS. A urine-based assay could provide a simpler, non-invasive alternative; however, limited biomarker transfer into urine may pose a major challenge. This study aimed to evaluate the detectability and diagnostic potential of urinary and serum NfL and GFAP for distinguishing MS patients from healthy controls.

The durability of vaccine-induced immunity is often limited by waning responses, antigenic drift, and anti-vector immunity, highlighting the need for innovative vaccination strategies. Heterologous prime–boost approaches can help overcome these barriers by exploiting the complementary strengths of distinct platforms. 

Synchronized oscillatory fluctuations in intracellular calcium concentration across extended neuronal networks represent a functional indicator of connectivity and signal coordination. In this study, a model of human immature neurons (differentiated from LUHMES precursors) has been used to establish a robust protocol for generating reproducible intracellular Ca²⁺ oscillations in both two-dimensional monolayers and three-dimensional spheroids

Multi-organ-chip (MOC) models provide a plethora of auspicious opportunities to replace current in vitro and in vivo models for a more systemic investigation of human (patho-)physiology for drug development and personalized medicine.

Human microglia are central regulators and actors in brain infections and neuro-inflammatory pathologies. However, access to such cells is limited, and studies systematically mapping the spectrum of their inflammatory states are scarce.

The immune response to implanted medical devices can impact their performance and longevity in the body. Instead of designing implants to produce the desired immune responses, this might more easily be achieved with the use of surface modification technology, which can alter the biological profile of the implant without compromising function or performance.