Publikationen

März 2025

Autoren: Joyeeta Dutta Hazra1 , Kuldeep Shrivastava1 , Lisa-Sophie Wüstner4 , Rachel Anunu1 , Erez Chervinsky1 , Somoday Hazra1 , Simone Beuter4 , Martin Kriebel4 , Mouna Maroun1 , Hansjuergen Volkmer4† and Gal Richter-Levin

Effects of TrkB-related induced metaplasticity within the BLA on anxiety, extinction learning, and plasticity in BLA-modulated brain regions

Neuronal plasticity within the basolateral amygdala (BLA) is fundamental for fear learning. Metaplasticity, the regulation of plasticity states, has emerged as a key mechanism mediating the subsequent impact of emotional and stressful experiences.

DOI

März 2025

Autoren: Gross T, Hundertmark T, Csiszár V, Sulyok AA, Gross N, Breiden M, Kitschen N, von Groll U, Niemöller C, Sánchez-Martín P, Heine A, Göpfert J, Szórádi T, Lübbert P, Koltay P, Porschewski P, Zengerle R, Jeney C

Lossless single-molecule counting to absolute quantify proteoforms

A novel immunoassay, termed Protein Interaction Coupling (PICO), is introduced to deliver clear, reference-free quantification of proteoforms - precise quantification. PICO employs a compartmentalized, homogeneous single-molecule assay with lossless and sensitive signal generation, capable of detecting down to a few molecules per reaction.

DOI

Februar 2025

Autoren: B Leticia Fernandez-Carballo, Michele Atzeni, Camille Escadafal, Martina Vettoretti, Steffen Geis, Selidji Todagbe Agnandji, Andre M Siqueira, Jullita Kenala Malava, Louis Banda, Anita L Kabwende, Ayodele Alabi, Juste Christin Bie Ondo, Marguerite Massinga-Loembe, Paulin N Essone, José Moreira, Aline da Rocha Matos, Braulia C Caetano, Marilda M Siqueira, Ana Maria Bispo de Filippis, Érica Aparecida Dos Santos Ribeiro da Silva, Maria Cristina S Lourenço, Julia Häring, Anna Günther, Meike Jakobi, Nicole Schneiderhan-Marra, Christine Hoogland, Patrícia Brasil, Sunil Pokharel, Stefano Ongarello, Victoria Harris, Aurélien Macé, Sue J Lee, Barbara Di Camillo, Sabine Dittrich

Cross-sectional evaluation of host biomarkers for guiding antibiotic use in bacterial and non-bacterial acute febrile illness in low- and middle-income tropical settings

To evaluate the effectiveness of 18 different host biomarkers in differentiating bacterial from non-bacterial acute febrile illness (AFI) in resource-limited settings, specifically in Brazil, Malawi and Gabon.

DOI

Februar 2025

Autoren: Michael Lehky, Tashveen Moonian, Tanja Michel, Daniel Junker, Mathias Müsken, Julia Strömpl, Patrick Nübling, Franziska Neumann, Andi Krumbholz, Gérard Krause, Nicole Schneiderhan-Marra, Joop van den Heuvel, Monika Strengert

A novel method for recombinant mammalian-expressed S-HBsAg virus-like particle production for assembly status analysis and improved anti-HBs serology

The Hepatitis B surface antigen (HBsAg) as the only lipid-associated envelope protein of the Hepatitis B virus (HBV) acts as cellular attachment and entry mediator of HBV making it the main target of neutralizing antibodies to provide HBV immunity after infection or vaccination. 

DOI

Februar 2025

Autoren: Kerkmann A, Schinke C, Dordevic A, Kern J, Bangemann N, Finck J, Blohmer JU, Ruprecht K, Göpfert JC, Otto C, Materne B, Endres M, Boehmerle W, Huehnchen P

Chemotherapy-induced cognitive impairment and its long-term development in patients with breast cancer: results from the observational CICARO study

Chemotherapy-induced cognitive impairment (CICI) is a well-recognized side effect of breast cancer treatment. However, prospective long-term evaluations of CICI using standardized neuropsychological tests are scarce.

DOI

Januar 2025

Autoren: Blum, J., Brüll, M., Hengstler, J. G., Dietrich, D. R., Gruber, A. J., Dipalo, M., Leist, M. Kraushaar, U.

The long way from raw data to NAM-based information: Overview on data layers and processing steps

Toxicological test methods generate raw data and provide instructions on how to use these to determine a final outcome such as a classification of test compounds as hits or non-hits.

DOI

Dezember 2024

Autoren: Nicole Vasilenko, Maria P. Tieck, Tanja Michel, Sonja Schembecker, Patricia Schwarz, Anna Guenther, Christoph Ruschil, Sven Poli, Ulf Ziemann, Antje Giede-Jeppe, Gisela Gabernet, Alex Dulovic, Markus C. Kowarik

In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis

The MS-specific, differential antibody response to EBV antigens confirms an altered immunological response to EBV in MS patients.

DOI

Dezember 2024

Autoren: Annabelle Neuhäusler, Katharina Rogg, Sebastian Schröder, Dieter Spiehl, Haris Zora, Elsa Arefaine, Julia Schettler, Hanna Hartmann, Andreas Blaeser

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel.

DOI

Dezember 2024

Autoren: Laubach, M., Hartmann, H., Holzapfel, B. M., Mayer-Wagner, S., Schenke-Layland, K., & Hutmacher, D. W.

3-D-Druck in der Chirurgie: Relevanz der Bewertung der Technologiereife in Forschungsstudien zum Bioprinting

Biologische 3‑D-Druckverfahren (sog. Bioprinting) sind eine Erweiterung dessen, was in den American Society for Testing and Materials(ASTM)- und International Organization for Standardization(ISO)-Normen als additive Fertigung definiert ist, und basieren auf dem automatisierten Druck von lebenden Zellen und Biomaterialien.

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