Rege­nerative bio­mate­rials

Our group is engaged in the development and improvement of regenerative therapies for musculoskeletal tissues (cartilage, intervertebral disc, and bone). We focus on cellular aspects during biomaterial development, cell-matrix-interactions and the testing of biomaterials. We are also interested in the development of validated methods for quality control of cell-based medicinal products and the definition of prognostic biomarkers.

Service offers

Biological Evaluation of Medical devices

Testing of materials, surfaces and functional biomaterials:

  • In vitro cytotoxicity according to DIN EN ISO 10993-5
  • Drug delivery and functionality assessment
  • Cell adhesion and proliferation
  • Development and performance of customer-specific tests

Coating and modification of surfaces

Development of coating processes:

  • Adhesion and process optimization
  • Modification of surface wettability
  • Barrier layers
  • Regulation of the degradation behavior of material and/or coating
  • Development of biocompatible coatings
  • Drug immobilization and delivery
  • Regulation of protein and cell adhesion
  • Development of anti-thrombogenic surfaces
  • Control of cell biological reactions

Evaluation of coating processes:

  • Analysis of the coating buildup and thickness
  • Surface wettability and topography testing
  • Testing of degradation kinetics and degradation products according to ISO 10993-13, ISO 10993-15
  • Analysis for drug release