Rege­nerative bio­mate­rials

Our group is engaged in the development and improvement of regenerative therapies for musculoskeletal tissues (cartilage, intervertebral disc, and bone). We focus on cellular aspects during biomaterial development, cell-matrix-interactions and the testing of biomaterials. We are also interested in the development of validated methods for quality control of cell-based medicinal products and the definition of prognostic biomarkers.

Services

Biomaterial testing (e.g. cytotoxicity, cell adhesion, cellular reactions)

  • In vitro cell cultures for testing of bio-active substances, e.g bioactivity of growth factors
  • Histological examinations

Techniques, methods, equipment

Primary cell cultures (chondrocytes, osteoblasts, mesenchymal stem cells) and in vitro differentiation

  • Organo-typical culture models, e.g. explant cultures
  • in vitro and in vivo models for examination of cell-based biomaterials
  • Various biochemical, molecular biological, and immunological analysis
  • FACS analytics
  • Histology

Network

Health area REGiNA (application centre for regenerative medicine between Neckar-Alb and Stuttgart)

Academic partners:
Universities of Heidelberg, Ulm, Tübingen, Reutlingen