MEA Derivatives

Dr. Udo Kraushaar
Group Leader Electrophysiology

MEA (microelectrode array) provides extracellular recordings with optional optical or electrical stimulation

It is performed on electrogenic tissue on top of substrate-integrated electrodes.

 

MEA has several advantages over other methods of electrophysiology:

  • Information on the network level
  • non-invasive
  • long-term recordings, cells can be cultured for days or weeks
  • "holistic" ion channel interactions

 

Application

  • Safety pharmacology (convulsive effects on neurons, cardiac arrhythmias on cardiac cells)
  • Neurotoxicity; neuronal modulation; LTP (long-term potentiation)
  • Neurodegeneration (organotypic cultivation on brain slices/retina)
  • MoA connection
  • Diabetes research
  • Retina research

MEA recordings can be performed with various models, including neurons, cardiomyocytes, brain slices, iPSC-derived neurons/cardiomyocytes, heart slices, etc. Contact us for more information.