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Displaying results 31 to 40 of 40.

Miniaturized protein profiling permits targeted signaling pathway analysis in individual circulating tumor cells to improve personalized treatment

Traditional genomic profiling and mutation analysis of single cells like Circulating Tumor Cells (CTCs) fails to capture post-translational and functional alterations of proteins, often leading to lim

Class switch toward IgG2 and IgG4 is more pronounced in BNT162b2 compared to mRNA-1273 COVID-19 vaccinees

Vaccination against SARS-CoV-2 induces antibodies that reduce the risk of severe disease.

Longitudinal analysis of humoral and cellular immunity in SARS-CoV-2 exposed families

Identification of previous SARS-CoV-2 infection typically relies on serology, yet T-cells play a key role in the adaptive immune response against SARS-CoV-2.

XBB.1.5 COVID-19 mRNA Vaccines Induce Inadequate Mucosal Immunity in Patients with Inflammatory Bowel Disease

Mucosal immunity plays a pivotal role in preventing infections with SARS-CoV-2. While COVID-19 mRNA vaccines induce robust systemic immune responses in patients with inflammatory bowel disease (IBD),

Clinical translation of 3D-printed patient-specific bone implants: a consensus statement

Extensive defects in long bones, resulting from trauma, disease, or other etiologies, impose significant morbidity on patients and may necessitate amputation, long-term disability, or premature mortal

Non-invasive physical plasma activates stimulator of interferon genes pathway in triple negative breast cancer and is associated with increased host immune response

Triple-negative breast cancer (TNBC), characterized by the absence of ER, PR, and HER2 receptors, remains one of the most aggressive breast cancer subtypes, with limited therapeutic options and a high

PET-based immunomapping of intratumoral CD4+ cells to monitor acquired resistance to checkpoint inhibitors

CD4 + T cells are crucial in shaping response and resistance to immunotherapy. To enhance our understanding of their multifaceted functions, we developed copper-64–radiolabeled nanobodies targeting th

Integration of solid-state nanopore arrays via dry bonding to photostructured microfluidic networks

The integration and parallelization of nanopore sensors are essential for improving the throughput of nanopore measurements. Solid-state nanopores traditionally have been used in isolation, which prev

Polyelectrolyte Multilayer Coatings As a Tunable Tool to Control Inflammatory Response to Biomaterials in Vitro

The immune response to implanted medical devices can impact their performance and longevity in the body. Instead of designing implants to produce the desired immune responses, this might more easily b

Gap Junctional Communication Required for the Establishment of Long-Term Robust Ca2+ Oscillations Across Human Neuronal Spheroids and Extended 2D Cultures

Synchronized oscillatory fluctuations in intracellular calcium concentration across extended neuronal networks represent a functional indicator of connectivity and signal coordination. In this study,

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