The Retinasensor: An In vitro Tool to Study Drug Effects on Retinal Signaling.

The Retinasensor: An In vitro Tool to Study Drug Effects on Retinal Signaling.
Guenther E, Herrmann T, Stett A
Advances in Network Electrophysiology Using Multi Electrode Arrays. 2006. Springer, Berlin: 321-331.

An in vitro preparation of the chicken retina was established on multi-electrode arrays. The so-called retinasensor allows the multi-site recording of micro-ERGs for hours and has been shown to be sensitive enough to assess drug effects on retinal function. The advantage of the system is that the retina can be isolated together with the retinal pigment epithelium as a whole by merely cutting the optic nerve. In contrast with other brain preparations, slicing of the tissue can be avoided and thus no damaged cells are present at the electrode-tissue interface that would interfere with the stimulation of healthy cell layers. A further advantage of the retinasensor is the recording of both micro-ERGs and ganglion cell activity. Because retinal ganglion cells do not contribute much to the ERG, additional information on the status of ganglion cells can be provided with the retinasensor as compared to ERG recordings in vivo. Taken together, the retinasensor offers a new assay system to reliably assess retinal function and dysfunction in vitro. Springer