- Deutsche Forschungsgemeinschaft
The amygdala contributes to emotional memory formation by mechanisms of synaptic plasticity. In the context of emotional and traumatic experiences, this is based on the modulation of the amydala by itself. Likewise, the amygdala also exerts a metaplastic impact on other brain areas such as hippocampus and medial prefrontal cortex. Under extreme conditions, amygdala modulation may lead to the formation of abnormal plasticity in these areas and to the development of trauma-related psychopathologies, such as depression and post-traumatic stress disorder. Amygdala plasticity and associated metaplasticity are tightly linked to the stabilization and function of GABAergic synapses. At the example of BDNF-dependent signalling, this project has the aim to unravel molecular mechanisms of GABAergic synapses that are involved in stress-induced psychopathologies. The results may contribute to the develoment of novel drugs.