Project Image:
Title of the project:
Production and characterization of cell-populated biomaterials for the treatment of various musculoskeletal diseases
Project leader:
Allgemeine Adresse Info
Project funding:
  • Bundesministerium für Bildung und Forschung (BMBF)
Project management:
  • Deutsches Zentrum für Luft- und Raumfahrt e.V. (DLR)
Funding reference number:

Regenerative medicine offers great potential for the treatment of injuries and chronic diseases of the intervertebral discs and joint cartilage. Disorders of bone healing could also be treated with regenerative concepts. In this project, which is part of the REGiNA health region, approvable cell therapies are being developed and optimised. For the implants, the patient's own cells are combined with biological carrier materials that give them biomechanical stability.


The aim of the projects combined in the REGiNA indication area "musculoskeletal system" is to develop new, approvable cell therapies or to further develop existing forms of therapy in such a way that they can be made accessible to a larger group of patients. In the future, these new therapies will be used to treat injuries and chronic diseases of intervertebral discs, joint cartilage and bone healing disorders (pseudarthrosis). The strategy applied for all three therapeutic approaches is based on the combination of selected stem cell populations, a suitable biomaterial and optimized, GMP-compatible manufacturing processes. In addition to production and optimized cultivation, the main focus is on the characterization of cells and cell-populated biomaterials. The best possible description of the purity, identity and quality of the cell populations used as well as the quality and efficacy of the end product are basic prerequisites for later approval according to the new tissue law and the guidelines of the EMA (European Medicine Agency).

Project partners:
  • Aesculap AG, Tuttlingen
  • IKET Tübingen
  • TETEC AG, Reutlingen
  • Universitätsklinikum Tübingen
  • ZRM Tübingen