PanImmun

In the project, a method for the identification of tumor-specific cytotoxic T cells, without knowledge of the tumor antigens recognized by T cells, is being further developed for use in pancreatic cancer. In addition to tumor-specific, cytotoxic T cells, helper T cells are also identified, produced by gene transfer and tested for tumor reactivity. To demonstrate the tumor reactivity of T cells, a microtumor model system is developed at NMI from pancreatic carcinoma tissue of patients recruited at the University Clinic for General, Visceral and Transplant Surgery Tübingen. This creates a new combination of cellular immunotherapy and diagnostic efficacy testing for pancreatic cancer.