Cellular assay systems

Model systems for drug development

The recent past has witnessed the failure of several drug development projects due to the lack of transferability of research findings into clinical practice. There is therefore a great need for model systems which can reproduce the patient's situation with precision and predict the effect of
a given substance.

Investigating complex organ systems and disease patterns

Innovative technology and platforms are developed at the NMI, in interdisciplinary projects. These cover the fields of cell biology, microfluidics and bioelectronics. Complex organ systems and disease patterns are studied in this way and new substances are tested under physiological conditions to assess their effectiveness and the risk of adverse effects. Using co-cultures of tumour spheroids and immunes cells deriving from patients, we test the efficiency of the latest cancer immunotherapy design.
Microphysiological systems can imitate the smallest functional unit in organs on a single microfluidic perfusion chip. Cell aggregates from cardiomyocytes or complex tissue, such as from the retina, are electrophysiologically addressed in the context of safety pharmacology.