Publications

Respiratory Syncytial Virus (RSV) is one of the leading causes of morbidity and mortality among infants and adult risk groups worldwide. Substantial case-underdetection and gaps in the understanding of reinfection dynamics of RSV limit reliable projection estimates.

Primary liver cancer, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), has low response rates to existing treatments, highlighting the urgent need for novel treatment options.

SCZ neural progenitors displayed altered expression and phosphorylation patterns related to Wnt and MAPK signaling, protein synthesis, cell cycle regulation and DNA damage response.

Variant-adapted COVID-19 vaccines are recommended for patients with inflammatory bowel disease (IBD). However, many patients rely on pre-existing immunity by original vaccines or prior infections.

Endothelial cells form the inner lining of our vascular system facilitating the supply of oxygen and nutrients to and removal of waste from surrounding tissues. In this work, we investigate the differences between ECs from various tissues regarding their biochemical composition, angiogenic potential, adaptation to flow, and coculture properties in vitro in the context of diabetes research.

The researchers have succeeded in demonstrating the influence of a brain region responsible for emotions, the amygdala, on the manifestation of anxiety symptoms by specifically altering the communication between nerve cells.

Traditional genomic profiling and mutation analysis of single cells like Circulating Tumor Cells (CTCs) fails to capture post-translational and functional alterations of proteins, often leading to limited treatment efficacy.

Animal studies and clinical trials suggest that maintenance of gammaaminobutyric acid (GABA)-ergic activity may be crucial in coping with stressful conditions, anxiety and mood disorders. Drugs highly efficient in promoting anxiolysis were shown to activate this system, particularly via the α2-subunit of type A receptors (GABAA α2).

Cardiac hypertrophy is characterized by remodeling of the myocardium, which involves alterations in the ECM (extracellular matrix) and cardiomyocyte structure. These alterations critically contribute to impaired contractility and relaxation, ultimately leading to heart failure.