Protein Conjugation Service
BioDevCenter
Protein conjugation enables the targeted functionalization of proteins with small molecules, drugs, labels, or solid-phase supports opening the door to a wide range of research, diagnostic, and therapeutic applications. Our service covers the entire spectrum of modern protein conjugations – from the production of fluorescently labeled proteins to the development of drug-antibody and drug-protein conjugates, to the immobilization of proteins on solid phases such as beads for chromatography or bioassays.
With expertise in chemical coupling strategies and protein biochemistry, we deliver customized, reproducible, and application-ready conjugates tailored to your project’s specific requirements.
Our services
- Chemical coupling
- Enzymatic coupling (position-specific)
- Site-selective or lysine-based coupling of drug molecules to proteins or antibodies
- Generation of drug-antibody conjugates (DACs) for research and pre-development studies
- Formation of drug-protein conjugates to enhance serum half-life or modulate pharmacokinetics
- Covalent coupling of proteins to beads, resins, or other solid supports
- Preparation of functionalized solid phases for e.g. affinity chromatography, enzyme reactor
- Production of immobilized capture reagents for bioassays and diagnostics
- Selection of suitable conjugation chemistries (e.g., maleimide-thiol, NHS-amine)
- Adjustment of coupling ratios and conditions to achieve optimal functional performance
- Analytical evaluation of conjugation efficiency and integrity
- Determination of conjugation degree (e.g., DAR for antibody conjugates)
- Assessment of protein integrity post-coupling
- Position-specific characterization of the coupling
- Functional validation of immobilized or drug-loaded proteins
Our methods
- Click chemistry
- NHS coupling
- Enzymatic coupling
NMI Natural and Medical Sciences Institute
at the University of Tübingen
Markwiesenstraße 55, 72770 Reutlingen
Tel.: +49 7121 51530-0
Mail:
info@nmi.de
Follow us now
