Complete Nanobody Service: Immunization, Screening, Characterization and Development of the Best Candidates
BioDevCenter
The generation of high-affinity and stable nanobodies begins with precisely planned immunization and culminates in comprehensively characterized top candidates. Our service guides you through the entire process – from selecting the optimal immunogen and alpaca immunization to sequencing, screening, engineering, and qualitative evaluation of the final nanobodies.
With modern workflows, years of expertise, and meticulous quality control, we deliver functional, customized nanobodies for research, diagnostics, and therapeutic development projects.
Our services
- Selection and design of the appropriate immunogen
- Monitoring of immunization at defined intervals
- Creation of a diverse phage display library
- Screening of the library to select specific binders (phage display)
- Selection and identification of nanobody clones (phage ELISA & NGS analysis)
- Prioritization of promising nanobody clones
- Production of selected candidates
- Molecular engineering to optimize stability, specificity, or expression
- Format design for multivalent binders or fusion proteins
- Determination of binding affinity
- Analysis of thermal and structural stability
- Provision of comprehensive datasets for further use
Our methods
- NGS sequencing
- Phage display screening assay
- Phage ELISA
- Cloning and expression
- Protein engineering
- Production and purification
NMI Natural and Medical Sciences Institute
at the University of Tübingen
Markwiesenstraße 55, 72770 Reutlingen
Tel.: +49 7121 51530-0
Mail:
info@nmi.de
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