Prof. Dr. Rumen Krastev

Areas of activity

polymer / polyelectrolyte thin films, nano technology, biomaterials, solid / liquid surfaces, foams

Stages of career

2011 - 2018 Head of Bioorganic Chemistry and Bioanalytics Division

2008 - 2018 Head of Biomaterials working group at the NMI

2005 - 2008 Research Associate at the Max Planck Institute for Colloids and Interfaces (MPI KG),                                              Group Leader - Soft Thin Films

2002 - 2005 Scientific research (neutron reflectometry) Hahn-Meitner Institut, Berlin

1996 - 2002 PostDoc / Scientific employee at MPI KG, Dept. Interfaces, Golm/Potsdam

1996              Doctorate at the University of Sofia

1993-1998     Research stay at Bristol University, GB

1986 - 1995    Junior Professor of Physical Chemistry and Surface Chemistry (University of Sofia, Bulgaria)

1985               Diploma, Chemistry - Inorganic and Physical Chemistry

Prof. Dr. Rumen Krastev


  • Altered Proinflammatory Responses to Polyelectrolyte Multilayer Coatings Are Associated with Differences in Protein Adsorption and Wettability
    Billing F, Walter B, Fink S, Arefaine E, Pickarski L, Maier S, Kretz R, Jakobi M, Feuerer N, Schneiderhan-Marra N, Burkhardt C, Templin M, Zeck A, Krastev R, Hartmann H, Shipp C.
    ACS Appl Mater Interfaces. 2021 Nov 24;13(46):55534-55549. doi: 10.1021/acsami.1c16175. Epub 2021 Nov 11. PMID: 34762399.
  • Polyelectrolyte Coatings for Surface Modification of Medical Implants
    Krastev R, Rudt A, Xiong X, Hartmann H
    Current Directions in Biomedical Engineering. 2018; 4(1): 217-220. DOI: 10.1515/cdbme-2018-0053
  • Biofunctionalization of surfaces using polyelectrolyte multilayers
    Hartmann H, Krastev R
    BioNanoMaterials. 2017; 18(1-2).
  • Controlled heparinase-catalyzed degradation of polyelectrolyte multilayer capsules with heparin as responsive layer
    Sun L, Xiong X, Qiaogen Z, Pingkai O, Krastev R
    Journal of Applied Polymer Science (ASAP). 2017 June 15, 134(23): 44916.
  • Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions
    Andreeva TD, Hartmann H, Taneva StG, Krastev R
    Journal of Materials Chemistry, 2016, B 4(44): 7092-7100.
  • Design of intelligent chitosan/heparin hollow microcapsules for drug delivery
    Sun L, Xiong X, Zou Q, Ouyang P, Burkhardt C, Krastev R
    Journal of Applied Polymer Science. 2017 Feb 5;134(5), 44425.
  • Fine-tuned PEGylation of chitosan to maintain optimal siRNA-nanoplex bioactivity
    Gutoaia A, Schuster L, Margutti S, Laufer S, Schlosshauer B, Krastev R, Stoll D, Hartmann H
    Carbohydr Polym. 2016 Jun 5;143:25-34. doi: 10.1016/j.carbpol.2016.01.010. Epub 2016 Jan 8.
  • The Hofmeister anion effect on morphology of polyelectrolyte multilayers for biofunctionalization of cardiovascular stents
    Andreeva TD, Danailova AK, Terziyska P, Krumrova SB, Taneva SG, Krastev R
    Bulgarian Chemical Communications. 2016 April; 48: 23 - 28.
  • Foam Stabilized by Fly Ash Nanoparticles for Enhancing Oil Recovery
    Eftekhari AA, Krastev R, Farajzadeh R
    Industrial & Engineering Chemistry Research. 2015; 54(50): 12482-12491.
  • Neutron reflectometry on samples with curved geometry
    Frueh J, Ruehm A, Moehwald H, Krastev R
    Joint Annual Report of the MLZ and FRM II: 104.
  • Reflectometry on curved interfaces
    Frueh J, Ruehm A, Moehwald H, Krastev R, Koehler R
    Physica B: Condensed Matter.2015 Jan 15; 457: 202-211.
  • Interactions in lipid stabilised foam films
    Toca-Herrera JL, Krasteva N, Muller HJ, Krastev R
    Adv Colloid Interface Sci. 2014 May;207:93-106. doi: 10.1016/j.cis.2014.02.016. Epub 2014 Feb 22.
  • Polyelectrolyte Multilayers as Functional Coatings for Controlled Biomolecular Interactions
    Xiong X, Hossfeld S, Margutti S, Krastev R
    2014. in: Biofunctional Surface Engineering, Pan Stanford Publishing; Auflage 1, Chapter 4: 47-69.
  • Surface relaxations as a tool to distinguish the dynamic interfacial properties of films formed by normal and diseased meibomian lipids
    Georgiev GA, Yokoi N, Ivanova S, Tonchev V, Nencheva Y, Krastev R
    Soft Matter. 2014 Aug 14;10(30):5579-88. doi: 10.1039/c4sm00758a.
  • Metallic oxide nanoparticles stimulate blood coagulation independent of their surface charge
    Steuer H, Krastev R, Lembert N
    J Biomed Mater Res B Appl Biomater. 2014 Jul;102(5):897-902. doi: 10.1002/jbm.b.33051. Epub 2013 Dec 18.
  • Polyelectrolyte Coatings for Surfaces Modification
    Hossfeld S, Xiong X, Krastev R
    WOMag. 2013 Feb: 22.
  • Hyaluronic acid / chitosan multilayer coatings on neuronal implants for localized delivery of siRNA nanoplexes
    Hartmann H, Hossfeld S, Schlosshauer B, Mittnacht U, Pego AP, Dauner M, Doser M, Stoll D, Krastev R
    J Control Release. 2013 Apr 4;168(3):289-297. doi: 10.1016/j.jconrel.2013.03.026.
  • Bioactive coronary stent coating based on layer-by-layer technology for siRNA release
    Hossfeld S, Nolte A, Hartmann H, Recke M, Schaller M, Walker T, Kjems J, Schlosshauer B, Stoll D, Wendel HP, Krastev R
    Acta Biomater. 2013 May; 9(5): 6741-6752. doi: 10.1016/j.actbio.2013.01.013.
  • Impact of polyelectrolytes and their corresponding multilayers to human primary endothelial cells
    Nolte A, Hossfeld S, Schroeppel B, Mueller A, Stoll D, Walker T, Wendel HP, Krastev R
    J Biomater Appl. 2013; 28 (1): 84-99. doi: 10.1177/0885328212437610
  • Foam-oil interaction in porous media: implications for foam assisted enhanced oil recovery
    Farajzadeh R, Andrianov A, Krastev R, Hirasaki GJ, Rossen WR
    Adv Colloid Interface Sci. 2012 Nov 15;183-184:1-13. doi: 10.1016/j.cis.2012.07.002. Epub 2012 Jul 31.
  • Thermodynamic studies on thin liquid films IV. Foam film stabilized by sodium dodecyl sulfate
    Iyota H, Ikeda N, Krastev R
    J Colloid Interface Sci. 2011 Dec 1;364(1):170-7. doi: 10.1016/j.jcis.2011.08.035. Epub 2011 Aug 22.
  • Foam films as thin liquid gas separation membranes
    Ramanathan M, Muller HJ, Mohwald H, Krastev R
    ACS Appl Mater Interfaces. 2011 Mar;3(3):633-7. Epub 2011 Feb 11. doi: 10.1021/am101126n.
  • Effect of gas type on foam film permeability and its implications for foam flow in porous media
    Farajzadeh R, Muruganathan RM, Rossen WR, Krastev R
    Adv Colloid Interface Sci. 2011 Oct 14;168(1-2):71-8. doi: 10.1016/j.cis.2011.03.005. Epub 2011 Mar 24.
  • Surface Chemistry Study of the Interactions of Benzalkonium Chloride with Films of Meibum, Corneal Cells Lipids, and Whole Tears
    Georgiev GA, Yokoi N, Koev K, Kutsarova E, Ivanova S, Kyumurkov A, Jordanova A, Krastev R, Lalchev Z
    Invest Ophthalmol Vis Sci. 2011 June. Investigative Ophthalmology & Visual Science. June 2011; 52(7): 4645-4654. doi:10.1167/iovs.10-627
  • Liquid- or solid-like behavior of [omim][BF4] at a solid interface?
    Köhler R, Restolho J, Krastev R, Shimizu K, Canoniga Lopes J, Saramago B
    J. Phys. Chem. Lett. 2011(2): 1551-1555.
  • Basic properties of foam films stabilized with tetraethyl ammonium salt of perfluoro octane sulfonate (PFOS)
    Ramanathan M, Mueller HJ, Vedula K, Mohwald H, Krastev R
    Colloids Surf A Physicochem. 2010 Feb; 354 (1-3): 1-7. DOI: 10.1016/j.colsurfa.2009.11.032
  • Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers
    Georgiev GA, Kutsarova E, Jordanova A, Krastev R, Lalchev Z
    Colloids Surf B Biointerfaces. 2010 Jul 1;78(2):317-27. Epub 2010 Mar 30. doi: 10.1016/j.colsurfb.2010.03.024
  • Schaumzerstörung und Schaumverhinderung: Der Wirkmechanismus von Simeticon in vitro
    Dittrich M, Miederer SE, Havertz B, Krastev R
    J Gastroenterol Hepatol Erkr. 2010; 8(3): 19-25.
  • Dynamics of thinning of foam films stabilized by n-dodecyl-beta-maltoside
    Stockle S, Blecua P, Mohwald H, Krastev R
    Langmuir. 2010 Apr 6;26(7):4865-72. doi: 10.1021/la9036748.
  • Changes of the molecular structure in polyelectrolyte multilayers under stress
    Fruh J, Kohler R, Mohwald H, Krastev R
    Langmuir. 2010 Oct 5;26(19):15516-22. doi: 10.1021/la1015324.
  • The formation of lipid bilayers on surfaces
    Gromelski S, Saraiva AM, Krastev R, Brezesinski G
    Colloids Surf B Biointerfaces. 2009 Dec 1;74(2):477-83. doi: 10.1016/j.colsurfb.2009.08.006. Epub 2009 Aug 12.
  • Neue Erkenntnisse zum Wirkmechanismus von Simeticon
    Dittrich M, Havertz B, Krastev R, Miederer Z
    Pharmazeutische Zeitung (PZ). 2009; 41: 86.
  • Absorption of Light and Heavy Water Vapours in Polyelectrolyte Multilayer Films
    Delajon C, Gutberlet T, Mohwald H, Krastev R
    Colloids Surf B Biointerfaces. 2009 Dec 1;74(2):462-7. doi: 10.1016/j.colsurfb.2009.08.051. Epub 2009 Sep 8.
  • Neutron Reflectometry Study of Swelling of Polyelectrolyte Multilayers in Water Vapours: Influence of Charge Density of the Polycation
    Kohler R, Donch I, Ott P, Laschewsky A, Fery A, Krastev R
    Langmuir. 2009 Oct 6;25(19):11576-85. doi: 10.1021/la901508w
  • Ordering of Fe3O4 Nanoparticles in Polyelectrolyte Multilayer Films
    Kolasinska M, Gutberlet T, Krastev R
    Langmuir. 2009 Sep 1;25(17):10292-7. DOI: 10.1021/la9011185