Prof. Dr. Katja Schenke-Layland

Stages of career

since 2018 Director, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany

since 2018 Co-Editor-in-Chief, Tissue Engineering, Part B (Mary Ann Liebert)

since 2011 Full Professor (W3), Eberhard Karls University Tübingen (EKUT), Institute for Biomedical Engineerin, Department of Medical Technology and Regenerative Medicine, Tübingen, Germany

since 2012 Executive Editor, Advanced Drug Delivery Reviews (ADDR) (Elsevier)

since 2018 Project Scientist, University of California Los Angeles (UCLA), Dept. of Medicine/ Cardiology, Cardiovascular Research Laboratories (CVRL), Los Angeles, CA, USA

2013 - 2018 Adjunct Associate Professor, UCLA, Dept. of Medicine/ Cardiology, Los Angeles, CA, USA

2016 - 2017 Director (interim, executive), Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Stuttgart, Germany

2013 - 2017 Department Head, Fraunhofer IGB, Dept. of Cell and Tissue Engineering, Stuttgart, Germany

2010 - 2013 Visiting Associate Professor, UCLA, Dept. of Medicine/ Cardiology, Los Angeles, CA, USA

2010 - 2014 ATTRACT-Group Leader, Fraunhofer IGB, Stuttgart, Germany

2010 - 2013 Deputy Department Head, Fraunhofer IGB, Dept. of Cell and Tissue Engineering, Stuttgart, Germany

2008 - 2009 Assistant Research Professor, UCLA, Dept. of Medicine/ Cardiology, Los Angeles, CA, USA

2005 - 2008 Postdoctoral Research Fellow, UCLA, Cardiovascular Research Laboratories, Los Angeles/CA, USA

2004 - 2005 Postdoctoral Research Fellow, Children’s Hospital Los Angeles, Saban Research Institute, Los Angeles/CA, USA

2001 - 2004 PhD in Biology/ Cardiovascular Tissue Engineering, Friedrich Schiller University (FSU) Jena, Germany

1995 - 2000 M.Sc. in Biology, Sociology, Psychology, Friedrich Schiller University (FSU) Jena, Germany

 

Further Information: Schenke-Layland Lab

Prof. Dr. Katja Schenke-Layland
Director
M.Sc. Biologie

Publications

  • Hyaluronic Acid-Functionalized Hybrid Gelatin-Poly-L-Lactide Scaffolds with Tunable Hydrophilicity
    Piccirillo G, Feuerer N, Carvajal Berrio DA, Layland SL, Reimer Hinderer S, Bochicchio B, Schenke-Layland K
    Tissue Eng Part C Methods. 2021 Nov;27(11):589-604. doi: 10.1089/ten.TEC.2021.0178. PMID: 34693733.
  • Targeted Protein Profiling of In Vivo NIPP-Treated Tissues Using DigiWest Technology
    Ruoff, F.; Henes, M.; Templin, M.; Enderle, M.; Bösmüller, H.; Wallwiener, D.; Brucker, S.Y.; Schenke-Layland, K.; Weiss, M.
    Appl. Sci. 2021, 11, 11238. https://doi.org/10.3390/app112311238
  • Development of a bi-layered cryogenic electrospun polylactic acid scaffold to study calcific aortic valve disease in a 3D co-culture model
    Stadelmann K, Weghofer A, Urbanczyk M, Maulana TI, Loskill P, Jones PD, Schenke-Layland K
    Acta Biomater. 2021 Nov 25:S1742-7061(21)00780-7. doi: 10.1016/j.actbio.2021.11.030. Epub ahead of print. PMID: 34839029.
  • Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
    Petrigliano FA, Liu NQ, Lee S, Tassey J, Sarkar A, Lin Y, Li L, Yu Y, Geng D, Zhang J, Shkhyan R, Bogdanov J, Van Handel B, Ferguson GB, Lee Y, Hinderer S, Tseng KC, Kavanaugh A, Crump JG, Pyle AD, Schenke-Layland K, Billi F, Wang L, Lieberman J, Hurtig M, Evseenko D
    NPJ Regen Med. 2021 Nov 23;6(1):77. doi: 10.1038/s41536-021-00187-3. PMID: 34815400; PMCID: PMC8611001.
  • Raman Imaging and Fluorescence Lifetime Imaging Microscopy for Diagnosis of Cancer State and Metabolic Monitoring
    Becker L, Janssen N, Layland SL, Mürdter TE, Nies AT, Schenke-Layland K, Marzi J
    Cancers (Basel). 2021 Nov 13;13(22):5682. doi: 10.3390/cancers13225682. PMID: 34830837; PMCID: PMC8616063.
  • Distinct Effects of Heparin and Interleukin-4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats
    Bonito V, Koch SE, Krebber MM, Carvajal-Berrio DA, Marzi J, Duijvelshoff R, Lurier EB, Buscone S, Dekker S, de Jong SMJ, Mes T, Vaessen KRD, Brauchle EM, Bosman AW, Schenke-Layland K, Verhaar MC, Dankers PYW, Smits AIPM, Bouten CVC
    Adv Healthc Mater. 2021 Nov;10(21):e2101103. doi: 10.1002/adhm.202101103. Epub 2021 Sep 14. PMID: 34523263.
  • Three Water Restriction Schedules Used in Rodent Behavioral Tasks Transiently Impair Growth and Differentially Evoke a Stress Hormone Response without Causing Dehydration
    Vasilev, D., Havel, D., Liebscher, S., Slesiona-Kuenzel, S., Logothetis, N. K., Schenke-Layland, K., & Totah, N. K.
    eNeuro vol. 8,6 ENEURO.0424-21.2021. 14 Dec. 2021, doi:10.1523/ENEURO.0424-21.2021
  • nflammatory and regenerative processes in bioresorbable synthetic pulmonary valves up to two years in sheep-Spatiotemporal insights augmented by Raman microspectroscopy
    De Kort BJ, Marzi J, Brauchle EM, Lichauco AM, Bauer HS, Serrero A, Dekker S, Cox MAJ, Schoen FJ, Schenke-Layland K, Bouten CVC, Smits AIPM
    Acta Biomater. 2021 Nov;135:243-259. doi: 10.1016/j.actbio.2021.09.005. Epub 2021 Sep 10. PMID: 34509697.
  • The Foreign Body Response to an Implantable Therapeutic Reservoir in a Diabetic Rodent Model
    Beatty R, Lu CE, Marzi J, Levey RE, Carvajal Berrio D, Lattanzi G, Wylie R, O'Connor R, Wallace E, Ghersi G, Salamone M, Dolan EB, Layland SL, Schenke-Layland K, Duffy GP
    Tissue Eng Part C Methods. 2021 Oct;27(10):515-528. doi: 10.1089/ten.TEC.2021.0163. PMID: 34541880.
  • Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model
    Armento, A.; Murali, A.; Marzi, J.; Almansa-Garcia, A.C.; Arango-Gonzalez, B.; Kilger, E.; Clark, S.J.; Schenke-Layland, K
    Biomolecules 2021, 11, 1621. https://doi.org/10.3390/biom11111621
  • Imaging of α-Synuclein Aggregates in a Rat Model of Parkinson's Disease Using Raman Microspectroscopy
    Sevgi F, Brauchle EM, Carvajal Berrio DA, Schenke-Layland K, Casadei N, Salker MS, Riess O, Singh Y
    Front Cell Dev Biol. 2021 Sep 10;9:664365. doi: 10.3389/fcell.2021.664365. PMID: 34568310; PMCID: PMC8461246.
  • Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone
    Jiménez-Altayó F, Marzi J, Galan M, Dantas AP, Ortega M, Rojas S, Egea G, Schenke-Layland K, Jiménez-Xarrié E, Planas AM
    J Cereb Blood Flow Metab. 2022 Jan;42(1):162-174. doi: 10.1177/0271678X211033362. Epub 2021 Sep 2. PMID: 34474613; PMCID: PMC8721773.
  • Organoids for the advancement of intraoperative diagnostic procedures
    Harland N, Amend B, Lipke N, Brucker SY, Fend F, Herkommer A, Lensch H, Sawodny O, Schäffer TE, Schenke-Layland K, Tarín Sauer C, Aicher W, Stenzl A.
    Urologe A. 2021 Sep;60(9):1159-1166. German. doi: 10.1007/s00120-021-01595-5. Epub 2021 Jul 13. PMID: 34255127.
  • Collagen and Endothelial Cell Coculture Improves β-Cell Functionality and Rescues Pancreatic Extracellular Matrix
    Zbinden A, Urbanczyk M, Layland SL, Becker L, Marzi J, Bosch M, Loskill P, Duffy GP, Schenke-Layland K
    Tissue Eng Part A. 2021 Jul;27(13-14):977-991. doi: 10.1089/ten.TEA.2020.0250. Epub 2020 Nov 6. PMID: 33023407.
  • Argyrin F Treatment-Induced Vulnerabilities Lead to a Novel Combination Therapy in Experimental Glioma
    Walter B, Canjuga D, Yüz S, Ghosh M, Bozko P, Przystal J, Govindarajan P, Anderle N, Keller AL, Tatagiba M, Schenke-Layland K, Rammensee HG, Stevanovic S, Malek N P, Schmees C, and TabatabaiG
    DOI: 10.1002/adtp.202100078
  • Generation and characterization of the human induced pluripotent stem cell line NMIi010-A from peripheral blood mononuclear cells of a healthy 49–year old male individual
    Keller AK, Binner A, Breitmeyer R, Vogel S, Anderle N, Rothbauer U, Schenke-Layland K, Schmees C
    Stem Cell Research Volume 54, July 2021, 102427, https://doi.org/10.1016/j.scr.2021.102427
  • Generation and characterization of the human induced pluripotent stem cell line NMIi010-A from peripheral blood mononuclear cells of a healthy 49–year old male individual
    Keller AL, Binner A, Breitmeyer R, Vogel S, Anderle N, Rothbauer U, Schenke-Layland K, Schmees C
    tem Cell Res. 2021 Jul;54:102427. doi: 10.1016/j.scr.2021.102427. Epub 2021 Jun 11. PMID: 34139596.
  • Human heart-forming organoids recapitulate early heart and foregut development
    Drakhlis L, Biswanath S, Farr CM, Lupanow V, Teske J, Ritzenhoff K, Franke A, Manstein F, Bolesani E, Kempf H, Liebscher S, Schenke-Layland K, Hegermann J, Nolte L, Meyer H, de la Roche J, Thiemann S, Wahl-Schott C, Martin U, Zweigerdt R
    Nat Biotechnol. 2021 Jun;39(6):737-746. doi: 10.1038/s41587-021-00815-9. Epub 2021 Feb 8. Erratum in: Nat Biotechnol. 2021 May 20;: PMID: 33558697; PMCID: PMC8192303.
  • Raman microspectroscopy and Raman imaging reveal biomarkers specific for thoracic aortic aneurysms
    Sugiyama, K., Marzi, J., Alber, J., Brauchle, E. M., Ando, M., Yamashiro, Y., Ramkhelawon, B., Schenke-Layland, K., & Yanagisawa, H. (
    Cell Rep Med. 2021 May 18; 2(5): 100261. Published online 2021 Apr 28. doi: 10.1016/j.xcrm.2021.100261
  • Immune response to SARS-CoV-2 variants of concern in vaccinated individuals
    Becker M, Dulovic A, Junker D, Ruetalo N, PKaiser PD, Pinilla YT, Heinzel C, Haering J, Traenkle B, Wagner TR, Layer M, Mehrlaender M, Mirakaj V, Held J, Planatscher H, Schenke-Layland K, Krause G, Strengert M, Bakchoul T, Althaus K, Fendel R, Kreidenweiss A, Koeppen M, Rothbauer U, Schindler M & Schneiderhan-Marra N
    NATURE COMMUNICATIONS| (2021) 12:3109 | https://doi.org/10.1038/s41467-021-23473-6 | www.nature.com/naturecommunications11234567890():,;
  • NeutrobodyPlex - monitoring SARS-CoV-2 neutralizing immune responses using nanobodies
    Wagner TR, Ostertag E, Kaiser PD, Gramlich M, Ruetalo N, Junker D, Haering J, Traenkle B, Becker M, Dulovic A, Schweizer H, Nueske S, Scholz A, Zeck A, Schenke-Layland K, Nelde A, Strengert M, Walz JS, Zocher G, Stehle T, Schindler M, Schneiderhan-Marra N, Rothbauer U
    EMBO Rep. 2021 May 5;22(5):e52325. doi: 10.15252/embr.202052325. Epub 2021 Apr 27. PMID: 33904225; PMCID: PMC8097376.
  • Integration of Electrospun Membranes into Low-Absorption Thermoplastic Organ-on-Chip
    Chuchuy J, Rogal J, Ngo T, Stadelmann K, Antkowiak L, Achberger K, Liebau S, Schenke-Layland K, Loskill P
    ACS Biomater Sci Eng. 2021 Jul 12;7(7):3006-3017. doi: 10.1021/acsbiomaterials.0c01062. Epub 2021 Feb 16. PMID: 33591723.
  • Fibronectin adsorption on oxygen plasma-treated polyurethane surfaces modulates endothelial cell response
    Daum R, Mrsic I, Hutterer J, Junginger A, Hinderer S, Meixner AJ, Gauglitz G, Chassé T, Schenke-Layland K
    J Mater Chem B. 2021 Feb 14;9(6):1647-1660. doi: 10.1039/d0tb02757j. Epub 2021 Jan 22. PMID: 33481972.
  • Laparoscopic Peritoneal Wash Cytology-Derived Primary Human Mesothelial Cells for In Vitro Cell Culture and Simulation of Human Peritoneum
    Holl M, Becker L, Keller AL, Feuerer N, Marzi J, Carvajal Berrio DA, Jakubowski P, Neis F, Pauluschke-Fröhlich J, Brucker SY, Schenke-Layland K, Krämer B, Weiss M
    Biomedicines. 2021 Feb 10;9(2):176. doi: 10.3390/biomedicines9020176. PMID: 33578986; PMCID: PMC7916778.
  • Macrophage retrieval from 3D biomaterials: A detailed comparison of common dissociation methods
    Nora Feuerer, Johannes Morschl, Ruben Daum, Martin Weiss, Svenja Hinderer, Katja Schenke-Layland, Christopher Shipp
    https://doi.org/10.1016/j.regen.2020.100035
  • Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration
    Zbinden A, Layland SL, Urbanczyk M, Carvajal Berrio DA, Marzi J, Zauner M, Hammerschmidt A, Brauchle EM, Sudrow K, Fink S, Templin M, Liebscher S, Klein G, Deb A, Duffy GP, Crooks GM, Eble JA, Mikkola HKA, Nsair A, Seifert M, Schenke-Layland K
    Adv Sci (Weinh). 2020 Dec 21;8(4):2002500. doi: 10.1002/advs.202002500. PMID: 33643791; PMCID: PMC7887579.
  • NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response
    Wagner T., Ostertag E., Kaiser P., Gramlich M., Ruetalo N., Junker D., Haering J., Traenkle B., Becker M., Dulovic A., Schweizer H., Nueske S., Scholz A., Zeck A., Schenke-Layland K., Nelde A., Strengert M., Walz J., Zocher G., Stehle T., Schindler M., Schneiderhan-Marra N., Rothbauer U
    In EMBO Reports 2021; 22(5):e52325. https://doi.org/10.15252/embr.202052325
  • Towards automation in biologics production via Raman micro-spectroscopy, laser-induced forward cell transfer and surface-enhanced Raman spectroscopy
    Jaeckle E, Brauchle E, Nottrodt N, Wehner M, Lensing R, Gillner A, Schenke-Layland K, Bach M, Burger-Kentischer A
    Journal of Biotechnology Volume 323, 10 November 2020, Pages 313-321 https://doi.org/10.1016/j.jbiotec.2020.09.001
  • HepaChip-MP – a twenty-four chamber microplate for a continuously perfused liver coculture model
    Busche M, Tomilova O, Schütte J, Werner S, Beer M, Groll N, Hagmeyer B, Pawlak M, Jones P D, Schmees C, Becker H, Schnabel J, Gall K, Hemmler R, Matz-Soja M, Damm G, Beuck S, Klaassen T, Moer J, Ullrich A, Runge D, Schenke-Layland K, Gebhardt R und Stelzle M
    Lab on a Chip, DOI: 10.1039/d0lc00357c
  • Imaging fibrosis in inflammatory diseases: Targeting exposed extracellular matrix
    Beziere N, Fuchs K, Maurer A, Reischl B, Brück J, Ghoreschi K, Carvajal Berrio D, Schenke-Layland K, Kohlhofer U, Quintanilla-Martinez L, Gawaz M, Kneilling M, Pichler B
    Theranostics in press
  • Comparative study of MSCA-1 and CD146 isolated periosteal cell subpopulations
    Umrath F, Thomalla C, Pöschel S, Schenke-Layland K, Reinert S, Alexander D
    Cell Physiol Biochem. 2018;51(3):1193-1206. doi: 10.1159/000495497. Epub 2018 Dec 12.
  • Stem cell-based organ-on-a-chip models for diabetes research
    Rogal J, Zbinden A, Schenke-Layland K, Loskill P
    Adv Drug Deliv Rev 2018 in press (Review)
  • Non-invasive characterization of hybrid gelatin: poly-L-lactide electrospun scaffolds with controlled structural properties using second harmonic generation and multiphoton imaging
    Piccirillo G, Ditaranto MV, Feuerer NFS, Carvajal Berrio DA, Brauchle EM, Pepe A, Bochicchioa B, Schenke-Layland K, Hinderer S
    Journal of Materials Chemistry B. 2018 Sept; 6(40): 6399-6412. DOI: 10.1039/c8tb02026d.
  • Improved long-term durability of allogeneic heart valves in the orthotopic sheep model
    Biermann AC, Marzi J, Brauchle E, Wichmann JL, Arendt CT, Puntmann V, Nagel E, Abdelaziz S, Winter AG, Brockbank KGM, Layland S, Schenke-Layland K, Stock UA
    Eur J Cardiothorac Surg. 2018 Aug 24. doi: 10.1093/ejcts/ezy292. [Epub ahead of print]
  • Biomechanical and biomolecular characterization of ECM in human colon carcinomas
    Brauchle E, Kasper J, Daum R, Schierbaum N, Falch C, Kirschniak A, Schäffer T, Schenke-Layland K
    Matrix Biol. 2018 Aug;68-69:180-193. doi: 10.1016/j.matbio.2018.03.016. Epub 2018 Mar 29.
  • Influence of aflibercept on platelet activation profile
    Sobolewska B, Golenko J, Poeschel S, Grimmel C, Gatsiou A, Sopova K, Biedermann T, Schenke-Layland K, Stellos K, Ziemssen F
    Exp Eye Res. 2018 Oct; 175:166-172. doi: 10.1016/j.exer.2018.06.009. Epub 2018 Jun 15. PMID: 29908884.
  • Steps toward Maturation of Embryonic Stem Cell-Derived Cardiomyocytes by Defined Physical Signals
    Shen N, Knopf A, Westendorf C, Kraushaar U, Riedl J, Bauer H, Poschel S, Layland SL, Holeiter M, Knolle S, Brauchle E, Nsair A, Hinderer S, Schenke-Layland K
    Stem Cell Reports. 2017 Jul 11;9(1):122-135. doi: 10.1016/j.stemcr.2017.04.021. Epub 2017 May 18.
  • Basement membrane proteins improve human islet survival in hypoxia: Implications for islet inflammation
    Brandhorst D, Brandhorst H, Lee Layland S, Acreman S, Schenke-Layland K, Johnson PRV
    Acta Biomater. 2022 Jan 1;137:92-102. doi: 10.1016/j.actbio.2021.10.013. Epub 2021 Oct 12. PMID: 34653695.