Prof. Dr. Katja Schenke-Layland

Publications

• The Use of Collagen-based Materials in Bone Tissue Engineering
  Lu Fan, Yanru Ren, Steffen Emmert, Ivica Vučković, Sven Najman, Reinhard Schnettler, Mike Barbeck, Katja Schenke-Layland, Xin Xiong
  Int. J. Mol. Sci. 2023, 24(4), 3744; https://doi.org/10.3390/ijms24043744
• Electrospinning of collagen: enzymatic and spectroscopic analyses reveal solvent-independent disruption of the triple-helical structure
  Dmitri Visser, Katharina Rogg, Ellena Fuhrmann, Julia Marzi, Katja Schenke-Layland, Hanna Hartmann
  Journal of Materials Chemistry B; DOI: https://doi.org/10.1039/d2tb02602c
• Green Chemistry for Biomimetic Materials: Synthesis and Electrospinning of High-Molecular-Weight Polycarbonate-Based Nonisocyanate Polyurethanes
  Visser, D.; Bakhshi, H.; Rogg, K.; Fuhrmann, E.; Wieland, F.; Schenke-Layland, K.; Meyer, W.; Hartmann, H.
  ACS Omega, 2022, DOI: https://doi.org/10.1021/acsomega.2c03731
• A Platform of Patient-Derived Microtumors Identifies Individual Treatment Responses and Therapeutic Vulnerabilities in Ovarian Cancer
  Anderle, N., Koch, A., Gierke, B., Keller, A. L., Staebler, A., Hartkopf, A., Brucker, S. Y., Pawlak, M., Schenke-Layland, K., & Schmees, C.
  Cancers, 14(12), 2895. https://doi.org/10.3390/cancers14122895
• Cell Type-Specific Anti-Adhesion Properties of Peritoneal Cell Treatment with Plasma-Activated Media (PAM)
  Holl, M., Rasch, M., Becker, L., Keller, A., Schultze-Rhonhof, L., Ruoff, F., Templin, M., Keller, S., Neis, F., Keßler, F., Andress, J., Bachmann, C., Krämer, B., Schenke-Layland, K., Brucker, S., Marzi, J., Weiss, M.
  10.3390/biomedicines10040927
• Noninvasive Physical Plasma as Innovative and Tissue-Preserving Therapy for Women Positive for Cervical Intraepithelial Neoplasia
  Marzi, J., Stope, M., Henes, M., Koch, A., Wenzel, T., Holl, M., Layland, S., Neis, F., Bösmüller, H., Ruoff, F., Templin, M., Krämer, B., Stäbler, A., Barz, J., Berrio, D., Enderle, M., Loskill, P., Brucker, S., Schenke-Layland, K., Weiss, M.
  10.3390/cancers14081933
• Basement membrane proteins improve human islet survival in hypoxia: Implications for islet inflammation
  Brandhorst D, Brandhorst H, Lee Layland S, Acreman S, Schenke-Layland K, Johnson PRV
  Acta Biomater. 2022 Jan 1;137:92-102. doi: https://doi.org/10.1016/j.actbio.2021.10.013. Epub 2021 Oct 12. PMID: 34653695.
• Hyaluronic Acid-Functionalized Hybrid Gelatin-Poly-L-Lactide Scaffolds with Tunable Hydrophilicity
  Piccirillo G, Feuerer N, Carvajal Berrio DA, Layland SL, Reimer Hinderer S, Bochicchio B, Schenke-Layland K
  Tissue Eng Part C Methods. 2021 Nov;27(11):589-604. doi: 10.1089/ten.TEC.2021.0178. PMID: 34693733.
• Targeted Protein Profiling of In Vivo NIPP-Treated Tissues Using DigiWest Technology
  Ruoff, F.; Henes, M.; Templin, M.; Enderle, M.; Bösmüller, H.; Wallwiener, D.; Brucker, S.Y.; Schenke-Layland, K.; Weiss, M.
  Appl. Sci. 2021, 11, 11238. https://doi.org/10.3390/app112311238
• Development of a bi-layered cryogenic electrospun polylactic acid scaffold to study calcific aortic valve disease in a 3D co-culture model
  Stadelmann K, Weghofer A, Urbanczyk M, Maulana TI, Loskill P, Jones PD, Schenke-Layland K
  Acta Biomater. 2021 Nov 25:S1742-7061(21)00780-7. doi: 10.1016/j.actbio.2021.11.030. Epub ahead of print. PMID: 34839029.
• Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
  Petrigliano FA, Liu NQ, Lee S, Tassey J, Sarkar A, Lin Y, Li L, Yu Y, Geng D, Zhang J, Shkhyan R, Bogdanov J, Van Handel B, Ferguson GB, Lee Y, Hinderer S, Tseng KC, Kavanaugh A, Crump JG, Pyle AD, Schenke-Layland K, Billi F, Wang L, Lieberman J, Hurtig M, Evseenko D
  NPJ Regen Med. 2021 Nov 23;6(1):77. doi: 10.1038/s41536-021-00187-3. PMID: 34815400; PMCID: PMC8611001.
• Raman Imaging and Fluorescence Lifetime Imaging Microscopy for Diagnosis of Cancer State and Metabolic Monitoring
  Becker L, Janssen N, Layland SL, Mürdter TE, Nies AT, Schenke-Layland K, Marzi J
  Cancers (Basel). 2021 Nov 13;13(22):5682. doi: 10.3390/cancers13225682. PMID: 34830837; PMCID: PMC8616063.
• Distinct Effects of Heparin and Interleukin-4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats
  Bonito V, Koch SE, Krebber MM, Carvajal-Berrio DA, Marzi J, Duijvelshoff R, Lurier EB, Buscone S, Dekker S, de Jong SMJ, Mes T, Vaessen KRD, Brauchle EM, Bosman AW, Schenke-Layland K, Verhaar MC, Dankers PYW, Smits AIPM, Bouten CVC
  Adv Healthc Mater. 2021 Nov;10(21):e2101103. doi: 10.1002/adhm.202101103. Epub 2021 Sep 14. PMID: 34523263.
• Three Water Restriction Schedules Used in Rodent Behavioral Tasks Transiently Impair Growth and Differentially Evoke a Stress Hormone Response without Causing Dehydration
  Vasilev, D., Havel, D., Liebscher, S., Slesiona-Kuenzel, S., Logothetis, N. K., Schenke-Layland, K., & Totah, N. K.
  eNeuro vol. 8,6 ENEURO.0424-21.2021. 14 Dec. 2021, doi:10.1523/ENEURO.0424-21.2021
• nflammatory and regenerative processes in bioresorbable synthetic pulmonary valves up to two years in sheep-Spatiotemporal insights augmented by Raman microspectroscopy
  De Kort BJ, Marzi J, Brauchle EM, Lichauco AM, Bauer HS, Serrero A, Dekker S, Cox MAJ, Schoen FJ, Schenke-Layland K, Bouten CVC, Smits AIPM
  Acta Biomater. 2021 Nov;135:243-259. doi: 10.1016/j.actbio.2021.09.005. Epub 2021 Sep 10. PMID: 34509697.
• The Foreign Body Response to an Implantable Therapeutic Reservoir in a Diabetic Rodent Model
  Beatty R, Lu CE, Marzi J, Levey RE, Carvajal Berrio D, Lattanzi G, Wylie R, O'Connor R, Wallace E, Ghersi G, Salamone M, Dolan EB, Layland SL, Schenke-Layland K, Duffy GP
  Tissue Eng Part C Methods. 2021 Oct;27(10):515-528. doi: 10.1089/ten.TEC.2021.0163. PMID: 34541880.
• Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model
  Armento, A.; Murali, A.; Marzi, J.; Almansa-Garcia, A.C.; Arango-Gonzalez, B.; Kilger, E.; Clark, S.J.; Schenke-Layland, K
  Biomolecules 2021, 11, 1621. https://doi.org/10.3390/biom11111621
• Imaging of α-Synuclein Aggregates in a Rat Model of Parkinson's Disease Using Raman Microspectroscopy
  Sevgi F, Brauchle EM, Carvajal Berrio DA, Schenke-Layland K, Casadei N, Salker MS, Riess O, Singh Y
  Front Cell Dev Biol. 2021 Sep 10;9:664365. doi: 10.3389/fcell.2021.664365. PMID: 34568310; PMCID: PMC8461246.
• Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone
  Jiménez-Altayó F, Marzi J, Galan M, Dantas AP, Ortega M, Rojas S, Egea G, Schenke-Layland K, Jiménez-Xarrié E, Planas AM
  J Cereb Blood Flow Metab. 2022 Jan;42(1):162-174. doi: 10.1177/0271678X211033362. Epub 2021 Sep 2. PMID: 34474613; PMCID: PMC8721773.
• Organoids for the advancement of intraoperative diagnostic procedures
  Harland N, Amend B, Lipke N, Brucker SY, Fend F, Herkommer A, Lensch H, Sawodny O, Schäffer TE, Schenke-Layland K, Tarín Sauer C, Aicher W, Stenzl A.
  Urologe A. 2021 Sep;60(9):1159-1166. German. doi: 10.1007/s00120-021-01595-5. Epub 2021 Jul 13. PMID: 34255127.
• Collagen and Endothelial Cell Coculture Improves β-Cell Functionality and Rescues Pancreatic Extracellular Matrix
  Zbinden A, Urbanczyk M, Layland SL, Becker L, Marzi J, Bosch M, Loskill P, Duffy GP, Schenke-Layland K
  Tissue Eng Part A. 2021 Jul;27(13-14):977-991. doi: 10.1089/ten.TEA.2020.0250. Epub 2020 Nov 6. PMID: 33023407.
• Argyrin F Treatment-Induced Vulnerabilities Lead to a Novel Combination Therapy in Experimental Glioma
  Walter B, Canjuga D, Yüz S, Ghosh M, Bozko P, Przystal J, Govindarajan P, Anderle N, Keller AL, Tatagiba M, Schenke-Layland K, Rammensee HG, Stevanovic S, Malek N P, Schmees C, and TabatabaiG
  DOI: 10.1002/adtp.202100078
• Generation and characterization of the human induced pluripotent stem cell line NMIi010-A from peripheral blood mononuclear cells of a healthy 49–year old male individual
  Keller AK, Binner A, Breitmeyer R, Vogel S, Anderle N, Rothbauer U, Schenke-Layland K, Schmees C
  Stem Cell Research Volume 54, July 2021, 102427, https://doi.org/10.1016/j.scr.2021.102427
• Generation and characterization of the human induced pluripotent stem cell line NMIi010-A from peripheral blood mononuclear cells of a healthy 49–year old male individual
  Keller AL, Binner A, Breitmeyer R, Vogel S, Anderle N, Rothbauer U, Schenke-Layland K, Schmees C
  tem Cell Res. 2021 Jul;54:102427. doi: 10.1016/j.scr.2021.102427. Epub 2021 Jun 11. PMID: 34139596.
• Human heart-forming organoids recapitulate early heart and foregut development
  Drakhlis L, Biswanath S, Farr CM, Lupanow V, Teske J, Ritzenhoff K, Franke A, Manstein F, Bolesani E, Kempf H, Liebscher S, Schenke-Layland K, Hegermann J, Nolte L, Meyer H, de la Roche J, Thiemann S, Wahl-Schott C, Martin U, Zweigerdt R
  Nat Biotechnol. 2021 Jun;39(6):737-746. doi: 10.1038/s41587-021-00815-9. Epub 2021 Feb 8. Erratum in: Nat Biotechnol. 2021 May 20;: PMID: 33558697; PMCID: PMC8192303.
• Raman microspectroscopy and Raman imaging reveal biomarkers specific for thoracic aortic aneurysms
  Sugiyama, K., Marzi, J., Alber, J., Brauchle, E. M., Ando, M., Yamashiro, Y., Ramkhelawon, B., Schenke-Layland, K., & Yanagisawa, H. (
  Cell Rep Med. 2021 May 18; 2(5): 100261. Published online 2021 Apr 28. doi: 10.1016/j.xcrm.2021.100261
• Immune response to SARS-CoV-2 variants of concern in vaccinated individuals
  Becker M, Dulovic A, Junker D, Ruetalo N, PKaiser PD, Pinilla YT, Heinzel C, Haering J, Traenkle B, Wagner TR, Layer M, Mehrlaender M, Mirakaj V, Held J, Planatscher H, Schenke-Layland K, Krause G, Strengert M, Bakchoul T, Althaus K, Fendel R, Kreidenweiss A, Koeppen M, Rothbauer U, Schindler M & Schneiderhan-Marra N
  NATURE COMMUNICATIONS| (2021) 12:3109 | https://doi.org/10.1038/s41467-021-23473-6 | www.nature.com/naturecommunications11234567890():,;
• NeutrobodyPlex - monitoring SARS-CoV-2 neutralizing immune responses using nanobodies
  Wagner TR, Ostertag E, Kaiser PD, Gramlich M, Ruetalo N, Junker D, Haering J, Traenkle B, Becker M, Dulovic A, Schweizer H, Nueske S, Scholz A, Zeck A, Schenke-Layland K, Nelde A, Strengert M, Walz JS, Zocher G, Stehle T, Schindler M, Schneiderhan-Marra N, Rothbauer U
  EMBO Rep. 2021 May 5;22(5):e52325. doi: 10.15252/embr.202052325. Epub 2021 Apr 27. PMID: 33904225; PMCID: PMC8097376.
• Integration of Electrospun Membranes into Low-Absorption Thermoplastic Organ-on-Chip
  Chuchuy J, Rogal J, Ngo T, Stadelmann K, Antkowiak L, Achberger K, Liebau S, Schenke-Layland K, Loskill P
  ACS Biomater Sci Eng. 2021 Jul 12;7(7):3006-3017. doi: 10.1021/acsbiomaterials.0c01062. Epub 2021 Feb 16. PMID: 33591723.
• Fibronectin adsorption on oxygen plasma-treated polyurethane surfaces modulates endothelial cell response
  Daum R, Mrsic I, Hutterer J, Junginger A, Hinderer S, Meixner AJ, Gauglitz G, Chassé T, Schenke-Layland K
  J Mater Chem B. 2021 Feb 14;9(6):1647-1660. doi: 10.1039/d0tb02757j. Epub 2021 Jan 22. PMID: 33481972.
• Laparoscopic Peritoneal Wash Cytology-Derived Primary Human Mesothelial Cells for In Vitro Cell Culture and Simulation of Human Peritoneum
  Holl M, Becker L, Keller AL, Feuerer N, Marzi J, Carvajal Berrio DA, Jakubowski P, Neis F, Pauluschke-Fröhlich J, Brucker SY, Schenke-Layland K, Krämer B, Weiss M
  Biomedicines. 2021 Feb 10;9(2):176. doi: 10.3390/biomedicines9020176. PMID: 33578986; PMCID: PMC7916778.
• Macrophage retrieval from 3D biomaterials: A detailed comparison of common dissociation methods
  Nora Feuerer, Johannes Morschl, Ruben Daum, Martin Weiss, Svenja Hinderer, Katja Schenke-Layland, Christopher Shipp
  https://doi.org/10.1016/j.regen.2020.100035
• Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration
  Zbinden A, Layland SL, Urbanczyk M, Carvajal Berrio DA, Marzi J, Zauner M, Hammerschmidt A, Brauchle EM, Sudrow K, Fink S, Templin M, Liebscher S, Klein G, Deb A, Duffy GP, Crooks GM, Eble JA, Mikkola HKA, Nsair A, Seifert M, Schenke-Layland K
  Adv Sci (Weinh). 2020 Dec 21;8(4):2002500. doi: 10.1002/advs.202002500. PMID: 33643791; PMCID: PMC7887579.
• NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response
  Wagner T., Ostertag E., Kaiser P., Gramlich M., Ruetalo N., Junker D., Haering J., Traenkle B., Becker M., Dulovic A., Schweizer H., Nueske S., Scholz A., Zeck A., Schenke-Layland K., Nelde A., Strengert M., Walz J., Zocher G., Stehle T., Schindler M., Schneiderhan-Marra N., Rothbauer U
  In EMBO Reports 2021; 22(5):e52325. https://doi.org/10.15252/embr.202052325
• Towards automation in biologics production via Raman micro-spectroscopy, laser-induced forward cell transfer and surface-enhanced Raman spectroscopy
  Jaeckle E, Brauchle E, Nottrodt N, Wehner M, Lensing R, Gillner A, Schenke-Layland K, Bach M, Burger-Kentischer A
  Journal of Biotechnology Volume 323, 10 November 2020, Pages 313-321 https://doi.org/10.1016/j.jbiotec.2020.09.001
• HepaChip-MP – a twenty-four chamber microplate for a continuously perfused liver coculture model
  Busche M, Tomilova O, Schütte J, Werner S, Beer M, Groll N, Hagmeyer B, Pawlak M, Jones P D, Schmees C, Becker H, Schnabel J, Gall K, Hemmler R, Matz-Soja M, Damm G, Beuck S, Klaassen T, Moer J, Ullrich A, Runge D, Schenke-Layland K, Gebhardt R und Stelzle M
  Lab on a Chip, DOI: 10.1039/d0lc00357c
• Imaging fibrosis in inflammatory diseases: Targeting exposed extracellular matrix
  Beziere N, Fuchs K, Maurer A, Reischl B, Brück J, Ghoreschi K, Carvajal Berrio D, Schenke-Layland K, Kohlhofer U, Quintanilla-Martinez L, Gawaz M, Kneilling M, Pichler B
  Theranostics in press
• Comparative study of MSCA-1 and CD146 isolated periosteal cell subpopulations
  Umrath F, Thomalla C, Pöschel S, Schenke-Layland K, Reinert S, Alexander D
  Cell Physiol Biochem. 2018;51(3):1193-1206. doi: 10.1159/000495497. Epub 2018 Dec 12.
• Stem cell-based organ-on-a-chip models for diabetes research
  Rogal J, Zbinden A, Schenke-Layland K, Loskill P
  Adv Drug Deliv Rev 2018 in press (Review)
• Non-invasive characterization of hybrid gelatin: poly-L-lactide electrospun scaffolds with controlled structural properties using second harmonic generation and multiphoton imaging
  Piccirillo G, Ditaranto MV, Feuerer NFS, Carvajal Berrio DA, Brauchle EM, Pepe A, Bochicchioa B, Schenke-Layland K, Hinderer S
  Journal of Materials Chemistry B. 2018 Sept; 6(40): 6399-6412. DOI: 10.1039/c8tb02026d.
• Improved long-term durability of allogeneic heart valves in the orthotopic sheep model
  Biermann AC, Marzi J, Brauchle E, Wichmann JL, Arendt CT, Puntmann V, Nagel E, Abdelaziz S, Winter AG, Brockbank KGM, Layland S, Schenke-Layland K, Stock UA
  Eur J Cardiothorac Surg. 2018 Aug 24. doi: 10.1093/ejcts/ezy292. [Epub ahead of print]
• Biomechanical and biomolecular characterization of ECM in human colon carcinomas
  Brauchle E, Kasper J, Daum R, Schierbaum N, Falch C, Kirschniak A, Schäffer T, Schenke-Layland K
  Matrix Biol. 2018 Aug;68-69:180-193. doi: 10.1016/j.matbio.2018.03.016. Epub 2018 Mar 29.
• Influence of aflibercept on platelet activation profile
  Sobolewska B, Golenko J, Poeschel S, Grimmel C, Gatsiou A, Sopova K, Biedermann T, Schenke-Layland K, Stellos K, Ziemssen F
  Exp Eye Res. 2018 Oct; 175:166-172. doi: 10.1016/j.exer.2018.06.009. Epub 2018 Jun 15. PMID: 29908884.
• Steps toward Maturation of Embryonic Stem Cell-Derived Cardiomyocytes by Defined Physical Signals
  Shen N, Knopf A, Westendorf C, Kraushaar U, Riedl J, Bauer H, Poschel S, Layland SL, Holeiter M, Knolle S, Brauchle E, Nsair A, Hinderer S, Schenke-Layland K
  Stem Cell Reports. 2017 Jul 11;9(1):122-135. doi: 10.1016/j.stemcr.2017.04.021. Epub 2017 May 18.