Prof. Dr. Hansjürgen Volkmer

Areas of activity

Molecular mechanisms of neuronal plasticity

Stages of career

Since 1998 Head of the Molecular Biology Department

1994 - 1998 Postdoc at the Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany

1989 - 1994 Postdoctoral research fellow at the Center for Molecular Neurobiology, Hamburg

1989 PhD in Genetics, University of Tübingen, Germany

1979 - 1984 Study of Biology, University of Tübingen

 
Prof. Dr. Hansjürgen Volkmer
Diplom-Biologe
T +49 (0)7121 51530-44

Projects

Publications

  • Intra-amygdala metaplasticity modulation of fear extinction learning
    Saha R., Kriebel M., Anunu R., Volkmer H., Richter-Levin G.
    DOI: 10.1111/ejn.15080
  • Disruption of Amygdala Tsc2 in Adolescence Leads to Changed Prelimbic Cellular Activity and Generalized Fear Responses at Adulthood in Rats
    Joly F, Jeckel P, Kriebel M, Raut S, El Massioui N, Vaillend C, Johnson LR, Volkmer H, Doyère V.
    Cereb Cortex. 2022 Feb 12:bhab506. doi: 10.1093/cercor/bhab506. Epub ahead of print. PMID: 35149865.
  • Human iPSC-Derived Glia as a Tool for Neuropsychiatric Research and Drug Development
    Heider J, Vogel S, Volkmer H and Breitmeyer R
    Int. J. Mol. Sci. 2021
  • Autism Spectrum Disorder Risk Factor Met Regulates the Organization of Inhibitory Synapses
    Jeckel P, Kriebel M, Volkmer H
    Front. Mol. Neurosci., 13 May 2021 | https://doi.org/10.3389/fnmol.2021.659856
  • Functional brain defects in a mouse model of a chromosomal t(1;11) translocation that disrupts DISC1 and confers increased risk of psychiatric illness
    Bonneau M, O' Sullivan ST, Gonzalez-Lozano MA, Baxter P, Gautier P, Marchisella E, Hardingham NR, Chesters RA, Torrance H, Howard DM, Jansen MA, McMillan M, Singh Y, Didier M, Koopmans F, Semple CA, McIntosh AM, Volkmer H, Loos M, Fox K, Hardingham GE, Vernon AC, Porteous DJ, Smit AB, Price DJ, Millar JK
    Transl Psychiatry . 2021 Feb 19;11(1):135. doi: 10.1038/s41398-021-01256-3.
  • The potential of induced pluripotent stem cells for discriminating neurodevelopmental disorders
    Stock R, Jeckel P, Kraushaar U, Wüst R, Fallgatter A, Volkmer H
    STEM CELLS Transl Med. 2021;10:50-56. https://doi.org/10.1002/sctm.20-0206
  • Generation and characterization of human induced pluripotent stem cells lines from four patients diagnosed with schizophrenia and one healthy control
    Stock R, Vogel S, Mau-Holzmann U, Kriebel M, Wüst R, Fallgatter A, Volkmer H
    Stem Cell Research, 48 (2020) 101961, https://doi.org/10.1016/j.scr.2020.101961
  • Interference With Complex IV as a Model of Age-Related Decline in Synaptic Connectivity
    Kriebel M, Ebel J, Battke F, Griesbach S, Volkmer H
    Front. Mol. Neurosci., 2020 (13), https://doi.org/10.3389/fnmol.2020.00043
  • The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience
    Ardi Z, Richter-Levin A, Xu L, Cao X, Volkmer H, Stork O, Richter-Levin G
    Sci Rep. 2019 Sep 18;9(1):13513. doi: 10.1038/s41598-019-49824-4.
  • Comparative characterization of humaninduced pluripotent stem cells (hiPSC) derived from patients with schizophreniaand autism
    Grunwald L-M, Stock R, Haag K, Buckenmaier S, Eberle M-C, Wildgruber D, Storchak H, Kriebel M, Weißgraeber S, Mathew L, Loos M, Li kw, Kraushaar U, Fallgatter AJ, Volkmer H
    Translational Psychiatry (2019) 9:179
  • Neurofascin Knock Down in the Basolateral Amygdala Mediates Resilience of Memory and Plasticity in the Dorsal Dentate Gyrus Under Stress
    Saha R, Kriebel M, Volkmer H, Richter-Levin G, Albrecht A
    Molecular Neurobiology. 2018 Sept; 55(9): 7317-7326. DOI: 10.1007/s12035-018-0930-2
  • Perturbation of GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Induces Trans-regional Metaplasticity at the Medial Prefrontal Cortex
    Saha R, Shrivastava K, Jing L, Schayek R, Maroun M, Kriebel M, Volkmer H, Richter-Levin G
    Cereb Cortex. 2017 Nov; 9:1-16. doi: 10.1093/cercor/bhx300.
  • GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Projection Neurons Modulate Fear Extinction
    Saha R, Knapp S, Chakraborty D, Horovitz O, Albrecht A, Kriebel M, Kaphzan H, Ehrlich I, Volkmer H, Richter-Levin G
    Neuropsychopharmacology. 2017 Jan;42(2):473-484. doi: 10.1038/npp.2016.205. Epub 2016 Sep 16.
  • GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Projection Neurons Modulate Fear Extinction
    Saha R, Knapp S, Chakraborty D, Horovitz O, Albrecht A, Kriebel M, Kaphzan H, Ehrlich I, Volkmer H, Richter-Levin G
    Neuropsychopharmacology. 2017 Jan;42(2):473-484. doi: 10.1038/npp.2016.205. Epub 2016 Sep 16.
  • Receptor tyrosine kinase EphA7 is required for interneuron connectivity at specific subcellular compartments of granule cells
    Beuter S, Ardi Z, Horovitz O, Wuchter J, Keller S, Saha R, Tripathi K, Anunu R, Kehat O, Kriebel M, Richter-Levin G, Volkmer H
    Scientific Reports. 2016 July 13;6:29710
  • Dentate Gyrus Local Circuit is Implicated in Learning Under Stress-a Role for Neurofascin
    Zitman FM, Lucas M, Trinks S, Grosse-Ophoff L, Kriebel M, Volkmer H, Richter-Levin G
    Mol Neurobiol (2016) 53:842–850 DOI 10.1007/s12035-014-9044-7
  • Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells
    Kaistha BP, Honstein T, Muller V, Bielak S, Sauer M, Kreider R, Fassan M, Scarpa A, Schmees C, Volkmer H, Gress TM, Buchholz, M
    Br J Cancer. 2014 Oct 28;111(9):1780-7. doi: 10.1038/bjc.2014.460. Epub 2014 Aug 19.
  • Stress modulation of hippocampal activity - Spotlight on the dentate gyrus
    Fa M, Xia L, Anunu R, Kehat O, Kriebel M, Volkmer H, Richter-Levin G
    Neurobiol Learn Mem. 2014 Jul;112C:53-60. doi: 10.1016/j.nlm.2014.04.008. Epub 2014 Apr 18.
  • Organisation and Control of Neuronal Connectivity and Myelination by Cell Adhesion Molecule Neurofascin
    Ebel J, Beuter S, Wuchter J, Kriebel M, Volkmer H
    2014. in: Berezin V, Walmod P (eds). Cell Adhesion Molecules. Advances in Neurobiology, Springer New York. 8: 231-247
  • Regulation of Adhesion by Flexible Ectodomains of IgCAMs
    Volkmer H, Schreiber J, Rathjen FG
    Neurochem Res. 2013 Jun;38(6):1092-9. doi: 10.1007/s11064-012-0888-9. Epub 2012 Oct 9.
  • A Comprehensive Small Interfering RNA Screen Identifies Signaling Pathways Required for Gephyrin Clustering
    Wuchter J, Beuter S, Treindl F, Herrmann T, Zeck G, Templin MF, Volkmer H
    The Journal of Neuroscience. 2012 Oct 17; 32(42):14821–14834
  • Neurofascin: A switch between neuronal plasticity and stability
    Kriebel M, Wuchter J, Trinks S, Volkmer H
    Int J Biochem Cell Biol. 2012 May; 44(5): 694-697. doi: 10.1016/j.biocel.2012.01.012
  • Developmental dynamics of gap junction based neuronal coupling in the rat inferior olive
    Mueller JR, Kriebel M, Volkmer H, Thier P
    Neuroscience Meeting Planer. Washington DC: Society for Neuroscience, 2011.
  • Enhanced predictive drug development: Functional screening of the GABAAR alpha1 subunit using receptor-specific RNA inference, MEA recordings and substance classification
    Bader BM, Kniest S, Jügelt K, Kriebel M, Volkmer H, Schroeder OH-U, Gramowski-Voss A
    euroscience Meeting Planer. Program No. 41.13/E24. 2011. Washington, DC: Society for Neuroscience, 2011.
  • Developmental dynamics of gap junction based neuronal coupling in the rat interior olive
    Mueller JR, Kriebel M, Volkmer H, Thier P
    Neuroscience, 2011
  • The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment
    Kriebel M, Metzger J, Trinks S, Chugh D, Harvey RJ, Harvey K, Volkmer H
    J Biol Chem. 2011 Jul 8; 286(27): 24385–24393. doi: 10.1074/jbc.M110.212191
  • The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment
    Kriebel M, Metzger J, Trinks S, Chugh D, Harvey RJ, Harvey K, Volkmer H
    J Biol Chem. 2011 Jul 8; 286(27): 24385–24393. doi: 10.1074/jbc.M110.212191
  • Cell-based microarrays of infectious adenovirus encoding short hairpin RNA (shRNA)
    Volkmer H, Weise F
    Methods Mol Biol. 2011;706:97-106.
  • Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets
    Swanton C, Larkin JM, Gerlinger M, Eklund AC, Boehme KA, Volkmer H, Howell M, Stamp G, Downward J, Gore M, Futreal PA, Escudier B, Andre F, Albiges L, Beuselinck B, Oudard S, Hoffmann J, Gyorffy B et al.
    Genome Med. 2010 Aug 11;2(8):53. doi: 10.1186/gm174.
  • Analysis of Non-canonical Fibroblast Growth Factor Receptor 1 (FGFR1) Interaction Reveals Regulatory and Activating Domains of Neurofascin
    Kirschbaum K, Kriebel M, Kranz EU, Poetz O, Volkmer H
    J Biol Chem. 2009 Oct 16;284(42):28533-42. doi: 10.1074/jbc.M109.004440. Epub 2009 Aug 7.
  • A novel reverse transduction adenoviral array for the functional analysis of shRNA libraries
    Oehmig A, Klotzbucher A, Thomas M, Weise F, Hagner U, Brundiers R, Waldherr D, Lingnau A, Knappik A, Kubbutat, MH, Joos TO, Volkmer H
    BMC Genomics. 2008 Sep 24;9:441. doi: 10.1186/1471-2164-9-441.
  • Identification of NCAM-binding peptides promoting neurite outgrowth via a heterotrimeric G-protein-coupled pathway
    Hansen RK, Christensen C, Korshunova I, Kriebel M, Burkarth N, Kiselyov VV, Olsen M, Ostergaard S, Holm A, Volkmer H, Walmod PS, Berezin V, Bock E
    J Neurochem. 2007 Nov;103(4):1396-407. Epub 2007 Sep 13. DOI: 10.1111/j.1471-4159.2007.04894.x
  • Neurofascin regulates the formation of gephyrin clusters and their subsequent translocation to the axon hillock of hippocampal neurons
    Burkarth N, Kriebel M, Kranz EU, Volkmer H
    Mol Cell Neurosci. 2007 Sep;36(1):59-70. Epub 2007 Jun 27. DOI: 10.1016/j.mcn.2007.06.001
  • Combination of engineered neural cell adhesion molecules and GDF-5 for improved neurite extension in nerve guide concepts
    Niere M, Braun B, Gass R, Sturany S, Volkmer H
    Biomaterials. 2006 Jun;27(18):3432-40. Epub 2006 Feb 23. DOI: 10.1016/j.biomaterials.2006.01.037
  • A regulated switch of chick neurofascin isoforms modulates ligand recognition and neurite extension.
    Pruss T, Kranz E U, Niere M, Volkmer H
    Mol Cell Neurosci. 2006 Feb;31(2):354-65. Epub 2005 Nov 28. DOI: 10.1016/j.mcn.2005.10.009
  • Functional re-establishment of the perforant pathway in organotypic co-cultures on microelectrode arrays
    Hofmann F, Guenther E, Hammerle H, Leibrock C, Berezin V, Bock E, Volkmer H
    Brain Res. 2004 Aug 13;1017(1-2):184-96. DOI: 10.1016/j.brainres.2004.05.044
  • Homophilic interactions of chick neurofascin in trans are important for neurite induction
    Pruss T, Niere M, Kranz EU, Volkmer H
    Eur J Neurosci. 2004 Dec;20(11):3184-8. DOI: 10.1111/j.1460-9568.2004.03773.x
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