Matthias Becker

Areas of activity

Assay development, multiplex immunoassays, bioinformatics, data analysis and visualization

Stages of career

2019 - Present  Scientist / Ph.D. student, NMI Reutlingen, Germany

2015 - 2018        M.Sc. Biochemistry, University of Tuebingen, Germany

2012 - 2015        B.Sc. Biochemistry, University of Tuebingen

Matthias Becker
Scientist Multiplex Immunoassays

Publications

  • Reduced serum neutralization capacity against SARS-CoV-2 variants in a multiplex ACE2 RBD competition assay
    Junker D, Dulovic A, Becker M, Wagner T R, Kaiser P D, Traenkle B, Rothbauer U, Kienzle K, Bunk S, Strümper C, Häberle H, Schmauder K, Malek N, Althaus K, Koeppen M, Bitzer M, Göpel S, Schneiderhan-Marra N
    medRxiv, https://doi.org/10.1101/2021.08.20.21262328
  • Diminishing immune responses against variants of concern in dialysis patients four months after SARS-CoV-2 mRNA vaccination
    Dulovic A, Strengert M, Morillas Ramos G, Becker M, Griesbaum J, Junker D, Lürken K, Beigel A, Wrenger E, Lonnemann G, Cossmann A, Stankov M, Dopfer-Jablonka A, Kaiser P, Traenkle B, Rothbauer U, Krause G, Schneiderhan-Marra N, Behrens G M.N.
    medRxiv, https://doi.org/10.1101/2021.08.16.21262115
  • A broadly neutralizing biparatopic Nanobody protects mice from lethal challenge with SARS-CoV-2 variants of concern
    Wagner T, Schnepf D, Beer J, Klingel K, Ruetalo N, Kaiser P, Junker D, Sauter M, raenkle B, Frecot D, Becker M, Schneiderhan-Marra N, Ohnemus A, Schwemmle M, Schindler M, Rothbauer U
    bioRxiv, doi: https://doi.org/10.1101/2021.08.08.455562
  • Cellular and humoral immunogenicity of a SARS-CoV-2 mRNA vaccine in patients on haemodialysis
    Strengert M, Becker M, Morillas Ramos G, Dulovic A, Gruber J, Juengling J, Lürken K, Beigel A, Wrenger E, Lonnemann G, Cossmann A, Stankov M, Dopfer-Jablonka A, Kaiser P, Traenkle B, Rothbauer U, Krause G, Schneiderhan-Marra N, Behrens G M.N.
    Lancet EBioMedicine, Published: August 11, 2021DOI:https://doi.org/10.1016/j.ebiom.2021.103524
  • Typically asymptomatic but with robust antibody formation: Children’s unique humoral immune response to SARS-CoV-2.
    Renk H, Dulovic A, Becker M, Fabricius D, Zernickel M, Junker D, Seidel A, Groß R, Hilger A, Bode S, Fritsch L, Frieh P, Haddad A, Görne T, Remppis J, Ganzemueller T, Dietz A, Huzly D, Hengel H, Kaier K, Weber S, Jacobsen EM, Kaise P, Traenkle B, Rothbauer U, Stich M, Tönshoff B, Hoffmann H, Müller B, Ludwig C, Jahrsdörfer B, Schrezenmeier H, Peter A, Hörber S, Iftner T, Münch J, Stamminger T, Groß HJ, Wolkewitz M, Engel C, Rizzi M, Henneke P, Franz AR, Debatin KM, Schneiderhan-Marra N, Janda A, Elling R
    medRxiv, doi: https://doi.org/10.1101/2021.07.20.21260863
  • NeutrobodyPlex - monitoring SARS-CoV-2 neutralizing immune responses using nanobodies
    Wagner TR, Ostertag E, Kaiser PD, Gramlich M, Ruetalo N, Junker D, Haering J, Traenkle B, Becker M, Dulovic A, Schweizer H, Nueske S, Scholz A, Zeck A, Schenke-Layland K, Nelde A, Strengert M, Walz JS, Zocher G, Stehle T, Schindler M, Schneiderhan-Marra N, Rothbauer U
    EMBO Rep. 2021 May 5;22(5):e52325. doi: 10.15252/embr.202052325. Epub 2021 Apr 27. PMID: 33904225; PMCID: PMC8097376.
  • Multiplexed Serum Antibody Screening Platform Using Virus Extracts from Endemic Coronaviridae and SARS-CoV-2
    Fink S., Ruoff F., Stahl A., Becker M., Kaiser P., Traenkle B., Junker D., Weise F., Ruetalo N., Hörber S., Peter A., Nelde A., Walz j., Krause G., Baillot A., Schenke-Layland K., Joos TO., Rothbauer U., Schneiderhan-Marra N., Schindler M., Templin MF
    ACS Infectious Diseases 2021; https://doi.org/10.1021/acsinfecdis.0c00725.
  • Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity
    Becker M, Strengert M, Junker D, Kaiser P, Kerrinnes T, Traenkle B, Dinter H, Häring J, Ghozzi S, Zeck A, Weise F, Peter A, Hörber S, Fink S, Ruoff F, Dulovic A, Bakchoul T, Baillot A, Lohse S, Cornberg M, Illig T, Gottlieb J, Smola S, Karch A, Berger K, Rammensee HG, Schenke-Layland K, Nelde A, Märklin M, Heitmann JS, Walz JS, Templin M, Joos TO, Rothbauer U, Krause K & Schneiderhan-Marra N
    NATURE COMMUNICATIONS | (2021) 12:1152 | https://doi.org/10.1038/s41467-021-20973-3 | www.nature.com/naturecommunications
  • Magnetic Bead-Based Immunoassay Allows Rapid, Inexpensive, and Quantitative Detection of Human SARS-CoV-2 Antibodies
    Huergo LF, Selim KA, Conzentino MS, Gerhardt ECM, Santos ARS, Wagner B, Alford JT, Deobald N, Pedrosa FO, de Souza EM, Nogueira MB, Raboni SM, Souto D, Rego FGM, Zanette DL, Aoki MN, Nardin JM, Fornazari B, Morales HMP, Borges VA, Nelde A, Walz JS, Becker M, Schneiderhan-Marra N, Rothbauer U, Reis RA, Forchhammer K
    ACS Sensors 2021, 6(3):703-708, https://doi.org/10.1021/acssensors.0c02544
  • NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response
    Wagner T., Ostertag E., Kaiser P., Gramlich M., Ruetalo N., Junker D., Haering J., Traenkle B., Becker M., Dulovic A., Schweizer H., Nueske S., Scholz A., Zeck A., Schenke-Layland K., Nelde A., Strengert M., Walz J., Zocher G., Stehle T., Schindler M., Schneiderhan-Marra N., Rothbauer U
    In EMBO Reports 2021; 22(5):e52325. https://doi.org/10.15252/embr.202052325
  • SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition
    Nelde A., Bilich T., Heitmann JS., Maringer Y., Salih HR., Roerden R., Luebke M., Bauer J., Rieth J., Wacker M., Peter A., Hörber S., Traenkle B., Kaiser PD., Rothbauer U., Becker M., Junker D., Krause G., Strengert M., Schneiderhan-Marra N., Joos TO., Kowalewski D.J., Stos-Zweifel V., Fehr M., Graf M., Gruber L., Rachfalski D., Preuß B., Hagelstein I., Märklin M., Bakchoul T., Gouttefangeas C., Kohlbacher O., Klein R., Stevanović S., Rammensee H.-G., Walz J.S.
    Nature Immunology 2021; 22:74–85, DOI: https://doi.org/10.1038/s41590-020-00808-x