Dr. Udo Kraushaar

Ares of activity

Function and dynamics of ion channels at the cellular level and in organo-near systems (acute and organotypic tissue preparations, cell clusters). Special emphasis is put on the clarification of neurobiological and cardiorelevant questions. 

Stages of career

2007 - Group leader electrophysiology

2004 - 2007     Research associate at Saarland University Hospital, Molecular Cell Biology Prof. Lipp

2002 - 2004     Postdoctoral Associate Yale University, USA, Neurobiology Prof. McCormick

2000 - 2002     Scientific assistant at the University of Freiburg, Physiology I  Prof. Jonas

1995 - 2000     PhD on synaptic transmission in the hippocampus

1995                 Diploma in Biology University of Kaiserslautern, Zoology Prof. Deitmer
Dr. Udo Kraushaar
Diplom-Biologie
T +49 (0)7121 51530-851

Projects

Publications

  • Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling
    Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M.
    Arch Toxicol. 2021 Oct 10. doi: 10.1007/s00204-021-03168-z. Epub ahead of print. PMID: 34628512.
  • Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons
    Loser D, Hinojosa MG, Blum J, Schaefer J, Brüll M, Johansson Y, Suciu I, Grillberger K, Danker T, Möller C, Gardner I, Ecker GF, Bennekou SH, Forsby A, Kraushaar U, Leist M
    Arch Toxicol (2021). https://doi.org/10.1007/s00204-021-03031-1
  • The potential of induced pluripotent stem cells for discriminating neurodevelopmental disorders
    Stock R, Jeckel P, Kraushaar U, Wüst R, Fallgatter A, Volkmer H
    STEM CELLS Transl Med. 2021;10:50-56. https://doi.org/10.1002/sctm.20-0206
  • Human neuronal signaling and communication assays to assess functional neurotoxicity
    Loser D, Schaefer J, Danker T, Möller C, Brüll M, Suciu I, Ückert AK, Klima S, Leist M, Kraushaar U.
    Arch Toxicol. 2021 Jan;95(1):229-252. doi: 10.1007/s00204-020-02956-3. Epub 2020 Dec 2. PMID: 33269408; PMCID: PMC7811517.
  • Incorporation of Stem Cell-Derived Astrocytes into Neuronal Organoids to Allow Neuro-Glial Interactions in Toxicological Studies
    Markus Brüll, Anna-Sophie Spreng, Simon Gutbier, Dominik Loser, Alice Krebs, Marvin Reich, Udo Kraushaar, Markus Britschgi, Marcel Leist
    ALTEX. 2020 Mar 7 doi:10.14573/altex.1911111
  • Assay Procedures for Compound Testing of hiPSC-Derived Cardiomyocytes Using Multiwell Microelectrode Arrays
    Udo Kraushaar and Elke Guenther
    Cell-Based Assays Using iPSCs for Drug Development and Testing (Mandenius C-F, Ross JA, eds), pp 197–208. New York, NY: Springer New York.
  • Comparative characterization of humaninduced pluripotent stem cells (hiPSC) derived from patients with schizophreniaand autism
    Grunwald L-M, Stock R, Haag K, Buckenmaier S, Eberle M-C, Wildgruber D, Storchak H, Kriebel M, Weißgraeber S, Mathew L, Loos M, Li kw, Kraushaar U, Fallgatter AJ, Volkmer H
    Translational Psychiatry (2019) 9:179
  • International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment
    Blinova K, Dang Q, Millard D, Smith G, Pierson J, Guo L, Brock M, Lu HR, Kraushaar U, Zeng H, Shi H, Zhang X, Sawada K, Osada T, Kanda Y, Sekino Y, Pang L, Feaster TK, Kettenhofen R, Stockbridge N, Strauss DG, Gintant G
    Cell Rep. 2018 Sep 25;24(13):3582-3592. doi: 10.1016/j.celrep.2018.08.079.
  • Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study
    Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G.
    Toxicol Sci. 2018 Aug 1;164(2):550-562. doi: 10.1093/toxsci/kfy110.
  • Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report
    Mulder P, de Korte T, Dragicevic E, Kraushaar U, Printemps R, Vlaming MLH, Braam SR, Valentin JP.
    J Pharmacol Toxicol Methods. 2018 May-Jun;91:36-42. doi: 10.1016/j.vascn.2018.01.003. Epub 2018 Feb 4.
  • Semitransparent carbon microelectrodes for opto- and electrophysiology
    Kshirsagar P, Martina M, Jones PD, Buckenmaier S, Kraushaar U, Chassé T, Fleischer M, Burkhardt CJ
    Journal of Micromechanics and Microengineering. 2018 April; 28 (7): 075007. doi:10.1088/1361-6439/aab9f0
  • Electrophysiological Characterization of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for the Development of new in vitro Assays in Preclinical Cardiac Risk Assessment of Drugs
    Küchler, S
    Masterthesis, 2017; Brandenburgische Technische Universität Cottbus-Senftenberg.
  • The influence of mechanical stress during the differentiation on the electrophysiological properties of human embryonic stem cell – derived cardiomyocytes
    Knolle, S
    Masterthesis, 2017; Brandenburgische Technische Universität Cottbus-Senftenberg.
  • Correlative Microscopy Combining Secondary Ion Mass Spectrometry and Electron Microscopy: Comparison of Intensity–Hue–Saturation and Laplacian Pyramid Methods for Image Fusion
    Vollnhals F, Audinot J-N, Wirtz, T, Mercier-Bonin M, Fourquaux I, Schroeppel B, Kraushaar U, Lev-Ram V, Ellisman MH, Eswara S
    Anal. Chem. (2017), Bd. 89, H. 20, S. 10702-10710, https://doi.org/10.1021/acs.analchem.7b01256
  • Steps toward Maturation of Embryonic Stem Cell-Derived Cardiomyocytes by Defined Physical Signals
    Shen N, Knopf A, Westendorf C, Kraushaar U, Riedl J, Bauer H, Poschel S, Layland SL, Holeiter M, Knolle S, Brauchle E, Nsair A, Hinderer S, Schenke-Layland K
    Stem Cell Reports. 2017 Jul 11;9(1):122-135. doi: 10.1016/j.stemcr.2017.04.021. Epub 2017 May 18.
  • Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA)
    Kraushaar U, Guenther E, Hess D
    Stem Cell-Derived Models in Toxicology. M. Clements and L. Roquemore. New York, NY: Springer New York; 2017. 293-309.
  • Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection
    Rast G, Kraushaar U, Buckenmaier S, Ittrich C, Guth BD
    J Pharmacol Toxicol Methods. 2016 Nov - Dec;82:74-82. doi: 10.1016/j.vascn.2016.08.002. Epub 2016 Aug 9.
  • Data collection for CiPA Myocyte study finalized within one month
    Kraushaar U
    HESI - http://hesiglobal.org/
  • Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection.
    Rast G, Kraushaar U, Buckenmaier S, Ittrich C, Guth BD
    J Pharmacol Toxicol Methods. 2016 Aug 9;82:74-82. doi: 10.1016/j.vascn.2016.08.002. [Epub ahead of print]
  • Smooth Muscle-Like Cells Generated from Human Mesenchymal Stromal Cells Display Marker Gene Expression and Electrophysiological Competence Comparable to Bladder Smooth Muscle Cells
    Brun J, Lutz KA, Neumayer KM, Klein G, Seeger T, Uynuk-Ool T, Worgotter K, Schmid S, Kraushaar U, Guenther E, Rolauffs B, Aicher WK, Hart ML
    PLoS One. 2015 Dec 16;10(12):e0145153. doi: 10.1371/journal.pone.0145153. eCollection 2015.
  • Isolation, expansion and transplantation of postnatal murine progenitor cells of the enteric nervous system
    Dettmann HM, Zhang Y, Wronna N, Kraushaar U, Guenther E, Mohr R, Neckel PH, Mack A, Fuchs J, Just L, Obermayr F
    PLoS One. 2014 May 28;9(5):e97792. doi: 10.1371/journal.pone.0097792. eCollection 2014.
  • Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays
    Schonecker S, Kraushaar U, Dufer M, Sahr A, Hardtner C, Guenther E, Walther R, Lendeckel U, Barthlen W, Krippeit-Drews P, Drews G
    Integr Biol (Camb). 2014 Mar 24; 2014(4):540-544
  • Cell-Based Therapy for the Deficient Urinary Sphincter
    Hart ML, Neumayer KMH, Vaegler M, Daum L, Amend B, Sievert KD, Di Giovanni S, Kraushaar U, Guenther E, Stenzl A, Aicher WK
    Curr Urol Rep. 2013 Oct;14(5):476-87. doi: 10.1007/s11934-013-0352-7.
  • PEDOT–CNT composite microelectrodes for recording and electrostimulation applications: fabrication, morphology, and electrical properties
    Gerwig R, Fuchsberger K, Schroeppel B, Link GS, Heusel G, Kraushaar U, Schuhmann W, Stett A, Stelzle M
    Front Neuroeng. 2012; 5: 8. Published online 2012 May 4. doi: 10.3389/fneng.2012.00008
  • Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays
    Pfeiffer T, Kraushaar U, Düfer M, Schönecker S, Haspel D, Günther E, Drews G, Krippeit-Drews P
    Europ. J. Physiol. 2011, 462 (6): 835-840. DOI 10.1007/s00424-011-1029-z
  • Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review
    Mandenius CF, Steel D, Noor F, Meyer T, Heinzle E, Asp J, Arain S, Kraushaar U, Bremer S, Class R, Sartipy P
    J Appl Toxicol. April 2011; 31(3): 191-205. https://doi.org/10.1002/jat.1663
  • TRPV Channel Expression in Human Skin and Possible Role in Thermally Induced Cell Death
    Radtke C, Sinis N, Sauter M, Jahn S, Kraushaar U, Guenther E, Rodemann HP, Rennekampff HO
    J Burn Care Res. 2011 Jan-Feb;32(1):150-9. DOI 10.1097/BCR.0b013e318203350c
  • Wnt/beta-catenin signaling activates and determines hepatic zonal expression of glutathione S-transferases in mouse liver
    Giera S, Braeuning A, Kohle C, Bursch W, Metzger U, Buchmann A, Schwarz M
    Toxicol Sci. 2010 May;115(1):22-33. Epub 2010 Jan 30. doi: 10.1093/toxsci/kfq033.
  • Biocompatible molecularly imprinted polymers for the voltage regulated uptake and release of l-glutamate in neutral pH solutions
    von Hauff E, Fuchs K, Hellmann D Ch, Parisi J, Weiler R, Burkhardt C, Kraushaar U, Guenther E
    Biosens Bioelectron. 2010 Oct 15;26(2):596-601. Epub 2010 Jul 16. doi: 10.1016/j.bios.2010.07.022
  • Cardiac slices as a predictive tool for arrhythmogenic potential of drugs and chemicals
    Meyer T, Stuerz K, Guenther E, Edamura M, Kraushaar U
    Expert Opin Drug Metab Toxicol. 2010 Dec;6(12):1461-75. Epub 2010 Nov 11. doi: 10.1517/17425255.2010.526601.
  • Inhomogeneity of Cell Properties In The Cardiomyocyte Derived HL-1 Cell Line
    Kraushaar U, Nagel J, Meyer T, Guenther E
    Proceedings MEA Meeting 2008, Reutlingen, BioPro edition; 5:186-187, ISBN 3-938345-05-5
Go back