Areas of activity
Biochemistry, development of mass spectrometry-based immunoassays, drug-drug interactions, molecular responses of cells and tissues to xenobiotics, validation of safety biomarkers.
Stages of career
2016 - present Managing Director of SIGNATOPE GmbH.
2010 - 2016 Group leader protein analytics, NMI
2014 - present Chair of the GBM Working Group Bioanalytics
Dr. Oliver Pötz
Projects
Publications
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Characterization of hepatic zonation in mice by mass-spectrometric and antibody-based proteomics approachesKling S, Lang B, Hammer HS, Naboulsi W, Sprenger H, Frenzel F, Pötz O, Schwarz M, Braeuning A, Templin MFBiol Chem. 2021 Oct 4. doi: 10.1515/hsz-2021-0314. Epub ahead of print. PMID: 34599868.
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Tris(hydroxymethyl)aminomethane Compatibility with N-Hydroxysuccinimide Ester Chemistry: Biotinylation of Peptides and Proteins in TRIS BufferKratzer U, Sommersdorf C, Maier S, Wagner TR, Templin M, Joos TO, Rothbauer U, Zeck A, Poetz OBioconjug Chem. 2021 Sep 15;32(9):1960-1965. doi: https://doi.org/10.1021/acs.bioconjchem.1c00283. Epub 2021 Aug 18. PMID: 34406760.
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Application of Mass Spectrometry-Based Immunoassays for the Species- and Tissue-Specific Quantification of Banned Processed Animal Proteins in FeedsSteinhilber A, Schmidt F, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos T, Poetz OAnalytical Chemistry. 2019 Feb 27. doi: 10.1021/acs.analchem.8b04652 Epub ahead of print
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Species Differentiation and Quantification of Processed Animal Proteins and Blood Products in Fish Feed Using an 8-Plex Mass Spectrometry-Based ImmunoassaySteinhilber AE, Schmidt FF, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos TO, Poetz OJ Agric Food Chem. 2018 Oct 3;66(39):10327-10335. doi: 10.1021/acs.jafc.8b03934. Epub 2018 Sep 24.
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Peptide-Based Sandwich Immunoassay for the Quantification of the Membrane Transporter Multidrug Resistance ProteinPoetz O, Dieze T, Hammer H, Weiß F, Sommersdorf C, Templin MF, Esdar C, Zimmermann A, Stevanovic S, Bedke J, Stenzl A, Joos TO.Anal Chem. 2018 May 1;90(9):5788-5794. doi: 10.1021/acs.analchem.8b00152. Epub 2018 Apr 12.
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Mass Spectrometry-Based Immunoassay for the Quantification of Banned Ruminant Processed Animal Proteins in Vegetal FeedsSteinhilber AE, Schmidt FF, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos T, Poetz OAnal Chem. 2018 Mar 20;90(6):4135-4143. doi: 10.1021/acs.analchem.8b00120. Epub 2018 Mar 7.
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Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture LysatesWeiß F, Hammer HS, Klein K, Planatscher H, Zanger UM, Norén A, Wegler C, Artursson P, Joos TO, Poetz ODrug Metab Dispos. 2018 Apr;46(4):387-396. doi: 10.1124/dmd.117.078626. Epub 2018 Jan 17.
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Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR miceMarx-Stoelting P, Ganzenberg K, Knebel C, Schmidt F, Rieke S, Hammer H, Schmidt F, Potz O, Schwarz M, Braeuning AArch Toxicol. 2017 Aug;91(8):2895-2907. doi: 10.1007/s00204-016-1925-2. Epub 2017 Jan 6.
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Innate immune system favors emergency monopoiesis at the expense of DC-differentiation to control systemic bacterial infection in micePasquevich KA, Bieber K, Gunter M, Grauer M, Potz O, Schleicher U, Biedermann T, Beer-Hammer S, Buhring HJ, Rammensee HG, Zender L, Autenrieth IB, Lengerke C, Autenrieth SEEur J Immunol. 2015 Oct;45(10):2821-33. doi: 10.1002/eji.201545530. Epub 2015 Jul 24.
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Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibitionBeck F, Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ, Mindukshev I, Potz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U, Zahedi RP, Sickmann ABlood. 2017 Jan 12;129(2):e1-e12. doi: 10.1182/blood-2016-05-714048. Epub 2016 Nov 9.
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Miniaturized Multiplexed Protein Binding AssaysTemplin MF, Poetz O, Schwenk JM, Stoll D, Joos TOW.-L. Xing and J. Cheng. Frontiers in Biochip Technology. Boston, MA: Springer US; 2006. 61-87.
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A Nexus Consisting of Beta-Catenin and Stat3 Attenuates BRAF Inhibitor Efficacy and Mediates Acquired Resistance to VemurafenibSinnberg T, Makino E, Krueger MA, Velic A, Macek B, Rothbauer U, Groll N, Potz O, Czemmel S, Niessner H, Meier F, Ikenberg K, Garbe C, Schittek BEBioMedicine. 2016 Jun;8:132-49. doi: 10.1016/j.ebiom.2016.04.037. Epub 2016 May 1.
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Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cellsKempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Gohring G, Drager G, Potz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt RNat Commun. 2016 Dec 9;7:13602. doi: 10.1038/ncomms13602.
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Coordinate regulation of Cyp2e1 by beta-catenin- and hepatocyte nuclear factor 1alpha-dependent signalingGroll N, Petrikat T, Vetter S, Colnot S, Weiss F, Poetz O, Joos TO, Rothbauer U, Schwarz M, Braeuning AToxicology. 2016 Mar 28;350-352:40-8. doi: 10.1016/j.tox.2016.05.004. Epub 2016 May 3.
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Evaluation of novel biomarkers of nephrotoxicity in Cynomolgus monkeys treated with gentamicinGautier JC, Zhou X, Yang Y, Gury T, Qu Z, Palazzi X, Leonard JF, Slaoui M, Veeranagouda Y, Guizon I, Boitier E, Filali-Ansary A, van den Berg BH, Poetz O, Joos T, Zhang T, Wang J, Detilleux P, Li BToxicol Appl Pharmacol. 2016 Jul 15;303:1-10. doi: 10.1016/j.taap.2016.04.012. Epub 2016 Apr 19.
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Inhibition of beta-catenin signaling by phenobarbital in hepatoma cells in vitroGroll N, Petrikat T, Vetter S, Wenz C, Dengjel J, Gretzmeier C, Weiss F, Poetz O, Joos TO, Schwarz M, Braeuning AToxicology. 2016 Aug 31;370:94-105. doi: 10.1016/j.tox.2016.09.018. Epub 2016 Sep 30.
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A bead-based western for high-throughput cellular signal transduction analysesTreindl F, Ruprecht B, Beiter Y, Schultz S, Dottinger A, Staebler A, Joos TO, Kling S, Poetz O, Fehm T, Neubauer H, Kuster B, Templin MFNat Commun. 2016 Sep 23;7:12852. doi: 10.1038/ncomms12852.
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Peptides in headlock - a novel high-affinity and versatile peptide-binding nanobody for proteomics and microscopyBraun MB, Traenkle B, Koch PA, Emele F, Weiss F, Poetz O, Stehle T, Rothbauer USci Rep. 2016 Jan 21;6:19211. doi: 10.1038/srep19211.
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Monitoring interactions and dynamics of endogenous beta-catenin with intracellular nanobodies in living cellsTraenkle B, Emele F, Anton R, Poetz O, Haeussler RS, Maier J, Kaiser PD, Scholz AM, Nueske S, Buchfellner A, Romer T, Rothbauer UMol Cell Proteomics. 2015 Mar;14(3):707-23. doi: 10.1074/mcp.M114.044016. Epub 2015 Jan 16.
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A Bead-Based Multiplex Sandwich Immunoassay to Assess the Abundance and Posttranslational Modification State of beta-CateninGroll N, Sommersdorf C, Joos TO, Poetz OMethods Mol Biol. 2015;1295:441-53. doi: 10.1007/978-1-4939-2550-6_31.
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Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometryWeiß F, Schnabel A, Planatscher H, van den Berg BHJ, Serschnitzki B, Nuessler AK, Thasler WE, Weiss TS, Reuss M, Stoll D, Templin MF, Joos TO, Marcus K, Poetz OSci Rep. 2015 Mar 4;5:8759. doi: 10.1038/srep08759.
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Towards multiplexed protein-protein interaction analysis using protein tag-specific nanobodiesGroll N, Emele F, Poetz O, Rothbauer UJ Proteomics. 2015 Sep 8;127(Pt B):289-99. doi: 10.1016/j.jprot.2015.04.017. Epub 2015 May 1.
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Bead-Based Peptide Arrays for Profiling the Specificity of Modification State-Specific AntibodiesFilomena A, Beiter Y, Templin MF, Joos TO, Schneiderhan-Marra N, Poetz OMethods Mol Biol. 2015;1348:251-65. doi: 10.1007/978-1-4939-2999-3_22.
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Identification of short terminal motifs enriched by antibodies using peptide mass fingerprintingPlanatscher H, Weiss F, Eisen D, Zell A, Joos T, Poetz OBioinformatics. 2014 May 1;30(9):1205-13. doi: 10.1093/bioinformatics/btu009. Epub 2014 Jan 9.
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Catch and measure-mass spectrometry-based immunoassays in biomarker researchWeiss F, van den Berg BH, Planatscher H, Pynn CJ, Joos TO, Poetz OBiochim Biophys Acta. 2014 May; 1844(5);927-932. doi: 10.1016/j.bbapap.2013.09.010.
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From spots to beads-PTM-peptide bead arrays for the characterization of anti-histone antibodiesHeubach Y, Planatscher H, Sommersdorf C, Maisch D, Maier J, Joos TO, Templin MF, Poetz OProteomics. 2013 Mar;13(6):1010-5. doi: 10.1002/pmic.201200383.
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Plasma levels of soluble glycoprotein VI (sGPVI) are associated with ischemic strokeWurster T, Poetz O, Stellos K, Kremmer E, Melms A, Schuster A, Nagel E, Joos T, Gawaz M, Bigalke BPlatelets. 2013;24(7):560-5. doi: 10.3109/09537104.2012.746455. Epub 2012 Dec 5.
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Concurrent epigenetic silencing of wnt/beta-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemiaMoskalev EA, Luckert K, Vorobjev IA, Mastitsky SE, Gladkikh AA, Stephan A, Schrenk M, Kaplanov KD, Kalashnikova OB, Poets O, Joos TO, Hoheisel JDBMC Cancer. 2012 Jun 6;12:213. doi: 10.1186/1471-2407-12-213.
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Combining ultracentrifugation and peptide termini group-specific immunoprecipitation for multiplex plasma protein analysisVolk S, Schreiber TD, Eisen D, Wiese C, Planatscher H, Pynn CJ, Stoll D, Templin MF, Joos TO, Poetz OMol Cell Proteomics. 2012 Jul;11(7):O111.015438. Epub 2012 Apr 23.
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A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteinsLuckert K, Gujral TS, Chan M, Sevecka M, Joos TO, Sorger PK, Macbeat G, Poetz OSci Signal. 2012 Jan 10;5(206):pl1. doi: 10.1126/scisignal.2002372.
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Conditional Disruption of Axin1 Leads to Development of Liver Tumors in MiceFeng GJ, Cotta W, Wei XQ, Poetz O, Evans R, Jarde T, Reed K, Meniel V, Williams GT, Clarke AR, Dale TCGastroenterologie. 2012;143:1650–1659. http://dx.doi.org/10.1053/j.gastro.2012.08.047
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Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptorsBauer M, Chicca A, Tamborrini M, Eisen D, Lerner R, Lutz B, Poetz O, Pluschke G, Gertsch JJ Biol Chem. 2012 Oct 26; 287(44): 36944–36967. doi: 10.1074/jbc.M112.382481
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Receptor tyrosine kinase inhibitor profiling using bead-based multiplex sandwich immunoassaysPoetz O, Schneiderhan-Marra N, Henzler T, Herget T, Joos TOMethods Mol Biol. 2012;795:191-202. doi: 10.1007/978-1-61779-337-0_13.
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A Miniaturized Ligand Binding Assay for EGFRSchwenk JM, Poetz O, Zeillinger R, Joos TInt J Proteomics. 2012; 2012: 247059. doi: 10.1155/2012/247059
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A generic operational strategy to qualify translational safety biomarkersMatheis K, Laurie D, Andriamandroso C, Arber N, Badimon L, Benain X, Bendjama K, Clavier I, Colman P, Firat H, Goepfert J, Hall S, Joos T, Kraus S, Kretschmer A, Merz M, Planatscher H, Schneiderhan-Marra NDrug Discov Today. 2011 July; 16(13-14): 600-608. DOI 10.1016/j.drudis.2011.04.011
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Snapshots of protein dynamics and posttranslational modifications in one experiment - [beta]-catenin and its functionsLuckert K, Goetschel F, Sorger PK, Hecht A, Joos TO, Poetz OMol Cell Proteomics. 2011 May;10(5):M110.007377. Epub 2011 Mar 4. doi: 10.1074/mcp.M110.007377
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Targeting peptide termini - a novel immunoaffinity approach to reduce complexity in mass spectrometric protein identificationHoeppe S, Schreiber TD, Planatscher H, Zell A, Templin MF, Stoll D, Joos TO, Poetz OMol Cell Proteomics. 2011 Feb;10(2):M110.002857. doi: 10.1074/mcp.M110.002857. Epub 2010 Oct 20.
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Optimal selection of epitopes for TXP-immunoaffinity mass spectrometryPlanatscher H, Supper J, Poetz O, Stoll D, Joos T, Templin MF, Zell AAlgorithms Mol Biol. 2010 Jun 25;5:28. doi: 10.1186/1748-7188-5-28
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Sequential multiplex analyte capturing for phosphor-protein profilingPoetz O, Henzler T, Hartmann M, Kazmaier C, Templin MF, Herget T, Joos TOMol Cell Proteomics. 2010 Nov; 9(11): 2474–2481. Published online 2010 Aug 3. doi: 10.1074/mcp.M110.002709
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Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS)Bigalke B, Stellos K, Weig HJ, Geisler T, Seizer P, Kremmer E, Potz O, Joos T, May AE, Lindemann S, Gawaz MBasic Res Cardiol. 2009 May;104(3):352-7. Epub 2009 Feb 3. doi: 10.1007/s00395-009-0779-7.
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Analysis of Non-canonical Fibroblast Growth Factor Receptor 1 (FGFR1) Interaction Reveals Regulatory and Activating Domains of NeurofascinKirschbaum K, Kriebel M, Kranz EU, Poetz O, Volkmer HJ Biol Chem. 2009 Oct 16;284(42):28533-42. doi: 10.1074/jbc.M109.004440. Epub 2009 Aug 7.
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Proteome wide screening using peptide affinity capturePoetz O, Hoeppe S, Templin MF, Stoll D, Joos TOProteomics. 2009 Mar;9(6):1518-23. doi: 10.1002/pmic.200800842.
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Influence of platelet count on the expression of platelet collagen receptor glycoprotein VI (GPVI) in patients with acute coronary syndromeBigalke B, Stellos K, Stakos D, Joos T, Potz O, Geisler T, Bischofs C, Kremmer E, Kramer BF, Seizer P, May AE, Lindemann S, Gawaz MThromb Haemost. 2009 May;101(5):911-5.
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A novel reverse transduction adenoviral array for the functional analysis of shRNA librariesOehmig A, Klotzbucher A, Thomas M, Weise F, Hagner U, Brundiers R, Waldherr D, Lingnau A, Knappik A, Kubbutat, MH, Joos TO, Volkmer HBMC Genomics. 2008 Sep 24;9:441. doi: 10.1186/1471-2164-9-441.
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Protein microarrays: catching the proteome.Poetz O, Schwenk JM, Kramer S, Stoll D, Templin MF, Joos TOMech Ageing Dev. 2005 Jan;126(1):161-70. DOI: 10.1016/j.mad.2004.09.030
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Protein microarrays for antibody profiling: Specificity and affinity determination on a chip.Poetz O, Ostendorp R, Brocks B, Schwenk JM, Stoll D, Joos TO, Templin MFProteomics. 2005 Jun;5(9):2402-11. DOI: 10.1002/pmic.200401299
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Protein microarrays: promising tools for proteomic researchTemplin MF, Stoll D, Schwenk JM, Pötz O, Kramer S, Joos TOProteomics. 2003 Nov;3(11):2155-66.