Dr. Oliver Pötz

Areas of activity

Biochemistry, development of mass spectrometry-based immunoassays, drug-drug interactions, molecular responses of cells and tissues to xenobiotics, validation of safety biomarkers.

Stages of career

2016 - present  Managing Director of SIGNATOPE GmbH.

2010 - 2016  Group leader protein analytics, NMI

2014 - present  Chair of the GBM Working Group Bioanalytics

Dr. Oliver Pötz


  • Characterization of hepatic zonation in mice by mass-spectrometric and antibody-based proteomics approaches
    Kling S, Lang B, Hammer HS, Naboulsi W, Sprenger H, Frenzel F, Pötz O, Schwarz M, Braeuning A, Templin MF
    Biol Chem. 2021 Oct 4. doi: 10.1515/hsz-2021-0314. Epub ahead of print. PMID: 34599868.
  • Tris(hydroxymethyl)aminomethane Compatibility with N-Hydroxysuccinimide Ester Chemistry: Biotinylation of Peptides and Proteins in TRIS Buffer
    Kratzer U, Sommersdorf C, Maier S, Wagner TR, Templin M, Joos TO, Rothbauer U, Zeck A, Poetz O
    Bioconjug Chem. 2021 Sep 15;32(9):1960-1965. doi: https://doi.org/10.1021/acs.bioconjchem.1c00283. Epub 2021 Aug 18. PMID: 34406760.
  • Application of Mass Spectrometry-Based Immunoassays for the Species- and Tissue-Specific Quantification of Banned Processed Animal Proteins in Feeds
    Steinhilber A, Schmidt F, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos T, Poetz O
    Analytical Chemistry. 2019 Feb 27. doi: 10.1021/acs.analchem.8b04652 Epub ahead of print
  • Species Differentiation and Quantification of Processed Animal Proteins and Blood Products in Fish Feed Using an 8-Plex Mass Spectrometry-Based Immunoassay
    Steinhilber AE, Schmidt FF, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos TO, Poetz O
    J Agric Food Chem. 2018 Oct 3;66(39):10327-10335. doi: 10.1021/acs.jafc.8b03934. Epub 2018 Sep 24.
  • Peptide-Based Sandwich Immunoassay for the Quantification of the Membrane Transporter Multidrug Resistance Protein
    Poetz O, Dieze T, Hammer H, Weiß F, Sommersdorf C, Templin MF, Esdar C, Zimmermann A, Stevanovic S, Bedke J, Stenzl A, Joos TO.
    Anal Chem. 2018 May 1;90(9):5788-5794. doi: 10.1021/acs.analchem.8b00152. Epub 2018 Apr 12.
  • Mass Spectrometry-Based Immunoassay for the Quantification of Banned Ruminant Processed Animal Proteins in Vegetal Feeds
    Steinhilber AE, Schmidt FF, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos T, Poetz O
    Anal Chem. 2018 Mar 20;90(6):4135-4143. doi: 10.1021/acs.analchem.8b00120. Epub 2018 Mar 7.
  • Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates
    Weiß F, Hammer HS, Klein K, Planatscher H, Zanger UM, Norén A, Wegler C, Artursson P, Joos TO, Poetz O
    Drug Metab Dispos. 2018 Apr;46(4):387-396. doi: 10.1124/dmd.117.078626. Epub 2018 Jan 17.
  • Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice
    Marx-Stoelting P, Ganzenberg K, Knebel C, Schmidt F, Rieke S, Hammer H, Schmidt F, Potz O, Schwarz M, Braeuning A
    Arch Toxicol. 2017 Aug;91(8):2895-2907. doi: 10.1007/s00204-016-1925-2. Epub 2017 Jan 6.
  • Innate immune system favors emergency monopoiesis at the expense of DC-differentiation to control systemic bacterial infection in mice
    Pasquevich KA, Bieber K, Gunter M, Grauer M, Potz O, Schleicher U, Biedermann T, Beer-Hammer S, Buhring HJ, Rammensee HG, Zender L, Autenrieth IB, Lengerke C, Autenrieth SE
    Eur J Immunol. 2015 Oct;45(10):2821-33. doi: 10.1002/eji.201545530. Epub 2015 Jul 24.
  • Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition
    Beck F, Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ, Mindukshev I, Potz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U, Zahedi RP, Sickmann A
    Blood. 2017 Jan 12;129(2):e1-e12. doi: 10.1182/blood-2016-05-714048. Epub 2016 Nov 9.
  • Miniaturized Multiplexed Protein Binding Assays
    Templin MF, Poetz O, Schwenk JM, Stoll D, Joos TO
    W.-L. Xing and J. Cheng. Frontiers in Biochip Technology. Boston, MA: Springer US; 2006. 61-87.
  • A Nexus Consisting of Beta-Catenin and Stat3 Attenuates BRAF Inhibitor Efficacy and Mediates Acquired Resistance to Vemurafenib
    Sinnberg T, Makino E, Krueger MA, Velic A, Macek B, Rothbauer U, Groll N, Potz O, Czemmel S, Niessner H, Meier F, Ikenberg K, Garbe C, Schittek B
    EBioMedicine. 2016 Jun;8:132-49. doi: 10.1016/j.ebiom.2016.04.037. Epub 2016 May 1.
  • Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
    Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Gohring G, Drager G, Potz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R
    Nat Commun. 2016 Dec 9;7:13602. doi: 10.1038/ncomms13602.
  • Coordinate regulation of Cyp2e1 by beta-catenin- and hepatocyte nuclear factor 1alpha-dependent signaling
    Groll N, Petrikat T, Vetter S, Colnot S, Weiss F, Poetz O, Joos TO, Rothbauer U, Schwarz M, Braeuning A
    Toxicology. 2016 Mar 28;350-352:40-8. doi: 10.1016/j.tox.2016.05.004. Epub 2016 May 3.
  • Evaluation of novel biomarkers of nephrotoxicity in Cynomolgus monkeys treated with gentamicin
    Gautier JC, Zhou X, Yang Y, Gury T, Qu Z, Palazzi X, Leonard JF, Slaoui M, Veeranagouda Y, Guizon I, Boitier E, Filali-Ansary A, van den Berg BH, Poetz O, Joos T, Zhang T, Wang J, Detilleux P, Li B
    Toxicol Appl Pharmacol. 2016 Jul 15;303:1-10. doi: 10.1016/j.taap.2016.04.012. Epub 2016 Apr 19.
  • Inhibition of beta-catenin signaling by phenobarbital in hepatoma cells in vitro
    Groll N, Petrikat T, Vetter S, Wenz C, Dengjel J, Gretzmeier C, Weiss F, Poetz O, Joos TO, Schwarz M, Braeuning A
    Toxicology. 2016 Aug 31;370:94-105. doi: 10.1016/j.tox.2016.09.018. Epub 2016 Sep 30.
  • A bead-based western for high-throughput cellular signal transduction analyses
    Treindl F, Ruprecht B, Beiter Y, Schultz S, Dottinger A, Staebler A, Joos TO, Kling S, Poetz O, Fehm T, Neubauer H, Kuster B, Templin MF
    Nat Commun. 2016 Sep 23;7:12852. doi: 10.1038/ncomms12852.
  • Peptides in headlock - a novel high-affinity and versatile peptide-binding nanobody for proteomics and microscopy
    Braun MB, Traenkle B, Koch PA, Emele F, Weiss F, Poetz O, Stehle T, Rothbauer U
    Sci Rep. 2016 Jan 21;6:19211. doi: 10.1038/srep19211.
  • Monitoring interactions and dynamics of endogenous beta-catenin with intracellular nanobodies in living cells
    Traenkle B, Emele F, Anton R, Poetz O, Haeussler RS, Maier J, Kaiser PD, Scholz AM, Nueske S, Buchfellner A, Romer T, Rothbauer U
    Mol Cell Proteomics. 2015 Mar;14(3):707-23. doi: 10.1074/mcp.M114.044016. Epub 2015 Jan 16.
  • A Bead-Based Multiplex Sandwich Immunoassay to Assess the Abundance and Posttranslational Modification State of beta-Catenin
    Groll N, Sommersdorf C, Joos TO, Poetz O
    Methods Mol Biol. 2015;1295:441-53. doi: 10.1007/978-1-4939-2550-6_31.
  • Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry
    Weiß F, Schnabel A, Planatscher H, van den Berg BHJ, Serschnitzki B, Nuessler AK, Thasler WE, Weiss TS, Reuss M, Stoll D, Templin MF, Joos TO, Marcus K, Poetz O
    Sci Rep. 2015 Mar 4;5:8759. doi: 10.1038/srep08759.
  • Towards multiplexed protein-protein interaction analysis using protein tag-specific nanobodies
    Groll N, Emele F, Poetz O, Rothbauer U
    J Proteomics. 2015 Sep 8;127(Pt B):289-99. doi: 10.1016/j.jprot.2015.04.017. Epub 2015 May 1.
  • Bead-Based Peptide Arrays for Profiling the Specificity of Modification State-Specific Antibodies
    Filomena A, Beiter Y, Templin MF, Joos TO, Schneiderhan-Marra N, Poetz O
    Methods Mol Biol. 2015;1348:251-65. doi: 10.1007/978-1-4939-2999-3_22.
  • Identification of short terminal motifs enriched by antibodies using peptide mass fingerprinting
    Planatscher H, Weiss F, Eisen D, Zell A, Joos T, Poetz O
    Bioinformatics. 2014 May 1;30(9):1205-13. doi: 10.1093/bioinformatics/btu009. Epub 2014 Jan 9.
  • Catch and measure-mass spectrometry-based immunoassays in biomarker research
    Weiss F, van den Berg BH, Planatscher H, Pynn CJ, Joos TO, Poetz O
    Biochim Biophys Acta. 2014 May; 1844(5);927-932. doi: 10.1016/j.bbapap.2013.09.010.
  • From spots to beads-PTM-peptide bead arrays for the characterization of anti-histone antibodies
    Heubach Y, Planatscher H, Sommersdorf C, Maisch D, Maier J, Joos TO, Templin MF, Poetz O
    Proteomics. 2013 Mar;13(6):1010-5. doi: 10.1002/pmic.201200383.
  • Plasma levels of soluble glycoprotein VI (sGPVI) are associated with ischemic stroke
    Wurster T, Poetz O, Stellos K, Kremmer E, Melms A, Schuster A, Nagel E, Joos T, Gawaz M, Bigalke B
    Platelets. 2013;24(7):560-5. doi: 10.3109/09537104.2012.746455. Epub 2012 Dec 5.
  • Concurrent epigenetic silencing of wnt/beta-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia
    Moskalev EA, Luckert K, Vorobjev IA, Mastitsky SE, Gladkikh AA, Stephan A, Schrenk M, Kaplanov KD, Kalashnikova OB, Poets O, Joos TO, Hoheisel JD
    BMC Cancer. 2012 Jun 6;12:213. doi: 10.1186/1471-2407-12-213.
  • Combining ultracentrifugation and peptide termini group-specific immunoprecipitation for multiplex plasma protein analysis
    Volk S, Schreiber TD, Eisen D, Wiese C, Planatscher H, Pynn CJ, Stoll D, Templin MF, Joos TO, Poetz O
    Mol Cell Proteomics. 2012 Jul;11(7):O111.015438. Epub 2012 Apr 23.
  • A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins
    Luckert K, Gujral TS, Chan M, Sevecka M, Joos TO, Sorger PK, Macbeat G, Poetz O
    Sci Signal. 2012 Jan 10;5(206):pl1. doi: 10.1126/scisignal.2002372.
  • Conditional Disruption of Axin1 Leads to Development of Liver Tumors in Mice
    Feng GJ, Cotta W, Wei XQ, Poetz O, Evans R, Jarde T, Reed K, Meniel V, Williams GT, Clarke AR, Dale TC
    Gastroenterologie. 2012;143:1650–1659. http://dx.doi.org/10.1053/j.gastro.2012.08.047
  • Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors
    Bauer M, Chicca A, Tamborrini M, Eisen D, Lerner R, Lutz B, Poetz O, Pluschke G, Gertsch J
    J Biol Chem. 2012 Oct 26; 287(44): 36944–36967. doi: 10.1074/jbc.M112.382481
  • Receptor tyrosine kinase inhibitor profiling using bead-based multiplex sandwich immunoassays
    Poetz O, Schneiderhan-Marra N, Henzler T, Herget T, Joos TO
    Methods Mol Biol. 2012;795:191-202. doi: 10.1007/978-1-61779-337-0_13.
  • A Miniaturized Ligand Binding Assay for EGFR
    Schwenk JM, Poetz O, Zeillinger R, Joos T
    Int J Proteomics. 2012; 2012: 247059. doi: 10.1155/2012/247059
  • A generic operational strategy to qualify translational safety biomarkers
    Matheis K, Laurie D, Andriamandroso C, Arber N, Badimon L, Benain X, Bendjama K, Clavier I, Colman P, Firat H, Goepfert J, Hall S, Joos T, Kraus S, Kretschmer A, Merz M, Planatscher H, Schneiderhan-Marra N
    Drug Discov Today. 2011 July; 16(13-14): 600-608. DOI 10.1016/j.drudis.2011.04.011
  • Snapshots of protein dynamics and posttranslational modifications in one experiment - [beta]-catenin and its functions
    Luckert K, Goetschel F, Sorger PK, Hecht A, Joos TO, Poetz O
    Mol Cell Proteomics. 2011 May;10(5):M110.007377. Epub 2011 Mar 4. doi: 10.1074/mcp.M110.007377
  • Targeting peptide termini - a novel immunoaffinity approach to reduce complexity in mass spectrometric protein identification
    Hoeppe S, Schreiber TD, Planatscher H, Zell A, Templin MF, Stoll D, Joos TO, Poetz O
    Mol Cell Proteomics. 2011 Feb;10(2):M110.002857. doi: 10.1074/mcp.M110.002857. Epub 2010 Oct 20.
  • Optimal selection of epitopes for TXP-immunoaffinity mass spectrometry
    Planatscher H, Supper J, Poetz O, Stoll D, Joos T, Templin MF, Zell A
    Algorithms Mol Biol. 2010 Jun 25;5:28. doi: 10.1186/1748-7188-5-28
  • Sequential multiplex analyte capturing for phosphor-protein profiling
    Poetz O, Henzler T, Hartmann M, Kazmaier C, Templin MF, Herget T, Joos TO
    Mol Cell Proteomics. 2010 Nov; 9(11): 2474–2481. Published online 2010 Aug 3. doi: 10.1074/mcp.M110.002709
  • Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS)
    Bigalke B, Stellos K, Weig HJ, Geisler T, Seizer P, Kremmer E, Potz O, Joos T, May AE, Lindemann S, Gawaz M
    Basic Res Cardiol. 2009 May;104(3):352-7. Epub 2009 Feb 3. doi: 10.1007/s00395-009-0779-7.
  • Analysis of Non-canonical Fibroblast Growth Factor Receptor 1 (FGFR1) Interaction Reveals Regulatory and Activating Domains of Neurofascin
    Kirschbaum K, Kriebel M, Kranz EU, Poetz O, Volkmer H
    J Biol Chem. 2009 Oct 16;284(42):28533-42. doi: 10.1074/jbc.M109.004440. Epub 2009 Aug 7.
  • Proteome wide screening using peptide affinity capture
    Poetz O, Hoeppe S, Templin MF, Stoll D, Joos TO
    Proteomics. 2009 Mar;9(6):1518-23. doi: 10.1002/pmic.200800842.
  • Influence of platelet count on the expression of platelet collagen receptor glycoprotein VI (GPVI) in patients with acute coronary syndrome
    Bigalke B, Stellos K, Stakos D, Joos T, Potz O, Geisler T, Bischofs C, Kremmer E, Kramer BF, Seizer P, May AE, Lindemann S, Gawaz M
    Thromb Haemost. 2009 May;101(5):911-5.
  • A novel reverse transduction adenoviral array for the functional analysis of shRNA libraries
    Oehmig A, Klotzbucher A, Thomas M, Weise F, Hagner U, Brundiers R, Waldherr D, Lingnau A, Knappik A, Kubbutat, MH, Joos TO, Volkmer H
    BMC Genomics. 2008 Sep 24;9:441. doi: 10.1186/1471-2164-9-441.
  • Protein microarrays: catching the proteome.
    Poetz O, Schwenk JM, Kramer S, Stoll D, Templin MF, Joos TO
    Mech Ageing Dev. 2005 Jan;126(1):161-70. DOI: 10.1016/j.mad.2004.09.030
  • Protein microarrays for antibody profiling: Specificity and affinity determination on a chip.
    Poetz O, Ostendorp R, Brocks B, Schwenk JM, Stoll D, Joos TO, Templin MF
    Proteomics. 2005 Jun;5(9):2402-11. DOI: 10.1002/pmic.200401299
  • Protein microarrays: promising tools for proteomic research
    Templin MF, Stoll D, Schwenk JM, Pötz O, Kramer S, Joos TO
    Proteomics. 2003 Nov;3(11):2155-66.