Research interests
- Development, validation and screening with antigen arrays and multiplex serological immunoassays for the detection of pathogen infection
- Development and application of miniaturized multiplexed immunoassays in proteome research for pharmaceutical and clinical applications
Curriculum vitae
since 11/2019 Deputy Head of Department Pharma and Biotech
since 01/2018 Head of Biochemistry
06/2007 – 12/2017 Deputy Head of Department Biochemistry
05/2005 Project manager and laboratory manager at the NMI Reutlingen
2003-2005 Scientific employee at the University of Ulm, University Women's Hospital, Endocrinological and Oncological Laboratory, working group Prof. Helmut Deißler
2002 External PhD thesis (Dr. rer. nat) at the University of Tübingen, supervised by Prof. Bernhard Brüne (Medical Clinic IV, Nephrological Research Laboratories, University of Erlangen) and Prof. Dieter Mecke (University of Tübingen), Title: Molecular Mechanism of Nitric Oxide Mediated Accumulation of Tumor Suppressor p53
2011 Internship at "MD Anderson" in the group of Assistant Professor Yanping Zhang, Houston, Texas, USA
1992 - 1998 Study of Biochemistry at the Eberhard-Karls-Universität Tübingen
Dr. Nicole Schneiderhan-Marra
Projects
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Predictive diagnostics of individual immune responses in different diseases
Publications
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The Impact of Biomaterial Cell Contact on the ImmunopeptidomeGhosh M, Hartmann H, Jakobi M, März L, Bichmann L, Freudenmann L K, Mühlenbruch L, Segan S, Rammensee H-G, Schneiderhan-Marra N, Shipp C, Stevanovic S, Joos T OFront. Bioeng. Biotechnol., 2020, Vol. 8 https://doi.org/10.3389/fbioe.2020.571294
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Systematic Investigation of Polyurethane Biomaterial Surface Roughness on Human Immune Responses in vitroSegan S, Jakobi M, Khokhani P, Klimosch S, Billing F, Schneider M, Martin D, Metzger U, Biesemeier A, Xiong X, Mukherjee A, Steuer H, Keller B-M, Joos T, Schmolz M, Rothbauer U, Hartmann H, Burkhardt C, Lorenz G ,Schneiderhan-Marra N, and Shipp CBioMed Research International, 2020, https://doi.org/10.1155/2020/3481549
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A mass spectrometry guided approach for the identification of novel vaccine candidates in gramnegative pathogensHornburg D, Kruse T, Anderl F, Daschkin C, Semper R P, Klar K, Guenther A, Mejías-Luque R, Schneiderhan-Marra N, Mann M, Meissner F & Gerhard MSci Rep 9, 17401 (2019) https://doi.org/10.1038/s41598-019-53493-8
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A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteerRammensee H-G, Wiesmüller K-H, Chandran P A, Zelab H, Rusch E, Gouttefangea C, Kowalewski D J, Di Marco M, Hean S P, Walz J S, Gloria Y C, Bödder J, Schertel J-M, Tunger A, Müller L, Kießler M, Wehner R, Schmitz M, Jakobi M, Schneiderhan-Marra N, Klein R, Laske K, Artzner K, Backert L, Schuster H, Schwenck J, Weber A N R, Pichler B J, Kneilling M, la Fougère C, Forchhammer S, Metzler G, Bauer J, Weide B, Schippert W, Stevanovic S u. Löffler M WJournal for ImmunoTherapy of Cancer (2019) 7:307 https://doi.org/10.1186/s40425-019-0796-5
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Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasisHerster F, Bittner Z, Archer N K, Dickhöfer S, Eisel D, Eigenbrod T, Knorpp T, Schneiderhan-Marra N, Löffler M W, Kalbacher H, Vierbuchen T, Heine H, Miller, L S, Hartl D, Freund L, Schäkel K, Heister M, Ghoreschi K, & Weber ANature communications, 11(1), 105. https://doi.org/10.1038/s41467-019-13756-4
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A mass spectrometry guided approach for the identification of novel vaccine candidates in gramnegative pathogensHornburg D, Kruse T, Anderl F, Daschkin C, Semper R. P., Klar K, Guenther A, Mejías-Luque R, Schneiderhan-Marra N, Mann M, Meissner F & Gerhard MSci Rep 9, 17401 (2019). https://doi.org/10.1038/s41598-019-53493-8
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Serum inflammatory profile for the discrimination of clinical subtypes in Parkinson’s diseaseYilmaz R, Strafella A, Bernard A, Schulte C, van den Huevel L, Schneiderhan-Marra N, Knorpp T, Joos T, Leypoldt F, Geritz J, Hansen C, Apel A, Gasser T, Lang A, Berg D, Maetzler W, Marras CFront Neurol., 2018 Dec 21 DOI:/10.3389/fneur.2018.01123
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Low-picomolar, label-free procalcitonin analytical detection with an electrolyte-gated organic field-effect transistor based electronic immunosensor. Biosens BioelectronSeshadri P, Manoli K, Schneiderhan-Marra N, Anthes U, Wierzchowiec P, Bonrad K, Di Franco C, Torsi L.Biosens Bioelectron. 2018 May 1;104:113-119. doi: 10.1016/j.bios.2017.12.041. Epub 2017 Dec 26.
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Validation of HAV biomarker 2A for differential diagnostic of hepatitis A infected and vaccinated individuals using multiplex serologyBohm K, Filomena A, Schneiderhan-Marra N, Krause G, Sievers CVaccine. 2017 Oct 13;35(43):5883-5889. doi: 10.1016/j.vaccine.2017.08.089. Epub 2017 Sep 14.
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Performance of a Multiplex Serological Helicobacter pylori Assay on a Novel Microfluidic Assay PlatformFilomena A, Guenther A, Planatscher H, Topin F, She J, Formichella L, Terradot L, Gerhard M, Joos TO, Meyer H, Schneiderhan-Marra NProteomes. 2017 Oct 3;5(4). pii: E24. doi: 10.3390/proteomes5040024.
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Study of the Humoral Immune Response towards HCV Genotype 4 Using a Bead-Based Multiplex Serological AssayFilomena A, Göpfert JC, Duffy D, Pol S, Abdel-Hamid M, Esmat G, Fontanet A, Albert M, Joos T, Schneiderhan-Marra NHigh-Throughput. 2017; 6(4): 15.
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Development of a Bead-Based Multiplex Assay for the Analysis of the Serological Response against the Six Pathogens HAV, HBV, HCV, CMV, T. gondii, and H. pyloriFilomena A, Pessler F, Akmatov M, Krause G, Duffy D, Gärtner B, Gerhard M, Albert M, Joos T, Schneiderhan-Marra N,High-Throughput. 2017; 6(4): 14.
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Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's diseaseBrockmann K, Schulte C, Schneiderhan-Marra N, Apel A, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Bernard A, Gasser T, Marras C, Schule B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Berg D, Maetzler WEur J Neurol. 2017 Feb;24(2):427-e6. doi: 10.1111/ene.13223.
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A standardized production pipeline for high profile targets from Mycobacterium tuberculosisMilewski MC, Broger T, Kirkpatrick J, Filomena A, Komadina D, Schneiderhan-Marra N, Wilmanns M, Parret AHProteomics Clin Appl. 2016 Oct;10(9-10):1049-1057. doi: 10.1002/prca.201600033. Epub 2016 Aug 3.
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Personalized peptide vaccine induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patientLoffler MW, Anoop Chandran P, Laske K, Schroeder C, Bonzheimm I, Walzer M, Hilke FJ, Trautwein N, Kowalewski DJ, Schuster H, Gunder M, Carcamo Yanez VA, Mohr C, Sturm M, Nguyen HP, Riess O, Bauer P, Nahnsen S, Nadalin S, Zieker D, Glatzle J, Thiel K, Schneiderhan-Marra N, Clasen S, Bosmuller H, Fend F, Kohlbacher O, Gouttefangeas C, Stevanovic S, Konigsrainer A, Rammensee HGJ Hepatol. 2016 Oct;65(4):849-855. doi: 10.1016/j.jhep.2016.06.027. Epub 2016 Jul 7.
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Inflammatory profile in LRRK2-associated prodromal and clinical PDBrockmann K, Apel A, Schulte C, Schneiderhan-Marra N, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Gasser T, Schule B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Marras C, Berg D, Maetzler WJ Neuroinflammation. 2016 May 24;13(1):122. doi: 10.1186/s12974-016-0588-5.
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Pre-Analytical Parameters Affecting Vascular Endothelial Growth Factor Measurement in Plasma: Identifying ConfoundersWalz JM, Boehringer D, Deissler HL, Faerber L, Goepfert JC, Heiduschka P, Kleeberger SM, Klettner A, Krohne TU, Schneiderhan-Marra N, Ziemssen F, Stahl APLoS One. 2016 Jan 5;11(1):e0145375. doi: 10.1371/journal.pone.0145375. eCollection 2016.
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Bead-Based Peptide Arrays for Profiling the Specificity of Modification State-Specific AntibodiesFilomena A, Beiter Y, Templin MF, Joos TO, Schneiderhan-Marra N, Poetz OMethods Mol Biol. 2015;1348:251-65. doi: 10.1007/978-1-4939-2999-3_22.
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Characterization of immunologically active drugs in a novel organotypic co-culture model of the human gut and whole bloodSchmohl M, Schneiderhan-Marra N, Baur N, Hefner K, Blum M, Stein GM, Joos TO, Schmolz MInt Immunopharmacol. 2012 Oct 24;14(4):722-728. doi: 10.1016/j.intimp.2012.10.010.
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Receptor tyrosine kinase inhibitor profiling using bead-based multiplex sandwich immunoassaysPoetz O, Schneiderhan-Marra N, Henzler T, Herget T, Joos TOMethods Mol Biol. 2012;795:191-202. doi: 10.1007/978-1-61779-337-0_13.
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A generic operational strategy to qualify translational safety biomarkersMatheis K, Laurie D, Andriamandroso C, Arber N, Badimon L, Benain X, Bendjama K, Clavier I, Colman P, Firat H, Goepfert J, Hall S, Joos T, Kraus S, Kretschmer A, Merz M, Planatscher H, Schneiderhan-Marra NDrug Discov Today. 2011 July; 16(13-14): 600-608. DOI 10.1016/j.drudis.2011.04.011
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Molecular indicators of non-sentinel node status in breast cancer determined in preoperative biopsies by multiplexed sandwich immunoassaysSauer G, Schneiderhan-Marra N, Muche R, Koretz K, Kazmaier C, Kreienberg R, Joos T, Deissler HJ Cancer Res Clin Oncol. 2011 Aug;137(8):1175-84. Epub 2011 Apr 24.
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Triple-negative breast cancer: present challenges and new perspectivesPodo F, Buydens LM, Degani H, Hilhorst R, Klipp E, Gribbestad IS, Van Huffel S, van Laarhoven HW, Luts J, Monleon D, Postma GJ, Schneiderhan-Marra N, Santoro F, Wouters H, Russnes HG, Sorlie T et al.Mol Oncol. 2010 Jun;4(3):209-29. Epub 2010 Apr 24. doi: 10.1016/j.molonc.2010.04.006
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Multiplexed immunoassays for the analysis of breast cancer biopsiesSchneiderhan-Marra N, Sauer G, Kazmaier C, Hsu HY, Koretz K, Deissler H, Joos TOAnal Bioanal Chem. 2010 Aug;397(8):3329-38. doi: 10.1007/s00216-010-3873-7. Epub 2010 Jul 18.
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Protein microarrays for personalized medicineYu X, Schneiderhan-Marra N, Joos TOClin Chem. 2010 Mar;56(3):376-87. Epub 2010 Jan 14. doi: 10.1373/clinchem.2009.137158
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Protein-protein-interactions in a multiplexed, miniaturized format a functional analysis of Rho GTPase activation and inhibitionSchmohl M, Rimmele S, Potz O, Kloog Y, Gierschik P, Joos TO, Schneiderhan-Marra NProteomics. 2010 Apr;10(8):1716-20. doi: 10.1002/pmic.200900597.
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Bead-based protein-protein interaction assays for the analysis of Rho GTPase signalingRimmele S, Gierschik P, Joos TO, Schneiderhan-Marra NJ Mol Recognit. 2010 Nov-Dec;23(6):543-50. doi: 10.1002/jmr.1051.
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Prediction of Nodal Involvement in Breast Cancer Based on Multiparametric Protein Analyses from Preoperative Core Needle Biopsies of the Primary Lesion.Sauer G, Schneiderhan-Marra N, Kazmaier C, Hutzel K, Koretz K, Muche R, Kreienberg R, Joos T, Deissler HClin Cancer Res. 2008 Jun 1;14(11):3345-3353. doi: 10.1158/1078-0432.CCR-07-4802.
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A Cryptic Vascular Endothelial Growth Factor T-Cell Epitope: Identification and Characterization by Mass Spectrometry and T-Cell AssaysWeinzierl AO, Maurer D, Altenberend F, Schneiderhan-Marra N, Klingel K, Schoor O, Wernet D, Joos T, Rammensee HG, Stevanovic S (2008)Cancer Res. 2008 Apr 1;68(7):2447-54. doi: 10.1158/0008-5472.CAN-07-2540
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Protein Microarrays - A Promising Tool for Cancer DiagnosisSchneiderhan-Marra N, Kirn A, Döttinger A, Templin M, Sauer G, Deissler H, Joos TOCancer Genomics & Proteomics. 2005 Jan; 2(1): 37-42.
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Retinoblastoma susceptibility gene product pRB activates hypoxia-inducible factor-1 (HIF-1)Budde A, Schneiderhan-Marra N, Petersen G, Brune BOncogene. 2005; 24(10): 1802-8. DOI: 10.1038/sj.onc.1208369