Dr. Nicole Schneiderhan-Marra

Research interests   

- Development, validation and screening with antigen arrays and multiplex serological immunoassays for the detection of pathogen infection

- Development and application of miniaturized multiplexed immunoassays in proteome research for pharmaceutical and clinical applications

 

Curriculum vitae

Since 2020 Head of Department Pharma and Biotech

11/2019 - 2020   Deputy Head of Department Pharma and Biotech

since 01/2018  Head of Biochemistry

06/2007 – 12/2017 Deputy Head of Department Biochemistry

05/2005 Project manager and laboratory manager at the NMI Reutlingen

2003-2005 Scientific employee at the University of Ulm, University Women's Hospital, Endocrinological and Oncological Laboratory, working group Prof. Helmut Deißler

2002 External PhD thesis (Dr. rer. nat) at the University of Tübingen, supervised by Prof. Bernhard Brüne (Medical Clinic IV, Nephrological Research Laboratories, University of Erlangen) and Prof. Dieter Mecke (University of Tübingen), Title: Molecular Mechanism of Nitric Oxide Mediated Accumulation of Tumor Suppressor p53

2011 Internship at "MD Anderson" in the group of Assistant Professor Yanping Zhang, Houston, Texas, USA

1992 - 1998 Study of Biochemistry at the Eberhard-Karls-Universität Tübingen

Dr. Nicole Schneiderhan-Marra
Head of Dept. Pharma and Biotech, Group Leader Multiplex Immunoassays
Biochemist

Publications

  • Reduced serum neutralization capacity against SARS-CoV-2 variants in a multiplex ACE2 RBD competition assay
    Junker D, Dulovic A, Becker M, Wagner T R, Kaiser P D, Traenkle B, Rothbauer U, Kienzle K, Bunk S, Strümper C, Häberle H, Schmauder K, Malek N, Althaus K, Koeppen M, Bitzer M, Göpel S, Schneiderhan-Marra N
    medRxiv, https://doi.org/10.1101/2021.08.20.21262328
  • Diminishing immune responses against variants of concern in dialysis patients four months after SARS-CoV-2 mRNA vaccination
    Dulovic A, Strengert M, Morillas Ramos G, Becker M, Griesbaum J, Junker D, Lürken K, Beigel A, Wrenger E, Lonnemann G, Cossmann A, Stankov M, Dopfer-Jablonka A, Kaiser P, Traenkle B, Rothbauer U, Krause G, Schneiderhan-Marra N, Behrens G M.N.
    medRxiv, https://doi.org/10.1101/2021.08.16.21262115
  • A broadly neutralizing biparatopic Nanobody protects mice from lethal challenge with SARS-CoV-2 variants of concern
    Wagner T, Schnepf D, Beer J, Klingel K, Ruetalo N, Kaiser P, Junker D, Sauter M, raenkle B, Frecot D, Becker M, Schneiderhan-Marra N, Ohnemus A, Schwemmle M, Schindler M, Rothbauer U
    bioRxiv, doi: https://doi.org/10.1101/2021.08.08.455562
  • Cellular and humoral immunogenicity of a SARS-CoV-2 mRNA vaccine in patients on haemodialysis
    Strengert M, Becker M, Morillas Ramos G, Dulovic A, Gruber J, Juengling J, Lürken K, Beigel A, Wrenger E, Lonnemann G, Cossmann A, Stankov M, Dopfer-Jablonka A, Kaiser P, Traenkle B, Rothbauer U, Krause G, Schneiderhan-Marra N, Behrens G M.N.
    Lancet EBioMedicine, Published: August 11, 2021DOI:https://doi.org/10.1016/j.ebiom.2021.103524
  • Typically asymptomatic but with robust antibody formation: Children’s unique humoral immune response to SARS-CoV-2.
    Renk H, Dulovic A, Becker M, Fabricius D, Zernickel M, Junker D, Seidel A, Groß R, Hilger A, Bode S, Fritsch L, Frieh P, Haddad A, Görne T, Remppis J, Ganzemueller T, Dietz A, Huzly D, Hengel H, Kaier K, Weber S, Jacobsen EM, Kaise P, Traenkle B, Rothbauer U, Stich M, Tönshoff B, Hoffmann H, Müller B, Ludwig C, Jahrsdörfer B, Schrezenmeier H, Peter A, Hörber S, Iftner T, Münch J, Stamminger T, Groß HJ, Wolkewitz M, Engel C, Rizzi M, Henneke P, Franz AR, Debatin KM, Schneiderhan-Marra N, Janda A, Elling R
    medRxiv, doi: https://doi.org/10.1101/2021.07.20.21260863
  • The immune response to the SLActive titanium dental implant surface in vitro is predominantly driven by innate immune cell
    Billing F, Jakobi M, Martin D, Gerlach K, Arefaine E, Weiss M, Schneiderhan-Marra N, Hartmann H, C
    Journal of Immunology and Regenerative Medicine Volume 13, August 2021, 100047; https://doi.org/10.1016/j.regen.2021.100047
  • Immune response to SARS-CoV-2 variants of concern in vaccinated individuals
    Becker M, Dulovic A, Junker D, Ruetalo N, PKaiser PD, Pinilla YT, Heinzel C, Haering J, Traenkle B, Wagner TR, Layer M, Mehrlaender M, Mirakaj V, Held J, Planatscher H, Schenke-Layland K, Krause G, Strengert M, Bakchoul T, Althaus K, Fendel R, Kreidenweiss A, Koeppen M, Rothbauer U, Schindler M & Schneiderhan-Marra N
    NATURE COMMUNICATIONS| (2021) 12:3109 | https://doi.org/10.1038/s41467-021-23473-6 | www.nature.com/naturecommunications11234567890():,;
  • HDX-MS for Epitope Characterization of a Therapeutic ANTIBODY Candidate on the Calcium-Binding Protein Annexin-A1
    Gramlich M, Hays HCW, Crichton S, Kaiser PD, Heine A, Schneiderhan-Marra N, Rothbauer U, Stoll D, Maier S, Zeck A
    Antibodies (Basel). 2021 Mar 19;10(1):11. doi: 10.3390/antib10010011. PMID: 33808657; PMCID: PMC8006148. Copy Downloa
  • Multiplexed Serum Antibody Screening Platform Using Virus Extracts from Endemic Coronaviridae and SARS-CoV-2
    Fink S., Ruoff F., Stahl A., Becker M., Kaiser P., Traenkle B., Junker D., Weise F., Ruetalo N., Hörber S., Peter A., Nelde A., Walz j., Krause G., Baillot A., Schenke-Layland K., Joos TO., Rothbauer U., Schneiderhan-Marra N., Schindler M., Templin MF
    ACS Infectious Diseases 2021; acsinfecdis.0c00725.
  • Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity
    Becker M, Strengert M, Junker D, Kaiser P, Kerrinnes T, Traenkle B, Dinter H, Häring J, Ghozzi S, Zeck A, Weise F, Peter A, Hörber S, Fink S, Ruoff F, Dulovic A, Bakchoul T, Baillot A, Lohse S, Cornberg M, Illig T, Gottlieb J, Smola S, Karch A, Berger K, Rammensee HG, Schenke-Layland K, Nelde A, Märklin M, Heitmann JS, Walz JS, Templin M, Joos TO, Rothbauer U, Krause K & Schneiderhan-Marra N
    NATURE COMMUNICATIONS | (2021) 12:1152 | https://doi.org/10.1038/s41467-021-20973-3 | www.nature.com/naturecommunications
  • Magnetic Bead-Based Immunoassay Allows Rapid, Inexpensive, and Quantitative Detection of Human SARS-CoV-2 Antibodies
    Huergo LF, Selim KA, Conzentino MS, Gerhardt ECM, Santos ARS, Wagner B, Alford JT, Deobald N, Pedrosa FO, de Souza EM, Nogueira MB, Raboni SM, Souto D, Rego FGM, Zanette DL, Aoki MN, Nardin JM, Fornazari B, Morales HMP, Borges VA, Nelde A, Walz JS, Becker M, Schneiderhan-Marra N, Rothbauer U, Reis RA, Forchhammer K
    ACS Sensors 2021, 6(3):703-708, DOI: 10.1021/acssensors.0c02544
  • The Impact of Biomaterial Cell Contact on the Immunopeptidome
    Ghosh M, Hartmann H, Jakobi M, März L, Bichmann L, Freudenmann L K, Mühlenbruch L, Segan S, Rammensee H-G, Schneiderhan-Marra N, Shipp C, Stevanovic S, Joos T O
    Front. Bioeng. Biotechnol., 2020, Vol. 8 https://doi.org/10.3389/fbioe.2020.571294
  • NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response
    Wagner T., Ostertag E., Kaiser P., Gramlich M., Ruetalo N., Junker D., Haering J., Traenkle B., Becker M., Dulovic A., Schweizer H., Nueske S., Scholz A., Zeck A., Schenke-Layland K., Nelde A., Strengert M., Walz J., Zocher G., Stehle T., Schindler M., Schneiderhan-Marra N., Rothbauer U
    In EMBO Reports 2021; 22(5):e52325. doi: 10.15252/embr.202052325
  • SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition
    Nelde A., Bilich T., Heitmann JS., Maringer Y., Salih HR., Roerden R., Luebke M., Bauer J., Rieth J., Wacker M., Peter A., Hörber S., Traenkle B., Kaiser PD., Rothbauer U., Becker M., Junker D., Krause G., Strengert M., Schneiderhan-Marra N., Joos TO., Kowalewski D.J., Stos-Zweifel V., Fehr M., Graf M., Gruber L., Rachfalski D., Preuß B., Hagelstein I., Märklin M., Bakchoul T., Gouttefangeas C., Kohlbacher O., Klein R., Stevanović S., Rammensee H.-G., Walz J.S.
    Nature Immunology 2021; 22:74–85, DOI: 10.1038/s41590-020-00808-x
  • Systematic Investigation of Polyurethane Biomaterial Surface Roughness on Human Immune Responses in vitro
    Segan S, Jakobi M, Khokhani P, Klimosch S, Billing F, Schneider M, Martin D, Metzger U, Biesemeier A, Xiong X, Mukherjee A, Steuer H, Keller B-M, Joos T, Schmolz M, Rothbauer U, Hartmann H, Burkhardt C, Lorenz G ,Schneiderhan-Marra N, and Shipp C
    BioMed Research International, 2020, https://doi.org/10.1155/2020/3481549
  • A mass spectrometry guided approach for the identification of novel vaccine candidates in gramnegative pathogens
    Hornburg D, Kruse T, Anderl F, Daschkin C, Semper R P, Klar K, Guenther A, Mejías-Luque R, Schneiderhan-Marra N, Mann M, Meissner F & Gerhard M
    Sci Rep 9, 17401 (2019) https://doi.org/10.1038/s41598-019-53493-8
  • A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer
    Rammensee H-G, Wiesmüller K-H, Chandran P A, Zelab H, Rusch E, Gouttefangea C, Kowalewski D J, Di Marco M, Hean S P, Walz J S, Gloria Y C, Bödder J, Schertel J-M, Tunger A, Müller L, Kießler M, Wehner R, Schmitz M, Jakobi M, Schneiderhan-Marra N, Klein R, Laske K, Artzner K, Backert L, Schuster H, Schwenck J, Weber A N R, Pichler B J, Kneilling M, la Fougère C, Forchhammer S, Metzler G, Bauer J, Weide B, Schippert W, Stevanovic S u. Löffler M W
    Journal for ImmunoTherapy of Cancer (2019) 7:307 https://doi.org/10.1186/s40425-019-0796-5
  • Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis
    Herster F, Bittner Z, Archer N K, Dickhöfer S, Eisel D, Eigenbrod T, Knorpp T, Schneiderhan-Marra N, Löffler M W, Kalbacher H, Vierbuchen T, Heine H, Miller, L S, Hartl D, Freund L, Schäkel K, Heister M, Ghoreschi K, & Weber A
    Nature communications, 11(1), 105. https://doi.org/10.1038/s41467-019-13756-4
  • A mass spectrometry guided approach for the identification of novel vaccine candidates in gramnegative pathogens
    Hornburg D, Kruse T, Anderl F, Daschkin C, Semper R. P., Klar K, Guenther A, Mejías-Luque R, Schneiderhan-Marra N, Mann M, Meissner F & Gerhard M
    Sci Rep 9, 17401 (2019). https://doi.org/10.1038/s41598-019-53493-8
  • Serum inflammatory profile for the discrimination of clinical subtypes in Parkinson’s disease
    Yilmaz R, Strafella A, Bernard A, Schulte C, van den Huevel L, Schneiderhan-Marra N, Knorpp T, Joos T, Leypoldt F, Geritz J, Hansen C, Apel A, Gasser T, Lang A, Berg D, Maetzler W, Marras C
    Front Neurol., 2018 Dec 21 DOI:/10.3389/fneur.2018.01123
  • Low-picomolar, label-free procalcitonin analytical detection with an electrolyte-gated organic field-effect transistor based electronic immunosensor. Biosens Bioelectron
    Seshadri P, Manoli K, Schneiderhan-Marra N, Anthes U, Wierzchowiec P, Bonrad K, Di Franco C, Torsi L.
    Biosens Bioelectron. 2018 May 1;104:113-119. doi: 10.1016/j.bios.2017.12.041. Epub 2017 Dec 26.
  • Validation of HAV biomarker 2A for differential diagnostic of hepatitis A infected and vaccinated individuals using multiplex serology
    Bohm K, Filomena A, Schneiderhan-Marra N, Krause G, Sievers C
    Vaccine. 2017 Oct 13;35(43):5883-5889. doi: 10.1016/j.vaccine.2017.08.089. Epub 2017 Sep 14.
  • Performance of a Multiplex Serological Helicobacter pylori Assay on a Novel Microfluidic Assay Platform
    Filomena A, Guenther A, Planatscher H, Topin F, She J, Formichella L, Terradot L, Gerhard M, Joos TO, Meyer H, Schneiderhan-Marra N
    Proteomes. 2017 Oct 3;5(4). pii: E24. doi: 10.3390/proteomes5040024.
  • Study of the Humoral Immune Response towards HCV Genotype 4 Using a Bead-Based Multiplex Serological Assay
    Filomena A, Göpfert JC, Duffy D, Pol S, Abdel-Hamid M, Esmat G, Fontanet A, Albert M, Joos T, Schneiderhan-Marra N
    High-Throughput. 2017; 6(4): 15.
  • Development of a Bead-Based Multiplex Assay for the Analysis of the Serological Response against the Six Pathogens HAV, HBV, HCV, CMV, T. gondii, and H. pylori
    Filomena A, Pessler F, Akmatov M, Krause G, Duffy D, Gärtner B, Gerhard M, Albert M, Joos T, Schneiderhan-Marra N,
    High-Throughput. 2017; 6(4): 14.
  • Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease
    Brockmann K, Schulte C, Schneiderhan-Marra N, Apel A, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Bernard A, Gasser T, Marras C, Schule B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Berg D, Maetzler W
    Eur J Neurol. 2017 Feb;24(2):427-e6. doi: 10.1111/ene.13223.
  • A standardized production pipeline for high profile targets from Mycobacterium tuberculosis
    Milewski MC, Broger T, Kirkpatrick J, Filomena A, Komadina D, Schneiderhan-Marra N, Wilmanns M, Parret AH
    Proteomics Clin Appl. 2016 Oct;10(9-10):1049-1057. doi: 10.1002/prca.201600033. Epub 2016 Aug 3.
  • Personalized peptide vaccine induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient
    Loffler MW, Anoop Chandran P, Laske K, Schroeder C, Bonzheimm I, Walzer M, Hilke FJ, Trautwein N, Kowalewski DJ, Schuster H, Gunder M, Carcamo Yanez VA, Mohr C, Sturm M, Nguyen HP, Riess O, Bauer P, Nahnsen S, Nadalin S, Zieker D, Glatzle J, Thiel K, Schneiderhan-Marra N, Clasen S, Bosmuller H, Fend F, Kohlbacher O, Gouttefangeas C, Stevanovic S, Konigsrainer A, Rammensee HG
    J Hepatol. 2016 Oct;65(4):849-855. doi: 10.1016/j.jhep.2016.06.027. Epub 2016 Jul 7.
  • Inflammatory profile in LRRK2-associated prodromal and clinical PD
    Brockmann K, Apel A, Schulte C, Schneiderhan-Marra N, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Gasser T, Schule B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Marras C, Berg D, Maetzler W
    J Neuroinflammation. 2016 May 24;13(1):122. doi: 10.1186/s12974-016-0588-5.
  • Pre-Analytical Parameters Affecting Vascular Endothelial Growth Factor Measurement in Plasma: Identifying Confounders
    Walz JM, Boehringer D, Deissler HL, Faerber L, Goepfert JC, Heiduschka P, Kleeberger SM, Klettner A, Krohne TU, Schneiderhan-Marra N, Ziemssen F, Stahl A
    PLoS One. 2016 Jan 5;11(1):e0145375. doi: 10.1371/journal.pone.0145375. eCollection 2016.
  • Bead-Based Peptide Arrays for Profiling the Specificity of Modification State-Specific Antibodies
    Filomena A, Beiter Y, Templin MF, Joos TO, Schneiderhan-Marra N, Poetz O
    Methods Mol Biol. 2015;1348:251-65. doi: 10.1007/978-1-4939-2999-3_22.
  • Characterization of immunologically active drugs in a novel organotypic co-culture model of the human gut and whole blood
    Schmohl M, Schneiderhan-Marra N, Baur N, Hefner K, Blum M, Stein GM, Joos TO, Schmolz M
    Int Immunopharmacol. 2012 Oct 24;14(4):722-728. doi: 10.1016/j.intimp.2012.10.010.
  • Receptor tyrosine kinase inhibitor profiling using bead-based multiplex sandwich immunoassays
    Poetz O, Schneiderhan-Marra N, Henzler T, Herget T, Joos TO
    Methods Mol Biol. 2012;795:191-202. doi: 10.1007/978-1-61779-337-0_13.
  • A generic operational strategy to qualify translational safety biomarkers
    Matheis K, Laurie D, Andriamandroso C, Arber N, Badimon L, Benain X, Bendjama K, Clavier I, Colman P, Firat H, Goepfert J, Hall S, Joos T, Kraus S, Kretschmer A, Merz M, Planatscher H, Schneiderhan-Marra N
    Drug Discov Today. 2011 July; 16(13-14): 600-608. DOI 10.1016/j.drudis.2011.04.011
  • Molecular indicators of non-sentinel node status in breast cancer determined in preoperative biopsies by multiplexed sandwich immunoassays
    Sauer G, Schneiderhan-Marra N, Muche R, Koretz K, Kazmaier C, Kreienberg R, Joos T, Deissler H
    J Cancer Res Clin Oncol. 2011 Aug;137(8):1175-84. Epub 2011 Apr 24.
  • Triple-negative breast cancer: present challenges and new perspectives
    Podo F, Buydens LM, Degani H, Hilhorst R, Klipp E, Gribbestad IS, Van Huffel S, van Laarhoven HW, Luts J, Monleon D, Postma GJ, Schneiderhan-Marra N, Santoro F, Wouters H, Russnes HG, Sorlie T et al.
    Mol Oncol. 2010 Jun;4(3):209-29. Epub 2010 Apr 24. doi: 10.1016/j.molonc.2010.04.006
  • Multiplexed immunoassays for the analysis of breast cancer biopsies
    Schneiderhan-Marra N, Sauer G, Kazmaier C, Hsu HY, Koretz K, Deissler H, Joos TO
    Anal Bioanal Chem. 2010 Aug;397(8):3329-38. doi: 10.1007/s00216-010-3873-7. Epub 2010 Jul 18.
  • Protein microarrays for personalized medicine
    Yu X, Schneiderhan-Marra N, Joos TO
    Clin Chem. 2010 Mar;56(3):376-87. Epub 2010 Jan 14. doi: 10.1373/clinchem.2009.137158
  • Protein-protein-interactions in a multiplexed, miniaturized format a functional analysis of Rho GTPase activation and inhibition
    Schmohl M, Rimmele S, Potz O, Kloog Y, Gierschik P, Joos TO, Schneiderhan-Marra N
    Proteomics. 2010 Apr;10(8):1716-20. doi: 10.1002/pmic.200900597.
  • Bead-based protein-protein interaction assays for the analysis of Rho GTPase signaling
    Rimmele S, Gierschik P, Joos TO, Schneiderhan-Marra N
    J Mol Recognit. 2010 Nov-Dec;23(6):543-50. doi: 10.1002/jmr.1051.
  • Prediction of Nodal Involvement in Breast Cancer Based on Multiparametric Protein Analyses from Preoperative Core Needle Biopsies of the Primary Lesion.
    Sauer G, Schneiderhan-Marra N, Kazmaier C, Hutzel K, Koretz K, Muche R, Kreienberg R, Joos T, Deissler H
    Clin Cancer Res. 2008 Jun 1;14(11):3345-3353. doi: 10.1158/1078-0432.CCR-07-4802.
  • A Cryptic Vascular Endothelial Growth Factor T-Cell Epitope: Identification and Characterization by Mass Spectrometry and T-Cell Assays
    Weinzierl AO, Maurer D, Altenberend F, Schneiderhan-Marra N, Klingel K, Schoor O, Wernet D, Joos T, Rammensee HG, Stevanovic S (2008)
    Cancer Res. 2008 Apr 1;68(7):2447-54. doi: 10.1158/0008-5472.CAN-07-2540
  • Protein Microarrays - A Promising Tool for Cancer Diagnosis
    Schneiderhan-Marra N, Kirn A, Döttinger A, Templin M, Sauer G, Deissler H, Joos TO
    Cancer Genomics & Proteomics. 2005 Jan; 2(1): 37-42.
  • Retinoblastoma susceptibility gene product pRB activates hypoxia-inducible factor-1 (HIF-1)
    Budde A, Schneiderhan-Marra N, Petersen G, Brune B
    Oncogene. 2005; 24(10): 1802-8. DOI: 10.1038/sj.onc.1208369
  • Immune response to SARS-CoV-2 variants of concern in vaccinated individuals
    Becker M, Dulovic A, Junker D, Ruetalo N, PKaiser PD, Pinilla YT, Heinzel C, Haering J, Traenkle B, Wagner TR, Layer M, Mehrlaender M, Mirakaj V, Held J, Planatscher H, Schenke-Layland K, Krause G, Strengert M, Bakchoul T, Althaus K, Fendel R, Kreidenweiss A, Koeppen M, Rothbauer U, Schindler M & Schneiderhan-Marra N
    NATURE COMMUNICATIONS| (2021) 12:3109 | https://doi.org/10.1038/s41467-021-23473-6 | www.nature.com/naturecommunications11234567890():,;
  • Antibody-mediated procoagulant platelets in SARS-CoV-2- vaccination associated immune thrombotic thrombocytopenia
    Althaus K, Möller P, Uzun G, Singh A, Beck A, Bettag M, Bösmüller H, Guthoff M, Dorn F, Petzold GC, Henkes H, Heyne N, Jumaa H, Kreiser K, Limpach C, Luz B, Maschke M, Müller JA, Münch J, Nagel S, Pötzsch B, Müller J, Schlegel C, Viardot A, Bäzner H, Wolf M, Pelzl L, Warm V, Willinek WA, Steiner J, Schneiderhan-Marra N, Vollherbst D, Sachs UJ, Fend F, Bakchoul T.
    Haematologica. 2021; doi: 10.3324/haematol.2021.279000.