Stages of career
since Jan 2000 Head of BioMEMS & Sensors group
1996 - 2000 Senior Scientist, NMI, Dept. Applied Physics
1995 - 1996 Postdoc, Max-Planck Institute for Colloid and Interface Sciences, Berlin
1992 - 1994 Postdoc, IBM Almaden Research Center, San Jose, USA,
Polymer Science & Technology Department
1992 Ph.D. thesis, Technical University of Munich, Biophysics Institute, Prof. E. Sackmann;
1982 - 1988 Physics study at the University of Erlangen and the Technical University of Munich
Dr. Martin Stelzle
Group Leader BioMEMS and sensors
Diplom-Physiker
T +49 (0)7121 51530-75
Projects
Publications
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Continous, non-invasive monitoring of oxygen consumption in a parallelized microfluidic in vitro system provides novel insight into the response to nutrients and drugs of primary human hepatocytesBusche N, Rabl D, Fischer J, Schmees C, Mayr T, Gebhardt R, Stelzle MDOI: https://doi.org/10.17179/excli2021-4351
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Parallelizable Microfluidic Platform to Model and Assess In Vitro Cellular Barriers: Technology and Application to Study the Interaction of 3D Tumor Spheroids with Cellular BarriersNair A L , Mesch L, Schulz I, Becker H , Raible J, Kiessling H, Werner S, Rothbauer U , Schmees C, Busche M, Trennheuser S, Fricker G and Stelzle MBiosensors 2021, 11, 314. https://doi.org/10.3390/bios11090314
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HepaChip-MP – a twenty-four chamber microplate for a continuously perfused liver coculture modelBusche M, Tomilova O, Schütte J, Werner S, Beer M, Groll N, Hagmeyer B, Pawlak M, Jones P D, Schmees C, Becker H, Schnabel J, Gall K, Hemmler R, Matz-Soja M, Damm G, Beuck S, Klaassen T, Moer J, Ullrich A, Runge D, Schenke-Layland K, Gebhardt R und Stelzle MLab on a Chip, DOI: 10.1039/d0lc00357c
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Multimodal Chemosensor-Based, Real-Time Biomaterial/Cell Interface MonitoringKubon M, Hartmann H, Moschallski M, Burkhardt C, Link G, Werner S, Stelzle MAdvanced Biosystems. 2018; 2(6):1700236.
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Measurement of temperature dependent heat flow rate from human limbs towards thermoelectric cooling deviceLink G, Stelzle MMed Devices Diagn Eng. 2017; 2(1): 72-74.
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A novel microfluidic 3D platform for culturing pancreatic ductal adenocarcinoma cells: comparison with in vitro cultures and in vivo xenograftsBeer M, Kuppalu N, Stefanini M, Becker H, Schulz I, Manoli S, Schuette J, Schmees C, Casazza A, Stelzle M, Arcangeli ASci Rep. 2017 Apr 25;7(1):1325. doi: 10.1038/s41598-017-01256-8.
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Auf Herz und Nieren prüfenHagmeyer B, Becker H, Werner S, Stelzle M (2016).Physik Journal. 2016; 10:31
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Introduction to polymer-based solid-contact ion-selective electrodes-basic concepts, practical considerations, and current research topicsBieg C, Fuchsberger K, Stelzle MAnal Bioanal Chem. 2017 Jan;409(1):45-61. doi: 10.1007/s00216-016-9945-6. Epub 2016 Oct 1.
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Expanding an efficient, electrically driven and CNT-tagged P450 system into the third dimension: a nanowired CNT containing and enzyme stabilising 3D sol-gel electrodeLlaudet E, Darimont D, Samba R, Matiychyn I, Stelzle M, Weissenborn MJ, Hauer B (2016).Chembiochem. 2016 Jul 15;17(14):1367-73. doi: 10.1002/cbic.201600173. Epub 2016 Jun 17.
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Can Nanofluidic Chemical Release Enable Fast, High Resolution Neurotransmitter-Based Neurostimulation?Jones PD, Stelzle MFront Neurosci. 2016 Mar 31;10:138. doi: 10.3389/fnins.2016.00138. eCollection 2016.
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Electrochemical etching of micro-pores in medical grade cobalt–chromium alloy as reservoirs for drug eluting stentsFuchsberger K, Binder K, Burkhardt C, Freudigmann Ch, Herrmann M, Stelzle MJ Mater Sci Mater Med. 2016 Mar;27(3):47. doi: 10.1007/s10856-015-5660-7. Epub 2016 Jan 12.
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Towards plug and play filling of microfluidic devices by utilizing networks of capillary stop valvesHagmeyer B, Zechnall F, Stelzle MBiomicrofluidics. 2014 Sep 19;8(5):056501. doi: 10.1063/1.4896063. eCollection 2014 Sep.
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Organ-Like Cell Cultures in Microfluidic SystemsLi D, Schütte J, Stelzle M2015 in: Li D. (eds) Encyclopedia of Microfluidics and Nanofluidics. Springer, New York, NY.
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Application of PEDOT-CNT Microelectrodes for Neurotransmitter SensingSamba R, Fuchsberger K, Matiychyn I, Epple S, Kiesel L, Stett A, Schuhmann W, Stelzle MElectroanalysis. 2014 March; 26(3): 548-555. https://doi.org/10.1002/elan.201300547
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Chemische und physikalische Analyse eines ionenleitfähigen Terpolymers für die elektrochemische SensorikBieg, CMaster-Thesis. Fakultät Angewandte Chemie, Hochschule Reutlingen. 2013. 53 Seiten.
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Impedanzsensorik in mikrofluidischen ZellkultursystemenSpoo MBachelor-Thesis. Fakultät Mechatronik/Elektrotechnik, Hochschule Esslingen. 2013. 94 Seiten.
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Rastmechanik zur Aufnahme und Fixierung von MikrofluidiksystemenLi ABachelor-Thesis. Studiengang Medizintechnik, Jade Hochschule, Wilhelmshaven. 2013. 81 Seiten.
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Is the Enhanced Adhesion of PEDOT Thin Films on Electrodes Due to Sulfur - Gold Interaction? - An XPS StudySamba R, Chassé T, Stelzle MThe Open Surface Science Journal. 2013; 5: 17-20.
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PEDOT–CNT composite microelectrodes for recording and electrostimulation applications: fabrication, morphology, and electrical propertiesGerwig R, Fuchsberger K, Schroeppel B, Link GS, Heusel G, Kraushaar U, Schuhmann W, Stett A, Stelzle MFront Neuroeng. 2012; 5: 8. Published online 2012 May 4. doi: 10.3389/fneng.2012.00008
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Towards quantification of biocompatibility: Monitoring ingrowth behavior of biomaterials in tissue with a microsensor implantKubon M, Moschallski M, Ensslen T, Link G, Werner S, Burkhardt C, Hartmann H, Schlosshauer B, Urban G, Stelzle MIEEE Conference Paper, 2011, doi: 10.1109/TRANSDUCERS.2011.5969289
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Numerical modelling and measurement of cell trajectories in 3-D under the influence of dielectrophoretic and hydrodynamic forcesHolzner F, Hagmeyer B, Schütte J, Kubon M, Angres B, Stelzle MElectrophoresis. 2011 August; 32(17): 2366-2376. DOI 10.1002/elps.201100026
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A microsensor system to probe physiological environments and tissue responseKubon M, Moschallski M, Link G, Ensslen T, Werner S, Burkhardt C, Nisch W, Scholz B, Schlosshauer B, Urban G, Stelzle MIEEE Conference Paper, 2010, doi: 10.1109/TRANSDUCERS.2011.5969289
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Artificial microorgans: a microfluidic tool for in vitro assessment of toxicitySchütte J, Stelzle MBioanalysis. 2011; 3(21): 2373-2375. DOI 10.4155/bio.11.230
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"Artificial micro organs"-a microfluidic device for dielectrophoretic assembly of liver sinusoidsSchutte J, Hagmeyer B, Holzner F, Kubon M, Werner S, Freudigmann C, Benz K, Bottger J, Gebhardt R, Becker H, Stelzle MBiomed Microdevices. 2011 Jun;13(3):493-501. doi: 10.1007/s10544-011-9517-7.
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Towards implantable sensors and actuators (Part 1): A microsensor device to probe biological and physiological environmentsKubon M, Moschallski M, Werner S, Link G, Burkhardt C, Nisch W, Urban G & Stelzle MBiomedizinische Technik / Biomedical Engineering (2010), 10.1515/bmt.2010.711
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Towards implantable sensors and actuators (Part 2): Avian ex ovo culture as quasi-in vivo environmentKubon M, Moschallski M, Link G, Werner S, Burkhardt C, Nisch W, Scholz B, Schlosshauer B, Urban G & Stelzle MBiomedizinische Technik / Biomedical Engineering (2010), 10.1515/bmt.2010.520
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Ex ovo culture: An in vivo model for microsensorarray implantsKubon M, Moschallski M, Link GS, Werner S, Burkhardt C, Nisch W, Scholz B, Schlosshauer B, Urban G, Stelzle M7th International Meeting on Substrate-Integrated Microelectrode Arrays Reutlingen, 2010, NMI, BioPro.
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MicroPrep: chip-based dielectrophoretic purification of mitochondriaMoschallski M, Hausmann M, Posch A, Paulus A, Kunz N, Duong TT, Angres B, Fuchsberger K, Steuer H, Stoll D, Werner S, Hagmeyer B, Stelzle MElectrophoresis. 2010 Aug;31(15):2655-63. doi: 10.1002/elps.201000097.
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From Bioseparation to "Artificial Micro Organs" - microfluidic chip based particle manipulation techniquesStelzle M (2010)Microfluidics, BioMEMS, and Medical Microsystems VIII. 2010 Feb; 7593: 75930G.
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Chemical stimulation of adherent cells by localized application of acetylcholine from a microfluidic systemZibek S, Hagmeyer B, Stett A, Stelzle MFront Neuroeng. 2010 Nov 26;3:113. doi: 10.3389/fneng.2010.00113. eCollection 2010.
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A method for patterned in situ biofunctionalization in injection-molded microfluidic devicesSchuette J, Freudigmann C, Benz K, Bottger J, Gebhardt R, Stelzle MLab Chip. 2010 Oct 7;10(19):2551-8. doi: 10.1039/c005307d. Epub 2010 Jul 30.
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Micro- and Nanopatterning of Surfaces Employing Self Assembly of Nanoparticles and Its Application in Biotechnology and Biomedical EngineeringBurkhardt C, Fuchsberger K, Nisch W, Stelzle MLithography. M. Wang. 2010. Wien, IN-TECH: 629-644.
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Chemical stimulation of cells – microsystem, experiment & modellingZibek S, Hagmeyer B, Stett A, Stelzle MProceedings MEA Meeting 2008, Reutlingen, BioPro edition, Vol.5, p.266-269, ISBN 3-938345-05-5
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Localized functional chemical stimulation of TE 671 cells cultured on nanoporous membrane by calcein and acetylcholine.Zibek S, Stett A, Koltay P, Hu M, Zengerle R, Nisch W, Stelzle MBiophys J. 2007 Jan 1;92(1):L04-6. Epub 2006 Nov 3. DOI: 10.1529/biophysj.106.096743
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Low temperature adhesion bonding for BioMEMSKentsch J, Breisch S, Stelzle MJournal of Micromechanics and Microengineering. 2006 March; 16 (4): 802-807.
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Accumulation and trapping of hepatitis A virus particles by electrohydrodynamic flow and dielectrophoresisGrom F, Kentsch J, Muller T, Schnelle T, Stelzle MElectrophoresis. 2006 Apr;27(7):1386-93. DOI: 10.1002/elps.200500416
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Measuring single-bond rupture forces using high electric fields in microfluidic channels and DNA oligomers as force tags.Breisch S, Gonska J, Deissler H, Stelzle MBiophys J. 2005 Sep;89(3):L19-21. Epub 2005 Jul 22. DOI: 10.1529/biophysj.105.066795
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Selective chemical surface modification of fluidic microsystems and characterization studiesBreisch S, de Heij B, Löhr M, Stelzle MJ. Micromechanics and Microengineering. 2004 Jan; 14(4): 497-505.
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Microdevices for manipulation and accumulation of micro- and nanoparticles by dielectrophoresis.Dürr M, Kentsch J, Muller T, Schnelle T, Stelzle MElectrophoresis. 2003 Feb;24(4):722-31. DOI: 10.1002/elps.200390087