Dr. Martin Stelzle

Stages of career

since Jan 2000   Head of BioMEMS & Sensors group

1996 - 2000  Senior Scientist, NMI, Dept. Applied Physics

1995 - 1996   Postdoc, Max-Planck Institute for Colloid and Interface Sciences, Berlin

1992 - 1994   Postdoc, IBM Almaden Research Center, San Jose, USA,
Polymer Science & Technology Department

1992   Ph.D. thesis, Technical University of Munich, Biophysics Institute, Prof. E. Sackmann;

1982 - 1988   Physics study at the University of Erlangen and the Technical University of Munich
Dr. Martin Stelzle
Group Leader BioMEMS and sensors
Diplom-Physiker
T +49 (0)7121 51530-75

Projects

Publications

  • Continous, non-invasive monitoring of oxygen consumption in a parallelized microfluidic in vitro system provides novel insight into the response to nutrients and drugs of primary human hepatocytes
    Busche N, Rabl D, Fischer J, Schmees C, Mayr T, Gebhardt R, Stelzle M
    DOI: https://doi.org/10.17179/excli2021-4351
  • Parallelizable Microfluidic Platform to Model and Assess In Vitro Cellular Barriers: Technology and Application to Study the Interaction of 3D Tumor Spheroids with Cellular Barriers
    Nair A L , Mesch L, Schulz I, Becker H , Raible J, Kiessling H, Werner S, Rothbauer U , Schmees C, Busche M, Trennheuser S, Fricker G and Stelzle M
    Biosensors 2021, 11, 314. https://doi.org/10.3390/bios11090314
  • HepaChip-MP – a twenty-four chamber microplate for a continuously perfused liver coculture model
    Busche M, Tomilova O, Schütte J, Werner S, Beer M, Groll N, Hagmeyer B, Pawlak M, Jones P D, Schmees C, Becker H, Schnabel J, Gall K, Hemmler R, Matz-Soja M, Damm G, Beuck S, Klaassen T, Moer J, Ullrich A, Runge D, Schenke-Layland K, Gebhardt R und Stelzle M
    Lab on a Chip, DOI: 10.1039/d0lc00357c
  • Multimodal Chemosensor-Based, Real-Time Biomaterial/Cell Interface Monitoring
    Kubon M, Hartmann H, Moschallski M, Burkhardt C, Link G, Werner S, Stelzle M
    Advanced Biosystems. 2018; 2(6):1700236.
  • Measurement of temperature dependent heat flow rate from human limbs towards thermoelectric cooling device
    Link G, Stelzle M
    Med Devices Diagn Eng. 2017; 2(1): 72-74.
  • A novel microfluidic 3D platform for culturing pancreatic ductal adenocarcinoma cells: comparison with in vitro cultures and in vivo xenografts
    Beer M, Kuppalu N, Stefanini M, Becker H, Schulz I, Manoli S, Schuette J, Schmees C, Casazza A, Stelzle M, Arcangeli A
    Sci Rep. 2017 Apr 25;7(1):1325. doi: 10.1038/s41598-017-01256-8.
  • Auf Herz und Nieren prüfen
    Hagmeyer B, Becker H, Werner S, Stelzle M (2016).
    Physik Journal. 2016; 10:31
  • Introduction to polymer-based solid-contact ion-selective electrodes-basic concepts, practical considerations, and current research topics
    Bieg C, Fuchsberger K, Stelzle M
    Anal Bioanal Chem. 2017 Jan;409(1):45-61. doi: 10.1007/s00216-016-9945-6. Epub 2016 Oct 1.
  • Expanding an efficient, electrically driven and CNT-tagged P450 system into the third dimension: a nanowired CNT containing and enzyme stabilising 3D sol-gel electrode
    Llaudet E, Darimont D, Samba R, Matiychyn I, Stelzle M, Weissenborn MJ, Hauer B (2016).
    Chembiochem. 2016 Jul 15;17(14):1367-73. doi: 10.1002/cbic.201600173. Epub 2016 Jun 17.
  • Can Nanofluidic Chemical Release Enable Fast, High Resolution Neurotransmitter-Based Neurostimulation?
    Jones PD, Stelzle M
    Front Neurosci. 2016 Mar 31;10:138. doi: 10.3389/fnins.2016.00138. eCollection 2016.
  • Electrochemical etching of micro-pores in medical grade cobalt–chromium alloy as reservoirs for drug eluting stents
    Fuchsberger K, Binder K, Burkhardt C, Freudigmann Ch, Herrmann M, Stelzle M
    J Mater Sci Mater Med. 2016 Mar;27(3):47. doi: 10.1007/s10856-015-5660-7. Epub 2016 Jan 12.
  • Towards plug and play filling of microfluidic devices by utilizing networks of capillary stop valves
    Hagmeyer B, Zechnall F, Stelzle M
    Biomicrofluidics. 2014 Sep 19;8(5):056501. doi: 10.1063/1.4896063. eCollection 2014 Sep.
  • Organ-Like Cell Cultures in Microfluidic Systems
    Li D, Schütte J, Stelzle M
    2015 in: Li D. (eds) Encyclopedia of Microfluidics and Nanofluidics. Springer, New York, NY.
  • Application of PEDOT-CNT Microelectrodes for Neurotransmitter Sensing
    Samba R, Fuchsberger K, Matiychyn I, Epple S, Kiesel L, Stett A, Schuhmann W, Stelzle M
    Electroanalysis. 2014 March; 26(3): 548-555. https://doi.org/10.1002/elan.201300547
  • Chemische und physikalische Analyse eines ionenleitfähigen Terpolymers für die elektrochemische Sensorik
    Bieg, C
    Master-Thesis. Fakultät Angewandte Chemie, Hochschule Reutlingen. 2013. 53 Seiten.
  • Impedanzsensorik in mikrofluidischen Zellkultursystemen
    Spoo M
    Bachelor-Thesis. Fakultät Mechatronik/Elektrotechnik, Hochschule Esslingen. 2013. 94 Seiten.
  • Rastmechanik zur Aufnahme und Fixierung von Mikrofluidiksystemen
    Li A
    Bachelor-Thesis. Studiengang Medizintechnik, Jade Hochschule, Wilhelmshaven. 2013. 81 Seiten.
  • Is the Enhanced Adhesion of PEDOT Thin Films on Electrodes Due to Sulfur - Gold Interaction? - An XPS Study
    Samba R, Chassé T, Stelzle M
    The Open Surface Science Journal. 2013; 5: 17-20.
  • PEDOT–CNT composite microelectrodes for recording and electrostimulation applications: fabrication, morphology, and electrical properties
    Gerwig R, Fuchsberger K, Schroeppel B, Link GS, Heusel G, Kraushaar U, Schuhmann W, Stett A, Stelzle M
    Front Neuroeng. 2012; 5: 8. Published online 2012 May 4. doi: 10.3389/fneng.2012.00008
  • Towards quantification of biocompatibility: Monitoring ingrowth behavior of biomaterials in tissue with a microsensor implant
    Kubon M, Moschallski M, Ensslen T, Link G, Werner S, Burkhardt C, Hartmann H, Schlosshauer B, Urban G, Stelzle M
    IEEE Conference Paper, 2011, doi: 10.1109/TRANSDUCERS.2011.5969289
  • Numerical modelling and measurement of cell trajectories in 3-D under the influence of dielectrophoretic and hydrodynamic forces
    Holzner F, Hagmeyer B, Schütte J, Kubon M, Angres B, Stelzle M
    Electrophoresis. 2011 August; 32(17): 2366-2376. DOI 10.1002/elps.201100026
  • A microsensor system to probe physiological environments and tissue response
    Kubon M, Moschallski M, Link G, Ensslen T, Werner S, Burkhardt C, Nisch W, Scholz B, Schlosshauer B, Urban G, Stelzle M
    IEEE Conference Paper, 2010, doi: 10.1109/TRANSDUCERS.2011.5969289
  • Artificial microorgans: a microfluidic tool for in vitro assessment of toxicity
    Schütte J, Stelzle M
    Bioanalysis. 2011; 3(21): 2373-2375. DOI 10.4155/bio.11.230
  • "Artificial micro organs"-a microfluidic device for dielectrophoretic assembly of liver sinusoids
    Schutte J, Hagmeyer B, Holzner F, Kubon M, Werner S, Freudigmann C, Benz K, Bottger J, Gebhardt R, Becker H, Stelzle M
    Biomed Microdevices. 2011 Jun;13(3):493-501. doi: 10.1007/s10544-011-9517-7.
  • Towards implantable sensors and actuators (Part 1): A microsensor device to probe biological and physiological environments
    Kubon M, Moschallski M, Werner S, Link G, Burkhardt C, Nisch W, Urban G & Stelzle M
    Biomedizinische Technik / Biomedical Engineering (2010), 10.1515/bmt.2010.711
  • Towards implantable sensors and actuators (Part 2): Avian ex ovo culture as quasi-in vivo environment
    Kubon M, Moschallski M, Link G, Werner S, Burkhardt C, Nisch W, Scholz B, Schlosshauer B, Urban G & Stelzle M
    Biomedizinische Technik / Biomedical Engineering (2010), 10.1515/bmt.2010.520
  • Ex ovo culture: An in vivo model for microsensorarray implants
    Kubon M, Moschallski M, Link GS, Werner S, Burkhardt C, Nisch W, Scholz B, Schlosshauer B, Urban G, Stelzle M
    7th International Meeting on Substrate-Integrated Microelectrode Arrays Reutlingen, 2010, NMI, BioPro.
  • MicroPrep: chip-based dielectrophoretic purification of mitochondria
    Moschallski M, Hausmann M, Posch A, Paulus A, Kunz N, Duong TT, Angres B, Fuchsberger K, Steuer H, Stoll D, Werner S, Hagmeyer B, Stelzle M
    Electrophoresis. 2010 Aug;31(15):2655-63. doi: 10.1002/elps.201000097.
  • From Bioseparation to "Artificial Micro Organs" - microfluidic chip based particle manipulation techniques
    Stelzle M (2010)
    Microfluidics, BioMEMS, and Medical Microsystems VIII. 2010 Feb; 7593: 75930G.
  • Chemical stimulation of adherent cells by localized application of acetylcholine from a microfluidic system
    Zibek S, Hagmeyer B, Stett A, Stelzle M
    Front Neuroeng. 2010 Nov 26;3:113. doi: 10.3389/fneng.2010.00113. eCollection 2010.
  • A method for patterned in situ biofunctionalization in injection-molded microfluidic devices
    Schuette J, Freudigmann C, Benz K, Bottger J, Gebhardt R, Stelzle M
    Lab Chip. 2010 Oct 7;10(19):2551-8. doi: 10.1039/c005307d. Epub 2010 Jul 30.
  • Micro- and Nanopatterning of Surfaces Employing Self Assembly of Nanoparticles and Its Application in Biotechnology and Biomedical Engineering
    Burkhardt C, Fuchsberger K, Nisch W, Stelzle M
    Lithography. M. Wang. 2010. Wien, IN-TECH: 629-644.
  • Chemical stimulation of cells – microsystem, experiment & modelling
    Zibek S, Hagmeyer B, Stett A, Stelzle M
    Proceedings MEA Meeting 2008, Reutlingen, BioPro edition, Vol.5, p.266-269, ISBN 3-938345-05-5
  • Localized functional chemical stimulation of TE 671 cells cultured on nanoporous membrane by calcein and acetylcholine.
    Zibek S, Stett A, Koltay P, Hu M, Zengerle R, Nisch W, Stelzle M
    Biophys J. 2007 Jan 1;92(1):L04-6. Epub 2006 Nov 3. DOI: 10.1529/biophysj.106.096743
  • Low temperature adhesion bonding for BioMEMS
    Kentsch J, Breisch S, Stelzle M
    Journal of Micromechanics and Microengineering. 2006 March; 16 (4): 802-807.
  • Accumulation and trapping of hepatitis A virus particles by electrohydrodynamic flow and dielectrophoresis
    Grom F, Kentsch J, Muller T, Schnelle T, Stelzle M
    Electrophoresis. 2006 Apr;27(7):1386-93. DOI: 10.1002/elps.200500416
  • Measuring single-bond rupture forces using high electric fields in microfluidic channels and DNA oligomers as force tags.
    Breisch S, Gonska J, Deissler H, Stelzle M
    Biophys J. 2005 Sep;89(3):L19-21. Epub 2005 Jul 22. DOI: 10.1529/biophysj.105.066795
  • Selective chemical surface modification of fluidic microsystems and characterization studies
    Breisch S, de Heij B, Löhr M, Stelzle M
    J. Micromechanics and Microengineering. 2004 Jan; 14(4): 497-505.
  • Microdevices for manipulation and accumulation of micro- and nanoparticles by dielectrophoresis.
    Dürr M, Kentsch J, Muller T, Schnelle T, Stelzle M
    Electrophoresis. 2003 Feb;24(4):722-31. DOI: 10.1002/elps.200390087
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