Research focus
- Characterization of surface properties (physicochemical, biological)
- Coating / modification of surfaces: Regulation of the adhesion of proteins, bacteria, cells
- Analysis and functionalization of biodegradable materials
- Immobilization and controlled release of active substances
- Biomaterial processing: bioprinting, electrospinning
- Services and R&D for Medical device companies
Curriculum vitae
since 2017 Head of Department Biomedicine and Materials Sciences, NMI, Reutlingen
since 2016 Group leader Regenerative Biomaterials, NMI, Reutlingen
2015-2016 Deputy Group Leader Biomaterials, NMI, Reutlingen
2013-2015 Project leader, Group Biomaterials NMI, Reutlingen
2008-2013 Scientist, Group Regenerative Medicine I, NMI, Reutlingen
2007-2008 Post-Doc, Institute for Medical Microbiology and Hygiene, University of Tübingen,
2003-2006 PhD, Institute for Medical Microbiology and Hygiene, University of Tübingen, on host cell response after bacterial infection: apoptosis inhibition, HIF-1 activation
2002-2003 Diploma thesis, Chair of Biotechnology, University of Würzburg, on biocompatibility and functionality of biomaterials for immunoisolated transplantation of mammalian cells
1998-2002 Biology studies, University of Würzburg, Germany
Dr. Hanna Hartmann
Publications
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The Impact of Biomaterial Cell Contact on the ImmunopeptidomeGhosh M, Hartmann H, Jakobi M, März L, Bichmann L, Freudenmann L K, Mühlenbruch L, Segan S, Rammensee H-G, Schneiderhan-Marra N, Shipp C, Stevanovic S, Joos T OFront. Bioeng. Biotechnol., 2020, Vol. 8 https://doi.org/10.3389/fbioe.2020.571294
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Systematic Investigation of Polyurethane Biomaterial Surface Roughness on Human Immune Responses in vitroSegan S, Jakobi M, Khokhani P, Klimosch S, Billing F, Schneider M, Martin D, Metzger U, Biesemeier A, Xiong X, Mukherjee A, Steuer H, Keller B-M, Joos T, Schmolz M, Rothbauer U, Hartmann H, Burkhardt C, Lorenz G ,Schneiderhan-Marra N, and Shipp CBioMed Research International, 2020, https://doi.org/10.1155/2020/3481549
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Polyelectrolyte Coatings for Surface Modification of Medical ImplantsKrastev R, Rudt A, Xiong X, Hartmann HCurrent Directions in Biomedical Engineering. 2018; 4(1): 217-220. DOI: 10.1515/cdbme-2018-0053
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Multimodal Chemosensor-Based, Real-Time Biomaterial/Cell Interface MonitoringKubon M, Hartmann H, Moschallski M, Burkhardt C, Link G, Werner S, Stelzle MAdvanced Biosystems. 2018; 2(6):1700236.
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Biofunctionalization of surfaces using polyelectrolyte multilayersHartmann H, Krastev RBioNanoMaterials. 2017; 18(1-2). https://doi.org/10.1515/bnm-2016-0015
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Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anionsAndreeva TD, Hartmann H, Taneva StG, Krastev RJournal of Materials Chemistry, 2016, B 4(44): 7092-7100.
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Fine-tuned PEGylation of chitosan to maintain optimal siRNA-nanoplex bioactivityGutoaia A, Schuster L, Margutti S, Laufer S, Schlosshauer B, Krastev R, Stoll D, Hartmann HCarbohydr Polym. 2016 Jun 5;143:25-34. doi: 10.1016/j.carbpol.2016.01.010. Epub 2016 Jan 8.
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miR-124 disinhibits neurite outgrowth in an inflammatory environmentHartmann H, Hoehne K, Rist E, Louw AM, Schlosshauer BCell Tissue Res. 2015 Oct;362(1):9-20. doi: 10.1007/s00441-015-2183-y. Epub 2015 Apr 29.
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Immunoliposomes for Targeted Delivery of an Antifibrotic DrugSchuster L, Seifert O, Vollmer S, Kontermann RE, Schlosshauer B, Hartmann HMol Pharm. 2015 Sep 8;12(9):3146-57. doi: 10.1021/acs.molpharmaceut.5b00012. Epub 2015 Jul 28.
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Polyelectrolyte multilayers as functional coatings for controlled biomolecular interactionsHartmann H, Schlosshauer BIn: Biofunctional Surface Engineering. M. Scholz (Ed), Pan Stanford Publishing 2014: 27-46.
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Hyaluronic acid / chitosan multilayer coatings on neuronal implants for localized delivery of siRNA nanoplexesHartmann H, Hossfeld S, Schlosshauer B, Mittnacht U, Pego AP, Dauner M, Doser M, Stoll D, Krastev RJ Control Release. 2013 Apr 4;168(3):289-297. doi: 10.1016/j.jconrel.2013.03.026.
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Bioactive coronary stent coating based on layer-by-layer technology for siRNA releaseHossfeld S, Nolte A, Hartmann H, Recke M, Schaller M, Walker T, Kjems J, Schlosshauer B, Stoll D, Wendel HP, Krastev RActa Biomater. 2013 May; 9(5): 6741-6752. doi: 10.1016/j.actbio.2013.01.013.
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Neuronal and glial responses to siRNA-coated nerve guide implants in vitroHoffmann N, Mittnacht U, Hartmann H, Baumer Y, Kjems J, Oberhoffner S, Schlosshauer BNeurosci Lett. 2011 Apr 20;494(1):14-8. Epub 2011 Feb 23. DOI 10.1016/j.neulet.2011.02.043
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Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowthMittnacht U, Hartmann H, Hein S, Oliveira H, Dong M, Pego AP, Kjems J, Howard KA, Schlosshauer BNano Lett. 2010 Oct 13;10(10):3933-9. doi: 10.1021/nl1016909.
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Fremdkörper-Reaktionen auf Biomaterialien und Strategien zum Funktionserhalt von ImplantatenHartmann H, Schlosshauer BBIOmaterialien. 2010 Nov; 11(1):15-23. DOI 10.1515/BIOMAT.2010.11.1.15
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Phagocytosis and postphagocytic reaction of cord blood and adult blood monocyte after infection with green fluorescent protein-labeled Escherichia coli and group B StreptococciGille C, Leiber A, Mundle I, Spring B, Abele H, Spellerberg B, Hartmann H, Poets ChF, Orlikowsky TWCytometry B Clin Cytom. 2009 Jul;76B(4):271-84
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Hypoxia-independent activation of HIF-1 by Enterobacteriaceae and their siderophoresHartmann H, Eltzschig HK, Wurz H, Hantke K, Rakin A, Yazdi AS, Matteoli G, Bohn E, Karhausen J, Neumann D, Autenrieth IB, Colgan SP, Kempf VAJGastroenterology. 2008 Mar;134(3):756-67
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Induktion von Blutgefäßwachstum: Eine einzigartige Eigenschaft von Bartonella henselaeEberhardt C, Hartmann H, Kempf VAJBiospektrum. 1/2006
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Rapid identification of Staphylococcus aureus in blood cultures by a combination of fluorescence in situ hybridization using peptide nucleic acid probes and flow cytometryHartmann H, Stender H, Schäfer A, Autenrieth IB, Kempf VAJJ Clin Microbiol. 2005 Sep; 43(9): 4855-7.