Areas of activity
Characterization of surface properties (physicochemical, biological), Coating / modification of surfaces: Regulation of the adhesion of proteins, bacteria, cells, Analysis and functionalization of biodegradable materials, Immobilization and controlled release of active substances, Biomaterial processing: bioprinting, electrospinning, Services and R&D for Medical device companies
Stages of career
2017 - Present Head of Department Biomedicine and Materials Sciences, NMI, Reutlingen
2016 - Present Group leader Regenerative Biomaterials, NMI, Reutlingen
2015 - 2016 Deputy Group Leader Biomaterials, NMI, Reutlingen
2013 - 2015 Project leader, Group Biomaterials NMI, Reutlingen
2008 - 2013 Scientist, Group Regenerative Medicine I, NMI, Reutlingen
2007 - 2008 Post-Doc, Institute for Medical Microbiology and Hygiene, University of Tübingen,
2003 - 2006 PhD, Institute for Medical Microbiology and Hygiene, University of Tübingen, on host cell response after bacterial infection: apoptosis inhibition, HIF-1 activation
2002 - 2003 Diploma thesis, Chair of Biotechnology, University of Würzburg, on biocompatibility and functionality of biomaterials for immunoisolated transplantation of mammalian cells
1998 - 2002 Biology studies, University of Würzburg, Germany
Projects
Publications
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Lead-binding biogenic polyelectrolyte multilayer coating for lead retention in perovskite solar cellsKörte, F., Wessendorf, C., Schnabel, T., Herrmann, M., Schröppel, B., Stadelmann, K., Arefaine, E., Busch, L., Daum, R., Ahlswede, E., Hartmann, H.RSC Adv., 2022, 12, 34381, https://DOI: 10.1039/d2ra05692e
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Electrospinning of collagen: enzymatic and spectroscopic analyses reveal solvent-independent disruption of the triple-helical structureDmitri Visser, Katharina Rogg, Ellena Fuhrmann, Julia Marzi, Katja Schenke-Layland, Hanna HartmannJournal of Materials Chemistry B; DOI: https://doi.org/10.1039/d2tb02602c
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Green Chemistry for Biomimetic Materials: Synthesis and Electrospinning of High-Molecular-Weight Polycarbonate-Based Nonisocyanate PolyurethanesVisser, D.; Bakhshi, H.; Rogg, K.; Fuhrmann, E.; Wieland, F.; Schenke-Layland, K.; Meyer, W.; Hartmann, H.ACS Omega, 2022, DOI: https://doi.org/10.1021/acsomega.2c03731
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Non-Invasive Three-Dimensional Cell Analysis in Bioinks by Raman ImagingMarzi J, Fuhrmann E, Brauchle E, Singer V, Pfannstiel J, Schmidt I, Hartmann HACS Applied Materials & Interfaces 2022 14 (27), 30455-30465; DOI: https://doi.org/10.1021/acsami.1c24463
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Altered Proinflammatory Responses to Polyelectrolyte Multilayer Coatings Are Associated with Differences in Protein Adsorption and WettabilityBilling F, Walter B, Fink S, Arefaine E, Pickarski L, Maier S, Kretz R, Jakobi M, Feuerer N, Schneiderhan-Marra N, Burkhardt C, Templin M, Zeck A, Krastev R, Hartmann H, Shipp C.ACS Appl Mater Interfaces. 2021 Nov 24;13(46):55534-55549. doi: 10.1021/acsami.1c16175. Epub 2021 Nov 11. PMID: 34762399.
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The immune response to the SLActive titanium dental implant surface in vitro is predominantly driven by innate immune cellBilling F, Jakobi M, Martin D, Gerlach K, Arefaine E, Weiss M, Schneiderhan-Marra N, Hartmann H, CJournal of Immunology and Regenerative Medicine Volume 13, August 2021, 100047; https://doi.org/10.1016/j.regen.2021.100047
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The Impact of Biomaterial Cell Contact on the ImmunopeptidomeGhosh M, Hartmann H, Jakobi M, März L, Bichmann L, Freudenmann L K, Mühlenbruch L, Segan S, Rammensee H-G, Schneiderhan-Marra N, Shipp C, Stevanovic S, Joos T OFront. Bioeng. Biotechnol., 2020, Vol. 8 https://doi.org/10.3389/fbioe.2020.571294
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Systematic Investigation of Polyurethane Biomaterial Surface Roughness on Human Immune Responses in vitroSegan S, Jakobi M, Khokhani P, Klimosch S, Billing F, Schneider M, Martin D, Metzger U, Biesemeier A, Xiong X, Mukherjee A, Steuer H, Keller B-M, Joos T, Schmolz M, Rothbauer U, Hartmann H, Burkhardt C, Lorenz G ,Schneiderhan-Marra N, and Shipp CBioMed Research International, 2020, https://doi.org/10.1155/2020/3481549
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Polyelectrolyte Coatings for Surface Modification of Medical ImplantsKrastev R, Rudt A, Xiong X, Hartmann HCurrent Directions in Biomedical Engineering. 2018; 4(1): 217-220. DOI: 10.1515/cdbme-2018-0053
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Multimodal Chemosensor-Based, Real-Time Biomaterial/Cell Interface MonitoringKubon M, Hartmann H, Moschallski M, Burkhardt C, Link G, Werner S, Stelzle MAdvanced Biosystems. 2018; 2(6):1700236.
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Biofunctionalization of surfaces using polyelectrolyte multilayersHartmann H, Krastev RBioNanoMaterials. 2017; 18(1-2). https://doi.org/10.1515/bnm-2016-0015
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Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anionsAndreeva TD, Hartmann H, Taneva StG, Krastev RJournal of Materials Chemistry, 2016, B 4(44): 7092-7100.
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Fine-tuned PEGylation of chitosan to maintain optimal siRNA-nanoplex bioactivityGutoaia A, Schuster L, Margutti S, Laufer S, Schlosshauer B, Krastev R, Stoll D, Hartmann HCarbohydr Polym. 2016 Jun 5;143:25-34. doi: 10.1016/j.carbpol.2016.01.010. Epub 2016 Jan 8.
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miR-124 disinhibits neurite outgrowth in an inflammatory environmentHartmann H, Hoehne K, Rist E, Louw AM, Schlosshauer BCell Tissue Res. 2015 Oct;362(1):9-20. doi: 10.1007/s00441-015-2183-y. Epub 2015 Apr 29.
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Immunoliposomes for Targeted Delivery of an Antifibrotic DrugSchuster L, Seifert O, Vollmer S, Kontermann RE, Schlosshauer B, Hartmann HMol Pharm. 2015 Sep 8;12(9):3146-57. doi: 10.1021/acs.molpharmaceut.5b00012. Epub 2015 Jul 28.
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Polyelectrolyte multilayers as functional coatings for controlled biomolecular interactionsHartmann H, Schlosshauer BIn: Biofunctional Surface Engineering. M. Scholz (Ed), Pan Stanford Publishing 2014: 27-46.
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Hyaluronic acid / chitosan multilayer coatings on neuronal implants for localized delivery of siRNA nanoplexesHartmann H, Hossfeld S, Schlosshauer B, Mittnacht U, Pego AP, Dauner M, Doser M, Stoll D, Krastev RJ Control Release. 2013 Apr 4;168(3):289-297. doi: 10.1016/j.jconrel.2013.03.026.
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Bioactive coronary stent coating based on layer-by-layer technology for siRNA releaseHossfeld S, Nolte A, Hartmann H, Recke M, Schaller M, Walker T, Kjems J, Schlosshauer B, Stoll D, Wendel HP, Krastev RActa Biomater. 2013 May; 9(5): 6741-6752. doi: 10.1016/j.actbio.2013.01.013.
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Towards quantification of biocompatibility: Monitoring ingrowth behavior of biomaterials in tissue with a microsensor implantKubon M, Moschallski M, Ensslen T, Link G, Werner S, Burkhardt C, Hartmann H, Schlosshauer B, Urban G, Stelzle MIEEE Conference Paper, 2011, doi: 10.1109/TRANSDUCERS.2011.5969289
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A microsensor system to probe physiological environments and tissue responseKubon M, Moschallski M, Link G, Ensslen T, Werner S, Burkhardt C, Nisch W, Scholz B, Schlosshauer B, Urban G, Stelzle MIEEE Conference Paper, 2010, doi: 10.1109/TRANSDUCERS.2011.5969289
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Neuronal and glial responses to siRNA-coated nerve guide implants in vitroHoffmann N, Mittnacht U, Hartmann H, Baumer Y, Kjems J, Oberhoffner S, Schlosshauer BNeurosci Lett. 2011 Apr 20;494(1):14-8. Epub 2011 Feb 23. DOI 10.1016/j.neulet.2011.02.043
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Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowthMittnacht U, Hartmann H, Hein S, Oliveira H, Dong M, Pego AP, Kjems J, Howard KA, Schlosshauer BNano Lett. 2010 Oct 13;10(10):3933-9. doi: 10.1021/nl1016909.
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Fremdkörper-Reaktionen auf Biomaterialien und Strategien zum Funktionserhalt von ImplantatenHartmann H, Schlosshauer BBIOmaterialien. 2010 Nov; 11(1):15-23. DOI 10.1515/BIOMAT.2010.11.1.15
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Phagocytosis and postphagocytic reaction of cord blood and adult blood monocyte after infection with green fluorescent protein-labeled Escherichia coli and group B StreptococciGille C, Leiber A, Mundle I, Spring B, Abele H, Spellerberg B, Hartmann H, Poets ChF, Orlikowsky TWCytometry B Clin Cytom. 2009 Jul;76B(4):271-84
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Hypoxia-independent activation of HIF-1 by Enterobacteriaceae and their siderophoresHartmann H, Eltzschig HK, Wurz H, Hantke K, Rakin A, Yazdi AS, Matteoli G, Bohn E, Karhausen J, Neumann D, Autenrieth IB, Colgan SP, Kempf VAJGastroenterology. 2008 Mar;134(3):756-67
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Induktion von Blutgefäßwachstum: Eine einzigartige Eigenschaft von Bartonella henselaeEberhardt C, Hartmann H, Kempf VAJBiospektrum. 1/2006
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Rapid identification of Staphylococcus aureus in blood cultures by a combination of fluorescence in situ hybridization using peptide nucleic acid probes and flow cytometryHartmann H, Stender H, Schäfer A, Autenrieth IB, Kempf VAJJ Clin Microbiol. 2005 Sep; 43(9): 4855-7.