Dr. Hanna Hartmann

Research focus

    Medical devices and biocompatibility
    Coating / modification of surfaces: Regulation of the adhesion of proteins, bacteria, cells, etc.
    Immobilization and controlled release of active substances
    Characterization of surface properties and biological reactions

Curriculum vitae

since 2017 Head of Department Biomedicine and Materials Sciences

since 2016 Group leader Regenerative Biomaterials, NMI, Reutlingen

2015-2016 Deputy Group Leader, Biomaterials, NMI, Reutlingen
Focus on medical devices, surface coating and analytics, biocompatibility

2013-2015 Project leader, Biomaterials Working Group, NMI, ReutlingeN
Topics. characterization/modification of surfaces for medical applications, polymer/polyelectrolyte coatings Characterization/modification of surfaces for medical applications, polymer/polyelectrolyte coatings, immobilization of biomolecules

2008-2013 Scientist, Working Group Regenerative Medicine I, NMI, ReutlingeN
Topics: fibrosis inhibition, nerve regeneration, RNAi nanoparticles for cell response control: Fibrosis inhibition, nerve regeneration, RNAi nanoparticles to control cell response, cell-specific addressing

2007-2008 Post-Doc, Institute for Medical Microbiology and Hygiene, University of Tübingen, Germany
Topics. Influences of bacteria on infected target cells, apoptosis inhibition and regulation of transcription factors Influences of bacteria on infected target cells, apoptosis inhibition and regulation of transcription factors 

2003-2006 PhD, Institute for Medical Microbiology and Hygiene, University of Tübingen, "Host cell response after bacterial infection: apoptosis inhibition by Bartonella henselae and HIF-1 activation by Enterobacteriaceae" (in German)

2002-2003 Diploma thesis, Chair of Biotechnology, University of Würzburg, Biocompatibility and Functionality Investigation of Biomaterial for Immunoisolated Transplantation of Mammalian Cells

1998-2002 Biology studies, University of Würzburg, Germany

Dr. Hanna Hartmann

Head of Dept. Biomedicine and Material Sciences
Diplom-Biologin
T +49 (0)7121 51530-872
F +49 (0)7121 51530-62

Publications

  • Polyelectrolyte Coatings for Surface Modification of Medical Implants
    Krastev R, Rudt A, Xiong X, Hartmann H
    Current Directions in Biomedical Engineering. 2018; 4(1): 217-220. DOI: 10.1515/cdbme-2018-0053
  • Multimodal Chemosensor-Based, Real-Time Biomaterial/Cell Interface Monitoring
    Kubon M, Hartmann H, Moschallski M, Burkhardt C, Link G, Werner S, Stelzle M
    Advanced Biosystems. 2018; 2(6):1700236.
  • Biofunctionalization of surfaces using polyelectrolyte multilayers
    Hartmann H, Krastev R
    BioNanoMaterials. 2017; 18(1-2). https://doi.org/10.1515/bnm-2016-0015
  • Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions
    Andreeva TD, Hartmann H, Taneva StG, Krastev R
    Journal of Materials Chemistry B 4(44): 7092-7100.
  • Fine-tuned PEGylation of chitosan to maintain optimal siRNA-nanoplex bioactivity
    Gutoaia A, Schuster L, Margutti S, Laufer S, Schlosshauer B, Krastev R, Stoll D, Hartmann H
    Carbohydr Polym. 2016 Jun 5;143:25-34. doi: 10.1016/j.carbpol.2016.01.010. Epub 2016 Jan 8.
  • miR-124 disinhibits neurite outgrowth in an inflammatory environment
    Hartmann H, Hoehne K, Rist E, Louw AM, Schlosshauer B
    Cell Tissue Res. 2015 Oct;362(1):9-20. doi: 10.1007/s00441-015-2183-y. Epub 2015 Apr 29.
  • Immunoliposomes for Targeted Delivery of an Antifibrotic Drug
    Schuster L, Seifert O, Vollmer S, Kontermann RE, Schlosshauer B, Hartmann H
    Mol Pharm. 2015 Sep 8;12(9):3146-57. doi: 10.1021/acs.molpharmaceut.5b00012. Epub 2015 Jul 28.
  • Immunoliposomes for Targeted Delivery of an Antifibrotic Drug
    Schuster L, Seifert, O, Vollmer S, Kontermann RE, Schlosshauer B, Hartmann H
    Mol Pharm. 2015 Sep 8;12(9):3146-57. doi: 10.1021/acs.molpharmaceut.5b00012. Epub 2015 Jul 28.
  • Polyelectrolyte multilayers as functional coatings for controlled biomolecular interactions
    Hartmann H, Schlosshauer B
    In: Biofunctional Surface Engineering. M. Scholz (Ed), Pan Stanford Publishing 2014: 27-46.
  • Hyaluronic acid / chitosan multilayer coatings on neuronal implants for localized delivery of siRNA nanoplexes
    Hartmann H, Hossfeld S, Schlosshauer B, Mittnacht U, Pego AP, Dauner M, Doser M, Stoll D, Krastev R
    J Control Release. 2013 Apr 4;168(3):289-297. doi: 10.1016/j.jconrel.2013.03.026.
  • Bioactive coronary stent coating based on layer-by-layer technology for siRNA release
    Hossfeld S, Nolte A, Hartmann H, Recke M, Schaller M, Walker T, Kjems J, Schlosshauer B, Stoll D, Wendel HP, Krastev R
    Acta Biomater. 2013 May; 9(5): 6741-6752. doi: 10.1016/j.actbio.2013.01.013.
  • Neuronal and glial responses to siRNA-coated nerve guide implants in vitro
    Hoffmann N, Mittnacht U, Hartmann H, Baumer Y, Kjems J, Oberhoffner S, Schlosshauer B
    Neurosci Lett. 2011 Apr 20;494(1):14-8. Epub 2011 Feb 23. DOI 10.1016/j.neulet.2011.02.043
  • Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth
    Mittnacht U, Hartmann H, Hein S, Oliveira H, Dong M, Pego AP, Kjems J, Howard KA, Schlosshauer B
    Nano Lett. 2010 Oct 13;10(10):3933-9. doi: 10.1021/nl1016909.
  • Sequential multiplex analyte capturing for phosphor-protein profiling
    Poetz O, Henzler T, Hartmann M, Kazmaier C, Templin MF, Herget T, Joos TO
    Mol Cell Proteomics. 2010 Nov; 9(11): 2474–2481. Published online 2010 Aug 3. doi: 10.1074/mcp.M110.002709
  • Fremdkörper-Reaktionen auf Biomaterialien und Strategien zum Funktionserhalt von Implantaten
    Hartmann H, Schlosshauer B
    BIOmaterialien. 2010 Nov; 11(1):15-23. DOI 10.1515/BIOMAT.2010.11.1.15