Dr. Hanna Hartmann

Areas of activity

Characterization of surface properties (physicochemical, biological), Coating / modification of surfaces: Regulation of the adhesion of proteins, bacteria, cells, Analysis and functionalization of biodegradable materials, Immobilization and controlled release of active substances, Biomaterial processing: bioprinting, electrospinning, Services and R&D for Medical device companies

Stages of career

2017 - Present Head of Department Biomedicine and Materials Sciences, NMI, Reutlingen

2016 - Present Group leader Regenerative Biomaterials, NMI, Reutlingen

2015 - 2016 Deputy Group Leader Biomaterials, NMI, Reutlingen

2013 - 2015 Project leader, Group Biomaterials NMI, Reutlingen

2008 - 2013      Scientist, Group Regenerative Medicine I, NMI, Reutlingen

2007 - 2008      Post-Doc, Institute for Medical Microbiology and Hygiene, University of Tübingen,

2003 - 2006      PhD, Institute for Medical Microbiology and Hygiene, University of Tübingen, on host cell response after bacterial infection: apoptosis inhibition, HIF-1 activation

2002 - 2003      Diploma thesis, Chair of Biotechnology, University of Würzburg, on biocompatibility and functionality of biomaterials for immunoisolated transplantation of mammalian cells

1998 - 2002      Biology studies, University of Würzburg, Germany

Dr. Hanna Hartmann

Diplom-Biologin

T +49 (0)7121 51530-872

E hanna.hartmann@nmi.de

Projects

Publications

Lead-binding biogenic polyelectrolyte multilayer coating for lead retention in perovskite solar cells

Körte, F., Wessendorf, C., Schnabel, T., Herrmann, M., Schröppel, B., Stadelmann, K., Arefaine, E., Busch, L., Daum, R., Ahlswede, E., Hartmann, H.

RSC Adv., 2022, 12, 34381, https://DOI: 10.1039/d2ra05692e
Electrospinning of collagen: enzymatic and spectroscopic analyses reveal solvent-independent disruption of the triple-helical structure

Dmitri Visser, Katharina Rogg, Ellena Fuhrmann, Julia Marzi, Katja Schenke-Layland, Hanna Hartmann

Journal of Materials Chemistry B; DOI: https://doi.org/10.1039/d2tb02602c
Green Chemistry for Biomimetic Materials: Synthesis and Electrospinning of High-Molecular-Weight Polycarbonate-Based Nonisocyanate Polyurethanes

Visser, D.; Bakhshi, H.; Rogg, K.; Fuhrmann, E.; Wieland, F.; Schenke-Layland, K.; Meyer, W.; Hartmann, H.

ACS Omega, 2022, DOI: https://doi.org/10.1021/acsomega.2c03731
Non-Invasive Three-Dimensional Cell Analysis in Bioinks by Raman Imaging

Marzi J, Fuhrmann E, Brauchle E, Singer V, Pfannstiel J, Schmidt I, Hartmann H

ACS Applied Materials & Interfaces 2022 14 (27), 30455-30465; DOI: https://doi.org/10.1021/acsami.1c24463
Altered Proinflammatory Responses to Polyelectrolyte Multilayer Coatings Are Associated with Differences in Protein Adsorption and Wettability

Billing F, Walter B, Fink S, Arefaine E, Pickarski L, Maier S, Kretz R, Jakobi M, Feuerer N, Schneiderhan-Marra N, Burkhardt C, Templin M, Zeck A, Krastev R, Hartmann H, Shipp C.

ACS Appl Mater Interfaces. 2021 Nov 24;13(46):55534-55549. doi: 10.1021/acsami.1c16175. Epub 2021 Nov 11. PMID: 34762399.
The immune response to the SLActive titanium dental implant surface in vitro is predominantly driven by innate immune cell

Billing F, Jakobi M, Martin D, Gerlach K, Arefaine E, Weiss M, Schneiderhan-Marra N, Hartmann H, C

Journal of Immunology and Regenerative Medicine Volume 13, August 2021, 100047; https://doi.org/10.1016/j.regen.2021.100047
The Impact of Biomaterial Cell Contact on the Immunopeptidome

Ghosh M, Hartmann H, Jakobi M, März L, Bichmann L, Freudenmann L K, Mühlenbruch L, Segan S, Rammensee H-G, Schneiderhan-Marra N, Shipp C, Stevanovic S, Joos T O

Front. Bioeng. Biotechnol., 2020, Vol. 8 https://doi.org/10.3389/fbioe.2020.571294
Systematic Investigation of Polyurethane Biomaterial Surface Roughness on Human Immune Responses in vitro

Segan S, Jakobi M, Khokhani P, Klimosch S, Billing F, Schneider M, Martin D, Metzger U, Biesemeier A, Xiong X, Mukherjee A, Steuer H, Keller B-M, Joos T, Schmolz M, Rothbauer U, Hartmann H, Burkhardt C, Lorenz G ,Schneiderhan-Marra N, and Shipp C

BioMed Research International, 2020, https://doi.org/10.1155/2020/3481549
Polyelectrolyte Coatings for Surface Modification of Medical Implants

Krastev R, Rudt A, Xiong X, Hartmann H

Current Directions in Biomedical Engineering. 2018; 4(1): 217-220. DOI: 10.1515/cdbme-2018-0053
Multimodal Chemosensor-Based, Real-Time Biomaterial/Cell Interface Monitoring

Kubon M, Hartmann H, Moschallski M, Burkhardt C, Link G, Werner S, Stelzle M

Advanced Biosystems. 2018; 2(6):1700236.
Biofunctionalization of surfaces using polyelectrolyte multilayers

Hartmann H, Krastev R

BioNanoMaterials. 2017; 18(1-2). https://doi.org/10.1515/bnm-2016-0015
Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions

Andreeva TD, Hartmann H, Taneva StG, Krastev R

Journal of Materials Chemistry, 2016, B 4(44): 7092-7100.
Fine-tuned PEGylation of chitosan to maintain optimal siRNA-nanoplex bioactivity

Gutoaia A, Schuster L, Margutti S, Laufer S, Schlosshauer B, Krastev R, Stoll D, Hartmann H

Carbohydr Polym. 2016 Jun 5;143:25-34. doi: 10.1016/j.carbpol.2016.01.010. Epub 2016 Jan 8.
miR-124 disinhibits neurite outgrowth in an inflammatory environment

Hartmann H, Hoehne K, Rist E, Louw AM, Schlosshauer B

Cell Tissue Res. 2015 Oct;362(1):9-20. doi: 10.1007/s00441-015-2183-y. Epub 2015 Apr 29.
Immunoliposomes for Targeted Delivery of an Antifibrotic Drug

Schuster L, Seifert O, Vollmer S, Kontermann RE, Schlosshauer B, Hartmann H

Mol Pharm. 2015 Sep 8;12(9):3146-57. doi: 10.1021/acs.molpharmaceut.5b00012. Epub 2015 Jul 28.
Polyelectrolyte multilayers as functional coatings for controlled biomolecular interactions

Hartmann H, Schlosshauer B

In: Biofunctional Surface Engineering. M. Scholz (Ed), Pan Stanford Publishing 2014: 27-46.
Hyaluronic acid / chitosan multilayer coatings on neuronal implants for localized delivery of siRNA nanoplexes

Hartmann H, Hossfeld S, Schlosshauer B, Mittnacht U, Pego AP, Dauner M, Doser M, Stoll D, Krastev R

J Control Release. 2013 Apr 4;168(3):289-297. doi: 10.1016/j.jconrel.2013.03.026.
Bioactive coronary stent coating based on layer-by-layer technology for siRNA release

Hossfeld S, Nolte A, Hartmann H, Recke M, Schaller M, Walker T, Kjems J, Schlosshauer B, Stoll D, Wendel HP, Krastev R

Acta Biomater. 2013 May; 9(5): 6741-6752. doi: 10.1016/j.actbio.2013.01.013.
Towards quantification of biocompatibility: Monitoring ingrowth behavior of biomaterials in tissue with a microsensor implant

Kubon M, Moschallski M, Ensslen T, Link G, Werner S, Burkhardt C, Hartmann H, Schlosshauer B, Urban G, Stelzle M

IEEE Conference Paper, 2011, doi: 10.1109/TRANSDUCERS.2011.5969289
A microsensor system to probe physiological environments and tissue response

Kubon M, Moschallski M, Link G, Ensslen T, Werner S, Burkhardt C, Nisch W, Scholz B, Schlosshauer B, Urban G, Stelzle M

IEEE Conference Paper, 2010, doi: 10.1109/TRANSDUCERS.2011.5969289
Neuronal and glial responses to siRNA-coated nerve guide implants in vitro

Hoffmann N, Mittnacht U, Hartmann H, Baumer Y, Kjems J, Oberhoffner S, Schlosshauer B

Neurosci Lett. 2011 Apr 20;494(1):14-8. Epub 2011 Feb 23. DOI 10.1016/j.neulet.2011.02.043
Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth

Mittnacht U, Hartmann H, Hein S, Oliveira H, Dong M, Pego AP, Kjems J, Howard KA, Schlosshauer B

Nano Lett. 2010 Oct 13;10(10):3933-9. doi: 10.1021/nl1016909.
Fremdkörper-Reaktionen auf Biomaterialien und Strategien zum Funktionserhalt von Implantaten

Hartmann H, Schlosshauer B

BIOmaterialien. 2010 Nov; 11(1):15-23. DOI 10.1515/BIOMAT.2010.11.1.15
Phagocytosis and postphagocytic reaction of cord blood and adult blood monocyte after infection with green fluorescent protein-labeled Escherichia coli and group B Streptococci

Gille C, Leiber A, Mundle I, Spring B, Abele H, Spellerberg B, Hartmann H, Poets ChF, Orlikowsky TW

Cytometry B Clin Cytom. 2009 Jul;76B(4):271-84
Hypoxia-independent activation of HIF-1 by Enterobacteriaceae and their siderophores

Hartmann H, Eltzschig HK, Wurz H, Hantke K, Rakin A, Yazdi AS, Matteoli G, Bohn E, Karhausen J, Neumann D, Autenrieth IB, Colgan SP, Kempf VAJ

Gastroenterology. 2008 Mar;134(3):756-67
Induktion von Blutgefäßwachstum: Eine einzigartige Eigenschaft von Bartonella henselae

Eberhardt C, Hartmann H, Kempf VAJ

Biospektrum. 1/2006
Rapid identification of Staphylococcus aureus in blood cultures by a combination of fluorescence in situ hybridization using peptide nucleic acid probes and flow cytometry

Hartmann H, Stender H, Schäfer A, Autenrieth IB, Kempf VAJ

J Clin Microbiol. 2005 Sep; 43(9): 4855-7.

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