Dr. Hanna Hartmann

Research focus

- Characterization of surface properties (physicochemical, biological)

- Coating / modification of surfaces: Regulation of the adhesion of proteins, bacteria, cells

- Analysis and functionalization of biodegradable materials  

- Immobilization and controlled release of active substances  

- Biomaterial processing: bioprinting, electrospinning

- Services and R&D for Medical device companies

Curriculum vitae

since 2017 Head of Department Biomedicine and Materials Sciences, NMI, Reutlingen

since 2016 Group leader Regenerative Biomaterials, NMI, Reutlingen

2015-2016 Deputy Group Leader Biomaterials, NMI, Reutlingen

2013-2015 Project leader, Group Biomaterials NMI, Reutlingen

2008-2013 Scientist, Group Regenerative Medicine I, NMI, Reutlingen

2007-2008 Post-Doc, Institute for Medical Microbiology and Hygiene, University of Tübingen,

2003-2006 PhD, Institute for Medical Microbiology and Hygiene, University of Tübingen, on host cell response after bacterial infection: apoptosis inhibition, HIF-1 activation

2002-2003 Diploma thesis, Chair of Biotechnology, University of Würzburg, on biocompatibility and functionality of biomaterials for immunoisolated transplantation of mammalian cells

1998-2002 Biology studies, University of Würzburg, Germany

Dr. Hanna Hartmann
Head of Dept. Biomedicine and Material Sciences
T +49 (0)7121 51530-872
F +49 (0)7121 51530-62


  • The immune response to the SLActive titanium dental implant surface in vitro is predominantly driven by innate immune cell
    Billing F, Jakobi M, Martin D, Gerlach K, Arefaine E, Weiss M, Schneiderhan-Marra N, Hartmann H, C
    Journal of Immunology and Regenerative Medicine Volume 13, August 2021, 100047; https://doi.org/10.1016/j.regen.2021.100047
  • The Impact of Biomaterial Cell Contact on the Immunopeptidome
    Ghosh M, Hartmann H, Jakobi M, März L, Bichmann L, Freudenmann L K, Mühlenbruch L, Segan S, Rammensee H-G, Schneiderhan-Marra N, Shipp C, Stevanovic S, Joos T O
    Front. Bioeng. Biotechnol., 2020, Vol. 8 https://doi.org/10.3389/fbioe.2020.571294
  • Systematic Investigation of Polyurethane Biomaterial Surface Roughness on Human Immune Responses in vitro
    Segan S, Jakobi M, Khokhani P, Klimosch S, Billing F, Schneider M, Martin D, Metzger U, Biesemeier A, Xiong X, Mukherjee A, Steuer H, Keller B-M, Joos T, Schmolz M, Rothbauer U, Hartmann H, Burkhardt C, Lorenz G ,Schneiderhan-Marra N, and Shipp C
    BioMed Research International, 2020, https://doi.org/10.1155/2020/3481549
  • Polyelectrolyte Coatings for Surface Modification of Medical Implants
    Krastev R, Rudt A, Xiong X, Hartmann H
    Current Directions in Biomedical Engineering. 2018; 4(1): 217-220. DOI: 10.1515/cdbme-2018-0053
  • Multimodal Chemosensor-Based, Real-Time Biomaterial/Cell Interface Monitoring
    Kubon M, Hartmann H, Moschallski M, Burkhardt C, Link G, Werner S, Stelzle M
    Advanced Biosystems. 2018; 2(6):1700236.
  • Biofunctionalization of surfaces using polyelectrolyte multilayers
    Hartmann H, Krastev R
    BioNanoMaterials. 2017; 18(1-2). https://doi.org/10.1515/bnm-2016-0015
  • Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions
    Andreeva TD, Hartmann H, Taneva StG, Krastev R
    Journal of Materials Chemistry, 2016, B 4(44): 7092-7100.
  • Fine-tuned PEGylation of chitosan to maintain optimal siRNA-nanoplex bioactivity
    Gutoaia A, Schuster L, Margutti S, Laufer S, Schlosshauer B, Krastev R, Stoll D, Hartmann H
    Carbohydr Polym. 2016 Jun 5;143:25-34. doi: 10.1016/j.carbpol.2016.01.010. Epub 2016 Jan 8.
  • miR-124 disinhibits neurite outgrowth in an inflammatory environment
    Hartmann H, Hoehne K, Rist E, Louw AM, Schlosshauer B
    Cell Tissue Res. 2015 Oct;362(1):9-20. doi: 10.1007/s00441-015-2183-y. Epub 2015 Apr 29.
  • Immunoliposomes for Targeted Delivery of an Antifibrotic Drug
    Schuster L, Seifert O, Vollmer S, Kontermann RE, Schlosshauer B, Hartmann H
    Mol Pharm. 2015 Sep 8;12(9):3146-57. doi: 10.1021/acs.molpharmaceut.5b00012. Epub 2015 Jul 28.
  • Polyelectrolyte multilayers as functional coatings for controlled biomolecular interactions
    Hartmann H, Schlosshauer B
    In: Biofunctional Surface Engineering. M. Scholz (Ed), Pan Stanford Publishing 2014: 27-46.
  • Hyaluronic acid / chitosan multilayer coatings on neuronal implants for localized delivery of siRNA nanoplexes
    Hartmann H, Hossfeld S, Schlosshauer B, Mittnacht U, Pego AP, Dauner M, Doser M, Stoll D, Krastev R
    J Control Release. 2013 Apr 4;168(3):289-297. doi: 10.1016/j.jconrel.2013.03.026.
  • Bioactive coronary stent coating based on layer-by-layer technology for siRNA release
    Hossfeld S, Nolte A, Hartmann H, Recke M, Schaller M, Walker T, Kjems J, Schlosshauer B, Stoll D, Wendel HP, Krastev R
    Acta Biomater. 2013 May; 9(5): 6741-6752. doi: 10.1016/j.actbio.2013.01.013.
  • Towards quantification of biocompatibility: Monitoring ingrowth behavior of biomaterials in tissue with a microsensor implant
    Kubon M, Moschallski M, Ensslen T, Link G, Werner S, Burkhardt C, Hartmann H, Schlosshauer B, Urban G, Stelzle M
    IEEE Conference Paper, 2011, doi: 10.1109/TRANSDUCERS.2011.5969289
  • A microsensor system to probe physiological environments and tissue response
    Kubon M, Moschallski M, Link G, Ensslen T, Werner S, Burkhardt C, Nisch W, Scholz B, Schlosshauer B, Urban G, Stelzle M
    IEEE Conference Paper, 2010, doi: 10.1109/TRANSDUCERS.2011.5969289
  • Neuronal and glial responses to siRNA-coated nerve guide implants in vitro
    Hoffmann N, Mittnacht U, Hartmann H, Baumer Y, Kjems J, Oberhoffner S, Schlosshauer B
    Neurosci Lett. 2011 Apr 20;494(1):14-8. Epub 2011 Feb 23. DOI 10.1016/j.neulet.2011.02.043
  • Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth
    Mittnacht U, Hartmann H, Hein S, Oliveira H, Dong M, Pego AP, Kjems J, Howard KA, Schlosshauer B
    Nano Lett. 2010 Oct 13;10(10):3933-9. doi: 10.1021/nl1016909.
  • Fremdkörper-Reaktionen auf Biomaterialien und Strategien zum Funktionserhalt von Implantaten
    Hartmann H, Schlosshauer B
    BIOmaterialien. 2010 Nov; 11(1):15-23. DOI 10.1515/BIOMAT.2010.11.1.15
  • Phagocytosis and postphagocytic reaction of cord blood and adult blood monocyte after infection with green fluorescent protein-labeled Escherichia coli and group B Streptococci
    Gille C, Leiber A, Mundle I, Spring B, Abele H, Spellerberg B, Hartmann H, Poets ChF, Orlikowsky TW
    Cytometry B Clin Cytom. 2009 Jul;76B(4):271-84
  • Hypoxia-independent activation of HIF-1 by Enterobacteriaceae and their siderophores
    Hartmann H, Eltzschig HK, Wurz H, Hantke K, Rakin A, Yazdi AS, Matteoli G, Bohn E, Karhausen J, Neumann D, Autenrieth IB, Colgan SP, Kempf VAJ
    Gastroenterology. 2008 Mar;134(3):756-67
  • Induktion von Blutgefäßwachstum: Eine einzigartige Eigenschaft von Bartonella henselae
    Eberhardt C, Hartmann H, Kempf VAJ
    Biospektrum. 1/2006
  • Rapid identification of Staphylococcus aureus in blood cultures by a combination of fluorescence in situ hybridization using peptide nucleic acid probes and flow cytometry
    Hartmann H, Stender H, Schäfer A, Autenrieth IB, Kempf VAJ
    J Clin Microbiol. 2005 Sep; 43(9): 4855-7.