Areas of activity
Neurotechnologies and applications, CMOS - based neurochips, Parallel detection of neuronal activity with 16000 sensors, Capacitive stimulation of neuronal activity with capacitor arrays, Tissue analysis - chip coupling, multi-electrode arrays, Neuronal cell cultures (rat), Electrical stimulation, retina, Detection/analysis of extracellular activity in rabbit, rat and mouse retinas, Detection/analysis of single cell activity and field potentials in blind retinas, Electrical stimulation of healthy and blind retinas
Stages of career
Since 2020 Univ.Prof. TU Wien Institute of Electrodynamics, Microwave and Circuit Engineering
2010 -2020 Group leader at the NMI
2006 - 2010 Senior Postdoc, Max Planck Inst. Neurobiology, Martinsried
2003 - 2005 Postdoctoral researcher at Mass. General Hospital & Harvard Medical School, Boston, USA.
1998 - 2002 Dr. rer. nat., Biophysics, TU Munich & Max Planck Inst. Biochemistry
1992 - 1998 Physics studies at the TU Munich
Publications
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Cyclosporine A Protects Retinal Explants against HypoxiaSchnichels, S., Schultheiss, M., Klemm, P., Blak, M., Herrmann, T., Melchinger, M., Bartz-Schmidt, K. U., Löscher, M., Zeck, G., Spitzer, M. S., & Hurst, JInternational journal of molecular sciences, 22(19), 10196. https://doi.org/10.3390/ijms221910196
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Discrimination of simple objects decoded from the output of retinal ganglion cells upon sinusoidal electrical stimulationCorna A, Ramesh P, Jetter F, Lee MJ, Macke JH, Zeck GPublished 17 June 2021 • © 2021 The Author(s). Published by IOP Publishing Ltd Journal of Neural Engineering, Volume 18, Number 4 https://doi.org/10.1088/1741-2552/ac0679
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HDAC inhibition ameliorates cone survival in retinitis pigmentosa miceSamardzija M, Corna A, Gomez-Sintes R, Jarboui MA, Armento A, Roger JE, Petridou E, Haq W, Paquet-Durand F, Zrenner E, de la Villa P, Zeck G, Grimm C, Boya P, Ueffing M, Trifunović DCell Death Differ. 2021 Apr;28(4):1317-1332. doi: 10.1038/s41418-020-00653-3. Epub 2020 Nov 6. PMID: 33159184; PMCID: PMC8026998.
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Spatial and temporal resolution of optogenetically recovered vision in ChR2-transduced mouse retinaReh M, Lee MJ, Schmierer J, Zeck GJ Neural Eng. 2021 Apr 6;18(5). doi: 10.1088/1741-2552/abe39a. PMID: 33545694.
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Human Cerebrospinal Fluid Induces Neuronal Excitability Changes in Resected Human Neocortical and Hippocampal Brain SlicesWickham J, Corna A, Schwarz N, Uysal B, Layer N, Honegger J B, Wuttke T V, Koch H, Zeck GFront. Neurosci., 2020 (14), https://doi.org/10.3389/fnins.2020.00283
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Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retinaHöfling L, Oesterle J, Berens P, Zeck GScientific reports, 2020, 10(1), https://www.nature.com/articles/s41598-020-61899-y
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Electrode-size dependent thresholds in subretinal neuroprosthetic stimulationCorna A, Herrmann T, Zeck G.J Neural Eng. 2018 Aug;15(4):045003. doi: 10.1088/1741-2552/aac1c8. Epub 2018 May 2.
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Functional characterization of the retinal output upon optogenetic stimulationM Reh, M Kriebel, R Thewes and G ZeckMEA Meeting 2018; Reutlingen, Deutschland. doi:10.3389/conf.fncel.2018.38.00045
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Combining two photon microscopy and CMOS MEA to uncover the mechanism of aberrant activity in blind retinaLee M-J, Srivastava P, Rogerson L, Berens P, Euler T, Schubert T, Zeck GMEA Meeting 2018, 10.3389/conf.fncel.2018.38.00022, 2018
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Evaluation of short pulse laser damage to the retinal pigment epithelium layerRamos S, Reh M, Zeck G, Heussner NBiophotonics: Photonic Solutions for Better Health Care VI. 2018 April; 10685.
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A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivoYger P, Spampinato GLB, Esposito E, Lefebvre B, Deny S, Gardella C, Zeck G, Picaud S, Duebel J, Marre OElife. 2018 Mar 20;7. pii: e34518. doi: 10.7554/eLife.34518.
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Investigation of the functional retinal output using Microelectrode arraysZeck GMethods Mol Biol. 2018;1695:81-88. doi: 10.1007/978-1-4939-7407-8_8.
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Subretinal electrical stimulation reveals intact network activity in the blind mouse retinaStutzki H, Helmhold F, Eickenscheidt M, Zeck GJ Neurophysiol. 2016 Oct 1;116(4):1684-1693. doi: 10.1152/jn.01095.2015. Epub 2016 Jul 13.
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Unsupervised neural spike sorting for high-density microelectrode arrays with convolutive independent component analysisLeibig C, Wachtler T, Zeck GJ Neurosci Methods. 2016 Sep 15;271:1-13. doi: 10.1016/j.jneumeth.2016.06.006. Epub 2016 Jun 15.
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Electrochemical noise and impedance of Au electrode/electrolyte interfaces enabling extracellular detection of glioma cell populationsRocha PR, Schlett P, Kintzel U, Mailander V, Vandamme LK, Zeck G, Gomes HL, Biscarini F, de Leeuw DMSci Rep. 2016 Oct 6;6:34843. doi: 10.1038/srep34843.
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Visualizing Epithelial-Mesenchymal Transition Using the Chromobody TechnologyMaier J, Traenkle B, Rothbauer UCancer Res. 2016 Oct 1;76(19):5592-5596. Epub 2016 Sep 15.
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PEDOT-CNT coated electrodes stimulate retinal neurons at low voltage amplitudes and low charge densitiesSamba R, Herrmann T, Zeck GJ Neural Eng. 2015 Feb;12(1):016014. doi: 10.1088/1741-2560/12/1/016014. Epub 2015 Jan 14.
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Aberrant activity in degenerated retinas revealed by electrical imagingZeck GFrontiers in Cellular Neuroscience. 2016; 10 :15. doi: 10.3389/fncel.2016.00025
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Hypothermia Protects and Prolongs the Tolerance Time of Retinal Ganglion Cells against IschemiaSchultheiss M, Schnichels S, Hermann T, Hurst J, Feldkaemper M, Arango-Gonzalez B, Ueffing M, Bartz-Schmidt KU, Zeck G, Spitzer MSPLoS One. 2016 Feb 5;11(2):e0148616. doi: 10.1371/journal.pone.0148616. eCollection 2016.
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PEDOT-CNT coated electrodes stimulate retinal neurons at low voltage amplitudes and low charge densitiesSamba R, Herrmann T, Zeck GJ Neural Eng. 2015 Feb;12(1):016014. doi: 10.1088/1741-2560/12/1/016014. Epub 2015 Jan 14.
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Daylight vision repair by cell transplantationSantos-Ferreira T, Postel K, Stutzki H, Kurth T, Zeck G, Ader MStem Cells. 2015 Jan; 33(1):79-90. doi: 10.1002/stem.1824.
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Rhythmic Ganglion Cell Activity in Bleached and Blind Adult Mouse RetinasMenzler J, Channappa L, Zeck GPLoS One. 2014 Aug 25;9(8):e106047. doi: 10.1371/journal.pone.0106047. eCollection 2014.
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Action potentials in retinal ganglion cells are initiated at the site of maximal curvature of the extracellular potentialEickenscheidt M, Zeck GJ Neural Eng. 2014 Jun;11(3):036006. doi: 10.1088/1741-2560/11/3/036006. Epub 2014 Apr 24.
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Inflammatory stimulation preserves physiological properties of retinal ganglion cells after optic nerve injuryStutzki H, Leibig C, Andreadaki A, Fischer D, Zeck GFront Cell Neurosci. 2014; 8: 38. doi: 10.3389/fncel.2014.00038
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Axonale Leitungsgeschwindigkeiten in der Kaninchenretina gemessen mit MultitransistorarrayThoma MDiplomarbeit. Physik-Department, Technische Universität München. 2012. 61 Seiten.
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A Comprehensive Small Interfering RNA Screen Identifies Signaling Pathways Required for Gephyrin ClusteringWuchter J, Beuter S, Treindl F, Herrmann T, Zeck G, Templin MF, Volkmer HThe Journal of Neuroscience. 2012 Oct 17; 32(42):14821–14834
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Electrical stimulation of retinal neurons in epiretinal and subretinal configuration using a multicapacitor arrayEickenscheidt M, Jenkner M, Thewes R, Fromherz P, Zeck GJ Neurophysiol. 2012 May;107(10):2742-55. Epub 2012 Feb 22.
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Extracellular voltage noise probes the interfaces between retina and silicon chipZeitler R, Fromherz P, Zeck GApplied Physics Letters. 2011 Dec; 99: 263702. DOI 10.1063/1.3672224
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Axonal transmission in the retina introduces a small dispersion of relative timing in the ganglion cell population responseZeck G, Lambacher A, Fromherz PPLoS One. 2011;6(6):e20810. Epub 2011 Jun 2.
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Network oscillations in rod-degenerated mouse retinasMenzler J, Zeck GJ Neurosci. 2011 Feb 9;31(6):2280-91. DOI: 10.1523/JNEUROSCI.4238-10.2011