Dr. Günther Zeck

Areas of activity

Neurotechnologies and applications, CMOS - based neurochips, Parallel detection of neuronal activity with 16000 sensors, Capacitive stimulation of neuronal activity with capacitor arrays, Tissue analysis - chip coupling, multi-electrode arrays, Neuronal cell cultures (rat), Electrical stimulation, retina, Detection/analysis of extracellular activity in rabbit, rat and mouse retinas, Detection/analysis of single cell activity and field potentials in blind retinas, Electrical stimulation of healthy and blind retinas

Stages of career

Since 2020 Univ.Prof. TU Wien Institute of Electrodynamics, Microwave and Circuit Engineering

2010 -2020 Group leader at the NMI

2006 - 2010 Senior Postdoc, Max Planck Inst. Neurobiology, Martinsried

2003 - 2005 Postdoctoral researcher at Mass. General Hospital & Harvard Medical School, Boston, USA.

1998 - 2002 Dr. rer. nat., Biophysics, TU Munich & Max Planck Inst. Biochemistry

1992 - 1998 Physics studies at the TU Munich

Dr. Günther Zeck

Associate Scientist at NMI - Prof. TU Wien Institute of Electrodynamics, Microwave and Circuit Engineering

Diplom-Physiker

E guenther.zeck@nmi.de

Projects

Publications

Cyclosporine A Protects Retinal Explants against Hypoxia

Schnichels, S., Schultheiss, M., Klemm, P., Blak, M., Herrmann, T., Melchinger, M., Bartz-Schmidt, K. U., Löscher, M., Zeck, G., Spitzer, M. S., & Hurst, J

International journal of molecular sciences, 22(19), 10196. https://doi.org/10.3390/ijms221910196
Discrimination of simple objects decoded from the output of retinal ganglion cells upon sinusoidal electrical stimulation

Corna A, Ramesh P, Jetter F, Lee MJ, Macke JH, Zeck G

Published 17 June 2021 • © 2021 The Author(s). Published by IOP Publishing Ltd Journal of Neural Engineering, Volume 18, Number 4 https://doi.org/10.1088/1741-2552/ac0679
HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice

Samardzija M, Corna A, Gomez-Sintes R, Jarboui MA, Armento A, Roger JE, Petridou E, Haq W, Paquet-Durand F, Zrenner E, de la Villa P, Zeck G, Grimm C, Boya P, Ueffing M, Trifunović D

Cell Death Differ. 2021 Apr;28(4):1317-1332. doi: 10.1038/s41418-020-00653-3. Epub 2020 Nov 6. PMID: 33159184; PMCID: PMC8026998.
Spatial and temporal resolution of optogenetically recovered vision in ChR2-transduced mouse retina

Reh M, Lee MJ, Schmierer J, Zeck G

J Neural Eng. 2021 Apr 6;18(5). doi: 10.1088/1741-2552/abe39a. PMID: 33545694.
Human Cerebrospinal Fluid Induces Neuronal Excitability Changes in Resected Human Neocortical and Hippocampal Brain Slices

Wickham J, Corna A, Schwarz N, Uysal B, Layer N, Honegger J B, Wuttke T V, Koch H, Zeck G

Front. Neurosci., 2020 (14), https://doi.org/10.3389/fnins.2020.00283
Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retina

Höfling L, Oesterle J, Berens P, Zeck G

Scientific reports, 2020, 10(1), https://www.nature.com/articles/s41598-020-61899-y
Electrode-size dependent thresholds in subretinal neuroprosthetic stimulation

Corna A, Herrmann T, Zeck G.

J Neural Eng. 2018 Aug;15(4):045003. doi: 10.1088/1741-2552/aac1c8. Epub 2018 May 2.
Functional characterization of the retinal output upon optogenetic stimulation

M Reh, M Kriebel, R Thewes and G Zeck

MEA Meeting 2018; Reutlingen, Deutschland. doi:10.3389/conf.fncel.2018.38.00045
Combining two photon microscopy and CMOS MEA to uncover the mechanism of aberrant activity in blind retina

Lee M-J, Srivastava P, Rogerson L, Berens P, Euler T, Schubert T, Zeck G

MEA Meeting 2018, 10.3389/conf.fncel.2018.38.00022, 2018
Evaluation of short pulse laser damage to the retinal pigment epithelium layer

Ramos S, Reh M, Zeck G, Heussner N

Biophotonics: Photonic Solutions for Better Health Care VI. 2018 April; 10685.
A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo

Yger P, Spampinato GLB, Esposito E, Lefebvre B, Deny S, Gardella C, Zeck G, Picaud S, Duebel J, Marre O

Elife. 2018 Mar 20;7. pii: e34518. doi: 10.7554/eLife.34518.
Investigation of the functional retinal output using Microelectrode arrays

Zeck G

Methods Mol Biol. 2018;1695:81-88. doi: 10.1007/978-1-4939-7407-8_8.
Subretinal electrical stimulation reveals intact network activity in the blind mouse retina

Stutzki H, Helmhold F, Eickenscheidt M, Zeck G

J Neurophysiol. 2016 Oct 1;116(4):1684-1693. doi: 10.1152/jn.01095.2015. Epub 2016 Jul 13.
Unsupervised neural spike sorting for high-density microelectrode arrays with convolutive independent component analysis

Leibig C, Wachtler T, Zeck G

J Neurosci Methods. 2016 Sep 15;271:1-13. doi: 10.1016/j.jneumeth.2016.06.006. Epub 2016 Jun 15.
Electrochemical noise and impedance of Au electrode/electrolyte interfaces enabling extracellular detection of glioma cell populations

Rocha PR, Schlett P, Kintzel U, Mailander V, Vandamme LK, Zeck G, Gomes HL, Biscarini F, de Leeuw DM

Sci Rep. 2016 Oct 6;6:34843. doi: 10.1038/srep34843.
Visualizing Epithelial-Mesenchymal Transition Using the Chromobody Technology

Maier J, Traenkle B, Rothbauer U

Cancer Res. 2016 Oct 1;76(19):5592-5596. Epub 2016 Sep 15.
PEDOT-CNT coated electrodes stimulate retinal neurons at low voltage amplitudes and low charge densities

Samba R, Herrmann T, Zeck G

J Neural Eng. 2015 Feb;12(1):016014. doi: 10.1088/1741-2560/12/1/016014. Epub 2015 Jan 14.
Aberrant activity in degenerated retinas revealed by electrical imaging

Zeck G

Frontiers in Cellular Neuroscience. 2016; 10 :15. doi: 10.3389/fncel.2016.00025
Hypothermia Protects and Prolongs the Tolerance Time of Retinal Ganglion Cells against Ischemia

Schultheiss M, Schnichels S, Hermann T, Hurst J, Feldkaemper M, Arango-Gonzalez B, Ueffing M, Bartz-Schmidt KU, Zeck G, Spitzer MS

PLoS One. 2016 Feb 5;11(2):e0148616. doi: 10.1371/journal.pone.0148616. eCollection 2016.
PEDOT-CNT coated electrodes stimulate retinal neurons at low voltage amplitudes and low charge densities

Samba R, Herrmann T, Zeck G

J Neural Eng. 2015 Feb;12(1):016014. doi: 10.1088/1741-2560/12/1/016014. Epub 2015 Jan 14.
Daylight vision repair by cell transplantation

Santos-Ferreira T, Postel K, Stutzki H, Kurth T, Zeck G, Ader M

Stem Cells. 2015 Jan; 33(1):79-90. doi: 10.1002/stem.1824.
Rhythmic Ganglion Cell Activity in Bleached and Blind Adult Mouse Retinas

Menzler J, Channappa L, Zeck G

PLoS One. 2014 Aug 25;9(8):e106047. doi: 10.1371/journal.pone.0106047. eCollection 2014.
Action potentials in retinal ganglion cells are initiated at the site of maximal curvature of the extracellular potential

Eickenscheidt M, Zeck G

J Neural Eng. 2014 Jun;11(3):036006. doi: 10.1088/1741-2560/11/3/036006. Epub 2014 Apr 24.
Inflammatory stimulation preserves physiological properties of retinal ganglion cells after optic nerve injury

Stutzki H, Leibig C, Andreadaki A, Fischer D, Zeck G

Front Cell Neurosci. 2014; 8: 38. doi: 10.3389/fncel.2014.00038
Axonale Leitungsgeschwindigkeiten in der Kaninchenretina gemessen mit Multitransistorarray

Thoma M

Diplomarbeit. Physik-Department, Technische Universität München. 2012. 61 Seiten.
A Comprehensive Small Interfering RNA Screen Identifies Signaling Pathways Required for Gephyrin Clustering

Wuchter J, Beuter S, Treindl F, Herrmann T, Zeck G, Templin MF, Volkmer H

The Journal of Neuroscience. 2012 Oct 17; 32(42):14821–14834
Electrical stimulation of retinal neurons in epiretinal and subretinal configuration using a multicapacitor array

Eickenscheidt M, Jenkner M, Thewes R, Fromherz P, Zeck G

J Neurophysiol. 2012 May;107(10):2742-55. Epub 2012 Feb 22.
Extracellular voltage noise probes the interfaces between retina and silicon chip

Zeitler R, Fromherz P, Zeck G

Applied Physics Letters. 2011 Dec; 99: 263702. DOI 10.1063/1.3672224
Axonal transmission in the retina introduces a small dispersion of relative timing in the ganglion cell population response

Zeck G, Lambacher A, Fromherz P

PLoS One. 2011;6(6):e20810. Epub 2011 Jun 2.
Network oscillations in rod-degenerated mouse retinas

Menzler J, Zeck G

J Neurosci. 2011 Feb 9;31(6):2280-91. DOI: 10.1523/JNEUROSCI.4238-10.2011

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