Dr. Frank Weise

Areas of activity

We focus on the analysis of cellular responses to gene expression in order to validate target genes for the pharmaceutical industry. Furthermore, we aim at developing improved cell culture models (co-culture, inflammatory response to exposure to hazardous substances), which, due to their more physiological nature, allow higher predictivity.

Stages of career

since 2009 Group leader of Target Expressions Systems

2002 - 2009 Head of laboratory in the Dept. of Molecular Biology

1998 - 2002 Post-doctoral fellow at the Max Planck Institute of Biology, Tübingen

1997 Doctoral degree at the Free University of Berlin (bacteriophage DNA replication)

1994 - 1996 Doctoral fellow at the National Centre of Biotechnology, Madrid, Spain

1987 - 1993 Student of biochemistry at the Free University of Berlin


Dr. Frank Weise
T +49 (0)7121 51530-56


  • Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity
    Becker M, Strengert M, Junker D, Kaiser P, Kerrinnes T, Traenkle B, Dinter H, Häring J, Ghozzi S, Zeck A, Weise F, Peter A, Hörber S, Fink S, Ruoff F, Dulovic A, Bakchoul T, Baillot A, Lohse S, Cornberg M, Illig T, Gottlieb J, Smola S, Karch A, Berger K, Rammensee HG, Schenke-Layland K, Nelde A, Märklin M, Heitmann JS, Walz JS, Templin M, Joos TO, Rothbauer U, Krause K & Schneiderhan-Marra N
    NATURE COMMUNICATIONS | (2021) 12:1152 | https://doi.org/10.1038/s41467-021-20973-3 | www.nature.com/naturecommunications
  • A touch of glue to complete bacteriophage assembly: the Tail-to-Head Joining Protein (THJP) family
    Auzat I, Petitpas I, Lurz R, Weise F, Tavares P
    Mol Microbiol. 2014 Jan 21;91(6): 1164-1178. doi: 10.1111/mmi.12526.
  • A New In Vitro Model to Study Cellular Responses after Thermomechanical Damage in Monolayer Cultures
    Hettler A, Werner S, Eick S, Laufer S, Weise F
    PLoS One. 2013; 8(12): e82635. doi: 10.1371/journal.pone.0082635
  • Cell-based microarrays of infectious adenovirus encoding short hairpin RNA (shRNA)
    Volkmer H, Weise F
    Methods Mol Biol. 2011;706:97-106.
  • A novel reverse transduction adenoviral array for the functional analysis of shRNA libraries
    Oehmig A, Klotzbucher A, Thomas M, Weise F, Hagner U, Brundiers R, Waldherr D, Lingnau A, Knappik A, Kubbutat, MH, Joos TO, Volkmer H
    BMC Genomics. 2008 Sep 24;9:441. doi: 10.1186/1471-2164-9-441.
  • Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein in Trypanosoma brucei.
    Engstler M, Thilo L, Weise F, Grunfelder CG, Schwarz H, Boshart M, Overath P
    J Cell Sci. 2004 Mar 1;117(Pt 7):1105-15. DOI: 10.1242/jcs.00938
  • Endocytosis of a glycosylphosphatidylinositol-anchored protein via clathrin-coated vesicles, sorting by default in endosomes, and exocytosis via RAB11-positive carriers.
    Grunfelder CG, Engstler M, Weise F, Schwarz H, Stierhof YD, Morgan GW, Field MC, Overath P
    Mol Biol Cell. 2003 May;14(5):2029-40. Epub 2003 Feb 6. doi: 10.1091/mbc.E02-10-0640