People

Nicole Anderle
Scientist Tumor Biology
T +49 (0)7121 51530-867
F +49 (0)7121 51530-62
Christine Dürr
Technical assistant Tumor Biology
T +49 (0)7121 51530-77
F +49 (0)7121 51530-62
Anna-Lena Keller
Scientist Tumor Biology
T +49 (0)7121 51530-868
F +49 (0)7121 51530-62
Dr. Christian Schmees
Group Leader Tumor biology
T +49 (0)7121 51530-881
F +49 (0)7121 51530-16

Research interests

  • Patient-derived ex-vivo tumor models and their application in preclinical compound efficacy testing
  • Tumor-Immune cell interactions with a focus on T lymphocytes and macrophages
  • Optogenetic modulation of cell-cell communication and cell signalling
  • CRISPR-based genome editing for target validation and cell engineering

 

Academic career

since 2014
Head of Tumor Biology, NMI

2011 - 2014
Senior Scientist, Tumor Biology Group, NMI

2010 - 2011
Senior Scientist at the Department of Systemic Cell Biology (Prof. Philippe Bastiaens), Max-Planck-Institute of Molecular Physiology, Dortmund, Germany

2006 – 2010
Research Fellow at the Ludwig Institute for Cancer Research (LICR; Prof. Carl-Henrik Heldin) Uppsala, Sweden (Scholarships from LICR and DFG (German Research Foundation) “Investigation of Differences in Regulation of intracellular trafficking of PDGF α- and β-receptors”

2002 – 2006
PhD in Tumor Immunology at the Department of Medicine II, Technical University of Munich, Germany

1996 – 2002
Biochemistry studies at the University of Halle-Wittenberg and University of Tübingen, Germany;
Degree: Diploma

Publications

Schmees C, Villaseñor R, Zheng W, Ma H, Zerial M, Heldin CH, Hellberg C. Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V. Mol Biol Cell. 2012 Jul;23(13):2571-82.

Hellberg C, Schmees C, Karlsson S, Ahgren A, Heldin CH. Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling. Mol Biol Cell. 2009 Jun;20(12):2856-63.

Schmees C, Gerhard M, Treptau T, Voland P, Schwendy S, Rad R, Prinz C. VacA-associated inhibition of T-cell function: reviewed and reconsidered. Helicobacter. 2006 Jun;11(3):144-6.

Schmees C, Prinz C, Treptau T, Rad R, Hengst L, Voland P, Bauer S, Brenner L, Schmid RM, Gerhard M. Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase. Gastroenterology. 2007 May;132(5):1820-33.

Gerhard M, Schmees C, Voland P, Endres N, Sander M, Reindl W, Rad R, Oelsner M, Decker T, Mempel M, Hengst L, Prinz C. A secreted low-molecular-weight protein from Helicobacter pylori induces cell-cycle arrest of T cells. Gastroenterology. 2005 May;128(5):1327-39.

Dr. Simge Yüz
Scientist Tumour biology
T +49 (0)7121 51530-867
F +49 (0)7121 51530-62

Areas of activity:
Patient-derived ex-vivo 3D tumor models and their preclinical application in compound efficacy testing
Cell interactions between patient-derived tumor cells and autologous T lymphocytes
Modulation of cell-cell communication and signaling with optogenetics

Stages of career:
since 2018   Postdoctoral researcher, NMI

2014-2018   PhD in Biosciences, MPI for Medical Research/University of Heidelberg, Heidelberg
Mentor: Prof. Dr. Joachim P. Spatz
Title: Re-programming cell interactions with light-dependent heterodimers

2012-2014   M. Sc. in Biology, LMU, Munich/Germany

2007-2012  B.Sc. in Biology, METU, Ankara/Turkey

2006-2011   B.Sc. in Chemistry, METU, Ankara/Turkey

Publications:
Yüz SG, Ricken J, Wegner SW. Independent Control over Multiple Cell Types in Space and Time Using Orthogonal Blue and Red Light Switchable Cell Interactions. Advanced Science. 2018 Aug; 5(8): 1800446.

Yüz SG, Rasoulinejad S, Müller M, Wegner AE, Wegner SW. Blue Light Switchable Cell-Cell Interactions Provide Reversible and Spatiotemporal Control Towards Bottom-Up Tissue Engineering. Advanced Biosystems. 2019 Jan 18, https://doi.org/10.1002/adbi.201800310

Student Assistants

Anja Pohl
Student Assistant Tumor Biology