Areas of activity
Development of patient-derived preclinical tumor models, immuno-oncology with focus on autologous T cells, macrophages and dendritic cells
Stages of career
09/2018 - Present Doktorandin, Tumorbiologie, NMI
08/2017 - 10/2017 Research Scholar, California Pacific Medical Center Research Institute, San Francisco
05/2016 - 09/2016 Research Intern, Tumorbiologie, NMI
2014 - 2018 Molecular Cell Biology and Immunology (Master of Science), Eberhard Karls Universität Tübingen
2012 - 2014 Biology (Bachelor of Science), Universität Hohenheim
Stages of career
Since 2022 Head of Department Biomedicine and Material Sciences, NMI, Reutlingen
2017 - 2021 Head of Department, Analytical Chemistry, Core Facility University of Hohenheim
2010 - 2017 Group Leader, Institute of Interfacial Engineering and Plasma Technology, University of Stuttgart
2010 - 2017 Project Manager, Interfacial Engineering and Materials Science, Fraunhofer Institute for Interfacial Engineering and Biotechnology (part-time position)
2001 - 2010 Team leader in the field of bioinorganic chemistry, Institute of Inorganic Chemistry, University of Stuttgart
1998 - 2001 Postdoc, Institute of Inorganic Chemistry, University of Stuttgart
1990 - 1993 PhD, Institute of Inorganic Chemistry, University of Stuttgart, on homogeneously catalytically relevant rhodium and iridium complexes for hydride transfer reactions
11/1988 - 12/1989 Research Assistant, Institute of Inorganic Chemistry, TU Munich
10/1982 - 10/1988 Study of Chemistry, TU Munich
Areas of activity
Microfluidics for applications as Lab on a Chip, for separation of biological particles, sample preparation in microfluidics systems, joining technologies for microfluidics, integration of electrodes in microfluidics.
Stages of career
2007 PhD in microsystems technology on immobilization of proteins in hydrogel microarrays on polymer substrates
2003 - 2007 Scientific assistant at the Chair of Chemistry and Physics of Interfaces, Institute for Microsystems Technology, University of Freiburg
1998 - 2003 Studied microsystems technology at the University of Freiburg.
Areas of activity
Nanotechnology, nanolithography with electron and ion beams, electron beam and ion beam induced material deposition (additive nanolithography), electron microscopy, development of preparation methods, thin film technology, microsystems technology
Stages of career
2018 - Present Group Leader Applied Materials Science and Electron Microscopy
2008 - 2017 Group Leader Microsystems and Nanotechnology
1998 - 2007 Research Associate at the NMI, Project Manager
1995 - 1997 Research assistant at the Hearing Research Centre Tübingen
1997 Doctorate at the University of Tübingen
1986 - 1992 Research Assistant, PhD Student, University of Tübingen, Institute of Applied Physics
1979 - 1986 Physics studies, University of Tübingen
Areas of activity
assay development (miniaturized, parallelized assay systems and convetional sandwich-ELISA's), anitbody characterisation and validation, contract research measurements, DigiWest
Stages of career
2001 - Present Technical assistant assay development
1990 - 2001 Staff Member ("Kreiskliniken Reutlingen, Institut für Labordiagnostik")
1988 - 1990 Education: technical assistant ("Staatlich anerkannte Lehranstalt für Technische Assistenten in der Medizin am Hygieneinstitut der Universität Tuebingen")
Areas of activity
Development, validation and screening of multiplex serological immunoassays for the detection of pathogen infection
Implementation of multiplex serological immunoassays in epidemiological cohorts
Automation of multiplex immunoassay screening
Development of multiplex immunoassays in proteome research for pharmaceutical and clinical applications
Stages of career
Since 2022 – today Deputy Group Leader Multiplex Immunoassays
2020 – 2022 – Postdoc and Project Manager, Multiplex Immunoassays at the NMI
2020 – Postdoc, Max Planck Institute for Biology, Tübingen
2015 – 2019 – Dr.rer.nat, Max Planck Institute for Biology, Tübingen, supervised by Apl Prof. Adrian Streit
2013 – 2014 – MSc in Industrial and Commercial Biotechnology at Newcastle University, UK
2010 – 2013 – BSc in Bioveterinary Sciences at the University of Liverpool, UK
Areas of Activity
DigiWest, cellular signaling, protein profiling
Stages of career
2018 - Present Scientist / Ph.D. student (Assay Development) at the NMI
2017 - 2018 Scientist, Cellendes GmbH, Reutlingen
2016 - 2017 Certified food chemist, CVUA Sigmaringen
2009 - 2015 Food chemistry studies (diploma), Karlsruhe Institute of Technology
Areas of activity
primary cell cultures (musculoskeletal cell types), Adhesion / Vitality Experiments, assay-based characterization of the performance of cell biomaterial cultures, Identification of prognostic markers for autologous chondrocyte transplants
Stages of carees
2008 - Present Research Associate, Department of Regenerative Medicine II, NMI
2006 - 2007 Studies Biomedical Engineering (Master of Science) at the Albstadt- Sigmaringen University of Applied Sciences
2002 - 2006 Study of Biotechnology (Bachelor of Engineering) at the Furtwangen University of Applied Sciences
Areas of activity
Surface modification and electrochemistry for sensor applications
Stages of career
2006 - 2009 Further education in mathematics and physics and studies of nanobiotechnology, TU Kaiserslautern (DISC)
2006 - 2009 Further education in mathematics and physics and studies of nanobiotechnology, TU Kaiserslautern (DISC)
1999 - 2006 Dipl. Biologist, University of Bayreuth, Diploma thesis with Prof. Dr. Erwin Beck, Plant Physiology on effects of artificial auxins on cell division and elongation growth of tobacco cell cultures
1999 Process control, Hoechst Trevira GmbH & Co KG in Bobingen
1996 - 1999 Apprenticeship as chemical laboratory assistant, Hoechst Trevira GmbH & Co KG, Bobingen
1995 - 1996 Studied Mathematics, University of Augsburg
Areas of activity
Optimization during the development of microfluidic systems using numerical simulations, Development of LabVIEW-based software, e.g. for the control of microfluidic components
Stages of career
2018 - Present Groupleader IT
2008 - 2018 Research associate in the group BioMEMS and Sensor Technology
2007 / 2008 Diploma thesis at the NMI in the group BioMEMS and Sensor Technology, implementation and simulation of physical models in FlexPDE® for the description of particle transport in liquids according to local application
1999 - 2008 Studied Bioinformatics at the Eberhard Karls University Tübingen
Areas of activity
Characterization of surface properties (physicochemical, biological), Coating / modification of surfaces: Regulation of the adhesion of proteins, bacteria, cells, Analysis and functionalization of biodegradable materials, Immobilization and controlled release of active substances, Biomaterial processing: bioprinting, electrospinning, Services and R&D for Medical device companies
Stages of career
2017 - Present Head of Department Biomedicine and Materials Sciences, NMI, Reutlingen
2016 - Present Group leader Regenerative Biomaterials, NMI, Reutlingen
2015 - 2016 Deputy Group Leader Biomaterials, NMI, Reutlingen
2013 - 2015 Project leader, Group Biomaterials NMI, Reutlingen
2008 - 2013 Scientist, Group Regenerative Medicine I, NMI, Reutlingen
2007 - 2008 Post-Doc, Institute for Medical Microbiology and Hygiene, University of Tübingen,
2003 - 2006 PhD, Institute for Medical Microbiology and Hygiene, University of Tübingen, on host cell response after bacterial infection: apoptosis inhibition, HIF-1 activation
2002 - 2003 Diploma thesis, Chair of Biotechnology, University of Würzburg, on biocompatibility and functionality of biomaterials for immunoisolated transplantation of mammalian cells
1998 - 2002 Biology studies, University of Würzburg, Germany
Areas of activity
HPLC, Size exclusion chromatography, MALDI-TOF, polymer analytics, polyelectrolyte multilayers, degradation of polyesters, peptides
Stages of career
2018 - Present Laboratory Assistant NMI, Group Biofuncationalized Surfaces
2008 - 2018 Laboratory Assistant NMI, Group Biomaterials
1993 - 2008 Laboratory Assistant Group NMI Peptides (Peptide synthesis and analytics)
1990 - 1993 Training Laboratory Assistant, University of Tuebingen (Institute for Biochemistry)
Areas of activity
Electrical stimulation and derivation of nerve cells in tissue sections and cell culture. Analysis of activity patterns of neuronal networks in vitro. Characterization of microelectrode arrays. Development, support and application of MEA technology.
Stages of career
1999 - Present Scientific assistant at the NMI Reutlingen
1988-1998 Study of Physics at the University of Tübingen, Diploma Thesis at the NMI Reutlingen
Areas of activity
nanotechnology, neurotechnology, microfluidics, microsensors, elektrochemical sensors, nanopores, nanofluidics, electrophysiology, neuro implants, microelectrode arrays
Stages of career
01/2012 - Present NMI Natural and Medical Sciences Institute at the University of Tuebingen
01/2018 - Present Group Leader, Biomedical Micro and Nano Engineering
07/2015 - 12/2017 Scientist, Microsystems and Nanotechnology
01/2012 - 06/2015 Scientist, BioMEMS and Sensors
2013 - Present Deputy Director, NMI
2008 - 2014 Director Strategic Alliances, EDI GmbH, Reutlingen (part time)
1984 – 1990 Study of Biochemistry, University of Tübingen
He is a member of the Scientific Advisory Board of the Plasma Proteomics Institute in Washington, DC, USA and a member of the Scientific Advisory Board of Myriad RBM Inc. in Austin, Texas, USA.
Dr. Joos is the author of >100 scientific papers. He is recognized worldwide as an expert and opinion leader in the technology field of biomarkers and their clinical applications and basic research.
Dr. Joos is co-founder of SIGNATOPE GmbH, Reutlingen. SIGNATOPE develops innovative protein tests with which biomarkers for organ damage and drug interactions can be detected in all pharma-relevant species.
Areas of activity
polymer / polyelectrolyte thin films, nano technology, biomaterials, solid / liquid surfaces, foams
Stages of career
2011 - 2018 Head of Bioorganic Chemistry and Bioanalytics Division
2008 - 2018 Head of Biomaterials working group at the NMI
2005 - 2008 Research Associate at the Max Planck Institute for Colloids and Interfaces (MPI KG), Group Leader - Soft Thin Films
2002 - 2005 Scientific research (neutron reflectometry) Hahn-Meitner Institut, Berlin
1996 - 2002 PostDoc / Scientific employee at MPI KG, Dept. Interfaces, Golm/Potsdam
1996 Doctorate at the University of Sofia
1993-1998 Research stay at Bristol University, GB
1986 - 1995 Junior Professor of Physical Chemistry and Surface Chemistry (University of Sofia, Bulgaria)
1985 Diploma, Chemistry - Inorganic and Physical Chemistry
Ares of activity
Function and dynamics of ion channels at the cellular level and in organo-near systems (acute and organotypic tissue preparations, cell clusters). Special emphasis is put on the clarification of neurobiological and cardiorelevant questions.
Stages of career
2007 - Group leader electrophysiology
2004 - 2007 Research associate at Saarland University Hospital, Molecular Cell Biology Prof. Lipp
2002 - 2004 Postdoctoral Associate Yale University, USA, Neurobiology Prof. McCormick
2000 - 2002 Scientific assistant at the University of Freiburg, Physiology I Prof. Jonas
1995 - 2000 PhD on synaptic transmission in the hippocampus
1995 Diploma in Biology University of Kaiserslautern, Zoology Prof. Deitmer
Areas of activity
Light microscopic methods (confocal, wide field microscopy; high content analysis), Neuronal model systems in vitro and in vivo, Drug testing in neuronal culture systems, Molecular genetic knockdown methods (shRNA, miRNA, siRNA) in vitro and in vivo, Individualized lentiviral transduction systems, Immunocyto-, histochemistry; 3D-reconstruction of biological sample material, Non-marking detection method
Stages of career
2008 - Present project manager, Department of Molecular Neurobiology, NMI
2005 - 2008 Research associate at the Department of Molecular Biology, NMI
2005 Postdoctoral research fellow, Institute for Developmental Biochemistry, Georg-August-Universität Göttingen
2005 PhD in Developmental Biology at the Georg-August-University Göttingen on morphogenetic factors of head development in vertebrates
1996 - 2001 Study of Biology at the Georg-August-Universität Göttingen
1995 - 1996 Study of Social Sciences with focus on Economics, Psychology at the Justus-Liebig-University Gießen, Germany
Areas of activity
Organ-on-Chip Systems, Cell and Tissue Technologies, Experimental Regenerative Medicine, Biomechanics
Stages of career
05/2021 - present Full Professor for Organ-on-Chip Systems, Department of Biomedical Engineering, Faculty of Medicine Eberhard Karls University Tübingen, Tübingen, Germany
05/2021 - present Head of Organ-on-Chip Group Department of Biomedicine and Materials Sciences, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany
11/2018 - present Coordinator of the EUROoC PhD training program
03/2016 - present Advisor for PhD students and (under)graduate researchers, NMI, Fraunhofer IGB & University of Tübingen
06/2019 – 04/2021 Head of Innovation Field Cell and Tissue Technologies, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart, Germany
01/2018 – 04/2021 Assistant Professor for Experimental Regenerative Medicine, Department of Women’s Health, Faculty of Medicine Eberhard Karls University Tübingen, Tübingen, Germany
03/2016 – 05/2019 Fraunhofer Attract Group Leader Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart, Germany
Stages of career
since 2012 NMI, Project leader Nano analytics, Head of NMI Nano analytic laboratory, Physicist2007 - 2012 Senior experimental Officer, Marie-Curie senior research fellow (EU/FP7), CRANN/Trinity College, Dublin, Ireland
2005 - 2007 Staff engineer, Physicis, Qimonda, Dresden, Germany
2004 - 2005 Senior researcher, Physicist, Infineon, Cooperate Research (CPR) Munich, Germany
1999 - 2004 Senior engineer, Physicist, Infineon, Mask House, Munich, Germany
1997 - 1999 Physicist; Masterstudent, NMI Reutlingen,Germany
1997 - 1998 Kleindiek Nanotechnik, Reutlingen, Germany
Research interests
- cleaning validation
- corrosion investigations
- process analytics
Curriculum vitae
Since January 2019 Group Leader "Interface Characterization in the Production Process" at the NMI Reutlingen
2012 - 2018 Project Manager Medical Technology at the NMI Reutlingen
2007 - 2012 Product Manager at ancosys GmbH
2004 - 2007 Technical Editor at ancosys GmbH
2002 - 2004 Technical editor with focus on multimedia at Tanner Documents in Reutlingen, Germany
1999 - 2002 Programming of multimedia lecture contents as scientific employee at the University of Tübingen
1995 - 1999 Parental leave
1992 - 1995 PhD in Physical Chemistry at the University of Tübingen
1984 - 1991 Study of Chemistry at the University of Tübingen
Stages of career
since 2022 Group Leader Biophotonics & Spectroscopy, NMI, Reutlingen
since 2020 Scientist, Department for Medical Technologies and Regenerative Medicine, University of Tübingen
2019 – 2021 Scientist, Regenerative Biomaterials Group, NMI, Reutlingen
2015 – 2019 Dissertation, Research Institute for Women’s Health, University Hospital Tübingen
2014 Approbation as Pharmacist
2013 – 2014 Diploma Thesis, Pharmaceutical Technology, Teva GmbH, Ulm
2009 – 2013 Studies of Pharmacy, University of Freiburg
Arbeitsgebiete
Entwicklung, Validierung und Automatisierung sowie Screening multiplexer Immunoassays
- - für die Infektionsdiagnostik
- - für epidemiologische Studien
- - für die klinische Forschung
- - für pharmazeutische und klinische Anwendungen
- - für die Vakzinentwicklung
Einführung neuer Screening-Technologien, z. B. der Transfer von Serum- zu DBS-Screenings
Werdegang mit den wichtigsten Stationen
seit 2021 Post-Doc Wissenschaftlerin und Projektleiterin am NMI Reutlingen
2016-2021 Promotion (Dr. rer. nat.), Graduiertenschule Chemische Biologie „Fast-Track-Programm“
(KoRS-CB) mit Stipendium und Wissenschaftliche Angestellte, Exzellenzinitiative Universität Konstanz, Arbeitsgruppe Prof. Dr. Christof R. Hauck (Zellbiologie, Infektionskrankheiten)
2015 Forschungsaufenthalt am Pathologischen Institut Bern, Schweiz
2014-2016 MSc in Life Sciences an der Universität Konstanz
2011-2014 Bsc in Life Sciences an der Universität Konstanz
Areas of activity
Micro- and Nanotechnology, thin film technology, Electron and ion beam technology, Electron microscopy and microanalysis, Vacuum and cryo technology
Stages of career
2013 - present Senior Scientist, Nanoanalytics, Retirement, NMI Reutlingen
1987 - 2013 Group Leader and Project Leader Technical Physics, NMI Reutlingen
1985 - 1978 Scientist Materials Analysis, Electron Microscopy, MPA University Stuttgart
1980 - 1985 Scientific employee and PhD student, Institute of Applied Physics, University of Tübingen
1987 Doctorate Dr. rer. nat. , University of Tübingen Studies of Physics, University of Munich and University of Tübingen
Areas of activity
- Development and application of protein microarrays and miniaturized multiplex immunoassays for proteome research
- Research, development and service projects with partners in the pharmaceutical industry and clinical research
- Reverse-phase protein arrays (RPA) for the analysis of protein signal transduction in treated cell systems and tissues (tumors)
- Investigations into the elucidation of disease mechanisms
- Mechanisms of action of drug candidates
- Search for early diagnostic, pharmacodynamic and predictive biomarkers for use in individual medicine
Stages of career
since 04/2005 Group leader Protein Profiling at the NMI
1999 - 2005 Co-founder of Zeptosens in Witterswil, Switzerland (SpinOff Novartis, now Bayer Technology Services) and Director Protein Microarrays; responsible for the development and commercialization of microarray solutions for proteomics; (co-)inventor of numerous patents
1994 - 1999 Novartis Pharma AG, Basel, Switzerland
Laboratory Manager In Vitro Metabolism, ADME, Preclinical Drug Development
Head of Bioanalytical Research Laboratory (formerly Ciba-Geigy AG), significantly involved in the development of optical planar waveguide technology, basic patents.
1991 - 1994 Postdoctoral student at the Institute of Physical Chemistry of Polymers and Membranes, Working Group for Biomembranes (Prof. Horst Vogel), Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland; development of electrical and optical biosensors, membrane receptor assays.
1988 - 1991 Doctoral thesis at the Biocenter of the University of Basel, Institute for Biophysical Chemistry; electrical single channel measurements, peptide-based pore forming toxins
1982 - 1988 University of Würzburg; studies of physics, subsidiary subject Biotechnology
Areas of activity
Biochemistry, development of mass spectrometry-based immunoassays, drug-drug interactions, molecular responses of cells and tissues to xenobiotics, validation of safety biomarkers.
Stages of career
2016 - present Managing Director of SIGNATOPE GmbH.
2010 - 2016 Group leader protein analytics, NMI
2014 - present Chair of the GBM Working Group Bioanalytics
Stages of career
since Oct. 2018 Head of Administration of the NMI
Nov. 2015 - Sep. 2018 Head of Administration of the Fraunhofer Institute for Interfacial Engineering and Biotechnology
Apr. 2009 - Oct. 2015 Head of Human Resources, Deputy Head of Administration
Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart
Sep. 1999 - March 2009 Human Resources, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart
Stages of career
since 2018 Director, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany
since 2018 Co-Editor-in-Chief, Tissue Engineering, Part B (Mary Ann Liebert)
since 2011 Full Professor (W3), Eberhard Karls University Tübingen (EKUT), Institute for Biomedical Engineering, Department of Medical Technology and Regenerative Medicine, Tübingen, Germany
2013 - 2018 Adjunct Associate Professor, UCLA, Dept. of Medicine/ Cardiology, Los Angeles, CA, USA
2016 - 2017 Director (interim, executive), Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Stuttgart, Germany
2010 - 2014 ATTRACT-Group Leader, Fraunhofer IGB, Stuttgart, Germany
2010 - 2013 Deputy Department Head, Fraunhofer IGB, Dept. of Cell and Tissue Engineering, Stuttgart, Germany
2008 - 2009 Assistant Research Professor, UCLA, Dept. of Medicine/ Cardiology, Los Angeles, CA, USA
2005 - 2008 Postdoctoral Research Fellow, UCLA, Cardiovascular Research Laboratories, Los Angeles/CA, USA
2004 - 2005 Postdoctoral Research Fellow, Children’s Hospital Los Angeles, Saban Research Institute, Los Angeles/CA, USA
2001 - 2004 PhD in Biology/ Cardiovascular Tissue Engineering, Friedrich Schiller University (FSU) Jena, Germany
1995 - 2000 M.Sc. in Biology, Sociology, Psychology, Friedrich Schiller University (FSU) Jena, Germany
Further Information: Schenke-Layland Lab
Areas of activity
Patient-derived ex-vivo tumor models and their application in preclinical compound efficacy testing, Tumor-Immune cell interactions with a focus on T lymphocytes and macrophages, Optogenetic modulation of cell-cell communication and cell signalling, CRISPR-based genome editing for target validation and cell engineering
Stages of career
since 2014 Head of Tumor Biology, NMI
2011 - 2014 Senior Scientist, Tumor Biology Group, NMI
2010 - 2011 Senior Scientist at the Department of Systemic Cell Biology (Prof. Philippe Bastiaens), Max-Planck-Institute of Molecular Physiology, Dortmund, Germany
2006 – 2010 Research Fellow at the Ludwig Institute for Cancer Research (LICR; Prof. Carl-Henrik Heldin) Uppsala, Sweden (Scholarships from LICR and DFG (German Research Foundation) “Investigation of Differences in Regulation of intracellular trafficking of PDGF α- and β-receptors”
2002 – 2006 PhD in Tumor Immunology at the Department of Medicine II, Technical University of Munich, Germany
1996 – 2002 Biochemistry studies at the University of Halle-Wittenberg and University of Tübingen, Germany;
Degree: Diploma
Publications
Schmees C, Villaseñor R, Zheng W, Ma H, Zerial M, Heldin CH, Hellberg C. Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V. Mol Biol Cell. 2012 Jul;23(13):2571-82.
Hellberg C, Schmees C, Karlsson S, Ahgren A, Heldin CH. Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling. Mol Biol Cell. 2009 Jun;20(12):2856-63.
Schmees C, Gerhard M, Treptau T, Voland P, Schwendy S, Rad R, Prinz C. VacA-associated inhibition of T-cell function: reviewed and reconsidered. Helicobacter. 2006 Jun;11(3):144-6.
Schmees C, Prinz C, Treptau T, Rad R, Hengst L, Voland P, Bauer S, Brenner L, Schmid RM, Gerhard M. Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase. Gastroenterology. 2007 May;132(5):1820-33.
Gerhard M, Schmees C, Voland P, Endres N, Sander M, Reindl W, Rad R, Oelsner M, Decker T, Mempel M, Hengst L, Prinz C. A secreted low-molecular-weight protein from Helicobacter pylori induces cell-cycle arrest of T cells. Gastroenterology. 2005 May;128(5):1327-39.
Areas of activity
Development, validation and screening with antigen arrays and multiplex serological immunoassays for the detection of pathogen infection
, Development and application of miniaturized multiplexed immunoassays in proteome research for pharmaceutical and clinical applications
Stages of career
Since 2020 Head of Department Pharma and Biotech
11/2019 - 2020 Deputy Head of Department Pharma and Biotech
since 01/2018 Head of Biochemistry
06/2007 – 12/2017 Deputy Head of Department Biochemistry
05/2005 Project manager and laboratory manager at the NMI Reutlingen
2003 - 2005 Scientific employee at the University of Ulm, University Women's Hospital, Endocrinological and Oncological Laboratory, working group Prof. Helmut Deißler
2002 External PhD thesis (Dr. rer. nat) at the University of Tübingen, supervised by Prof. Bernhard Brüne (Medical Clinic IV, Nephrological Research Laboratories, University of Erlangen) and Prof. Dieter Mecke (University of Tübingen), Title: Molecular Mechanism of Nitric Oxide Mediated Accumulation of Tumor Suppressor p53
2011 Internship at "MD Anderson" in the group of Assistant Professor Yanping Zhang, Houston, Texas, USA
1992 - 1998 Study of Biochemistry at the Eberhard-Karls-Universität Tübingen
Areas of activity
FIB/SEM Crossbeam, cryomicroscopy, preparation methods, Analytics of biological-technical interfaces, electron microscopy
Stages of career
Since 2009 research associate in the Microsystems and Nanotechnology Group at the NMI
2011 PhD in Applied Physics on the development of an ion optical transfer system for a mass spectrometer
2004 - 2009 Research Assistant at the Institute of Applied Physics, Working Group Electron and Ion Optics
1997 - 2004 Study of physics at the Eberhard-Karls University Tübingen
Areas of activity
Cellular signalling pathways, tumor biology, Biomarker identification and validation, assay development, miniaturized assay systems
Stages of career
since 2003 group leader assay development
2000 - today NMI
1996 - 2000 Research associate, Max Planck Institute for Developmental Biology, Tübingen
1994 - 1995 Postdoc, ICMB, University of Edinburgh, Scotland, UK
Areas of activity
Preclinical development of biologics, Discovery, production, functionalization and cellular testing of remobinant binding molecules (anitbodies, anitbody-derivatives, nanobodies) for diagnostics molecular imaging (PET imaging) and therapeutic immunomodulation
Stages of career
2020 - present Scientist at Recombinant Antibody Technologies Group with Prof. Dr. Ulrich Rothbauer
2013 - 2020 Postdoc at University of Tuebingen, Pharmaceutical Biotechnology Group with Prof. Dr. Ulrich Rothbauer
2010 -2013 Dissertation (Dr. rer. nat.; PhD) at NMI / Universtiy of Tuebingen with Prof. Dr. Michael Schwarz and Prof. Dr. Stefan Laufer: "The Role of PLexin A4 in the regulation of proliferation and apoptosis of Prostate Cancer Cells".
2009 Diploma Thesis in Biochemistry at NMI, Molecular Biology Groupd with Frank Weise: "Suitability analysis of the proteins G2E3, CCAR1, GREB1 and Nur77 as biomarker or therapeutic target for oncotherapy"
2002 - 2009 Study of Biochemistry at the Eberhard Karls University in Tuebingen and Montana State University in Bozeman, USA (2005 - 2006)
Areas of activity
Molecular neurobiology, Development of patient-derived iPSC-based in vitro cell culture systems in 2D and 3D for the research of neurodegenerative and psychiatric diseases
Stages of career
2020 - Present Research Assistant in Molecular Biology and Neurobiology, NMI
2017 - 2019 Master of Science in Biomedical Sciences in Sigmaringen
2013- 2017 Bachelor of Science in Molecular and Technical Medicine in Villingen-Schwenningen
Areas of activity
Molecular mechanisms of neuronal plasticity
Stages of career
Since 1998 Head of the Molecular Biology Department
1994 - 1998 Postdoc at the Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany
1989 - 1994 Postdoctoral research fellow at the Center for Molecular Neurobiology, Hamburg
1989 PhD in Genetics, University of Tübingen, Germany
1979 - 1984 Study of Biology, University of Tübingen
Areas of activity
We focus on the analysis of cellular responses to gene expression in order to validate target genes for the pharmaceutical industry. Furthermore, we aim at developing improved cell culture models (co-culture, inflammatory response to exposure to hazardous substances), which, due to their more physiological nature, allow higher predictivity.
Stages of career
since 2009 Group leader of Target Expressions Systems
2002 - 2009 Head of laboratory in the Dept. of Molecular Biology
1998 - 2002 Post-doctoral fellow at the Max Planck Institute of Biology, Tübingen
1997 Doctoral degree at the Free University of Berlin (bacteriophage DNA replication)
1994 - 1996 Doctoral fellow at the National Centre of Biotechnology, Madrid, Spain
1987 - 1993 Student of biochemistry at the Free University of Berlin
Areas of activity
System integration of electronics and microfluidics for biological applications in , Lab on a Chip Systems, Microfluidics - Design,, Peripheral systems for dielectrophoresis and fluidic control,, rapid prototyping: 3D CAD (SolidWorks®), CAM/CAE, micro milling, AVT, opt. Sensors/ Measurement technology
Stages of career
since 2009 Part-time Master's degree in Electrical Engineering/ Information Technology, Open University in Hagen, Germany
since 2007 Scientific employee/engineer at the AG BioMEMS und Sensorik
2003 - 2007 Studied Mechatronics at the FH Reutlingen
2001 - 2006 Scintec AG, Atmospheric Measurement Technology
Areas of activity
Biomaterials for medical and biotechnological approaches, in particular collagen-based biomaterials for regenerative medicine and enzyme immobilization, Functional characterization using physical-chemical and biological methods, Practical experience in molecular biology with cloning, expression in bacteria, fungi and mammalian cells, PCR, RT-PCR., Physical methods: AFM, Raman spectroscopy, DSC, IR.
Stages of career
Since 2017 group leader biofunctionalized surfaces
Since Oct. 2014 Deputy Group Leader, Group Biomaterials, NMI; Focus: Biotechnology and Surface Characterization:
Since Sept. 2012 Project leader Biomaterials Group
Since April 2011 Scientist Biomaterials Group at the NMI
2009 - 2011 Scientist at the Institute for Experimental Internal Medicine, University Hospital Magdeburg, focus NF-kB signaling
2008 - 2009 Scientist at the Institute of Technical Biochemistry (Group Biocatalysis), University of Stuttgart, focus on mutagenesis and enzyme expression.
2005 - 2008 PhD at the Fraunhofer IGB & Biological Institute of the University of Stuttgart: New insights into Structure and Function of Type I Collagen
2004 - 2004 Diploma thesis at Fraunhofer IGB: Functional characterization of Tsa1p in Candida albicans
2002 - 2004 Studied technical biology at the University of Stuttgart
1996 - 2000 Study of Bioprocess Engineering at Huaqiao University, China
Areas of activity
Analytical chemistry with focus on chromatography and mass spectrometry of peptides and proteins, Detailed characterization of recombinant proteins and protein conjugates, Determination of identity / investigation of polyclonality, Determination of the coupling density of protein conjugates, High sensitivity sequence variant analysis, Determination of correct disulfide bridging, GlycosylationDetermination of N- and C-terminal modifications, Oxidation, deamidation, succinimide formation, glycation, etc., Epitope mapping using H/D exchange and top down mass spectrometry, Immunoanalytical methods for the production and characterization of antibodies
Stages of career
2007 - 2011 Group leader, Roche Diagnostics GmbH, Penzberg
2006 - 2007 Postdoc at Roche Diagnostics GmbH, Penzberg
2004 Postdoc at Barnett Institute of Chemical and Biological Analysis Northeastern University, Boston, USA
2001 Dr. rer. nat. in Analytical Chemistry, Technical University Munich (TUM)
1992 - 1998 Chemistry studies and Dipl. Chem. at the TU Karlsruhe and TUM
Areas of activity
Neurotechnologies and applications, CMOS - based neurochips, Parallel detection of neuronal activity with 16000 sensors, Capacitive stimulation of neuronal activity with capacitor arrays, Tissue analysis - chip coupling, multi-electrode arrays, Neuronal cell cultures (rat), Electrical stimulation, retina, Detection/analysis of extracellular activity in rabbit, rat and mouse retinas, Detection/analysis of single cell activity and field potentials in blind retinas, Electrical stimulation of healthy and blind retinas
Stages of career
Since 2020 Univ.Prof. TU Wien Institute of Electrodynamics, Microwave and Circuit Engineering
2010 -2020 Group leader at the NMI
2006 - 2010 Senior Postdoc, Max Planck Inst. Neurobiology, Martinsried
2003 - 2005 Postdoctoral researcher at Mass. General Hospital & Harvard Medical School, Boston, USA.
1998 - 2002 Dr. rer. nat., Biophysics, TU Munich & Max Planck Inst. Biochemistry
1992 - 1998 Physics studies at the TU Munich
