Prof. Dr. Hansjürgen Volkmer - NMI.de

Arbeitsgebiete

Molekulare Mechanismen neuronaler Plastizität

Werdegang mit den wichtigsten Stationen

1998 - heute Leiter des Bereiches Molekularbiologie

1994 - 1998 Postdoc am Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch

1989 - 1994 Postdoc am Zentrum für Molekulare Neurobiologie, Hamburg

1989 Promotion in Genetik, Universität Tübingen

1979 - 1984 Studium der Biologie, Universität Tübingen

Prof. Dr. Hansjürgen Volkmer

Diplom-Biologe

T +49 (0)7121 51530-44

E hansjuergen.volkmer@nmi.de

Projekte

Publikationen

Intra-amygdala metaplasticity modulation of fear extinction learning

Saha R., Kriebel M., Anunu R., Volkmer H., Richter-Levin G.

DOI: 10.1111/ejn.15080
Disruption of Amygdala Tsc2 in Adolescence Leads to Changed Prelimbic Cellular Activity and Generalized Fear Responses at Adulthood in Rats

Joly F, Jeckel P, Kriebel M, Raut S, El Massioui N, Vaillend C, Johnson LR, Volkmer H, Doyère V.

Cereb Cortex. 2022 Feb 12:bhab506. doi: 10.1093/cercor/bhab506. Epub ahead of print. PMID: 35149865.
Human iPSC-Derived Glia as a Tool for Neuropsychiatric Research and Drug Development

Heider J, Vogel S, Volkmer H and Breitmeyer R

Int. J. Mol. Sci. 2021
Autism Spectrum Disorder Risk Factor Met Regulates the Organization of Inhibitory Synapses

Jeckel P, Kriebel M, Volkmer H

Front. Mol. Neurosci., 13 May 2021 | https://doi.org/10.3389/fnmol.2021.659856
Functional brain defects in a mouse model of a chromosomal t(1;11) translocation that disrupts DISC1 and confers increased risk of psychiatric illness

Bonneau M, O' Sullivan ST, Gonzalez-Lozano MA, Baxter P, Gautier P, Marchisella E, Hardingham NR, Chesters RA, Torrance H, Howard DM, Jansen MA, McMillan M, Singh Y, Didier M, Koopmans F, Semple CA, McIntosh AM, Volkmer H, Loos M, Fox K, Hardingham GE, Vernon AC, Porteous DJ, Smit AB, Price DJ, Millar JK

Transl Psychiatry . 2021 Feb 19;11(1):135. doi: 10.1038/s41398-021-01256-3.
The potential of induced pluripotent stem cells for discriminating neurodevelopmental disorders

Stock R, Jeckel P, Kraushaar U, Wüst R, Fallgatter A, Volkmer H

STEM CELLS Transl Med. 2021;10:50-56. https://doi.org/10.1002/sctm.20-0206
Generation and characterization of human induced pluripotent stem cells lines from four patients diagnosed with schizophrenia and one healthy control

Stock R, Vogel S, Mau-Holzmann U, Kriebel M, Wüst R, Fallgatter A, Volkmer H

Stem Cell Research, 48 (2020) 101961, https://doi.org/10.1016/j.scr.2020.101961
Interference With Complex IV as a Model of Age-Related Decline in Synaptic Connectivity

Kriebel M, Ebel J, Battke F, Griesbach S, Volkmer H

Front. Mol. Neurosci., 2020 (13), https://doi.org/10.3389/fnmol.2020.00043
The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience

Ardi Z, Richter-Levin A, Xu L, Cao X, Volkmer H, Stork O, Richter-Levin G

Sci Rep. 2019 Sep 18;9(1):13513. doi: 10.1038/s41598-019-49824-4.
Comparative characterization of humaninduced pluripotent stem cells (hiPSC) derived from patients with schizophreniaand autism

Grunwald L-M, Stock R, Haag K, Buckenmaier S, Eberle M-C, Wildgruber D, Storchak H, Kriebel M, Weißgraeber S, Mathew L, Loos M, Li kw, Kraushaar U, Fallgatter AJ, Volkmer H

Translational Psychiatry (2019) 9:179
Neurofascin Knock Down in the Basolateral Amygdala Mediates Resilience of Memory and Plasticity in the Dorsal Dentate Gyrus Under Stress

Saha R, Kriebel M, Volkmer H, Richter-Levin G, Albrecht A

Molecular Neurobiology. 2018 Sept; 55(9): 7317-7326. DOI: 10.1007/s12035-018-0930-2
Perturbation of GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Induces Trans-regional Metaplasticity at the Medial Prefrontal Cortex

Saha R, Shrivastava K, Jing L, Schayek R, Maroun M, Kriebel M, Volkmer H, Richter-Levin G

Cereb Cortex. 2017 Nov; 9:1-16. doi: 10.1093/cercor/bhx300.
GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Projection Neurons Modulate Fear Extinction

Saha R, Knapp S, Chakraborty D, Horovitz O, Albrecht A, Kriebel M, Kaphzan H, Ehrlich I, Volkmer H, Richter-Levin G

Neuropsychopharmacology. 2017 Jan;42(2):473-484. doi: 10.1038/npp.2016.205. Epub 2016 Sep 16.
GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Projection Neurons Modulate Fear Extinction

Saha R, Knapp S, Chakraborty D, Horovitz O, Albrecht A, Kriebel M, Kaphzan H, Ehrlich I, Volkmer H, Richter-Levin G

Neuropsychopharmacology. 2017 Jan;42(2):473-484. doi: 10.1038/npp.2016.205. Epub 2016 Sep 16.
Receptor tyrosine kinase EphA7 is required for interneuron connectivity at specific subcellular compartments of granule cells

Beuter S, Ardi Z, Horovitz O, Wuchter J, Keller S, Saha R, Tripathi K, Anunu R, Kehat O, Kriebel M, Richter-Levin G, Volkmer H

Scientific Reports. 2016 July 13;6:29710
Dentate Gyrus Local Circuit is Implicated in Learning Under Stress-a Role for Neurofascin

Zitman FM, Lucas M, Trinks S, Grosse-Ophoff L, Kriebel M, Volkmer H, Richter-Levin G

Mol Neurobiol (2016) 53:842–850 DOI 10.1007/s12035-014-9044-7
Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells

Kaistha BP, Honstein T, Muller V, Bielak S, Sauer M, Kreider R, Fassan M, Scarpa A, Schmees C, Volkmer H, Gress TM, Buchholz, M

Br J Cancer. 2014 Oct 28;111(9):1780-7. doi: 10.1038/bjc.2014.460. Epub 2014 Aug 19.
Stress modulation of hippocampal activity - Spotlight on the dentate gyrus

Fa M, Xia L, Anunu R, Kehat O, Kriebel M, Volkmer H, Richter-Levin G

Neurobiol Learn Mem. 2014 Jul;112C:53-60. doi: 10.1016/j.nlm.2014.04.008. Epub 2014 Apr 18.
Organisation and Control of Neuronal Connectivity and Myelination by Cell Adhesion Molecule Neurofascin

Ebel J, Beuter S, Wuchter J, Kriebel M, Volkmer H

2014. in: Berezin V, Walmod P (eds). Cell Adhesion Molecules. Advances in Neurobiology, Springer New York. 8: 231-247
Regulation of Adhesion by Flexible Ectodomains of IgCAMs

Volkmer H, Schreiber J, Rathjen FG

Neurochem Res. 2013 Jun;38(6):1092-9. doi: 10.1007/s11064-012-0888-9. Epub 2012 Oct 9.
A Comprehensive Small Interfering RNA Screen Identifies Signaling Pathways Required for Gephyrin Clustering

Wuchter J, Beuter S, Treindl F, Herrmann T, Zeck G, Templin MF, Volkmer H

The Journal of Neuroscience. 2012 Oct 17; 32(42):14821–14834
Neurofascin: A switch between neuronal plasticity and stability

Kriebel M, Wuchter J, Trinks S, Volkmer H

Int J Biochem Cell Biol. 2012 May; 44(5): 694-697. doi: 10.1016/j.biocel.2012.01.012
Developmental dynamics of gap junction based neuronal coupling in the rat inferior olive

Mueller JR, Kriebel M, Volkmer H, Thier P

Neuroscience Meeting Planer. Washington DC: Society for Neuroscience, 2011.
Enhanced predictive drug development: Functional screening of the GABAAR alpha1 subunit using receptor-specific RNA inference, MEA recordings and substance classification

Bader BM, Kniest S, Jügelt K, Kriebel M, Volkmer H, Schroeder OH-U, Gramowski-Voss A

euroscience Meeting Planer. Program No. 41.13/E24. 2011. Washington, DC: Society for Neuroscience, 2011.
Developmental dynamics of gap junction based neuronal coupling in the rat interior olive

Mueller JR, Kriebel M, Volkmer H, Thier P

Neuroscience, 2011
The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment

Kriebel M, Metzger J, Trinks S, Chugh D, Harvey RJ, Harvey K, Volkmer H

J Biol Chem. 2011 Jul 8; 286(27): 24385–24393. doi: 10.1074/jbc.M110.212191
The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment

Kriebel M, Metzger J, Trinks S, Chugh D, Harvey RJ, Harvey K, Volkmer H

J Biol Chem. 2011 Jul 8; 286(27): 24385–24393. doi: 10.1074/jbc.M110.212191
Cell-based microarrays of infectious adenovirus encoding short hairpin RNA (shRNA)

Volkmer H, Weise F

Methods Mol Biol. 2011;706:97-106.
Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets

Swanton C, Larkin JM, Gerlinger M, Eklund AC, Boehme KA, Volkmer H, Howell M, Stamp G, Downward J, Gore M, Futreal PA, Escudier B, Andre F, Albiges L, Beuselinck B, Oudard S, Hoffmann J, Gyorffy B et al.

Genome Med. 2010 Aug 11;2(8):53. doi: 10.1186/gm174.
Analysis of Non-canonical Fibroblast Growth Factor Receptor 1 (FGFR1) Interaction Reveals Regulatory and Activating Domains of Neurofascin

Kirschbaum K, Kriebel M, Kranz EU, Poetz O, Volkmer H

J Biol Chem. 2009 Oct 16;284(42):28533-42. doi: 10.1074/jbc.M109.004440. Epub 2009 Aug 7.
A novel reverse transduction adenoviral array for the functional analysis of shRNA libraries

Oehmig A, Klotzbucher A, Thomas M, Weise F, Hagner U, Brundiers R, Waldherr D, Lingnau A, Knappik A, Kubbutat, MH, Joos TO, Volkmer H

BMC Genomics. 2008 Sep 24;9:441. doi: 10.1186/1471-2164-9-441.
Identification of NCAM-binding peptides promoting neurite outgrowth via a heterotrimeric G-protein-coupled pathway

Hansen RK, Christensen C, Korshunova I, Kriebel M, Burkarth N, Kiselyov VV, Olsen M, Ostergaard S, Holm A, Volkmer H, Walmod PS, Berezin V, Bock E

J Neurochem. 2007 Nov;103(4):1396-407. Epub 2007 Sep 13. DOI: 10.1111/j.1471-4159.2007.04894.x
Neurofascin regulates the formation of gephyrin clusters and their subsequent translocation to the axon hillock of hippocampal neurons

Burkarth N, Kriebel M, Kranz EU, Volkmer H

Mol Cell Neurosci. 2007 Sep;36(1):59-70. Epub 2007 Jun 27. DOI: 10.1016/j.mcn.2007.06.001
Combination of engineered neural cell adhesion molecules and GDF-5 for improved neurite extension in nerve guide concepts

Niere M, Braun B, Gass R, Sturany S, Volkmer H

Biomaterials. 2006 Jun;27(18):3432-40. Epub 2006 Feb 23. DOI: 10.1016/j.biomaterials.2006.01.037
A regulated switch of chick neurofascin isoforms modulates ligand recognition and neurite extension.

Pruss T, Kranz E U, Niere M, Volkmer H

Mol Cell Neurosci. 2006 Feb;31(2):354-65. Epub 2005 Nov 28. DOI: 10.1016/j.mcn.2005.10.009
Functional re-establishment of the perforant pathway in organotypic co-cultures on microelectrode arrays

Hofmann F, Guenther E, Hammerle H, Leibrock C, Berezin V, Bock E, Volkmer H

Brain Res. 2004 Aug 13;1017(1-2):184-96. DOI: 10.1016/j.brainres.2004.05.044
Homophilic interactions of chick neurofascin in trans are important for neurite induction

Pruss T, Niere M, Kranz EU, Volkmer H

Eur J Neurosci. 2004 Dec;20(11):3184-8. DOI: 10.1111/j.1460-9568.2004.03773.x

Zurück