Prof. Dr. Burkhard Schlosshauer

Forschungsschwerpunkte

  • Neuronale und Gefäß-Regeneration
  • Blut-Hirn schranke
  • Fibrose/Adhäsion
  • Regenerative Medizin
  • Implantatentwicklung

Wissenschaftlicher Werdegang mit den wichtigsten Stationen

NMI Leiter Regenerative Medizin I

Habilitation (Zellbiologie) Universität Tübingen apl. Professor, Universität Tübingen

Max-Planck-Gästelabor, Institut für Zellbiologie, Academia Sinica, Shanghai, China

Wissenschaftlicher Mitarbeiter, Max-Planck-Institut für Entwicklungsbiologie, Tübingen

Postdoktorand, Yale Universität, New Haven, USA

Studium Biochemie

Lehrtätigkeit

  • Graduate School of Cellular and Molecular Neurosciences
  • Studiengang Biologie (BSc, MSc) Universität Tübingen
  • sieben Lehrpreise

Prof. Dr. Burkhard Schlosshauer

Wissenschaftler Grenzflächenimmunologie
Diplom-Biochemiker
T +49 (0)7121 51530-20
F +49 (0)7121 51530-16

Publikationen

  • Fine-tuned PEGylation of chitosan to maintain optimal siRNA-nanoplex bioactivity
    Gutoaia A, Schuster L, Margutti S, Laufer S, Schlosshauer B, Krastev R, Stoll D, Hartmann H
    Carbohydr Polym. 2016 Jun 5;143:25-34. doi: 10.1016/j.carbpol.2016.01.010. Epub 2016 Jan 8.
  • miR-124 disinhibits neurite outgrowth in an inflammatory environment
    Hartmann H, Hoehne K, Rist E, Louw AM, Schlosshauer B
    Cell Tissue Res. 2015 Oct;362(1):9-20. doi: 10.1007/s00441-015-2183-y. Epub 2015 Apr 29.
  • Immunoliposomes for Targeted Delivery of an Antifibrotic Drug
    Schuster L, Seifert O, Vollmer S, Kontermann RE, Schlosshauer B, Hartmann H
    Mol Pharm. 2015 Sep 8;12(9):3146-57. doi: 10.1021/acs.molpharmaceut.5b00012. Epub 2015 Jul 28.
  • Immunoliposomes for Targeted Delivery of an Antifibrotic Drug
    Schuster L, Seifert, O, Vollmer S, Kontermann RE, Schlosshauer B, Hartmann H
    Mol Pharm. 2015 Sep 8;12(9):3146-57. doi: 10.1021/acs.molpharmaceut.5b00012. Epub 2015 Jul 28.
  • Polyelectrolyte multilayers as functional coatings for controlled biomolecular interactions
    Hartmann H, Schlosshauer B
    In: Biofunctional Surface Engineering. M. Scholz (Ed), Pan Stanford Publishing 2014: 27-46.
  • Cell-type specific four-component hydrogel
    Aberle T, Franke K, Rist E, Benz K, Schlosshauer B
    PLoS One. 2014 Jan 27;9(1):e86740. doi: 10.1371/journal.pone.0086740. eCollection 2014.
  • Prostate carcinoma cell growth-inhibiting hydrogel supports axonal regeneration in vitro
    Franke K, Baur M, Daum L, Vaegler M, Sievert KD, Schlosshauer B
    Neurosci Lett. 2013 Apr 29;541:248-52. doi: 10.1016/j.neulet.2013.01.057. Epub 2013 Feb 15.
  • Bioactive coronary stent coating based on layer-by-layer technology for siRNA release
    Hossfeld S, Nolte A, Hartmann H, Recke M, Schaller M, Walker T, Kjems J, Schlosshauer B, Stoll D, Wendel HP, Krastev R
    Acta Biomater. 2013 May; 9(5): 6741-6752. doi: 10.1016/j.actbio.2013.01.013.
  • The recombinant bifunctional protein alphaCD133-GPVI promotes repair of the infarcted myocardium in mice
    Baumer Y, Leder C, Ziegler M, Schonberger T, Ochmann C, Perk A, Degen H, Schmid-Horch B, Elvers M, Munch G, Ungerer M, Schlosshauer B, Gawaz M
    J Thromb Haemost. 2012 Jun;10(6):1152-64. doi: 10.1111/j.1538-7836.2012.04710.x.
  • The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice
    Ziegler M, Elvers M, Baumer Y, Leder C, Ochmann C, Schonberger T, Jurgens T, Geisler T, Schlosshauer B, Lunov O, Engelhardt S, Simmet T, Gawaz M
    Circulation. 2012 Feb 7;125(5):685-96. Epub 2012 Jan 5
  • Bioartificial reconstruction of peripheral nerves using the rat median nerve model
    Sinis N, Kraus A, Drakotos D, Doser M, Schlosshauer B, Muller HW, Skouras E, Bruck JC, Werdin F
    Ann Anat. 2011 Jul;193(4):341-6. Epub 2011 Mar 22. DOI 10.1016/j.aanat.2011.02.018
  • Neuronal and glial responses to siRNA-coated nerve guide implants in vitro
    Hoffmann N, Mittnacht U, Hartmann H, Baumer Y, Kjems J, Oberhoffner S, Schlosshauer B
    Neurosci Lett. 2011 Apr 20;494(1):14-8. Epub 2011 Feb 23. DOI 10.1016/j.neulet.2011.02.043
  • Telomerase-based immortalization modifies the angiogenic/inflammatory responses of human coronary artery endothelial cells
    Baumer Y, Scholz B, Ivanov S, Schlosshauer B
    Exp Biol Med (Maywood). 2011 Jun 1;236(6):692-700. DOI: 10.1258/ebm.2011.010300
  • Ex ovo culture: An in vivo model for microsensorarray implants
    Kubon M, Moschallski M, Link GS, Werner S, Burkhardt C, Nisch W, Scholz B, Schlosshauer B, Urban G, Stelzle M
    7th International Meeting on Substrate-Integrated Microelectrode Arrays Reutlingen, 2010, NMI, BioPro.
  • Bioengineered glial strands for nerve regeneration
    Nichterwitz S, Hoffmann N, Hajosch R, Oberhoffner S, Schlosshauer B
    Neurosci Lett. 2010 Oct 29;484(2):118-22. Epub 2010 Aug 17. doi: 10.1016/j.neulet.2010.08.028
  • Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth
    Mittnacht U, Hartmann H, Hein S, Oliveira H, Dong M, Pego AP, Kjems J, Howard KA, Schlosshauer B
    Nano Lett. 2010 Oct 13;10(10):3933-9. doi: 10.1021/nl1016909.
  • Does telomerase reverse transcriptase induce functional de-differentiation of human endothelial cells?
    Baumer Y, Funk D, Schlosshauer B
    Cell Mol Life Sci. 2010 Jul;67(14):2451-65. doi: 10.1007/s00018-010-0349-z. Epub 2010 Mar 30.
  • Suppression of adverse angiogenesis in an albumin-based hydrogel for articular cartilage and intervertebral disc regeneration
    Scholz B, Kinzelmann C, Benz K, Mollenhauer J, Wurst H, Schlosshauer B
    Eur Cell Mater. 2010 Jul 13;20:24-36; discussion 36-7.
  • A novel gelatin sponge for accelerated hemostasis
    Hajosch R, Suckfuell M, Oesser S, Ahlers M, Flechsenhar K, Schlosshauer B
    J Biomed Mater Res B Appl Biomater. 2010 Aug;94(2):372-9. doi: 10.1002/jbm.b.31663.
  • A novel microsurgical nerve implantation technique preserving outer nerve layers
    Hajosch R, Grupp L, Nichterwitz D, Schlosshauer B
    J Neurosci Methods. 2010 Jun 15;189(2):205-9. doi: 10.1016/j.jneumeth.2010.04.007. Epub 2010 Apr 14.
  • Strategies for inducing the formation of bands of Büngner in peripheral nerve regeneration
    Ribeiro-Resende VT, Koenig B, Nichterwitz S, Oberhoffner S, Schlosshauer B
    Biomaterials. 2009 Oct;30(29):5251-9. Epub 2009 Jul 26. doi: 10.1016/j.biomaterials.2009.07.007.
  • Nerve fibroblast impact on Schwann cell behavior
    Dreesmann L, Mittnacht U, Lietz M, Schlosshauer B
    Eur J Cell Biol. 2009 May;88(5):285-300. doi: 10.1016/j.ejcb.2009.01.001. Epub 2009 Feb 25.
  • Electrical stimulation-induced release of beta-endorphin from genetically modified neuro-2a cells.
    Storn V, Kirschbaum M, Schlosshauer B, Mack AF, Fricke C
    Cell Transplant. 2008;17(5):543-8.
  • Permeability testing of biomaterial membranes
    Dreesmann L, Hajosch R, Ahlers M, Nuernberger JV, Schlosshauer B
    Biomed Mater. 2008 Sep;3(3):034119. Epub 2008 Aug 15. doi: 10.1088/1748-6041/3/3/034119
  • Long nerve gaps limit the regenerative potential of bioartificial nerve conduits filled with Schwann cells
    Sinis N, Schaller H-E, Schulte-Eversum C, Becker ST, Schlosshauer B, Doser M, Rösner H, Dietz K, Müller H-W, Haerle M
    Restor Neurol Neurosci. 2007;25(2):131-41.
  • Nervenregeneration
    Schlosshauer B
    Zeitschrift für Regenerative Medizin. 2007 Feb; 1:45-49.
  • The pro-angiogenic characteristics of a cross-linked gelatin matrix.
    Dreesmann L, Ahlers M, Schlosshauer B
    Biomaterials. 2007 Dec;28(36):5536-43. Epub 2007 Sep 21. DOI: 10.1016/j.biomaterials.2007.08.040
  • Aging Schwann cells in vitro
    Funk D, Fricke C, Schlosshauer B
    Eur J Cell Biol. 2007 Apr;86(4):207-19. Epub 2007 Feb 20. DOI: 10.1016/j.ejcb.2006.12.006
  • Blood-retina barriers
    Schlosshauer B
    Handbook of Neurochemistry and Molecular Neurobiology 3rd Edition, Vol. 11 Neural Membranes and Transport (Ed. A. Lajtha and M.E.A Reith), Springer Publishers, New York, Springer Publishers N.Y., pages 486-506.
  • Neuro tissue engineering of glial nerve guides and the impact of different cell types.
    Lietz M, Dreesmann L, Hoss M, Oberhoffner S, Schlosshauer B
    Biomaterials. 2006 Mar;27(8):1425-36. Epub 2005 Sep 19. DOI: 10.1016/j.biomaterials.2005.08.007
  • Physical and biological performance of a novel block copolymer nerve guide.
    Lietz M, Ullrich A, Schulte-Eversum C, Oberhoffner S, Fricke C, Muller HW, Schlosshauer B
    Biotechnol Bioeng. 2006 Jan 5;93(1):99-109. DOI: 10.1002/bit.20688
  • Tissue engineering of peripheral nerves
    Sinis N, Schaller HE, Schulte-Eversum C, Schlosshauer B, Doser M, Dietz K, Rosner H, Muller HW, Haerle M
    Handchir Mikrochir Plast Chir. 2006 Dec;38(6):378-89. DOI: 10.1016/S0074-7742(09)87011-6
  • Differential impact of semaphorin 3E and 3A on CNS axons.
    Steffensky M, Steinbach K, Schwarz U, Schlosshauer B
    Int J Dev Neurosci. 2006 Feb;24(1):65-72. Epub 2005 Dec 9. DOI: 10.1016/j.ijdevneu.2005.10.007
  • Synthetic Nerve Guide Implants in Humans: A Comprehensive Survey
    Schlosshauer B, Dreesmann L, Schaller HE, Sinis N
    Neurosurgery. 2006 Oct;59(4):740-7; discussion 747-8.
  • Functional Characterization and Comparison of the Outer Blood-Retina Barrier and the Blood-Brain Barrier.
    Steuer H, Jaworski A, Elger B, Kaussmann M, Keldenich J, Schneider H, Stoll D, Schlosshauer B
    Invest Ophthalmol Vis Sci. 2005 Mar;46(3):1047-53.
  • Nerve regeneration across a 2-cm gap in the rat median nerve using a resorbable nerve conduit filled with Schwann cells.
    Sinis N, Schaller HE, Schulte-Eversum C, Schlosshauer B, Doser M, Dietz K, Rosner H, Muller HW, Haerle M
    J Neurosurg. 2005 Dec;103(6):1067-76. DOI: 10.3171/jns.2005.103.6.1067
  • The Blood-brain Barrier and the Outer Blood-retina Barrier
    Schlosshauer B, Steuer H
    Medicinal Chemistry Reviews - Online. 2005; 1:11-26.
  • In vitro model of the outer blood-retina barrier
    Steuer H, Jaworski A, Stoll D, Schlosshauer B
    Brain Res Brain Res Protoc. 2004 Apr;13(1):26-36. DOI: 10.1016/j.brainresprot.2003.12.002
  • Nerve Guides
    Schlosshauer B, Lietz M
    Encyclopedia of Biomaterials and Biomadical Engineering. 2004 p. 1043-1045, DOI: 10.1081/E-EBBE 120007361.
  • Patch-clamping of primary cardiac cells with micro-openings in polyimide films.
    Stett A, Bucher V, Burkhardt C, Weber U, Nisch W
    Med Biol Eng Comput. 2003 Mar;41(2):233-40.
  • Rat Schwann cells in bioresorbable nerve guides to promote and accelerate axonal regeneration
    Schlosshauer B, Muller E, Schroder B, Planck H, Muller HW
    Brain Res. 2003 Feb 14;963(1-2):321-6.
  • Glial and neuronal regulation of the lipid carrier R-FABP
    Helle T, Deiss S, Schwarz U, Schlosshauer B
    Exp Cell Res. 2003 Jul 1;287(1):88-97.