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Udo Kraushaar
Dr. Udo Kraushaar
Diplom-Biologe
Elektrophysiologie
Tel.: 07121 51530-851
Fax: 07121 51530-16

Arbeitsgebiete
Funktion und Dynamik von Ionenkanälen auf zellulärer Ebene und in organnahen Systemen (akute und organotypische Gewebepräparationen, Zellverbünde). Besonderer Schwerpunkt liegt in der Klärung neurobiologischer und cardiorelevanter Fragestellungen.

Werdegang mit den wichtigsten Stationen
Seit 2007    stellv. Gruppenleiter Elektrophysiologie
2004-2007    Wiss. Mitarbeiter  Universitätsklinik des Saarlandes, Molekulare Zellbiologie Prof. Lipp
2002-2004    Postdoctoral  Associate Yale University, USA, Neurobiology Prof. McCormick
2000-2002    Wiss. Mitarbeiter Universität Freiburg, Physiologie I  Prof. Jonas
1995-2000    Promotion über synaptische Übertragung im Hippocampus
1995        Diplom Biologie Universität Kaiserslautern, Zoologie Prof. Deitmer

Zusätzliche Literatur:
Viero, C., Kraushaar, U., Ruppenthal, S., Kaestner, L. & Lipp, P. A primary culture system for sustained expression of a calcium sensor in preserved adult rat ventricular myocytes. Cell Calcium 43, 59–71 (2008).
Hasenstaub, A., Shu Y-S., Haider, B., Kraushaar, U., Duque, A. & McCormick, D.A. Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks. Neuron 47, 423–435 (2005).
Hefft, S., Kraushaar, U., Geiger, J.R.P. & Jonas, P. Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus. J Physiol 539, 201–208 (2002)..    Kraushaar, U. & Backus, K.H. Characterization of GABA(A) and glycine receptors in neurons of the developing rat inferior colliculus. Pflugers Arch 445, 279–288 (2002).
Kraushaar, U. & Jonas, P. Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse. J Neurosci 20, 5594–5607 (2000).
Berger, T., Schwarz, C., Kraushaar, U. & Monyer, H. Dentate gyrus basket cell GABAA receptors are blocked by Zn2+ via changes of their desensitization kinetics: an in situ patch-clamp and single-cell PCR study. J Neurosci 18, 2437–2448 (1998).
Götz, T., Kraushaar, U., Geiger, J., Lübke, J., Berger, T. & Jonas, P. Functional properties of AMPA and NMDA receptors expressed in identified types of basal ganglia neurons. J Neurosci 17, 204–215 (1997).

Publikationen

Kraushaar, U., Guenther, E., Hess, D. (2017).
Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA)
Stem Cell-Derived Models in Toxicology. M. Clements and L. Roquemore. New York, NY, Springer New York: 293-309.

Rast, G., Kraushaar, U., Buckenmaier, S., Ittrich, C., Guth, B. D. (2016).
Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection
J Pharmacol Toxicol Methods. 2016 Nov - Dec;82:74-82. doi: 10.1016/j.vascn.2016.08.002. Epub 2016 Aug 9.

Only approximately one month after being leveled-up to MEA core-site for CiPA Myocyte study we were able to complete the cultivation, recording and analysis of hiPSC-derived cardiomyocytes from Axiogenesis and Cellular Dynamics on the Multiwell system from Multi Channel Systems MCS.
21.11.2016 - Data collection for CiPA Myocyte study finalized within one month

Rast G, Kraushaar U, Buckenmaier S, Ittrich C, Guth BD
Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection.
J Pharmacol Toxicol Methods. 2016 Aug 9;82:74-82. doi: 10.1016/j.vascn.2016.08.002. [Epub ahead of print]

Brun, J., Lutz, K. A., Neumayer, K. M., Klein, G., Seeger, T., Uynuk-Ool, T., Worgotter, K., Schmid, S., Kraushaar, U., Guenther, E., Rolauffs, B., Aicher, W. K., Hart, M. L. (2015).
Smooth Muscle-Like Cells Generated from Human Mesenchymal Stromal Cells Display Marker Gene Expression and Electrophysiological Competence Comparable to Bladder Smooth Muscle Cells
PLoS One. 2015 Dec 16;10(12):e0145153. doi: 10.1371/journal.pone.0145153. eCollection 2015.

Dettmann, H. M., Zhang, Y., Wronna, N., Kraushaar, U., Guenther, E., Mohr, R., Neckel, P. H., Mack, A., Fuchs, J., Just, L., Obermayr, F. (2014).
Isolation, expansion and transplantation of postnatal murine progenitor cells of the enteric nervous system
PLoS One. 2014 May 28;9(5):e97792. doi: 10.1371/journal.pone.0097792. eCollection 2014.

Schonecker, S., Kraushaar, U., Dufer, M., Sahr, A., Hardtner, C., Guenther, E., Walther, R., Lendeckel, U., Barthlen, W., Krippeit-Drews, P., Drews, G. (2014).
Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays
Integr Biol (Camb). 2014 Mar 24.

Hart, ML, Neumayer, KMH, Vaegler, M., Daum, L., Amend, B., Sievert, K. D., Di Giovanni, S., Kraushaar, U., Guenther, E., Stenzl, A., Aicher, W. K. (2013).
Cell-Based Therapy for the Deficient Urinary Sphincter
Curr Urol Rep

Gerwig, R., Fuchsberger, K., Schroeppel, B., Link, G.S., Heusel, G., Kraushaar, U., Schuhmann, W., Stett, A., Stelzle, M. (2012).
PEDOT–CNT composite microelectrodes for recording and electrostimulation applications: fabrication, morphology, and electrical properties
Front Neuroeng 5: 8.

Pfeiffer, T., Kraushaar, U., Düfer, M., Schönecker, S., Haspel, D., Günther, E., Drews, G., Krippeit-Drews, P. (2011)
Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays
Europ. J. Physiol., 462 (6): 835-840.

Mandenius, C. F., Steel, D., Noor, F., Meyer, T., Heinzle, E., Asp, J., Arain, S., Kraushaar, U., Bremer, S., Class, R., Sartipy, P. (2011)
Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review
J Appl Toxicol. 2011 Feb 16. doi: 10.1002/jat.1663.

Meyer, T., Stuerz, K., Guenther, E., Edamura, M., Kraushaar, U. (2010)
Cardiac slices as a predictive tool for arrhythmogenic potential of drugs and chemicals
Expert Opin Drug Metab Toxicol. 2010 Dec;6(12):1461-75. Epub 2010 Nov 11.

Radtke, C., Sinis, N., Sauter, M., Jahn, S., Kraushaar, U., Guenther, E., Rodemann, H.P., Rennekampff, H.O. (2011)
TRPV Channel Expression in Human Skin and Possible Role in Thermally Induced Cell Death
J Burn Care Res. 2011 Jan-Feb;32(1):150-9.

von Hauff E., Fuchs K., Hellmann D. Ch., Parisi J., Weiler R., Burkhardt C., Kraushaar U., Guenther E. (2010)
Biocompatible molecularly imprinted polymers for the voltage regulated uptake and release of l-glutamate in neutral pH solutions
Biosens Bioelectron. 2010 Oct 15;26(2):596-601. Epub 2010 Jul 16.

Kraushaar, U., Nagel, J., Meyer, T., Guenther, E. (2008)
Inhomogeneity of Cell Properties In The Cardiomyocyte Derived HL-1 Cell Line
Proceedings MEA Meeting 2008, Reutlingen, BioPro edition, Vol.5, p.186-187, ISBN 3-938345-05-5

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